Article
Chemistry, Medicinal
Marine Duplantier, Elodie Lohou, Pascal Sonnet
Summary: The emergence and dissemination of multidrug-resistant bacteria, specifically Pseudomonas aeruginosa, pose a significant public health concern. This pathogen secretes virulence factors and forms biofilms during infection, enhancing its pathogenicity and drug resistance. Control of biofilm and virulence factor production is regulated by Quorum Sensing (QS). Developing anti-virulence agents that target QS shows promise as a new therapeutic strategy to combat antimicrobial resistance.
Review
Chemistry, Medicinal
Qiaoqiang Li, Shen Mao, Hong Wang, Xinyi Ye
Summary: The survival pressure caused by antibiotics prompts bacteria to develop drug resistance. Quorum sensing is an intercellular communication system that regulates bacterial virulence and biofilm formation. In Pseudomonas aeruginosa, the formation and diffusion of biofilm is closely related to the quorum sensing system. Quorum-sensing inhibitors can reduce bacterial toxicity and enhance sensitivity to antibiotics, making them a popular topic for research and development in anti-infection. This review provides an overview of the Pseudomonas aeruginosa quorum-sensing system and quorum-sensing inhibitors research, which will aid in the future development of novel inhibitors.
Article
Biochemistry & Molecular Biology
Suqi Hao, Dan Yang, Ling Zhao, Fei Shi, Gang Ye, Hualin Fu, Juchun Lin, Hongrui Guo, Ran He, Jianlong Li, Hongwei Chen, Muhammad Faraz Khan, Yinglun Li, Huaqiao Tang
Summary: EGCG, a bioactive ingredient in green tea, demonstrated significant inhibitory effects on the production of virulence factors in Pseudomonas aeruginosa, potentially serving as a candidate for quorum sensing inhibition to combat bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Ahmed Al Saqr, Mohammed F. Aldawsari, El-Sayed Khafagy, Moataz A. Shaldam, Wael A. H. Hegazy, Hisham A. Abbas
Summary: Pseudomonas aeruginosa can cause healthcare-associated infections through its virulence factors controlled by the quorum sensing system. Allopurinol, an FDA-approved drug, shows promising anti-virulence and anti-QS activities by competing with autoinducers and downregulating QS genes. It may be useful in future treatment of P. aeruginosa infections.
Article
Biotechnology & Applied Microbiology
Aishwarya Vetrivel, Preethi Vetrivel, Kavitha Dhandapani, Santhi Natchimuthu, Monica Ramasamy, Soundariya Madheswaran, Rajeswari Murugesan
Summary: The LasR inhibitors identified in this study were evaluated for their antibiofilm and antiquorum sensing activities against Pseudomonas aeruginosa PAO1. The selected compounds showed potent antibiofilm activity at sub-MICs without affecting the growth of P. aeruginosa PAO1. They also inhibited the production of quorum sensing-mediated virulence factors and exhibited lower cytotoxicity against peripheral blood lymphocytes. This study could pave a way to explore these compounds for the development of therapeutic agents against Pseudomonas aeruginosa biofilm-related infections.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Microbiology
Wen-Ru Li, Tao-Hua Zeng, Zhi-Qing Zhang, Qing-Shan Shi, Xiao-Bao Xie
Summary: In this study, it was found that geraniol can inhibit the growth of Pseudomonas aeruginosa, prolong the lag phase and growth period. Geraniol also suppresses the expression of the three quorum sensing systems of P. aeruginosa, thereby attenuating the virulence factors regulated by these systems. This research is significant for improving the treatment of bacterial infections caused by P. aeruginosa.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He, Shiling Feng, Helin Chen, Yu Zhang, Yuanze Gao, Yinglun Li, Huaqiao Tang
Summary: The study found that paeonol has good anti-biofilm activity against Gram-negative bacteria and anti-QS activity, effectively reducing the virulence of P. aeruginosa. In vivo studies showed that paeonol could reduce the pathogenicity of P. aeruginosa and enhance the survival rate of C. elegans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ya Fei Geng, Cheng Yang, Yi Zhang, Sheng Nan Tao, Jie Mei, Xu Chang Zhang, Ya Juan Sun, Bing Tian Zhao
Summary: This study investigated the potential of luteolin as a quorum sensing inhibitor against Pseudomonas aeruginosa, demonstrating its effectiveness in inhibiting biofilm formation, virulence factor production, and bacterial motility. Luteolin was also found to reduce the accumulation of QS signaling molecules and downregulate the transcription of QS genes, suggesting its promising role in combating drug-resistant infections caused by P. aeruginosa.
Review
Chemistry, Medicinal
Mohammad Anwar Hossain, Nadezhda A. German
Summary: In recent years, modulators of quorum sensing pathways in Pseudomonas aeruginosa have gained attention for their potential therapeutic applications, including enhancing the efficacy of existing therapeutic agents against resistant strains. Additionally, these chemical agents can be utilized in various fields such as developing anticancer therapeutics and artificial biological systems.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Jieying Pu, Shebin Zhang, Xi He, Jianming Zeng, Cong Shen, Yanfen Luo, Honglin Li, Yifei Long, Jianping Liu, Qian Xiao, Yang Lu, Bin Huang, Cha Chen
Summary: A novel QS regulatory sRNA AmiL has been identified in P. aeruginosa, which influences diverse QS-mediated virulence factors and regulates QS gene expression and C4-HSL production.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Lida V. Hernandez-Moreno, Ludy C. Pabon-Baquero, Juliet A. Prieto-Rodriguez, Oscar J. Patino-Ladino
Summary: This study describes the antibiofilm and quorum sensing inhibitory potential of extract and chemical components from Piper pertomentellum on Pseudomonas aeruginosa. The results show that the extract and compounds can reduce biofilm formation and the production of virulence factors in P. aeruginosa.
Article
Microbiology
Priyanikha Jayakumar, Alexandre R. T. Figueiredo, Rolf Kummerli
Summary: Pseudomonas aeruginosa populations undergo extensive genetic adaptation and diversification in various environments. Mutations in the quorum sensing (QS) system affect the expression of virulence factors and public goods. This study found that mutations in different QS systems lead to diverging effects on the QS trait profile, potentially impacting fitness and virulence.
Article
Plant Sciences
Muzamil Ahmad Rather, Kuldeep Gupta, Manabendra Mandal
Summary: The study evaluated the inhibitory effect of methanol extract of Cuphea carthagenensis on biofilm and quorum sensing (QS) activity in Pseudomonas aeruginosa, demonstrating a significant suppression of biofilm formation and virulence factors.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wen-Ru Li, Zhi-Qing Zhang, Kang Liao, Qing-Shan Shi, Xu-Bin Huang, Xiao-Bao Xie
Summary: Sulfur compounds found in garlic, such as diallyl trisulfide (DATS), diallyl disulfide (DADS), and diallyl sulfide (DAS), can inhibit the quorum sensing and virulence of Pseudomonas aeruginosa. Among these compounds, DATS exhibits the strongest inhibitory effects. These findings are significant for the control of P. aeruginosa virulence and pathogenicity.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2022)
Article
Microbiology
Zhidong Zhang, Yang Sun, Yuanyang Yi, Xiaoyu Bai, Liying Zhu, Jing Zhu, Meiying Gu, Yanlei Zhu, Ling Jiang
Summary: A strain of Streptomyces with quorum-sensing inhibitory activity was isolated from the Kumutag Desert in Xinjiang, and it effectively inhibited biofilm formation and virulence factor production in bacteria such as Pseudomonas aeruginosa.