Article
Oncology
Depei Kong, Chen Ye, Chenxi Zhang, Xiaochen Sun, Fubo Wang, Rui Chen, Guangan Xiao, Shipeng He, Jianrong Xu, Xiwu Rao, Jianzhong Ai, Xu Gao, Hong Li, Li Su
Summary: This study constructed a reporter gene system to screen compounds that could inhibit PCa-induced OB activation and found that Procoxacin effectively inhibits osteoblastic changes induced by PCa. It can directly kill OBs or suppress osteoclastic functions at low concentrations. Mechanism studies revealed that Procoxacin disrupts the feedback loop of the TGF-β/C-Raf/MAPK pathway and reduces osteogenic and osteolytic lesions in PCa-involved bones, leading to a decrease in metastases. This research provides a drug screening strategy based on the cancer-host microenvironment and demonstrates Procoxacin's potential as a therapeutic agent for PCa bone metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Xu Zhang, Peng Jiang, Chaojun Wang
Summary: Prostate cancer is unique in its ability to predominantly generate osteoblastic bone metastases, which account for over 90% of prostate cancer bone metastases. Prostate-specific antigen (PSA) plays a crucial role in this process by promoting osteomimicry of cancer cells, inhibiting osteoclast differentiation, and facilitating osteoblast proliferation and activation at metastatic sites. Furthermore, PSA activates osteogenic factors while suppressing osteolytic factors, contributing to the predominance of osteoblastic bone metastasis and bone remodeling in prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Kenjiro Kiyono, Shun Mabuchi, Akihisa Otaka, Yasuhiko Iwasaki
Summary: This article reports the potential of polyphosphodiesters (PPDEs) to enhance osteoblastic differentiation and target bone tissues in vivo. Two types of PPDEs, poly (ethylene sodium phosphate) (PEP center dot Na) and poly (propylene sodium phosphate) (PPP center dot Na), have been synthesized and shown to upregulate the gene expression of osteoblast-specific transcription factors in mouse osteoblastic-like cells. The mineralization of these cells is also enhanced by PPDEs with beta-glycerophosphate.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Oncology
Chuan-Yu Sun, Yuan-Yuan Mi, Sheng-Yang Ge, Qing-Feng Hu, Ke Xu, Yi-Jun Guo, Yi-Fan Tan, Yang Zhang, Fan Zhong, Guo-Wei Xia
Summary: This study explores the biological function of periostin (POSTN) in prostate cancer (PCa) bone metastasis. It is found that inhibiting POSTN can alleviate PCa bone metastasis and there is a positive feedback loop between PCa and osteoblasts mediated by POSTN. POSTN regulates PCa and osteoblast function through integrin receptors. These findings highlight the importance of targeting POSTN as a therapeutic approach for PCa bone metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Hyo Shik Shin, Hyun Jin Sun, Young Mi Whang, Young Joo Park, Do Joon Park, Sun Wook Cho
Summary: Metformin significantly reduced the viabilities of thyroid cancer cells and delayed tumor growth in bone metastasis. In the microenvironment of bone metastasis, metformin inhibited cancer cell growth, blocked cancer cell-induced osteoblastic RANKL production, which further activated osteoclastogenesis, and directly reduced osteoclast differentiation.
Article
Oncology
Kagenori Ito, Tomofumi Yamamoto, Yusuke Hayashi, Shun Sato, Jun Nakayama, Fumihiko Urabe, Takeo Shimasaki, Eijiro Nakamura, Yoshiyuki Matui, Hiroyuki Fujimoto, Takahiro Kimura, Shin Egawa, Takahiro Ochiya, Yusuke Yamamoto
Summary: Clinically, osteolytic phenotype is rare in prostate cancer, and the prognosis is worse than osteoblastic phenotype. SERPINA3 and LCN2 play roles in osteogenesis and tumor suppression in osteoblastic prostate cancer.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Shiyu Mao, Wentao Zhang, Fuhan Yang, Yadong Guo, Hong Wang, Yuan Wu, Ruiliang Wang, Niraj Maskey, Zongtai Zheng, Cheng Li, Wenchao Ma, Junfeng Zhang, Yang Yan, Xudong Yao
Summary: The study identified circ_0004296 as a circRNA associated with PCa metastasis through high-throughput RNA sequencing. Circ_0004296 was found to be downregulated in PCa tissues, blood, and urine, and its overexpression inhibited ETS1 expression, leading to the suppression of PCa metastasis. The downstream binding protein EIF4A3 was also identified as a potential therapeutic target for PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryo Kurokawa, Shimpei Kato, Hiroaki Koyama, Masanori Ishida, Mariko Kurokawa, Ryohei Kuroda, Tetsuo Ushiku, Haruki Kume, Osamu Abe
Summary: This study compares the clinical and CT imaging characteristics of prostate cancer patients with high-risk and intermediate-low-risk groups, focusing on bone metastases. The high-risk group shows significantly higher age, PSA levels, and frequencies of osteolytic or mixed bone metastases. This highlights the importance of considering high-risk prostate cancer in the differential diagnosis of bone metastases.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Endocrinology & Metabolism
Huai-Ching Tai, Shih-Wei Wang, Sanskruti Swain, Liang-Wei Lin, Hsiao-Chi Tsai, Shan-Chi Liu, Hsi-Chin Wu, Jeng-Hung Guo, Chun-Lin Liu, Yu-Wei Lai, Tien-Huang Lin, Shun-Fa Yang, Chih-Hsin Tang
Summary: Melatonin has been found to inhibit the migratory and invasive abilities of osteoblastic prostate cancer cells by targeting kinases and transcriptional activity, suggesting its potential as a therapeutic option for treating osteoblastic bone lesions in prostate cancer.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Guihuan Li, Mingming Fan, Zenan Zheng, Yihe Zhang, Zhishuai Zhang, Zhibin Huang, Wenyang Luo, Wanlu Zhao, Xiaoju Lai, Hua Chen, Fangyin Zeng, Fan Deng
Summary: Disseminated prostate cancer cells can go into a dormant state in the bone marrow with the help of osteoblastic PKD1/CREB1/GAS6 signaling. Dormant tumor cells are maintained in a non-proliferative state and can later develop into metastatic lesions. The circadian clock plays a crucial role in regulating the dormancy of prostate cancer cells. These findings provide insights into the mechanisms of tumor dormancy and highlight the potential importance of targeting circadian clock molecules for cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yoon-Hee Cheon, Chang Hoon Lee, Soojin Kim, Gyeong Do Park, Sung Chul Kwak, Hae Joong Cho, Ju-Young Kim, Myeung Su Lee
Summary: Pitavastatin shows potential as a candidate for treating osteoporosis by enhancing osteoblast differentiation and bone growth, as well as inhibiting osteoclast differentiation and bone resorption. Its mechanisms include inhibiting signaling pathways and downregulating transcription factors to regulate osteoclast activity, and stimulating osteoblast differentiation and mineralization to promote bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Ghaliah M. Alsawah, Mohammad Al-Obaida, Ebtissam M. Al-Madi
Summary: This study evaluated the effects of chitosan scaffold alone and in combination with simvastatin on immortalized human bone-marrow mesenchymal stem cells. The results showed that simvastatin impregnation led to a significant reduction in cell proliferation at day 14. However, there was no significant difference in osteoblastic differentiation among the experimental groups, indicating the potential regenerative capabilities of chitosan scaffold for bone-marrow mesenchymal stem cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Honghong Luo, Liyan Zou, Qian Yang, Cuiyun Yuan, Kun Ma, Shangpo Yang, Dehong Luo, Chenbin Liu, Zhou Liu
Summary: Enhanced spectral CT measurements are of great importance in differentiating OBM from BI and show a high correlation with plain spectral CT measurements.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Fan Wang, Petri Rummukainen, Terhi J. Heino, Riku Kiviranta
Summary: Wnt1 has been shown to play a crucial role in bone metabolism, influencing both early skeletal growth and adult bone formation. Deletion of Wnt1 in mesenchymal cells results in severe osteopenia and spontaneous fractures, indicating its importance in maintaining bone health throughout life.
Article
Orthopedics
Masayoshi Ishida, Naoyuki Kawao, Yuya Mizukami, Yoshimasa Takafuji, Hiroshi Kaji
Summary: This study demonstrates that Angptl1 suppresses osteoclast formation and enhances osteoblastic differentiation in mouse cells, while inhibiting adipogenic differentiation of 3T3-L1 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Kohei Taniguchi, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami Yamada, Nobuhisa Matsuhashi, Manabu Futamura, Yuko Ito, Yoshinori Otsuki, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Multidisciplinary Sciences
Kohei Taniguchi, Yuko Ito, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami Yamada, Yoshihito Nakagawa, Tarou Sugiyama, Manabu Futamura, Yoshinori Otsuki, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
SCIENTIFIC REPORTS
(2015)
Article
Oncology
Haruka Shinohara, Minami Kumazaki, Yosuke Minami, Yuko Ito, Nobuhiko Sugito, Yuki Kuranaga, Kohei Taniguchi, Nami Yamada, Yoshinori Otsuki, Tomoki Naoe, Yukihiro Akao
Article
Oncology
Nami Yamada, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Yukihiro Akao
Article
Oncology
Kohei Taniguchi, Miku Sakai, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami Yamada, Tatsushi Nakayama, Hiroshi Ueda, Yoshihito Nakagawa, Yuko Ito, Manabu Futamura, Bunji Uno, Yoshinori Otsuki, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
Editorial Material
Oncology
Nami O. Yamada
TRANSLATIONAL CANCER RESEARCH
(2016)
Article
Biology
Tuya Wang, Takanori Onouchi, Nami O. Yamada, Shuji Matsuda, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2017)
Article
Biology
Nami O. Yamada, Wenduerma, Shuji Matsuda, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Nami O. Yamada, Kazuki Heishima, Yukihiro Akao, Takao Senda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Chenguang Li, Takanori Onouchi, Masaya Hirayama, Kazuyoshi Sakai, Shuji Matsuda, Nami O. Yamada, Takao Senda
Summary: In this study, abnormal morphology of the hippocampus in APC(1638T/1638T) mice was found, and the failure of APC1638T to bind to AMPA-R and PSD-95 may result in reduced activity of hippocampal neurons in APC(1638T/1638T) mice.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Biology
Wenduerma, Nami O. Yamada, Tuya Wang, Takao Senda
Summary: The study reveals abnormalities in the proliferation and differentiation of intestinal stem cell lineages, as well as delayed shedding of apoptotic cells at the villus tips in APC1638T mice. These disruptions may contribute to the elongation of villi in the jejunum of APC1638T mice.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Review
Biology
Nami O. Yamada, Takao Senda
Summary: Recent studies have found that miRNAs are present in body fluids in a stable form, called circulating miRNAs, and are considered as mediators of intercellular communication like hormones and cytokines. Circulating miRNAs can be collected in a non-invasive manner and have been studied as potential biomarkers for various diseases, including cancers.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Correction
Biology
Nami O. Yamada, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Biology
Nami O. Yamada, Wenduerma, Takao Senda
Summary: In this study, we found that APC1638T mice exhibited large intestinal dysmotility and alterations in gut microbiota composition. We also observed over-activation of gut immune tissue. These findings contribute to our understanding of APC's functions in gastrointestinal motility and provide a basis for the development of novel therapies for gut dysmotility-related diseases.
MEDICAL MOLECULAR MORPHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuki Kuranaga, Nami Yamada, Maiko Kashiwaya, Moeko Nakamura, Lei Cui, Minami Kumazaki, Haruka Shinohara, Nobuhiko Sugito, Kohei Taniguchi, Yuko Ito, Tatsushi Nakayama, Bunji Uno, Akichika Itoh, Yukihiro Akao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)