Article
Biochemistry & Molecular Biology
Joao Pedro Barros Paiva, Millena Santos Cordeiro, Patricia Ribeiro Carvalho Franca, Luiz Octavio Pereira Branco, Isabela Souza Santos, Nanashara Figueiredo Reis, Patrick Pedro Pimentel, Thais Biondino Sardella Giorno, Evanoel Crizanto Lima, Patricia Dias Fernandes
Summary: Several new substances with anti-inflammatory properties were discovered and found to be more effective than existing drugs through experimental research. These substances have potential for further development and could become new drugs for the treatment of inflammatory conditions.
Article
Fisheries
Seung-Hyeon Kim, Ki-Woong Nam, Bassem Allam, Kwang-sik Choi, Kwan-Ha Park, Kyung-Il Park
Summary: The study investigated changes in nitric oxide (NO) levels, cyclooxygenase 2 (COX-2) activity, and allograft inflammatory factor-1 (AIF-1) gene expression levels in hemolymph samples collected from Manila clam exposed to pro- and anti-inflammatory substances. The results suggest that the mechanism of inflammatory responses in bivalves is very similar to that of vertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Dahae Lee, Akida Alishir, Tae Su Jang, Ki Hyun Kim
Summary: The study revealed that benzyl salicylate found in Cornus walteri has potential anti-inflammatory activity by inhibiting the production of inflammatory mediators and affecting the phosphorylation of certain protein kinases and the expression of transcription factors.
Article
Plant Sciences
Jean Paul Dzoyem, Dieu Ne Dort Nganteng, Raduis Melong, Pascal Wafo, Bonaventure Ngadjui, Eric Allemann, Florence Delie
Summary: This study identified pentacyclic triterpenes, specifically pomolic and tormentic acids, as the main active compounds responsible for the anti-inflammatory effects of Ocimum gratissimum extract. These compounds showed potential in inhibiting nitric oxide production, IFN-gamma cytokine secretion, COX enzyme activity, and inducing apoptosis in activated macrophages. The findings provide evidence for the traditional use of Ocimum gratissimum in treating inflammatory disorders and suggest the multitarget potential of pomolic and tormentic acids as future drugs for inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biology
Chun-Yu Lin, Shih-Han Kao, Ling-Chien Hung, Hsin-Ju Chien, Wen-Hung Wang, Yu-Wei Chang, Yen-Hsu Chen
Summary: The study indicates that TGII effectively reduces LPS-induced NO production and its upstream regulatory factors, suggesting its potential as a therapeutic agent for sepsis and other inflammatory diseases. TGII pre- or post-treatment significantly decreases the expression of pro-inflammatory proteins induced by LPS, and inhibits the production of NO and PGE2.
Article
Medicine, Research & Experimental
Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Lenuta Profire
Summary: The study focused on the design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives as a strategy for inflammatory diseases. Molecular docking study showed 6o as the most selective COX-2 inhibitor, while compound 6n exhibited the most antioxidant activity and NO release capacity. Further investigations on compounds 6i and 6n are recommended for their promising pharmacological profiles.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Sandra Madalina Constantin, Florentina Geanina Lupascu, Alin Viorel Focsa, Lenuta Profire
Summary: New nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold have been developed as a safer and more efficient multitarget therapeutic strategy, showing improved interactions with COX-2 target site, better NO releasing capacity, antioxidant effects, and increased safety in gastrointestinal side effects. This was confirmed through molecular docking study and in vitro assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Passent M. Abdel-Baki, Moshera M. El-Sherei, Amal E. Khaleel, Marwa M. Abdel-Aziz, Mona M. Okba
Summary: Iris confusa and its isolated compounds show anti-H. pylori activity and may serve as a potential source of drugs for H. pylori control.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ashraf Ullah Khan, Amna Khan, Adnan Khan, Bushra Shal, Abdul Aziz, Muhammad Naeem Ahmed, Salman Ul Islam, Hussain Ali, Adeeb Shehzad, Salman Khan
Summary: The study demonstrated that NCHDH and NTHDH exhibit significant anti-inflammatory and analgesic properties in both acute Carrageenan-induced inflammation model and chronic CFA-induced arthritis model. Additionally, these compounds showed potential in inducing antioxidants, preserving DNA integrity, and improving histological features in arthritis treatment. Moreover, NCHDH and NTHDH effectively attenuated the expression levels of inflammatory markers and induced heat shock proteins, suggesting their potential therapeutic effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Ruzzolini, Sofia Chioccioli, Noemi Monaco, Silvia Peppicelli, Elena Andreucci, Silvia Urciuoli, Annalisa Romani, Cristina Luceri, Katia Tortora, Lido Calorini, Giovanna Caderni, Chiara Nediani, Francesca Bianchini
Summary: Oleuropein in olive leaves has anti-inflammatory, anti-diabetic, and anti-cancer effects. The study found that oleuropein-rich leaf extracts promoted apoptosis and reduced iNOS activity in colon tumors and macrophages, suggesting a strong anti-inflammatory effect that may be crucial in inhibiting tumor-promoting activity caused by chronic inflammation.
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Sherien A. Abdelhady, Mennatallah A. Ali, Tamer A. Al-Shafie, Ebtsam M. Abdelmawgoud, Dalia M. Yacout, Mahmoud M. El-Mas
Summary: The study showed that combination of montelukast with diclofenac or celecoxib provided better control of paw inflammation in the rat formalin test and improvements in associated gastric damage. Furthermore, montelukast and celecoxib exhibited more significant alleviation of formalin-induced gastric damage compared to diclofenac.
INFLAMMATION RESEARCH
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anil Kumar, Gurleen Kour, Pankaj Chibber, Diksha Saroch, Chetan Kumar, Zabeer Ahmed
Summary: This study investigates the potential anti-inflammatory activity of AL-04, a thiol analogue derived from a natural compound. The study reveals the anti-inflammatory mechanism of AL-04 and its effectiveness against pro-inflammatory mediators. AL-04 also demonstrates analgesic potential and a high level of safety.
Article
Endocrinology & Metabolism
Ismail O. Ishola, Folasade M. Adamson, Olufunmilayo O. Adeyemi
METABOLIC BRAIN DISEASE
(2017)
Article
Chemistry, Medicinal
Charles O. Ochieng, Sylvia A. Opiyo, Edward W. Mureka, Ismail O. Ishola
Article
Pharmacology & Pharmacy
Ismail Ogunbayode Ishola, Charles C. Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U. Udokwu
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2017)
Article
Medicine, General & Internal
Ismail O. Ishola, Kayode O. Yemitan, Olasunmbo O. Afolayan, Charles C. Anunobi, Tobi E. Durojaiye
MEDICAL PRINCIPLES AND PRACTICE
(2018)
Article
Endocrinology & Metabolism
Ismail O. Ishola, A. A. Akinyede, T. P. Adeluwa, C. Micah
METABOLIC BRAIN DISEASE
(2018)
Article
Pharmacology & Pharmacy
Ismail O. Ishola, Onyinyechi E. Akataobi, Azeez A. Alade, Olufunmilayo O. Adeyemi
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2019)
Article
Endocrinology & Metabolism
Ismail O. Ishola, Abosi A. Jacinta, Olufunmilayo O. Adeyemi
METABOLIC BRAIN DISEASE
(2019)
Article
Neurosciences
Ismail O. Ishola, Mmesomachukwu O. Osele, Micah C. Chijioke, Olufunmilayo O. Adeyemi
Article
Neurosciences
I. O. Ishola, A. A. Akinyede, J. E. Eloke, J. P. Chaturvedi, T. Narender
NEUROTOXICITY RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Ismail O. Ishola, Aishat O. Balogun, Olufunmilayo O. Adeyemi
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2020)
Article
Neurosciences
I. O. Ishola, I. O. Awogbindin, T. G. Olubodun-Obadun, O. A. Oluwafemi, J. E. Onuelu, O. O. Adeyemi
Summary: This study investigates the ameliorative influence of morin on rotenone-induced Parkinson's disease (PD) and shows that morin possesses neuroprotective properties by enhancing antioxidant defense and anti-inflammatory mechanisms.
Article
Biochemistry & Molecular Biology
Ismail O. Ishola, Taiwo G. Olubodun-Obadun, Charles O. Ochieng, Mary C. Nwajuwe, Reign -el U. Mukoro, Olufunmilayo O. Adeyemi
Summary: This study found that the extracts from the aerial parts of Gymnosporia heterophylla have novel bioactive constituents with antidepressant-like and anxiolytic-like effects, possibly through enhancing monoaminergic signaling.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
I. O. Ishola, A. K. Oloyo, T. G. Olubodun-Obadun, O. D. Godswill, S. A. Omilabu, O. O. Adeyemi
Summary: This study found that Double Stem Cell can improve motor and cognitive functions in patients with Parkinson's disease by alleviating oxidative stress and neuroinflammation.
METABOLIC BRAIN DISEASE
(2023)
Article
Plant Sciences
Taiwo G. Olubodun-Obadun, Ismail O. Ishola, Timisola P. Adesokan, Blessing O. Anih, Olufunmilayo O. Adeyemi
Summary: This study investigates the antidepressant and anxiolytic effects of ethanol seed extract of Cajanus cajan in mice. The extract shows potential in treating anxiety and other neurological disorders, possibly through the involvement of monoaminergic systems and GABA receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Education & Educational Research
Johnson Enero Upahi, Umesh Ramnarain, Ismail Saheed Ishola
RESEARCH IN SCIENCE EDUCATION
(2020)