Article
Peripheral Vascular Disease
Katarzyna Hackert, Susanne Homann, Shakila Mir, Arne Beran, Simone Gorressen, Florian Funk, Jens W. Fischer, Maria Grandoch, Joachim P. Schmitt
Summary: 4-MU can attenuate inflammation and extracellular matrix remodeling in pressure-overloaded myocardium by reducing both resident and invading cardiac macrophages, leading to reduced myocardial fibrosis. Additionally, 4-MU also reduces left ventricular hypertrophy and increases cardiac output after TAC surgery.
Review
Cell Biology
Xin Liu, Guo-Ping Shi, Junli Guo
Summary: Pressure overload and heart failure are major causes of cardiovascular morbidity and mortality, where innate immune cells and inflammatory mediators play crucial roles. Different innate immune cells, including mast cells, macrophages, monocytes, neutrophils, dendritic cells, eosinophils, and natural killer T cells, exhibit varying levels of activity in these pathological processes, with some exacerbating cardiodysfunction and others displaying cardioprotective activities. Overall, immune regulation of cardiac innate immune cells holds promise as a therapeutic approach in experimental cardiac disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Lin Zhao, Xian-yun Jiang, Jing-jing Zhang, Jia-min Gou, Xiao-yu Yu, Shu-jin Wu, Lei Li
Summary: Apoptosis, or programmed cell death, plays a critical role in the development of heart failure. Sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, has been shown to inhibit apoptosis in myofibroblasts, non-muscle cells in the heart. In this study, the researchers investigated the role of the SPC receptor, calmodulin (CaM), in cardiomyocyte apoptosis and the associated signaling pathways. They found that SPC administration improved survival rate, cardiac hypertrophy, and cardiac fibrosis in mice with pressure overload-induced heart failure. In cardiomyocytes, SPC treatment inhibited cardiomyocyte hypertrophy, fibroblast-to-myofibroblast transition, and cell apoptosis. This was accompanied by reduced levels of pro-apoptotic proteins and phosphorylation of CaM, JNK, and p38, as well as increased levels of a cardiomyocyte-protective protein. The protective effect of SPC was annulled by a compound that increased CaM function. The researchers also demonstrated that SPC-mediated inhibition of cardiomyocyte apoptosis involved the regulation of p38 and JNK phosphorylation, which was downstream of CaM. These findings provide new evidence for SPC regulation of cardiomyocyte apoptosis and suggest it as a potential therapeutic target for cardiac remodeling following stress overload.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Lang Jiang, Lingyun Ren, Xin Guo, Jing Zhao, Hao Zhang, Shanshan Chen, Sheng Le, Hao Liu, Ping Ye, Manhua Chen, Jiahong Xia
Summary: The study revealed that DUSP9 plays a crucial role in cardiac hypertrophy, alleviating it by repressing ASK1, making it a promising prospective target for treating cardiac hypertrophy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lu Chen, Mingjue Li, Mengjia Shen, Yingqi Zhu, Kaitong Chen, Xiaoxia Huang, Cankun Zheng, Qiancheng Wang, Hairuo Lin, Wangjun Liao, Jianping Bin, Siyuan Ma, Yulin Liao
Summary: This study aims to explore potential common therapeutic targets for left ventricular hypertrophy (LVH) and right ventricular hypertrophy (RVH), and screen potential target drugs for further study. Through bioinformatics analysis and validation in mouse models, several hub genes associated with cardiac remodeling are identified. Dehydroisoandrosterone (DHEA) is identified as a potential therapeutic drug targeting both LVH and RVH.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Peripheral Vascular Disease
Preetinder K. K. Aujla, Mei Hu, Bridgette Hartley, Joshua W. W. Kranrod, Anissa Viveiros, Tolga Kilic, Caroline A. A. Owen, Gavin Y. Y. Oudit, John M. M. Seubert, Olivier Julien, Zamaneh Kassiri
Summary: ADAM15 plays a role in suppressing myocardial hypertrophy in pressure overload cardiomyopathy by regulating the interaction between integrins and laminin, as well as the calcineurin pathway. Loss of ADAM15 leads to worsened hypertrophy and dilation in a mouse model of cardiomyopathy. This study provides new insights into the pathogenesis of cardiomyopathies.
Article
Biochemistry & Molecular Biology
Shuaishuai Zhang, Jipeng Ma, Xiaowu Wang, Diancai Zhao, Jinglong Zhang, Liqing Jiang, Weixun Duan, Xiaoya Wang, Ziwei Hong, Zilin Li, Jincheng Liu
Summary: Post-menopausal women have a higher incidence of heart failure, which is mainly caused by cardiac hypertrophy and fibrosis, indicating a cardioprotective role of estrogen. The novel estrogen receptor G Protein Coupled Receptor 30 (GPR30) can attenuate myocardial fibrosis caused by ischemic heart disease, but its role in myocardial hypertrophy in ovariectomized mice has not been studied. This study found that G1, the specific agonist of GPR30, can attenuate myocardial hypertrophy and fibrosis in ovariectomized mice through AKT/mTOR mediated inhibition of autophagy, suggesting a potential drug treatment option for pressure overload-induced cardiac hypertrophy in postmenopausal women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, Istvan Baczko, Christoph Knosalla, Matthieu-P Schapranow, Gunnar Dittmar, Michael Gotthardt, Martin Falcke, Vera Regitz-Zagrosek, Titus Kuehne, Philipp Mertins
Summary: Pressure overload and volume overload in heart valve diseases lead to specific forms of cardiac remodeling. Proteome profiling of human left ventricular myocardial biopsies revealed differences in protein composition compared to controls, particularly in the areas of extracellular matrix, cytoskeleton, energy metabolism, and proteostasis. Sex-specific differences were also observed. These findings provide insight into the molecular mechanisms of cardiac remodeling in patients with heart valve diseases, which could help in developing personalized treatment strategies.
LIFE SCIENCE ALLIANCE
(2023)
Article
Multidisciplinary Sciences
Fabian Peisker, Maurice Halder, James Nagai, Susanne Ziegler, Nadine Kaesler, Konrad Hoeft, Ronghui Li, Eric M. J. Bindels, Christoph Kuppe, Julia Moellmann, Michael Lehrke, Christian Stoppe, Michael T. Schaub, Rebekka K. Schneider, Ivan Costa, Rafael Kramann
Summary: This study investigates the cellular heterogeneity and transcriptomic changes in the cardiac vascular and perivascular niche during heart failure. The researchers identify specific fibroblast and endothelial cell subpopulations that play important roles in cardiac fibrosis and response to injury, respectively. The findings contribute to a better understanding of hypertrophic cardiac remodeling.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Jihoon Nah, Akihiro Shirakabe, Risa Mukai, Peiyong Zhai, Eun Ah Sung, Andreas Ivessa, Wataru Mizushima, Yasuki Nakada, Toshiro Saito, Chengchen Hu, Yong Keun Jung, Junichi Sadoshima
Summary: This study found that Ulk1-mediated alternative mitophagy is a major mechanism mediating mitophagy in response to pressure overload in the heart. It plays an important role in mediating mitochondrial quality control mechanisms and protecting the heart against cardiac dysfunction.
CARDIOVASCULAR RESEARCH
(2022)
Article
Genetics & Heredity
Leiming Wu, Meng Jia, Lili Xiao, Zheng Wang, Rui Yao, Yanzhou Zhang, Lu Gao
Summary: TRIM44 aggravates pressure overload-induced cardiac hypertrophy via increasing TLR4-NOX4 associated ferroptosis. Targeting TRIM44 may become a new therapeutic method for preventing or treating pressure overload-induced cardiac hypertrophy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Immunology
Jin Bu, Shiyuan Huang, Jue Wang, Tong Xia, Hui Liu, Ya You, Zhaohui Wang, Kun Liu
Summary: Myocardial macrophages play crucial roles in cardiac remodeling and dysfunction. Activation of the GABA(A) receptor exacerbates myocardial hypertrophy and fibrosis, while blockade of the receptor may reverse these effects and improve pressure overload-induced heart failure.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eveliina Halmetoja, Irina Nagy, Zoltan Szabo, Tarja Alakoski, Raisa Yrjola, Laura Vainio, Eliina Viitavaara, Ruizhu Lin, Lea Rahtu-Korpela, Seppo Vainio, Risto Kerkela, Johanna Magga
Summary: Wnt11 is involved in early cardiac development and left ventricular compaction, but its role in postnatal cardiac maturation and response to stress in the adult heart is not well understood. This study found that Wnt11 deficiency does not affect cardiomyocyte proliferation or maturation, but does lead to enlargement of the heart. Additionally, Wnt11 deficiency does not exacerbate cardiac hypertrophy or remodeling in response to pressure overload.
Article
Biochemistry & Molecular Biology
Annakaisa Tirronen, Nicholas L. Downes, Jenni Huusko, Johanna P. Laakkonen, Tomi Tuomainen, Pasi Tavi, Marja Hedman, Seppo Yla-Herttuala
Summary: Experimental studies have shown that VEGFR-1 signaling plays a crucial role in cardiac remodeling during pressure overload, and its deficiency leads to changes in LVH and increased risk of sudden death.
Article
Cell Biology
Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu
Summary: This study reveals the association between miR-21 and pressure overload-induced cardiac remodeling in aged hearts. It suggests the potential therapeutic role of miR-21 in treating cardiac diseases in elderly individuals.
Article
Cardiac & Cardiovascular Systems
Detmar Kolijn, Steffen Pabel, Yanna Tian, Maria Lodi, Melissa Herwig, Albino Carrizzo, Saltanat Zhazykbayeva, Arpad Kovacs, Gabor A. Fulop, Ines Falcao-Pires, Peter H. Reusch, Sophie Van Linthout, Zoltan Papp, Loek van Heerebeek, Carmine Vecchione, Lars S. Maier, Michele Ciccarelli, Carsten Tschoepe, Andreas Muegge, Zsolt Bagi, Samuel Sossalla, Nazha Hamdani
Summary: This study demonstrated that empagliflozin reduces inflammation and oxidative stress in patients with HFpEF, thereby improving the NO-sGC-cGMP cascade and PKGI alpha activity. This leads to a decrease in pathological cardiomyocyte stiffness in HFpEF.
CARDIOVASCULAR RESEARCH
(2021)
Article
Critical Care Medicine
Maria Tafelmeier, Lili Luft, Elisabeth Zistler, Bernhard Floerchinger, Daniele Camboni, Marcus Creutzenberg, Florian Zeman, Christof Schmid, Lars Siegfried Maier, Stefan Wagner, Michael Arzt
Summary: Patients with sleep-disordered breathing are more likely to experience postoperative major pulmonary complications following cardiac surgery, with central sleep apnea, heart failure, and a history of transient ischemic attack or stroke significantly associated with these complications.
Article
Cardiac & Cardiovascular Systems
Christoph Fisser, Kristina Goetz, Andrea Hetzenecker, Kurt Debi, Florian Zeman, Okka W. Hamer, Florian Poschenrieder, Claudia Fellner, Stefan Stadler, Lars S. Maier, Michael Pfeifer, Stefan Buchner, Michael Arzt
Summary: The study found that within the first 12 weeks after acute myocardial infarction, obstructive sleep apnoea (OSA) was associated with cardiac spheric remodelling, while central sleep apnoea (CSA) and no sleep-disordered breathing (no SDB) were not. This suggests that negative intrathoracic pressure swings related to OSA may contribute to cardiac remodelling after acute myocardial infarction.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sabine Julia Maria Sag, Karin Menhart, Jirka Grosse, Florian Hitzenbichler, Frank Hanses, Arno Mohr, Bernd Salzberger, Matthaus Zerdzitzki, Michael Hilker, Leopold Rupprecht, Dirk Hellwig, Christof Schmid, Lars Siegfried Maier, Can Martin Sag
Summary: This study assessed the diagnostic value of FDG PET/CT in surgically managed IE patients. Results showed that combining FDG PET/CT with Duke criteria can increase the diagnostic sensitivity in PVE patients, with patients having false-negative scans observed to have higher prosthesis age.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christoph Fisser, Stefan Colling, Kurt Debl, Andrea Hetzenecker, Ulrich Sterz, Okka W. Hamer, Claudia Fellner, Lars S. Maier, Stefan Buchner, Michael Arzt
Summary: The study found that patients with acute myocardial infarction have higher volume of epicardial adipose tissue (EAT) compared to healthy individuals. High EAT is associated with more microvascular obstruction, greater ST-deviation, and larger infarct size.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yoichi Imori, Ken Kato, Victoria L. Cammann, Konrad A. Szawan, Manfred Wischnewsky, Sara Dreiding, Michael Wuerdinger, Maximilian Schoenberger, Vanya Petkova, David Niederseer, Rena A. Levinson, Davide Di Vece, Sebastiano Gili, Burkhardt Seifert, Masaki Wakita, Noriko Suzuki, Rodolfo Citro, Eduardo Bossone, Susanne Heiner, Maike Knorr, Thomas Jansen, Thomas Muenzel, Fabrizio D'Ascenzo, Jennifer Franke, Ioana Sorici-Barb, Hugo A. Katus, Annahita Sarcon, Jerold Shinbane, L. Christian Napp, Johann Bauersachs, Milosz Jaguszewski, Reiko Shiomura, Shunichi Nakamura, Hitoshi Takano, Michel Noutsias, Christof Burgdorf, Iwao Ishibashi, Toshiharu Himi, Wolfgang Koenig, Heribert Schunkert, Holger Thiele, Behrouz Kherad, Carsten Tschope, Burkert M. Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Shingo Mizuno, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Hiroki Mochizuki, Alexander Pott, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Adrian Banning, Toshiaki Isogai, Akihisa Kimura, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Yasuhiro Tomita, Monika Budnik, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Tsutomu Murakami, Yuji Ikari, Klaus Empen, Daniel Beug, Stephan B. Felix, Clement Delmas, Olivier Lairez, Tetsuo Yamaguchi, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, John D. Horowitz, Martin Kozel, Petr Tousek, Petr Widimsky, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Michael Neuhaus, Philippe Meyer, Jose David Arroja, Christina Chan, Paul Bridgman, Jan Galuszka, Gregor Poglajen, Pedro Carrilho-Ferreira, Fausto J. Pinto, Christian Hauck, Lars S. Maier, Kan Liu, Carlo Di Mario, Carla Paolini, Claudio Bilato, Matteo Bianco, Lucas Joerg, Hans Rickli, David E. Winchester, Christian Ukena, Michael Boehm, Jeroen J. Bax, Abhiram Prasad, Charanjit S. Rihal, Shigeru Saito, Yoshio Kobayashi, Thomas F. Luscher, Frank Ruschitzka, Wataru Shimizu, Jelena R. Ghadri, Christian Templin
Summary: This study compared clinical characteristics and in-hospital outcomes between Japanese and European takotsubo syndrome (TTS) patients, revealing differences in triggers and outcomes between the two ethnic groups. Despite worse in-hospital outcomes for Japanese patients, ethnicity itself does not appear to impact TTS patient outcomes. Machine learning analysis identified physical stressors as the most important prognostic factor for both Japanese and European TTS patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sabine J. M. Sag, Christina Strack, Judith Zeller, Margareta Mohr, Thomas Loew, Claas Lahmann, Lars S. Maier, Marcus Fischer, Andrea Baessler
Summary: This study investigated whether long-term successful weight reduction can reverse endothelial activation in individuals with obesity. The results showed that successful weight reduction led to greater improvements in inflammation and endothelial adhesion markers compared to individuals with obesity who did not achieve significant weight loss.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Stefanie Reynen, Michael Schlossbauer, Ute Hubauer, Julian Hupf, Arno Mohr, Evelyn Orso, Markus Zimmermann, Andreas Luchner, Lars S. Maier, Stefan Wallner, Carsten G. Jungbauer
Summary: This study found that urinary NT-proBNP provides significant predictive value in patients with acute chest pain and ACS, with a strong positive correlation with plasma NT-proBNP. Additionally, both urinary and plasma NT-proBNP were significant predictors for mortality and major adverse cardiac events in the entire study cohort and ACS subgroup.
Article
Biochemistry & Molecular Biology
Michael Arzt, Marzena A. Drzymalski, Sarah Ripfel, Sebastian Meindl, Alexander Biedermann, Melanie Durczok, Karoline Keller, Julian Mustroph, Sylvia Katz, Maria Tafelmeier, Simon Lebek, Bernhard Floerchinger, Daniele Camboni, Sigrid Wittmann, Johannes Backs, Christof Schmid, Lars S. Maier, Stefan Wagner
Summary: Patients with sleep-disordered breathing (SDB) have increased oxidized and activated CaMKII levels and CaMKII-dependent Ca spark frequency in the atrial myocardium, independent of major clinical confounders.
Article
Medicine, Research & Experimental
Manar Elkenani, Amal Z. Barakat, Torsten Held, Daniel Marques Rodrigues, Sherok Mobarak, Surabhi Swarnka, Ibrahim M. Adham, Belal A. Mohamed
Summary: This study reveals the crucial role of heat shock protein A4 (HSPA4) in maintaining skeletal muscle integrity. HSPA4 deficiency leads to myopathy and affects muscle autophagy and apoptosis. These findings may provide a novel therapeutic strategy for skeletal muscle diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Stefan Buchner, Michael Wester, Sarah Hobelsberger, Christoph Fisser, Kurt Debl, Andrea Hetzenecker, Okka W. Hamer, Florian Zeman, Lars S. Maier, Michael Arzt
Summary: Sleep-disordered breathing, particularly obstructive sleep apnea, may impair diastolic function in patients with preserved left ventricular ejection fraction after acute myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Matthias Scholz, Thomas Meyer, Lars S. Maier, Karl Heinrich Scholz
Summary: This study investigated the relationship between chronic total occlusion (CTO) in a non-infarct-related artery (NIRA) and adverse outcomes in ST-segment-elevation myocardial infarction (STEMI). The presence of CTO posed a threat to coronary blood supply, and the origin of intercoronary collaterals was associated with patient survival rate. The results showed that CTO collateralization from the IRA distal to the acute occlusion was associated with a better prognosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Maria Tafelmeier, Verka-Georgieva Blagoeva, Maximilian Trum, Philipp Hegner, Bernhard Floerchinger, Daniele Camboni, Marcus Creutzenberg, Florian Zeman, Christof Schmid, Lars Siegfried Maier, Stefan Wagner, Dominik Linz, Mathias Baumert, Michael Arzt
Summary: The study aimed to evaluate the association between common diseases and nocturnal hypoxemic burden in patients undergoing coronary artery bypass grafting surgery. The results showed that sleep-disordered breathing, obesity, and mild-to-moderate chronic obstructive pulmonary disease were significant predictors of increased nocturnal hypoxemic burden.
Review
Biochemistry & Molecular Biology
Michael Wester, Michael Arzt, Frederick Sinha, Lars Siegfried Maier, Simon Lebek
Summary: Heart failure with preserved ejection fraction (HFpEF) is a widespread disease with high morbidity and mortality, and sleep-disordered breathing (SDB) has been found to be closely associated with the development and progression of the obese HFpEF phenotype. Individualized therapeutic strategies and novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing are needed to improve treatment outcomes.
Article
Medicine, General & Internal
Andrej Preveden, Miodrag Golubovic, Marija Bjelobrk, Tatjana Miljkovic, Aleksandra Ilic, Snezana Stojsic, Dragan Gajic, Mila Glavaski, Lars S. Maier, Nduka Okwose, Dejana Popovic, Fausto Barlocco, Arsen Ristic, Guy A. MacGowan, Iacopo Olivotto, Nenad Filipovic, Djordje G. Jakovljevic, Lazar Velicki
Summary: This study revealed that female HCM patients tend to be older, have more severe symptoms, and show a more pronounced clinical presentation, despite being a minority in the patient population. Additionally, there are differences in echocardiographic findings and levels of N-terminal pro-brain natriuretic peptide between genders in HCM patients.
MEDICINA-LITHUANIA
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)