Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huimin Xu, Lingao Ju, Yaoyi Xiong, Mengxue Yu, Fenfang Zhou, Kaiyu Qian, Gang Wang, Yu Xiao, Xinghuan Wang
Summary: RNF126 is highly expressed in various cancers and acts as an oncogene in bladder cancer by promoting cell proliferation and metastasis through the EGFR/PI3K/AKT signaling pathway. It directly interacts with and regulates the stability of PTEN, an inhibitor of the PI3K/AKT pathway, through poly-ubiquitination. Knockdown of PTEN restores the effects of RNF126 silencing on cell proliferation, metastasis, and tumor formation in bladder cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A. Kim, Wooram Choi, Chae Young Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang, Han Gyung Kim, Young-Jun Jeon, Bokyoung Kim, Younghoon Kim, Kyung-Hee Kim, Byong Chul Yoo, Jeung-Whan Han, Narayana Parameswaran, Ji Hye Kim, Hoon Hur, Jae Youl Cho
Summary: The study explored the pathological role of a nonhistone methyltransferase in gastric cancer (GC), identified EEF1AKMT3 as a novel tumor suppressive methyltransferase, and revealed its mechanism of action through regulating the methylation of MAP2K7 and the degradation of TP53. The findings suggest potential targeted therapy in GC by manipulating the dysregulated EEF1AKMT3/MAP2K7/TP53 signaling axis.
Article
Genetics & Heredity
Prince Verma, Court K. M. Waterbury, Elizabeth M. Duncan
Summary: By analyzing the H3K4me3 signal on the planarian genome, it was found that Set1 plays a key role in creating this mark, with its depletion leading to abnormal stem cell phenotypes suggesting dysfunction of TSGs.
Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Article
Cell Biology
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M. E. Hozlem, Alexandros P. Drainans, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Summary: We developed a quantitative multiplexed approach based on lentiviral barcoding and CRISPR-Cas9-mediated genome editing to functionally study candidate regulators of tumor initiation and growth in small cell lung cancer (SCLC). Naphthalene pre-treatment enhanced lentiviral vector-mediated SCLC initiation and enabled high-throughput sequencing analysis of tumor clones. The analysis identified TSC1 in the PI3K-AKT-mTOR pathway as a robust tumor suppressor in SCLC. This approach will provide insight into drivers of SCLC and facilitate the development of precision therapies for specific SCLC genotypes.
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Clara Garcia-Vallicrosa, Juan M. Falcon-Perez, Felix Royo
Summary: The human CERS2 gene encodes a protein called CERS2, which has been found to have antitumor effects in various types of cancer, but promotes tumor growth in adenocarcinoma. This review focuses on the influence of CERS2 in bladder cancer, including its structure, activity, and the miRNAs that regulate its expression. Mechanistically, CERS2 may act as an antitumor protein through the production of long-chain ceramides, interaction with vacuolar ATPase, and inhibition of mitochondrial fission. Additionally, the expression of CERS2 in bladder cancer and its association with disease progression are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yilan Zhen, Macarena Pavez, Xinying Li
Summary: This review summarizes the role of Pcdh10 in neurological diseases and human cancers, emphasizing the importance of studying its properties for the development of targeted therapies. It also points out the need for further research to explore Pcdh10 functions in other pathways, cell types, and human pathologies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Fangdie Ye, Yingchun Liang, Zhang Cheng, Yufei Liu, Jimeng Hu, Weijian Li, Xinan Chen, Jiahao Gao, Haowen Jiang
Summary: Several studies have found a pathological imbalance of alternative splicing events in relation to cancer susceptibility. However, the association between heritable variation in splicing events and carcinogenicity has not been extensively explored. In this study, we analyzed data from The Cancer Genome Atlas database and identified 2751 prognostic-related splicing events. A risk model with seven prognostic-related splicing events was constructed, and it showed potential as an observation of immune infiltration and clinical response to immunotherapy. Our findings provide an important reference for further understanding the role of splicing events in the tumor microenvironment and immunotherapy efficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi, Dejun Huang
Summary: The study revealed that Cd-induced promoter hypermethylation of RASSF1A and DAPK1, decreasing their expression and leading to higher level of cell proliferation. Furthermore, Cd at low concentrations could influence DNA methylation, which may serve as the proliferative mechanism of Cd.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Colin F. Davenport, Tobias Scheithauer, Alessia Dunst, Frauke Sophie Bahr, Marie Dorda, Lutz Wiehlmann, Doan Duy Hai Tran
Summary: Downregulation of multiple tumor suppressor genes is crucial in cancer formation, with epigenetic modifications playing a significant role. Using nanopore sequencing technology, the study identified potential TSGs in HCC and demonstrated the tumor suppressor function of GCK in inhibiting HCC cell proliferation through lactate accumulation-induced energy crisis. These findings offer valuable insights for further understanding tumorigenesis in human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Article
Oncology
Chih-Ming Ho, Ting-Lin Yen, Tsai -Yen Chien, Shih-Hung Huang
Summary: CpG-island methylation plays a role in ovarian cancer progression and is associated with survival outcomes. Differential promoter methylation of tumor suppressor genes (TSGs) was observed, with RASSF1A hypomethylation and increased aggressiveness in mesenchymal-like OCSPCs. Overexpression of CCND2 and CDKN2B reduced the aggressiveness of mesenchymal-like OCSPCs and may serve as potential therapeutic targets for EOC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Brian M. Ortmann, Natalie Burrows, Ian T. Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise H. Jordon, Olivia Lombardi, Ana Penalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan
Summary: The histone H3K4 methyltransferase SET1B plays a crucial role in the transcriptional activity of HIF target genes, and its loss results in impaired cell growth and tumor formation. Experimental findings demonstrate that SET1B accumulates on chromatin in hypoxia and is recruited to HIF target genes by the HIF complex.
Article
Oncology
Juan Manuel Rubio Galisteo, Luis Fernandez, Enrique Gomez Gomez, Nuria de Pedro, Roque Cano Castineira, Ana Blanca Pedregosa, Ipek Guler, Julia Carrasco Valiente, Laura Esteban, Sheila Gonzalez, Nila Castello, Lissette Otero, Jorge Garcia, Enrique Segovia, Maria Jose Requena Tapia, Pilar Najarro
Summary: This study concludes that telomere-associated variables can serve as a new risk-score biomarker with the potential to enhance the predictive capacity of significant PCa in patients with PSA between 3-10 ng/ml.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Review
Urology & Nephrology
M. Alvarez-Maestro, F. Guerrero-Ramos, O. Rodriguez-Faba, J. L. Dominguez-Escrig, J. M. Fernandez-Gomez
Summary: For high-risk non-muscle invasive bladder cancer patients, ongoing research is exploring treatment options such as post-BCG failure drugs, microwave-induced chemohyperthermia, and electromotive drug administration.
ACTAS UROLOGICAS ESPANOLAS
(2021)
Review
Oncology
Antonio Lopez-Beltran, Alessia Cimadamore, Ana Blanca, Francesco Massari, Nuno Vau, Marina Scarpelli, Liang Cheng, Rodolfo Montironi
Summary: Several immune checkpoint inhibitors have been approved for the treatment of patients with metastatic urothelial carcinoma, showing promising efficacy in first-line or second-line therapy. PD-L1 expression may be a predictive factor for response to ICIs. Anti-PD-1 and PD-L1 antibodies have demonstrated durable responses in some mUC patients.
Review
Biochemistry & Molecular Biology
Jose Miguel Rivera-Caravaca, Anny Camelo-Castillo, Inmaculada Ramirez-Macias, Pablo Gil-Perez, Cecilia Lopez-Garcia, Maria Asuncion Esteve-Pastor, Esteban Orenes-Pinero, Antonio Tello-Montoliu, Francisco Marin
Summary: Peripheral artery disease (PAD) is often underestimated and undertreated, leading to dysregulated procoagulant, anticoagulant, and fibrinolytic pathways in patients. The combination of antiplatelets and anticoagulants has emerged as a potential alternative to antiplatelets alone, showing promising results in reducing cardiovascular outcomes without increasing bleeding risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Enrique Gomez-Gomez, Sara Moreno Sorribas, Jose Valero-Rosa, Ana Blanca, Juan Mesa, Joseba Salguero, Julia Carrasco-Valiente, Daniel Lopez-Ruiz, Francisco Jose Anglada-Curado
Summary: The study suggests that standard biopsy is crucial for detecting clinically significant prostate cancer in patients undergoing active surveillance, while adding standard biopsy does not increase the detection rate for PI-RADS 5 lesions. Targeted biopsy for PI-RADS 3 lesions is more effective in biopsy-naive patients and those with a previous negative biopsy history.
Article
Pathology
Antonio Lopez-Beltran, Ana Blanca, Alessia Cimadamore, Rodolfo Montironi, Rafael J. Luque, Metka Volavsek, Liang Cheng
Summary: This study aimed to categorize high-grade T1 bladder urothelial carcinoma into risk groups based on variant histology. The presence of variant histology was identified as a significant predictor of disease-free survival and cancer-specific survival in HGT1 bladder cancer. The study implies that treating micropapillary HGT1 urothelial carcinoma as a high-risk cancer is supported, and nested, glandular, and basaloid should also be considered high-risk due to their aggressive behavior and limited response to certain therapies.
Article
Multidisciplinary Sciences
Antonio Alcaraz, Alfredo Rodriguez-Antolin, Joaquin Carballido-Rodriguez, David Castro-Diaz, Jose Medina-Polo, Jesus M. Fernandez-Gomez, Vincenzo Ficarra, Joan Palou, Javier Ponce de Leon Roca, Javier C. Angulo, Manuel Esteban-Fuertes, Jose M. Cozar-Olmo, Noemi Perez-Leon, Jose M. Molero-Garcia, Antonio Fernandez-Pro Ledesma, Francisco J. Brenes-Bermudez, Jose Manasanch
Summary: In men with moderate to severe lower urinary tract symptoms associated with benign prostatic hyperplasia, treatment with tamsulosin and hexanic extract of Serenoa repens showed similar improvements in symptoms and quality of life, but tamsulosin had significantly more adverse effects.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Antonio Lopez-Beltran, Ana Blanca, Alessia Cimadamore, Rajan Gogna, Rodolfo Montironi, Liang Cheng
Summary: The study utilized NanoString technology to conduct gene expression analysis for molecular classification of bladder carcinoma, identifying three main subtypes - luminal, basal, and null/double negative. These subtypes showed significant differences in cancer-specific survival and other clinical parameters, potentially impacting patients' sensitivity to immunotherapy.
Review
Oncology
Alicia Cristina Pena-Romero, Esteban Orenes-Pinero
Summary: The relationship between the immune system and tumours is a crucial topic in cancer research. Immune cells in the tumour microenvironment can either support anti-tumour immunity or promote tumour progression. Understanding the influence of the tumour microenvironment on immune cells is essential for developing effective cancer treatments.
Article
Medicine, General & Internal
Antonio Alcaraz, David Castro-Diaz, Mauro Gacci, Andrea Salonia, Vincenzo Ficarra, Joaquin Carballido-Rodriguez, Alfredo Rodriguez-Antolin, Jose Medina-Polo, Jesus M. Fernandez-Gomez, Jose M. Cozar-Olmo, Santiago Bucar-Terrades, Noemi Perez-Leon, Francisco J. Brenes-Bermudez, Jose M. Molero-Garcia, Antonio Fernandez-Pro-Ledesma, Michael Herdman, Javier C. Angulo, Jose Manasanch
Summary: The objective of this study was to compare the efficacy and tolerability of two combination treatments for men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia. The results showed that treatment with TAM + HESr was as effective as TAM + 5ARI in a real-world setting, but with better tolerability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Ascension M. de los Reyes-Garcia, Jose Miguel Rivera-Caravaca, Laura Zapata-Martinez, Sonia Aguila, Andrea Veliz-Martinez, Nuria Garcia-Barbera, Pablo Gil-Perez, Pedro J. Guijarro-Carrillo, Esteban Orenes-Pinero, Cecilia Lopez-Garcia, Maria L. Lozano, Francisco Marin, Constantino Martinez, Rocio Gonzalez-Conejero
Summary: This study investigates the thromboinflammatory characteristics of acute coronary syndrome (ACS) in young patients. The results show that NETs and rs2431697 of miR-146a are related to the development and recurrence of cardiovascular pathology, and rs2431697 may predispose to adverse events in different cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Noemi Eiro, Antonio Medina, Luis O. Gonzalez, Maria Fraile, Ana Palacios, Safwan Escaf, Jesus M. Fernandez-Gomez, Francisco J. Vizoso
Summary: Men usually undergo a prostate needle biopsy after abnormal levels of serum prostate-specific antigen (PSA) or digital rectal exam. However, the traditional sextant technique misses a significant portion of cancers. To address this issue, the study evaluated the expression of matrix metalloproteases (MMPs) in prostate tissues using machine learning techniques. The findings showed that MMPs have higher expression in prostate cancer (PCa) compared to benign prostate tissues, suggesting their potential contribution to PCa diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ana Blanca, Antonio Lopez-Beltran, Kevin Lopez-Porcheron, Enrique Gomez-Gomez, Alessia Cimadamore, Andreia Bile-Silva, Rajan Gogna, Rodolfo Montironi, Liang Cheng
Summary: This study used NanoString technology to identify a set of genes predictive of clinical outcomes in bladder cancer patients. Two risk models were developed based on the molecular subtypes and expression levels of TP53, CCND1, and MKI67, which could be used to predict patient outcomes and guide treatment decisions.
Article
Oncology
Maria Frantzi, Zoran Culig, Isabel Heidegger, Marika Mokou, Agnieszka Latosinska, Marie C. Roesch, Axel S. Merseburger, Manousos Makridakis, Antonia Vlahou, Ana Blanca-Pedregosa, Julia Carrasco-Valiente, Harald Mischak, Enrique Gomez-Gomez
Summary: Prostate cancer is a common and deadly cancer in men. A biomarker model based on urinary peptides has been developed to detect prostate cancer without prior intervention, which shows good accuracy and has the potential to reduce invasive biopsies.
Review
Urology & Nephrology
J. Garcia Rodriguez, C. Gonzalez Ruiz de Leon, R. Sacristan Gonzalez, S. Mendez Ramirez, L. Modrego Ulecia, J. M. Fernandez-Gomez
Summary: This study examines the changes in the management of prostate cancer patients through individualized telematic care and establishes a classification system based on priorities to adapt to different stages of the disease. The findings suggest that telemedicine in prostate cancer provides a new opportunity for developing treatment and follow-up protocols to ensure patient safety and oncologic outcomes.
ACTAS UROLOGICAS ESPANOLAS
(2021)