Article
Biochemistry & Molecular Biology
Gabriel G. Dorighello, Leandro H. P. Assis, Thiago Rentz, Joseane Morari, Monique F. M. Santana, Marisa Passarelli, Neale D. Ridgway, Anibal E. Vercesi, Helena C. F. Oliveira
Summary: The expression of CETP in macrophages modulates mitochondrial structure and function, promotes an intracellular antioxidant state and oxidative metabolism, and reduces the expression of inflammatory genes and cholesterol accumulation.
Article
Medicine, Research & Experimental
Dawei Chen, Di Ran, Chao Wang, Yinyin Liu, Yonggang Ma, Ruilong Song, Yushi Gao, Zongping Liu
Summary: The study found that Cd exposure led to dysregulation of lipid metabolism in chicken embryo liver tissues and hepatocytes, as well as adverse effects on mitochondria, activating mitophagy through the PINK1/Parkin pathway. Inhibiting mitophagy could alleviate Cd-induced hepatic lipid accumulation, but exacerbate lipid accumulation in hepatocytes.
Article
Cardiac & Cardiovascular Systems
Lorenzo Da Dalt, Annalisa Moregola, Monika Svecla, Silvia Pedretti, Francesca Fantini, Mirko Ronzio, Patrizia Uboldi, Diletta Dolfini, Elena Donetti, Andrea Baragetti, Nico Mitro, Luca Scorrano, Giuseppe Danilo Norata
Summary: Impairment of mitochondrial fusion affects the development of liver steatosis and obesity. Mice lacking OPA1 are protected from high-fat diet-induced metabolic dysfunction due to reduced lipid absorption.
CARDIOVASCULAR RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Faustino Mollinedo, Consuelo Gajate
Summary: Edelfosine, an ether lipid, selectively induces apoptosis in tumor cells by interacting with cholesterol-rich lipid rafts, endoplasmic reticulum (ER), and mitochondria. Its mechanism involves recruitment of death receptors and ER stress signaling through lipid rafts in hematological cancer cells, and ER stress response in solid tumor cells. The involvement of lipid rafts and/or ER in edelfosine-induced apoptosis requires a mitochondrial-dependent step leading to cell death. Overexpression of Bcl-2 or Bcl-xL blocks this process. Additionally, edelfosine redistributes lipid rafts to mitochondria and recruits F1FO-ATP synthase into cholesterol-rich lipid rafts to induce cell death.
Article
Multidisciplinary Sciences
Nigel Unwin
Summary: This study reveals the arrangement of phospholipids and cholesterol in the cell membrane using cryoelectron microscopy. It shows that these lipids exhibit distinct properties in different layers of the membrane, with a particular close-packed linear structure formed in the inner layer with higher cholesterol concentration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Xue-Mei Wan, Chuan Zheng, Xue-Lei Zhou
Summary: Recent investigations have shown that puerarin can alleviate cadmium-induced hepatic damage by inhibiting oxidative stress. This study used mouse hepatocyte AML-12 cell line and found that puerarin prevents mitochondrial damage caused by cadmium exposure and restores mitochondrial network fragmentation through the Sirt1 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Leire Goicoechea, Laura Conde de la Rosa, Sandra Torres, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Summary: Cholesterol is a crucial component of cell membrane bilayers and has important physiological roles in mitochondria and its metabolism. Excessive mitochondrial cholesterol can lead to oxidative stress, cell death, and the development of various diseases.
Review
Nutrition & Dietetics
Zhanpeng Su, Zhixian Zong, Jinxia Deng, Jianping Huang, Guihua Liu, Bo Wei, Liao Cui, Gang Li, Huan Zhong, Sien Lin
Summary: Lipids have a diverse impact on cartilage growth, injury, and regeneration. Lipid metabolism is a complex process that affects different aspects of cartilage. Proper lipid supplementation can help preserve cartilage function, while excessive lipid buildup is detrimental. Understanding the role of lipid metabolism in cartilage metabolism can lead to the development of new treatment techniques for metabolic cartilage damage.
Article
Biochemistry & Molecular Biology
Yang Liu, Yuan Wang, Zhi Lin, Rui Kang, Daolin Tang, Jiao Liu
Summary: SLC25A22 acts as a metabolic repressor of ferroptosis by producing glutathione and monounsaturated fatty acids, providing a previously unrecognized defense pathway against ferroptotic cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Environmental Sciences
Xishuai Tong, Xiaohui Fu, Gengsheng Yu, Huayi Qu, Hui Zou, Ruilong Song, Yonggang Ma, Yan Yuan, Jianchun Bian, Jianhong Gu, Zongping Liu
Summary: Cadmium (Cd) is a harmful environmental heavy metal that accumulates in the body and causes various health problems. Polystyrene (PS), a type of microplastic, also has toxic effects. The study aimed to investigate the effects of PS on Cd-induced mitochondrial damage in the lungs of mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ikuma Hori, Hideyoshi Harashima, Yuma Yamada
Summary: Delivering drugs to mitochondria, the main source of energy in neurons, is a potential therapeutic strategy for neurodegenerative diseases. This paper focuses on the efficient delivery of the drug berberine (BBR) into mitochondria using a lipid nanoparticle and its pharmacological action in Neuro2a cells, showing increased ATP production and expression of mitochondrial ubiquitin ligase (MITOL). The findings highlight the importance of enhancing the accumulation of BBR in mitochondria for improved therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jiesi Xu, Siyu Chen, Wei Wang, Sin Man Lam, Yang Xu, Shaohua Zhang, Huimin Pan, Jingjing Liang, Xiahe Huang, Yu Wang, Ting Li, Yuqiang Jiang, Yingchun Wang, Mei Ding, Guanghou Shui, Hongyuan Yang, Xun Huang
Summary: The downregulation of CDP-DAG synthase 2 (Cds2) is associated with the development of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Deficiency of Cds2 impairs mitochondrial function and contributes to hepatic steatosis, inflammation, and fibrosis. Overexpression of phosphatidylserine decarboxylase (PISD) and dietary supplementation with a peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist can alleviate NASH-like phenotype and mitochondrial defects.
Article
Biochemistry & Molecular Biology
Chidozie N. Okoye, Don Stevens, Collins Kamunde
Summary: The study found that anoxia-reoxygenation and cadmium have different effects on H2O2 emission in fish liver mitochondria, depending on the substrate used, leading to different response patterns. Additionally, anoxia-reoxygenation inhibits mitochondrial respiration in a substrate-dependent manner.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Junzhao Yuan, Xiaoqian Huang, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian
Summary: This study aimed to assess the antagonistic effect of honokiol (HNK) on Cd-induced liver tissue damage and vacuolation in hepatocytes. It was found that HNK alleviated liver pathological damage and reduced liver cell apoptosis induced by Cd. The study demonstrated the toxic effect of Cd pollution on birds and how HNK mitigated these effects at the cellular level.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Liyang Li, Yifei Liu, Xuanqi Liu, Nannan Zheng, Yutong Gu, Yuanlin Song, Xiangdong Wang
Summary: This study investigates the molecular mechanisms by which cholesterol alters airway epithelial sensitivity to smoking. The results suggest that cholesterol overload is associated with chronic obstructive pulmonary disease (COPD) and airway epithelia-driven inflammation. External cholesterol affects airway epithelial sensitivity to inflammation by regulating the STARD3-MFN2 pathway, cholesterol redistribution, transport and accumulation, lipid transport regulators, and mitochondrial function and dynamics. MFN2 down-regulation increases airway epithelial sensitivity and production of interleukins (ILs) after smoking, partly by affecting fatty acid oxidation and mTOR phosphorylation. These findings provide insights into the molecular mechanisms of cholesterol-altered airway epithelial inflammation and have implications for biomarkers and therapeutic targets in improving patient outcomes.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Psychiatry
Hiren R. Modi, Kaizong Ma, Lisa Chang, Mei Chen, Stanley I. Rapoport
PSYCHIATRY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Yewon Cheon, Hyung-Wook Kim, Miki Igarashi, Hiren R. Modi, Lisa Chang, Kaizong Ma, Deanna Greenstein, Mary Wohltmann, John Turk, Stanley I. Rapoport, Ameer Y. Taha
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2012)
Article
Biochemistry & Molecular Biology
Hiren R. Modi, Mireille Basselin, Arneer Y. Taha, Lei O. Li, Rosalind A. Coleman, Meir Bialer, Stanley I. Rapoport
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2013)
Article
Clinical Neurology
Hiren R. Modi, Mireille Basselin, Stanley I. Rapoport
Article
Clinical Neurology
Jae Hyuk Yang, Amit Wasudeo Bhandarkar, Byung Gun Lim, Hitesh N. Modi, Seung Woo Suh
EUROPEAN SPINE JOURNAL
(2013)
Article
Clinical Neurology
Jae Hyuk Yang, Amit Wasudeo Bhandarkar, Barani Rathanvelu, Jin Ho Hwang, Jae Young Hong, Hitesh N. Modi, Seung Woo Suh
EUROPEAN SPINE JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Honey Modi, Marion Cornu, Bernard Thorens
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Orthopedics
Jae Hyuk Yang, Seung Woo Suh, Hitesh N. Modi, Easwar T. Ramani, Jae Young Hong, Jin Ho Hwang, Woon Yong Jung
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2013)
Article
Biochemistry & Molecular Biology
Hiren R. Modi, Ameer Y. Taha, Hyung-Wook Kim, Lisa Chang, Stanley I. Rapoport, Yewon Cheon
JOURNAL OF NEUROCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Vasken L. Keleshian, Hiren R. Modi, Stanley I. Rapoport, Jagadeesh S. Rao
JOURNAL OF NEUROCHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Hiren R. Modi, Qihong Wang, G. D. Sahithi, David Sherman, Elliot Greenwald, Alena V. Savonenko, Romergryko G. Geocadin, Nitish V. Thakor
Article
Biochemistry & Molecular Biology
Ameer Y. Taha, Mireille Basselin, Epolia Ramadan, Hiren R. Modi, Stanley I. Rapoport, Yewon Cheon
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2012)
Article
Neurosciences
Hyung-Wook Kim, Yewon Cheon, Hiren R. Modi, Stanley I. Rapoport, Jagadeesh S. Rao
PSYCHOPHARMACOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Hiren R. Modi, Qihong Wang, Sarah J. Olmstead, Elizabeth S. Khoury, Nirnath Sah, Yu Guo, Payam Gharibani, Rishi Sharma, Rangaramanujam M. Kannan, Sujatha Kannan, Nitish V. Thakor
Summary: This study demonstrates that early intervention with dendrimer-N-acetylcysteine conjugate (D-NAC) can improve post-cardiac arrest survival rate, motor deficits, and neurological recovery by targeting activated microglial cells and attenuating neuroinflammation. Early therapeutic intervention with a single dose of D-NAC shows sustained improvement in long-term outcomes, providing a promising approach for treating post-cardiac arrest syndrome.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Jae Hyuk Yang, Rathinavelu Barani, Amit Wasudeo Bhandarkar, Seung Woo Suh, Jae Young Hong, Hitesh N. Modi, Jae Hyuk Yang
CLINICAL JOURNAL OF SPORT MEDICINE
(2014)