Review
Cardiac & Cardiovascular Systems
Shiyuan Zhao, Wenxue Sun, Pei Jiang
Summary: The renin-angiotensin system (RAS) consists of two axes: the classic ACE/Ang II/AT1 axis, which regulates blood pressure, vascular oxidative stress, coagulation, and cellular proliferation, and the ACE2/Ang-(1-7)/Mas axis, which inhibits the former and improves fat metabolism, reduces inflammation and oxidative stress, enhances glucose tolerance and insulin sensitivity.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Jithin Kuriakose, Augusto C. Montezano, Rhian M. Touyz
Summary: ACE2 is a crucial protein in the renin-angiotensin system, responsible for regulating vascular tone and serving as the receptor for SARS-CoV and SARS-CoV-2. It plays a significant role in cardiovascular health and disease, potentially acting as a key mediator of vascular injury in COVID-19.
Review
Food Science & Technology
Wang Liao, Jianping Wu
Summary: Food protein-derived bioactive peptides, especially antihypertensive peptides, play an important role in regulating blood pressure through the ACE2/Ang (1-7)/MasR axis, demonstrating a new mechanism for reducing hypertension.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Taylor Morganstein, Zahraa Haidar, Joshua Trivlidis, Ilan Azuelos, Megan Jiaxin Huang, David H. Eidelman, Carolyn J. Baglole
Summary: Pulmonary fibrosis is a chronic lung disease affecting 3 million people worldwide, with a potential association with the ACE2/Ang-(1-7)/MasR axis due to its anti-fibrotic action. COVID-19 can lead to pulmonary fibrosis and is linked to smoking. Cannabis, similar to smoking, contains cannabinoids that may reduce inflammation and ACE2 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhongjie Wang, Wenhan Huang, Feifeng Ren, Lei Luo, Jun Zhou, Dongmei Huang, Mei Jiang, Huaan Du, Jinqi Fan, Lin Tang
Summary: The study demonstrated that Ang-(1-7) and AVE0991 can reduce inflammatory cytokine levels, inhibit joint inflammation and bone destruction, as well as alleviate myocardial interstitial fibrosis. Ang-(1-7) may mediate these effects through the Mas receptor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hang Pan, Wenhan Huang, Zhongjie Wang, Feifeng Ren, Lei Luo, Jun Zhou, Mengxue Tian, Lin Tang
Summary: The study showed that Ang-(1-7) inhibited pro-inflammatory cytokines while promoting anti-inflammatory cytokines, modulated macrophage polarization through the ACE2-Ang-(1-7)-MAS axis, and regulated TLR4 expression and NF-kappa B and MAPK pathways for anti-inflammatory effects. Additionally, splenomegaly and macrophage infiltration were observed in CLP-induced mouse models, with Ang-(1-7) effectively inhibiting M1 macrophage polarization.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Luan K. M. Souza, Kerolayne M. Nogueira, Thiago S. L. Araujo, Nayara A. Sousa, Francisca B. M. Sousa, Ana P. Oliveira, Thiago Sales, Karine Silva, Talita M. Rocha, Luzia K. A. M. Leal, Pedro J. C. Magalhaes, Marcellus H. L. P. Souza, Jand V. R. Medeiros
Summary: Activation of the ACE II pathway can reduce diarrhea by increasing Na+/K+-ATPase activity, decreasing gastrointestinal transit, and inhibiting contractions of intestinal smooth muscle, among other mechanisms. Therefore, activation of the ACE II/Ang-(1-7)/MasR axis may serve as an important pharmacological target for the treatment of diarrheal diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Virendra Tiwari, Jitendra Singh, Priya Tiwari, Swati Chaturvedi, Shivangi Gupta, Akanksha Mishra, Sonu Singh, Muhammad Wahajuddin, Kashif Hanif, Shubha Shukla
Summary: In this study, the role of the ACE2/Ang-(1-7)/Mas receptor axis in Alzheimer's disease (AD) was investigated using various methods. The results showed that activation of this axis could improve cognitive impairment and amyloid deposition in an AD-like rat model. These findings suggest the potential involvement of the ACE2/Ang-(1-7)/Mas axis in the pathophysiology of AD by regulating inflammation and cognitive functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Hongbing Fan, Wang Liao, Sandra T. Davidge, Jianping Wu
Summary: This study found that chicken muscle-derived peptide V-F can alleviate Ang II-induced inflammation in vascular smooth muscle cells through the ACE2/Ang (1-7)/MasR pathway, supporting its application in the prevention and treatment of hypertension and cardiovascular diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Runzhi Liu, Liying Zhong, Cong Wang, Yehai Sun, Wunjuan Ru, Wei Dai, Shengnan Yang, Aimin Zhong, XiuMei Xie, XiaoBin Chen, Shundong Li
Summary: MiR-3646 accelerates inflammatory response in Ang II-induced hVSMCs via the CYP2J2/EETs axis.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
J-X Xie, J. Hu, J. Cheng, C. Liu, X. Wei
Summary: This article reviews the role of the ACE2/Ang(1-7)/MasR axis in myocardial ischemia reperfusion injury and highlights its therapeutic potential.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Yan Wu, Xin Yang, Yuanyuan Ju, Fei Zhao
Summary: This study found that fraxinol has significant therapeutic effects in the treatment of acute lung injury (ALI). It works by balancing the ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas axis and inhibiting the activation of NLRP3 inflammasome.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Samuel N. Heyman, Thomas Walther, Zaid Abassi
Summary: Membrane-bound angiotensin converting enzyme (ACE) 2 acts as a receptor for the Sars-CoV-2 spike protein, allowing viral attachment to host cells. COVID-19 has shed light on the importance of ACE2 and Ang-(1-7), which may offer renoprotective effects in acute kidney injury (AKI) but could also have detrimental effects in certain conditions. Activation of the ACE2/Ang-(1-7)/MasR axis may provide renal protection in AKI patients.
JOURNAL OF CLINICAL MEDICINE
(2021)