Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

Title
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 3, Pages 942-950
Publisher
American Chemical Society (ACS)
Online
2010-01-01
DOI
10.1021/jm901472u

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