Article
Multidisciplinary Sciences
Sarathkumar Edachery, Prakash Patil, Rajashekar Mohan, Bhuvanesh Aradhya, Jayaprakash Shetty, Shama Prasada Kabekkodu, Manas Kumar Santra, Sathisha Jayanna Gonchigar, Praveenkumar Shetty
Summary: miR-936 is downregulated in metastatic prostate cancer, leading to the overexpression of its target gene ANXA2. miR-936 directly interacts with coding and 3'UTR regions of ANXA2 mRNA to regulate ANXA2 expression. Overexpression of miR-936 inhibits cell proliferation, migration, and invasion abilities in metastatic prostate cancer cells, and suppresses tumor formation in vivo. Therefore, miR-936 may serve as a targeted therapeutic molecule for metastatic prostate cancer control and prognosis improvement.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Wenting Pan, Zhouwei Zhang, Hannah Kimball, Fangfang Qu, Kyler Berlind, Konrad H. Stopsack, Gwo-Shu Mary Lee, Toni K. Choueiri, Philip W. Kantoff
Summary: The study revealed that treatment with AA increases pCREB1 levels, enhancing CBP/p300 activity, leading to global gene expression alterations and subsequent drug resistance development. Combining AA with therapies targeting resistance mechanisms may provide a more effective treatment strategy.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Zhao Wei, Song Wang, Yaning Xu, Wenzheng Wang, Fraser Soares, Musaddeque Ahmed, Ping Su, Tingting Wang, Elias Orouji, Xin Xu, Yong Zeng, Sujun Chen, Xiaoyu Liu, Tianwei Jia, Zhaojian Liu, Lutao Du, Yunshan Wang, Shaoyong Chen, Chuanxin Wang, Housheng Hansen He, Haiyang Guo
Summary: This study reveals that MYC interacts with CTCF protein and rewires the chromatin architecture in prostate cancer by modifying CTCF-mediated chromatin looping. MYC colocalizes with CTCF at certain genomic sites, enhancing CTCF occupancy and promoting CTCF-mediated chromatin looping, which disrupts the enhancer-promoter loops of genes related to neuroendocrine lineage plasticity.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Taewan Kim, Kwanyoung Jeong, Eunji Kim, Kwanghyun Yoon, Jinmi Choi, Jae Hyeon Park, Jae-Hwan Kim, Hyung Sik Kim, Hong-Duk Youn, Eun-Jung Cho
Summary: Menin plays a role in promoting tumor cell growth and metastasis in both AR-positive and AR-negative PCa cells. Inhibition of Menin significantly reduces the growth of PCa cells and induces apoptosis, regardless of the presence of AR. Transcriptome analysis shows that Menin inhibition disrupts the expression of many metastasis-associated genes in AR-negative cells, and Menin promotes cell migration in an AR-independent cellular context.
MOLECULES AND CELLS
(2022)
Article
Multidisciplinary Sciences
Nathalie Bock, Thomas Kryza, Ali Shokoohmand, Joan Rohl, Akhilandeshwari Ravichandran, Marie-Luise Wille, Colleen C. Nelson, Dietmar W. Hutmacher, Judith A. Clements
Summary: The all-human microtissue-engineered model of mineralized metastatic tissue plays a crucial role in understanding the bone tumor microenvironment and treatment response in mCRPC, with enzalutamide demonstrating better therapeutic efficacy compared to bicalutamide in a mineralized microenvironment.
Article
Cell Biology
Yueli Liu, Jiawen Wang, Corrigan Horton, Chuan Yu, Beatrice Knudsen, Joshua Stefanson, Kevin Hu, Ofir Stefanson, Jonathan Green, Charlene Guo, Qing Xie, Zhu A. Wang
Summary: This study reveals that stromal AR inhibits prostate cancer progression by restraining secretory luminal cells, and deletion of stromal AR exacerbates tumor progression and leads to changes in the cellular state of secretory luminal cells.
Article
Multidisciplinary Sciences
Haitham A. Elmarakeby, Justin Hwang, Rand Arafeh, Jett Crowdis, Sydney Gang, David Liu, Saud H. AlDubayan, Keyan Salari, Steven Kregel, Camden Richter, Taylor E. Arnoff, Jihye Park, William C. Hahn, Eliezer M. Van Allen
Summary: The development of a biologically informed deep learning model P-NET enables stratification of prostate cancer patients by treatment-resistance state and evaluation of molecular drivers of treatment resistance for therapeutic targeting with complete model interpretability. This approach shows superior performance in cancer state prediction using molecular data compared to other modeling approaches.
Article
Biochemistry & Molecular Biology
A. Cannistraci, P. Hascoet, A. Ali, P. Mundra, N. W. Clarke, V Pavet, R. Marais
Summary: This study explores the prognostic potential and functional role of miRs in prostate cancer, and identifies miR-378a and GLUT1 as potential therapeutic targets.
Article
Multidisciplinary Sciences
Sandor Spisak, Viktoria Tisza, Pier Vitale Nuzzo, Ji-Heui Seo, Balint Pataki, Dezso Ribli, Zsofia Sztupinszki, Connor Bell, Mersedeh Rohanizadegan, David R. Stillman, Sarah Abou Alaiwi, Alan B. Bartels, Marton Papp, Anamay Shetty, Forough Abbasi, Xianzhi Lin, Kate Lawrenson, Simon A. Gayther, Mark Pomerantz, Sylvan Baca, Norbert Solymosi, Istvan Csabai, Zoltan Szallasi, Alexander Gusev, Matthew L. Freedman
Summary: This study found that besides single-nucleotide polymorphisms (SNPs), other classes of polymorphisms may also be associated with disease risk. Through epigenome and genome editing, a specific type of multiple nucleotide length polymorphism (MNLP) was identified as the causal variant regulating the levels of a specific transcript. The study also discovered that MNLPs are candidate susceptibility variants at other prostate cancer risk loci. These results suggest the importance of investigating other classes of inherited variation as causal mediators of human traits in genome-wide association studies (GWAS).
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Aashika Sekar, Aaron Leiblich, S. Mark Wainwright, Claudia C. Mendes, Dhruv Sarma, Josephine E. E. U. Hellberg, Carina Gandy, Deborah C. I. Goberdhan, Freddie C. Hamdy, Clive Wilson
Summary: Sex hormones, like testosterone, play a crucial role in the development and growth of reproductive organs and prostate cancer. However, treatments that block the production of these hormones can result in the emergence of hormone-independent and lethal forms of the disease. In this study, researchers discovered that a fruit fly's steroid receptor can drive growth in the absence of hormone after mating, and this switch to steroid-independence is regulated by a gene equivalent to Retinoblastoma. Furthermore, they identified potential targets for suppressing this switch and preventing therapy-resistant tumors in humans.
Article
Cell Biology
Xiao Li, Fei Li, Fei Ye, Haotian Guo, Wentao Chen, Jia Jin, Yiran Wang, Pengfei Dai, Huili Shi, Hongru Tao, Wenzhen Dang, Yiluan Ding, Mingchen Wang, Hualiang Jiang, Kaixian Chen, Naixia Zhang, Dong Gao, Yuanyuan Zhang, Cheng Luo
Summary: In castration-resistant prostate cancer (CRPC), the limited response to androgen receptor (AR) antagonists is mainly attributed to the expression of AR-variants and restored AR signaling. We demonstrate that the metabolite spermine inhibits AR-FL and AR-V7 signaling and suppresses CRPC cell proliferation by directly binding and inhibiting PRMT1. Additionally, spermine supplementation restrains CRPC growth in vivo. Thus, spermine and PRMT1 inhibition may be powerful strategies for overcoming the limitations of current AR-based therapies in CRPC.
Article
Oncology
Jiaqian Liang, Liyang Wang, Larysa Poluben, Mannan Nouri, Seiji Arai, Lisha Xie, Olga S. Voznesensky, Laura Cato, Xin Yuan, Joshua W. Russo, Henry W. Long, Myles Brown, Shaoyong Chen, Steven P. Balk
Summary: In castration-resistant prostate cancer (CRPC), the splice variant ARv7 can function independently of the full length ARfl, with both contributing independently to overall AR activity.
Article
Biotechnology & Applied Microbiology
Dina Sabry, Samar Marzouk, Reem Zakaria, Heba A. Ibrahim, Mai Samir
BIOTECHNOLOGY LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Marwa Abdelgwad, Manal Ewaiss, Dina Sabry, Warda A. Khalifa, Zeinab M. Altaib, Maha Alhelf
Summary: This study examined the effects of BM-MSCs and UC-EPCs on the reversal of CCl4-induced hepatic injury. The results showed that the groups treated with BM-MSCs and UC-EPCs had increased albumin concentration and decreased ALT concentration compared to the untreated groups. The UC-EPCs treated group had significantly higher expression of MMP-2 and VEGF genes compared to the BM-MSCs treated group. Additionally, UC-EPCs were more effective than BM-MSCs in increasing HGF gene expression and immunohistochemistry of alpha-SMA and Ki-67. BM-MSCs had significantly lower TGF-beta expression compared to UC-EPCs.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Hend Ibrahim Shousha, Rabab Fouad, Tamer Mahmoud Elbaz, Dina Sabry, Mohamed Mahmoud Nabeel, Ahmed Hosni Abdelmaksoud, Aisha Mahmoud Elsharkawy, Zeinab Abdellatif Soliman, Ghada Habib, Ashraf Omar Abdelaziz
ARAB JOURNAL OF GASTROENTEROLOGY
(2020)
Correction
Biotechnology & Applied Microbiology
Dina Sabry, Samar Marzouk, Reem Zakaria, Heba A. Ibrahim, Mai Samir
BIOTECHNOLOGY LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Iman O. Sherif, Laila A. Al-Mutabagani, Dina Sabry, Nehal M. Elsherbiny
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Nehal S. Wahba, Rasha H. Abdel-Ghany, Salah A. Ghareib, Mohamed Abdel-Aal, Amira E. Alsemeh, Dina Sabry
Summary: The study investigates the nephroprotective effects of vildagliptin-metformin combination in an experimental model of fructose/salt-induced metabolic syndrome. It confirms the antioxidant, anti-inflammatory, and antifibrotic effects of the treatment, highlighting the potential of dipeptidyl peptidase-4 inhibition and sirtuin-1/5' adenosine monophosphate-activated protein kinase activation as therapeutic targets for renoprotection.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iman O. Sherif, Nora H. Al-Shaalan, Dina Sabry
Summary: The study investigated the therapeutic potential of BM-MSCs against CP-induced neurotoxicity, revealing that BM-MSCs could mitigate the biochemical and histopathological alterations induced by CP in a rat model. These findings suggest that BM-MSCs may serve as a promising neuroprotective agent against CP-induced neurotoxicity, providing a new treatment strategy for this condition.
Article
Dentistry, Oral Surgery & Medicine
Abir Tarek Mansour El-Mouelhy, Sherine Adel Nasry, Omnia Abou El-Dahab, Dina Sabry, Karim Fawzy El-Sayed
Summary: Cannabis and cigarettes smoke were found to induce DNA damage and cellular dedifferentiation in GF/G-MSCs of never smokers, negatively affecting cellular proliferation and viability; meanwhile, EC aerosol showed significantly lower impact on these properties.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Cell Biology
Nesrine Ebrahim, Omnia A. M. Badr, Mohamed M. Yousef, Amira Hassouna, Dina Sabry, Ayman Samir Farid, Ola Mostafa, Hajir A. Al Saihati, Yasmin Seleem, Eman Abd El Aziz, Ahmed Hassan Khalil, Ahmed Nawar, Ahmed A. Shoulah, Mohammad Aljasir, Amira Zaki Mohamed, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Mohamed Ahmed Eladl, Nicholas Robert Forsyth, Rabab F. Salim
Summary: This study successfully established three-dimensional liver organ scaffolds through decellularization and recellularization of rat livers, confirming the presence of ECM proteins and essential growth factors for liver regeneration. Upon seeding with iPSCs, the recellularized livers showed restored specific functions, including albumin secretion and urea synthesis.
Article
Biochemistry & Molecular Biology
Nesrine Ebrahim, Hajir A. Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman Abd El Aziz M. El Gebaly, Nashwa Hassan Abo-Rayah, Dina Sabry, Mohamed El-Sherbiny, Abdelmonem G. Madboly, Noha Ibrahim Hussien, Raja El Hasnaoui Saadani, Hasnaa Ali Ebrahim, Omnia A. M. Badr, Nehal M. Elsherbiny, Rabab F. Salim
Summary: This study aimed to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz-mediated cardiotoxicity model and elucidate the underlying mechanisms. The results showed that MSCs-derived exosomes could protect from and attenuate DOX/Trz-induced cardiotoxicity by modulating the NRG-1/HER2, MAPK, PI3K/AKT, PJNK/JNK, and PSTAT/STAT signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tasneem Soliman, Zoba Ali, Mohamed Zayed, Dina Sabry, Nermeen AbuBakr
Summary: This study demonstrated the potential effectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in treating osteoporosis.
DENTAL AND MEDICAL PROBLEMS
(2022)
Article
Pharmacology & Pharmacy
Fatma Y. Meligy, Hanan Sharaf El-Deen Mohammed, Tarek M. Mostafa, Mohamed M. Elfiky, Israa El-Sayed Mohamed Ashry, Ahmed M. Abd-Eldayem, Nermin Rizk, Dina Sabry, Eman S. H. Abd Allah, Salwa Fares Ahmed
Summary: This study compared the cardioprotective effects of mesenchymal stem cells (MSCs) and PUFAs in a rat model of gentamicin-induced cardiac degeneration. The results showed that both MSCs and PUFAs improved cardiac pathology, with MSCs showing higher efficacy compared to PUFAs. The protective effects were mediated through mechanisms involving cell proliferation and apoptosis.
Article
Chemistry, Medicinal
Heba F. F. Salem, Marwa Mohamed Abd El-Maboud, Amira S. A. Said, Mohamed Nabil Salem, Dina Sabry, Nadia Hussain, Omnia A. M. Abd El-Ghafar, Raghda R. S. Hussein
Summary: Nanomedicine is an important approach for targeting RA medication. The combination of methotrexate with gold nanoparticles can overcome the restrictions of methotrexate and improve its anti-arthritic effects.
Article
Genetics & Heredity
Heba Omar, Eman Obaya, Dina Sabry, Abeer Abdelkader, Moataz Maher, Dina Mekawy
Article
Pharmacology & Pharmacy
Hader Sakr, Akef A. Khowailed, Reham S. Al-Fakharany, Dina S. Abdel-Fattah, Ahmed A. Taha
REVIEWS ON RECENT CLINICAL TRIALS
(2020)