Article
Medicine, General & Internal
Christoph Tappeiner, Han Sol Bae, Kai Rothaus, Karoline Walscheid, Arnd Heiligenhaus
Summary: The study aimed to analyze the occurrence and risk factors for macular edema (ME) in patients with juvenile idiopathic arthritis-associated uveitis (JIA-U). The results indicated that older age, worse eye conditions, and higher laser-flare photometry values were independent risk factors for ME manifestation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jinsoo Kim, Min Seon Park, Soonil Kwon, Kwang Nam Kim, Han Wool Kim, Bum-Joo Cho
Summary: This study aimed to investigate the clinical features and risk factors of uveitis in Korean children with juvenile idiopathic arthritis (JIA). The JIA-associated uveitis (JIA-U) developed in 9.8% of JIA patients. The study found that the uveitis group had a higher prevalence of the oligoarthritis-persistent subtype and knee joint involvement, suggesting their association with JIA-U.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Marta Gruca, Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Agnieszka Wosiak, Aleksandra Stasiak, Karolina Sikorska, Jerzy Stanczyk, Elzbieta Smolewska
Summary: The aim of this study was to assess CVD risk factors in patients with JIA. IMT, metabolic parameters and health behaviors were evaluated. The study found that CVD risk factors were present in both groups, with more JIA patients having abnormal BMI compared to the control group. Dietary habits were not associated with IMT or other parameters in the JIA group. Only one JIA patient met the criteria for ideal cardiovascular health. The pursuit of ideal cardiovascular health should be given attention in the pediatric population, especially in patients with chronic diseases like JIA. Further studies are needed to apply carotid artery IMT measurement in assessing CVD risk.
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Pediatrics
Mikhail M. Kostik, Ekaterina V. Gaidar, Lubov S. Sorokina, Ilya S. Avrusin, Tatiana N. Nikitina, Eugenia A. Isupova, Irina A. Chikova, Yuri Yu. Korin, Elizaveta D. Orlova, Ludmila S. Snegireva, Vera V. Masalova, Margarita F. Dubko, Olga V. Kalashnikova, Vyacheslav G. Chasnyk
Summary: The presence of uveitis is a risk factor for JIA flare, while methotrexate can reduce the cumulative flare probability.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ophthalmology
Justine R. Smith, Janet M. Matthews, Diana Conrad, Anthony J. Hall, Rachael L. Niederer, Davinder Singh-Grewal, Mei-Ling Tay-Kearney, Jane M. Wells, Sophia L. Zagora, Peter J. McCluskey
Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Pierre Quartier
Summary: Children with early onset juvenile idiopathic arthritis, especially with positive antinuclear antibodies, may develop chronic anterior uveitis, which requires regular slit lamp examination and prompt treatment. Therapy options range from local steroid treatment to systemic immunomodulatory therapy, tailored to individual patient needs, with involvement of expert ophthalmologists and pediatricians. Treatment should not be easily interrupted and may need to be intensified in certain cases for optimal disease control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Achille Marino, Luca Marelli, Paolo Nucci, Roberto Caporali, Elisabetta Miserocchi
Summary: This study aimed to evaluate the efficacy and safety of subcutaneous tocilizumab in JIA patients with refractory uveitis. The results showed that SC-TCZ significantly reduced the rate of uveitis flare and achieved complete treatment response in some patients. Moreover, SC-TCZ was well-tolerated without any observed side effects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Immunology
Jie Zheng, Yong Wang, Jun Hu
Summary: This study explores the shared gene signatures and potential molecular mechanisms of polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU) through data analysis and functional enrichment analysis. Neutrophil degranulation may be considered a shared pathogenic mechanism, and the roles of ARID1A gene and hsa-miR-146a are worthy of further study. Additionally, periodic inspection of kidney function is also important.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Maria Pia Paroli, Alessandro Abbouda, Giuseppe Albanese, Massimo Accorinti, Alessandro Falcione, Leopoldo Spadea, Marino Paroli
Summary: In this retrospective study, patients over 16 years old with JIA-associated active uveitis were evaluated. The study found that some patients still had persistent uveitis in adulthood, which could lead to severe visual impairment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Karoline Baquet-Walscheid, Kai Rothaus, Martina Niewerth, Jens Klotsche, Kirsten Minden, Arnd Heiligenhaus
Summary: Data on uveitis in juvenile psoriatic arthritis (JPsA) are scarce. Patients with JPsA-associated uveitis (JPsA-U) have similar characteristics to uveitis patients in other categories of juvenile idiopathic arthritis (JIA). Children with early-onset JPsA are at a higher risk for ocular involvement.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Rodrigo Joel de Oliveira, Ana Carolina Londe, Debora Pessoa de Souza, Roberto Marini, Paula Teixeira Fernandes, Simone Appenzeller
Summary: This cross-sectional study aimed to evaluate the impact of physical activity and physical fitness on the health-related quality of life (HQoL) of adult patients with Juvenile Idiopathic Arthritis (JIA). The study found that the HQoL of JIA patients was reduced, but physically active patients had a better HQoL.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Saira Akbarali, Jugnoo S. Rahi, Andrew D. Dick, Kiren Parkash, Katie Etherton, Clive Edelsten, Xiaoxuan Liu, Ameenat L. Solebo
Summary: This study investigates the feasibility, acceptability, and performance of optical coherence tomography (OCT) imaging-based diagnosis of uveitis in children with juvenile idiopathic arthritis (JIA). The results show that OCT imaging is feasible, acceptable to patients, and has potential to transform pediatric practice in monitoring JIA uveitis. Manual image cell count using anterior segment OCT has high sensitivity and specificity for diagnosis of active inflammation. Further research is needed to determine the validity and cost-effectiveness of OCT imaging-based disease monitoring.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karoline Baquet-Walscheid, Lena Wildschuetz, Maren Kasper, Martin Busch, Solon Thanos, Dirk Bauer, Monika Stoll, Simone Koenig, Arnd Heiligenhaus
Summary: This study suggests that there are differential expressions of genes and proteins related to angiogenesis in the iris tissue associated with JIAU. These differences may lead to clinically visible alterations in the iris vasculature in selected cases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Ophthalmology
Sheila T. Angeles-Han, Virginia Miraldi Utz, Sherry Thornton, Grant Schulert, Jackeline Rodriguez-Smith, Adam Kauffman, Alyssa Sproles, Najima Mwase, Theresa Hennard, Alexei Grom, Mekibib Altaye, Gary N. Holland
Summary: In this study, inflammatory biomarkers in tears were successfully detected in children with JIA-U, with IL-8, sICAM-1, and S100A12 identified as potential biomarkers for uveitis activity.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Rheumatology
Amy Cassedy, Mekibib Altaye, Jennifer Andringa, Ashley M. Cooper, Carolyn Drews-Botsch, George Engelhard, Theresa Hennard, Gary N. Holland, Kirsten Jenkins, Scott R. Lambert, Jessi Lipscomb, Courtney McCracken, Deborah K. McCurdy, Joseph McDonald, Najima Mwase, Sampath Prahalad, Erin Stahl, Virginia Miraldi Utz, A. Adrienne Walker, Steven Yeh, Sheila T. Angeles-Han
Summary: The objective of this study was to revise and assess the validity of the EYE-Q questionnaire, which measures vision-related functioning and quality of life in children with uveitis. The study found that the EYE-Q is a valid tool for measuring these factors in pediatric uveitis patients.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Joseph McDonald, Amy Cassedy, Mekibib Altaye, Jennifer Andringa, Ashley M. Cooper, Carolyn Drews-Botsch, George Engelhard, Theresa Hennard, Gary N. Holland, Kirsten Jenkins, Scott R. Lambert, Jessi Lipscomb, Courtney McCracken, Deborah K. McCurdy, Najima Mwase, Sampath Prahalad, Jessica Shantha, Erin Stahl, Virginia Miraldi Utz, A. Adrienne Walker, Steven Yeh, Sheila T. Angeles-Han
Summary: Pediatric uveitis can have negative effects on quality of life, functioning, and mental health in children. The impact varies depending on the type of uveitis. Including vision-specific measures can provide a better understanding of the effects of uveitis.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Margaret H. Chang, Jessica G. Shantha, Jacob J. Fondriest, Mindy S. Lo, Sheila T. Angeles-Han
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2021)
Article
Rheumatology
Meghan Angley, Carolyn Drews-Botsch, Tene T. Lewis, Martina Badell, S. Sam Lim, Penelope P. Howards
Summary: This study found that among African American women, there is an increased risk of adverse perinatal outcomes even before a clinical diagnosis of SLE.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Letter
Rheumatology
Courtney McCracken, Jessica G. Shantha, Steven Yeh, Kirsten Jenkins, Kelly A. Rouster-Stevens, Scott R. Lambert, Sampath Prahalad, Carolyn Drews-Botsch, Sheila T. Angeles-Han
JOURNAL OF RHEUMATOLOGY
(2022)
Editorial Material
Rheumatology
Sheila T. Angeles-Han, Sunil K. Srivastava
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Immunology
Ilaria Maccora, Edoardo Marrani, Ilaria Pagnini, Maria Vincenza Mastrolia, Cinzia de Libero, Roberto Caputo, Gabriele Simonini
Summary: Childhood uveitis is a serious condition that can lead to blindness if not properly recognized and treated. This review discusses the main causes, diagnostic approach, risk factors, and difficulties in eye examination for childhood uveitis. The treatment options for childhood uveitis are also discussed in terms of choice, timing, and withdrawal.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Immunology
Ilaria Maccora, Preston Land, Virginia Miraldi Utz, Sheila T. Angeles-Han
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Ophthalmology
Dominick Canady, Caleb Hartley, Amy Cassedy, Chris Miller, Sheila T. Angeles-Han, Matthew Jusu Vandy, Gilberte Bastien, Natalie Weil, Steven Yeh, Jessica Shantha
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Jacob Fondriest, Amy Cassedy, Theresa Hennard, Carolyn Drews-Botsch, Jessi Lipscomb, Courtney McCracken, Joseph McDonald, Sampath Prahalad, Jessica Shantha, Virginia Utz, Steven Yeh, Sheila T. Angeles-Han
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)