Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Published 2012 View Full Article

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Title
Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors
Authors
Keywords
-
Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 21, Pages 9224-9239
Publisher
American Chemical Society (ACS)
Online
2012-09-17
DOI
10.1021/jm3009426

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