Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 17, Pages 6028-6039Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm200469u
Keywords
-
Categories
Ask authors/readers for more resources
Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the structure - activity relationship and the detailed physicochemical and in vivo pharmacokinetic properties of sotrastaurin (AEB071, 1), a novel maleimide-based PKC inhibitor currently in phase II clinical trials. Most notably, the preferred uptake of sotrastaurin into lymphoid tissues is an important feature, which is likely to contribute to its in vivo efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available