Article
Oncology
Tao Dong, Jaimin R. Shah, Abraham T. Phung, Christopher Larson, Ana B. Sanchez, Omonigho Aisagbonhi, Sarah L. Blair, Bryan Oronsky, William C. Trogler, Tony Reid, Andrew C. Kummel
Summary: This study investigated the activity of an oncolytic adenovirus in tumors with low CAR expression. The results showed that liposome-encapsulated virus and viruses without liposome encapsulation achieved complete remission in 58% and 33% of the tumors, respectively. The study also found that an increased inflammatory infiltrate inside the tumor microenvironment is key to achieving effective therapeutic results in tumors independent of CAR expression. In addition, encapsulated adenovirus demonstrated an increased inflammatory infiltrate and reduced growth in distant tumors, while unencapsulated virus had limited inflammatory infiltrate and no effect on distant tumors.
Article
Multidisciplinary Sciences
Alexander T. Baker, Ryan J. Boyd, Daipayan Sarkar, Alicia Teijeira-Crespo, Chun Kit Chan, Emily Bates, Kasim Waraich, John Vant, Eric Wilson, Chloe D. Truong, Magdalena Lipka-Lloyd, Petra Fromme, Josh Vermaas, Dewight Williams, LeeAnn Machiesky, Meike Heurich, Bolni M. Nagalo, Lynda Coughlan, Scott Umlauf, Po-Lin Chiu, Pierre J. Rizkallah, Taylor S. Cohen, Alan L. Parker, Abhishek Singharoy, Mitesh J. Borad
Summary: Vaccines using chimpanzee adenovirus, human adenovirus, and other types have played a crucial role in the pandemic but may induce rare side effects. Research shows these vaccines may bind with PF4, affecting the mechanism of HIT.
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Elena M. Gupalo, Liudmila Buryachkovskaya, Petr Chumachenko, Natalia A. Mironova, Oleg Yu. Narusov, Sergey N. Tereschenko, Sergey P. Golitsyn, Maha Othman
Summary: The study investigated the relationship of CAR expression in endomyocardial biopsy samples of DCM patients with heart failure functional class and IL-6 levels, revealing enhanced CAR expression in platelets of DCM patients and its association with elevated inflammatory factors. Additionally, mature cytomegalovirus and herpes simplex viruses particles were detected in some patients' platelets.
CARDIOVASCULAR PATHOLOGY
(2022)
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Lin Shen, Jing Zhang, Meng Xu, Ying Zheng, Mo Wang, Suzhen Yang, Bin Qin, Shunle Li, Lei Dong, Fei Dai
Summary: DDX3 functions as a tumor suppressor gene in colorectal cancer. Loss of DDX3 expression promotes cancer progression by regulating E-cadherin and beta-catenin signaling through the MAPK pathway. Targeting the MAPK pathway may be a therapeutic approach for advanced colorectal cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Leonie Herrmann, Louise Schelletter, Raimund Hoffrogge, Karsten Niehaus, Volker Rudolph, Martin Farr
Summary: During viral-induced myocarditis, neutrophil elastase may target and cleave CAR, reducing susceptibility to viral infections and potentially affecting the course of the disease.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biology
Amy Wang, Alexander R. Dunn, William Weis
Summary: Mechanotransduction at cell-cell adhesions is crucial for the structural integrity, organization, and morphogenesis of epithelia. The E-cadherin/beta-catenin/alpha E-catenin complexes can sense and transmit mechanical load by interacting with F-actin.
Article
Biochemistry & Molecular Biology
Junrong Liang, Lina Sun, Yujun Li, Wanning Liu, Danxiu Li, Ping Chen, Xin Wang, Juan Hui, Jinchi Zhou, Hao Liu, Tianyu Cao, Maogui Pang, Meng Guo, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study investigated the expression and function of DKK4 in colorectal cancer (CRC). The results showed that DKK4 was upregulated in CRC cell lines and tissues, and it inhibited cell metastasis by repressing the Wnt signaling pathway. Through experiments and analysis, the researchers also revealed the regulatory mechanism of DKK4 and its potential therapeutic application.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pelin Ozfiliz Kilbas, Nisan Denizce Can, Tugba Kizilboga, Fikret Ezberci, Hamdi Levent Doganay, Elif Damla Arisan, Gizem Dinler Doganay
Summary: Bag-1 is a crucial target in cancer, as its overexpression decreases the efficacy of chemotherapy drugs and its silencing enhances the apoptotic efficiency of therapeutics. In this study, stable Bag-1 knockout cells were generated to examine the cellular alterations. The findings showed that Bag-1 knockout led to hyperactive Akt signaling and changes in cellular morphology, which could be reversed by an Akt inhibitor.
Article
Cell Biology
Qianwen Wang, Chenxiang Qi, Pengxiang Min, Yueyuan Wang, Fengwen Ye, Tianxiang Xia, Yujie Zhang, Jun Du
Summary: By regulating MICAL2, the migratory ability of gastric cancer cells can be influenced, and it involves changes in the E-cadherin/beta-catenin signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Hao Wang, Wei Hou, Aldeb Perera, Carlee Bettler, Jordan R. Beach, Xianzhong Ding, Jun Li, Mitchell F. Denning, Asha Dhanarajan, Scott J. Cotler, Cara Joyce, Jun Yin, Fowsiyo Ahmed, Lewis R. Roberts, Wei Qiu
Summary: EphA2 expression is enriched in human HCC and loss of EphA2 can suppress the initiation and growth of HCC. Targeting EphA2 inhibits both AKT and JAK1/STAT3 signaling pathways in HCC, and a small molecule kinase inhibitor of EphA2 shows promising results in suppressing tumor progression in a murine model.
Article
Biochemistry & Molecular Biology
Jimin Han, Kaijun Lin, Xuezheng Zhang, Lingchen Yan, Jianjun Liu, Jia Liu
Summary: The study revealed the significant impact of PTEN and β-catenin on the proliferation of Lgr5+ hepatocytes, providing insights into the regulation of Lgr5+ hepatocyte proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Gen Chen, Ning An, Yu Zhu, Rui Zhou, Myung-Giun Noh, Hangun Kim, Hyoung Jae Lee, Yingjie Shen, Young-Chang Cho, Litai Jin, Weitao Cong, Jae-Hyuk Lee, Kwonseop Kim
Summary: The study revealed that the bFGF/FGFR1 signaling pathway can enhance the tumor progression of prostate cancer by strengthening delta-catenin.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang
Summary: CD58 is upregulated in HCC tissues and its overexpression is associated with poor prognosis in HCC patients. CD58 promotes proliferation and metastasis in HCC cells by activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 may serve as a prognostic biomarker and therapeutic target for HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Reshma Amin, Leonard Grinblat, Mansoor Husain
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Steven P. Marso, Florian M. M. Baeres, Stephen C. Bain, Bryan Goldman, Mansoor Husain, Michael A. Nauck, Neil R. Poulter, Richard E. Pratley, Anne Bloch Thomsen, John B. Buse
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Biology
Neal Callaghan, Shin-Haw Lee, Sina Hadipour-Lakmehsari, Xavier A. Lee, M. Ahsan Siraj, Amine Driouchi, Christopher M. Yip, Mansoor Husain, Craig A. Simmons, Anthony O. Gramolini
COMMUNICATIONS BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Subodh Verma, Udi Fainberg, Mansoor Husain, Soren Rasmussen, Lars Ryden, Maria Sejersten Ripa, John B. Buse
Summary: After re-categorization, semaglutide significantly reduced the risk of MACE in the established CVD subgroup, while showing a nonsignificant reduction in the CV risk factor subgroup. These results suggest potential CV benefits of semaglutide across the CV risk continuum in patients with type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Michael E. Nassif, Sheryl L. Windsor, Fengming Tang, Mansoor Husain, Silvio E. Inzucchi, Darren K. McGuire, Bertram Pitt, Benjamin M. Scirica, Bethany Austin, Michael W. Fong, Shane J. LaRue, Guillermo Umpierrez, Justin Hartupee, Yevgeniy Khariton, Ali O. Malik, Modele O. Ogunniyi, Nanette K. Wenger, Mikhail N. Kosiborod
Summary: This study found that using dapagliflozin can lead to improvement in lung fluid volume in patients with HF, as measured by remote dielectric sensing. This discovery provides a clue to unraveling the mechanisms of benefit of SGLT2 inhibitors in heart failure.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Patrick R. Lawler, Ewan C. Golighe, Jeffrey S. Berge, Matthew D. Neal, Bryan J. McVerry, Jose C. Nicolau, Michelle N. Gong, Marc Carrier, Robert S. Rosenson, Harmony R. Reynolds, Alexis F. Turgeon, Jorge Escobedo, David T. Huang, Charlotte A. Bradbury, Brett L. Houston, Lucy Z. Kornblith, Anand Kumar, Susan R. n Kah, Mary Cushman, Zoe McQuilten, Arthur S. Slutsky, Keri S. Kim, Anthony C. Gordon, Bridget-Anne Kirwan, Maria M. Brooks, Alisa M. Higgins, Roger J. Lewis, Elizabeth Lorenzi, Scott M. Berry, Lindsay R. Berry, Derek C. Angus, Colin J. McArthur, Steven A. Webb, Michael E. Farkouh, Judith S. Hochman, Ryan Zarychanski, Aaron W. Aday, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadzw, Benjamin Coiffard, Todd W. Costantini, Sophie de Brouwer, Lennie P. G. Derde, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Sebastian Garcia-Madrona, Timothy D. Girard, Lucas C. Godoy, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Naomi M. Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M. Hegde, Carolyn M. Hendrickson, R. Duncan Hite, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Vivek N. Iyer, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei L. Kindzelski, Andrew J. Kin, M. Margaret Knudson, Aaron E. Kornblith, Vidya Krishnan, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L. Lopez-Sendon Moreno, Sylvain A. Lother, Saurabh Malhotra, Miguel Marcos, Andrea Saud Marinez, John C. Marshall, Nicole Marten, Michael A. Matthay, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Steven C. Moore, Raquel Morillo Guerreor, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Yessica S. Perez Gonzalez, Mauricio Pompilio, Matthew E. Prekker, John G. Quigley, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T. Saunders, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Manu Shankar-Hari, John P. Sheehan, Aneesh B. Singhal, Dayna Solvaso, Simon J. Stanworth, Tobias Tritschler, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J. Wells, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Fernando G. Zampieri
Summary: This study showed that therapeutic-dose anticoagulation with heparin in non-critically ill patients with Covid-19 increased the likelihood of survival to hospital discharge and reduced the need for cardiovascular or respiratory organ support compared to usual-care thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Ewan C. Goligher, Charlotte A. Bradbury, Bryan J. McVerry, Patrick R. Lawler, Jeffrey S. Berger, Michelle N. Gong, Marc Carrier, Harmony R. Reynolds, Anand Kumar, Alexis F. Turgeon, Lucy Z. Kornblith, Susan R. Kahn, John C. Marshall, Keri S. Kim, Brett L. Houston, Lennie P. G. Derde, Mary Cushman, Tobias Tritschler, Derek C. Angus, Lucas C. Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E. Farkouh, Maria M. Brooks, Roger J. Lewis, Lindsay R. Berry, Elizabeth Lorenzi, Anthony C. Gordon, Scott M. Berry, Colin J. McArthur, Matthew D. Neal, Judith S. Hochman, Steven A. Webb, Ryan Zarychanski, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W. Costantini, Sophie de Brouwer, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Heather F. Eng, Jorge Escobedo, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Joshua D. Froess, Zhuxuan Fu, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Timothy D. Girard, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Rashan Haniffa, Sheila M. Hegde, Carolyn M. Hendrickson, Alisa M. Higgins, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, David T. Huang, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J. King, Aaron E. Kornblith, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A. Lother, Nicole Marten, Andrea Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Jose C. Nicolau, Brenda Nunez-Garcia, John J. Park, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Mauricio Pompilio, John G. Quigley, Robert S. Rosenson, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler O. Santos, Lewis Satterwhite, Christina T. Saunders, Jake Schreiber, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Aneesh B. Singhal, Arthur S. Slutsky, Dayna Solvason, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Yongqi Zhong
Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Zhuxuan Fu, Philip Jones, Lydia C. Kwee, Sheryl L. Windsor, Olga Ilkayeva, Christopher B. Newgard, Kenneth B. Margulies, Mansoor Husain, Silvio E. Inzucchi, Darren K. McGuire, Bertram Pitt, Benjamin M. Scirica, David E. Lanfear, Michael E. Nassif, Ali Javaheri, Robert J. Mentz, Mikhail N. Kosiborod, Svati H. Shah
Summary: This study explored the effects of dapagliflozin on metabolic pathways in HFrEF patients, showing an increase in ketone-related and fatty acid metabolite clusters. It also identified metabolic biomarkers associated with adverse HFrEF outcomes, suggesting a potential role for altered ketone and fatty acid biology with sodium-glucose cotransporter-2 inhibitors.
Article
Clinical Neurology
W. David Strain, Ofir Frenkel, Martin A. James, Lawrence A. Leiter, Soren Rasmussen, Peter M. Rothwell, Maria Sejersten Ripa, Thomas C. Truelsen, Mansoor Husain
Summary: This post hoc analysis found that GLP-1 RA drug semaglutide can reduce stroke risk in patients with type 2 diabetes, especially the risk of small-vessel occlusion, compared to placebo.
Review
Cardiac & Cardiovascular Systems
Nikolaus Marx, Mansoor Husain, Michael Lehrke, Subodh Verma, Naveed Sattar
Summary: Multiple large cardiovascular outcome trials have shown that SGLT2 inhibitors and GLP-1 receptor agonists significantly reduce cardiovascular disease risk in patients with type 2 diabetes, including major adverse cardiovascular events and heart failure. These drugs have received strong recommendations in diabetes and cardiology guidelines, but their usage remains low.
Article
Endocrinology & Metabolism
Vanita R. R. Aroda, Umut Erhan, Peter Jelnes, Juris J. J. Meier, Morten Tind Abildlund, Richard Pratley, Tina Vilsboll, Mansoor Husain
Summary: Glucagon-like peptide-1 receptor agonists, including oral and subcutaneous semaglutide, are effective in improving glycaemic control and reducing cardiovascular risk. This study analyzed adverse events from clinical trials and found that the most common side effects were gastrointestinal disorders, which decreased with continued therapy.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Kashvi Gupta, John A. Spertus, Mary Birmingham, Kensey L. Gosch, Mansoor Husain, Dalane W. Kitzman, Bertram Pitt, Sanjiv J. Shah, James L. Januzzi, Ildiko Lingvay, Javed Butler, Mikhail Kosiborod, David E. Lanfear
Summary: The health status of Black patients with heart failure is worse compared to White patients. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) can reduce cardiovascular mortality and improve health status in heart failure patients, but it is unclear if the effect is similar across races. The study found that SGLT2i improves health status equally for Black and White patients.
Article
Cardiac & Cardiovascular Systems
Michael E. Nassif, Sheryl L. Windsor, Kensey Gosch, Barry A. Borlaug, Mansoor Husain, Silvio E. Inzucchi, Dalane W. Kitzman, Darren K. McGuire, Bertram Pitt, Benjamin M. Scirica, Sanjiv J. Shah, Guillermo Umpierrez, Bethany A. Austin, Sumant Lamba, Taiyeb Khumri, Kavita Sharma, Mikhail N. Kosiborod
Summary: The benefits of SGLT2 inhibitors on symptoms and physical limitations in patients with heart failure are consistent and clinically meaningful across the full range of ejection fraction (EF), according to a pooled analysis of two trials.
CIRCULATION-HEART FAILURE
(2023)
Letter
Endocrinology & Metabolism
Subodh Verma, Mansoor Husain, Christian M. Madsen, Lawrence A. Leiter, Anja Birk Kuhlman, Tina Vilsboll, Soren Rasmussen, Peter Libby
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yusaku Mori, Marel Gonzalez Medina, Zhiwei Liu, June Guo, Luke S. Dingwell, Simon Chiang, Carl Ronald Kahn, Mansoor Husain, Adria Giacca
Summary: The study found that the vasculoprotective effects of insulin on inhibiting neointimal growth require action in both endothelial cells and vascular smooth muscle cells.
DIABETES & VASCULAR DISEASE RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)