期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 49, 期 3, 页码 R149-R156出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-12-0151
关键词
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资金
- Generalitat de Catalunya (autonomous government of Catalonia) [2009/SGR00853]
- Spanish Ministerio de Ciencia e Innovacion [BFU2010-19119/BFI, SAF2011-23631, SAF2009-13093]
- Instituto de Salud Carlos III [PS09/01789]
- Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo (CYTED) [610RT0405]
- SEP-CONACYT Grant [000177594]
Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downstream molecules involved in key pathways related to cell survival such as STAT3, PI3K, MAPK, AMPK, CDK5 and GSK3 beta. Collectively, these pathways act in a coordinated manner and form a network that is fully involved in Lep physiological response. Although the major interest in Lep is related to its role in the regulation of energy balance, and since resistance to Lep affects is the primary risk factor for obesity, the interest on their effects on brain cognition and neuroprotection is increasing. Thus, Lep and Lep mimetic compounds now await and deserve systematic exploration as the orchestrator of protective responses in the nervous system. Moreover, Lep might promote the activation of a cognitive process that may retard or even partially reverse selected aspects of Alzheimer's disease or ageing memory loss. Journal of Molecular Endocrinology (2012) 49, R149-R156
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