Neuroprotective and anti-ageing role of leptin

Leptin: A Novel Therapeutic Strategy for Alzheimer's Disease

(2017) Nikolaos Tezapsidis et al.   JOURNAL OF ALZHEIMERS DISEASE

Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Steven J. Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipids and Cognition

(2017) John E. Morley et al.   JOURNAL OF ALZHEIMERS DISEASE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Brain-Derived Neurotrophic Factor, Food Intake Regulation, and Obesity

(2011) Haydeé Rosas-Vargas et al.   ARCHIVES OF MEDICAL RESEARCH

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol

(2011) Gurdeep Marwarha et al.   CELLULAR SIGNALLING

Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimers Disease

(2011) L. Arab et al.   Current Neuropharmacology

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Leptin, adiponectin, and resistin secretion and diurnal rhythmicity are unaltered in Parkinson's disease

(2011) Nasir Ahmad Aziz et al.   MOVEMENT DISORDERS

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

(2011) Peter R. Moult et al.   NEUROPHARMACOLOGY

Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis

(2011) Laszlo Otvos et al.   PEPTIDES

Towards a serotonin-dependent leptin roadmap in the brain

(2011) Franck Oury et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirtuin activators: Designing molecules to extend life span

(2010) Antoni Camins et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Leptin Reduces Infarct Size in Association with Enhanced Expression of CB2, TRPV1, SIRT-1 and Leptin Receptor

(2010) Yosefa Avraham et al.   CURRENT NEUROVASCULAR RESEARCH

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

(2010) Gurdeep Marwarha et al.   JOURNAL OF NEUROCHEMISTRY

Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

(2010) P. R. Moult et al.   JOURNAL OF NEUROSCIENCE

The relationship between body mass index and incidental mild cognitive impairment, Alzheimer’s disease, and Vascular Dementia in elderly

(2010) Huseyin Doruk et al.   Journal of Nutrition Health & Aging

Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

(2010) Peter R. Moult et al.   Cell Adhesion & Migration

Leptin and ghrelin concentrations and weight loss in Parkinson’s disease

(2009) U. Fiszer et al.   ACTA NEUROLOGICA SCANDINAVICA

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human IL6 enhances leptin action in mice

(2009) M. Sadagurski et al.   DIABETOLOGIA

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

30 Days of Continuous Olanzapine Infusion Determines Energy Imbalance, Glucose Intolerance, Insulin Resistance, and Dyslipidemia in Mice

(2009) Roberto Coccurello et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Cdk5/p35 Kinases Modulate Leptin-Induced STAT3 Signaling

(2009) Yi He et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Weight loss, body fat mass, and leptin in Parkinson's disease

(2009) Birgitta Lorefält et al.   MOVEMENT DISORDERS

Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

(2009) Steven J. Greco et al.   NEUROSCIENCE LETTERS

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells

(2009) Philip Wing-Lok Ho et al.   NEUROTOXICITY RESEARCH

Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells

(2008) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of a pharmacologically improved peptide agonist of the leptin receptor

(2008) Laszlo Otvos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Leptin protects hippocampal CA1 neurons against ischemic injury

(2008) Feng Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials

(2008) Armando P. Signore et al.   JOURNAL OF NEUROCHEMISTRY

Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice

(2008) Ebru Erbayat-Altay et al.   NEUROSCIENCE LETTERS

Leptin Is Induced in the Ischemic Cerebral Cortex and Exerts Neuroprotection Through NF-κB/c-Rel–Dependent Transcription

(2008) Alessandra Valerio et al.   STROKE

Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents

(2007) Lin Xu et al.   JOURNAL OF CLINICAL INVESTIGATION