Article
Medicine, Research & Experimental
Hongzhang Yang, Lei Zhang, Huanhuan Liu, Yunming Zhang, Zhaobiao Mou, Xueyuan Chen, Jingchao Li, Fengming He, Zijing Li
Summary: 18F-labeled fluorothiophosphate (FTP) synthons with high radiochemical yields can be rapidly generated in reaction solutions using wet [18F]F- without the need for substrate pre-modification or lengthy radiosynthesis procedures. This simplified one-pot 18F-labeling method allows for the visualization and translation of a variety of biomolecules, making it valuable for modern positron emission tomography techniques.
Article
Environmental Sciences
Thibaut Pollina, Adam G. Larson, Fabien Lombard, Hongquan Li, David Le Guen, Sebastien Colin, Colomban de Vargas, Manu Prakash
Summary: Oceans cover 97% of the Earth's water and are home to microscopic plankton that play a crucial role in global biogeochemical cycles. However, assessing marine plankton has been challenging due to the vastness of the oceans and the logistical and economic constraints of sampling. In this study, researchers present a modular open-source strategy called PlanktoScope, which allows for versatile and reconfigurable imaging of plankton samples. The PlanktoScope is small, affordable, and can be controlled from any WiFi-enabled device, making it suitable for both laboratory and field use.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Rachael Fay, Imre Toro, Anna-Lena Schinke, Branko Simic, Jonas Schaefer, Birgit Dreier, Andreas Plueckthun, Jason P. Holland
Summary: Designed ankyrin repeat proteins (DARPins) modified with enzymatic methods and Zr-89-radiolabeled can serve as a new class of protein-based radiotracers for PET, exhibiting high specificity and affinity in HER2/neu-positive tumors.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Rachael Fay, Imre Toero, Anna-Lena Schinke, Branko Simic, Jonas V. Schaefer, Birgit Dreier, Andreas Pluckthun, Jason P. Holland
Summary: In this study, a genetically engineered protein called G3-DARPin was modified with enzymatic methods and radiolabeled for positron emission tomography (PET) applications. The results demonstrated that DARPins are an attractive platform for generating a new class of protein-based radiotracers for PET.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Organic
Heather M. Stein, Surendra R. Gundam, Aditya Bansal, Nicholas R. Nelson, Geoffry L. Curran, Timothy R. DeGrado, Mark A. Frye, John D. Port, Val J. Lowe, Melissa E. Murray, Mukesh K. Pandey
Summary: This study synthesized two PET probes and evaluated their permeability through the blood-brain barrier and affinity towards GSK-3 alpha/beta. The results showed that [F-18]F-CNPIFE had higher brain uptake compared to [F-18]F-CNBI, making it a promising PET probe for imaging GSK-3 alpha/beta.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biophysics
Jeong Hoon Lee, Pan Kee Bae, Hyunho Kim, Yoon Ji Song, So Yeon Yi, Jungsun Kwon, Joon-Seok Seo, Jeong-min Lee, Han-Sang Jo, Seon Mee Park, Hee Sue Park, Kyeong Seob Shin, Seok Chung, Yong Beom Shin
Summary: The on-site microfluidic serological assay proposed in the study allows for timely decisions to be made regarding patient status and population-wide screening for controlling the COVID-19 pandemic. The developed assay showed enhanced sensitivity and specificity for clinical samples of SARS CoV-2 patients, enabling daily monitoring of IgM/IgG titers and patterns to provide important insight into the immune response to the virus. Monitoring these titers promotes rapid on-site detection and comprehensive understanding of the immune response in COVID-19 patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yanke Shan, Bin Wang, Huachuan Huang, Keding Yan, Wenzhi Li, Shouyu Wang, Fei Liu
Summary: In this study, a high-throughput multimodal immunoassay platform is proposed for rapid on-site diagnostics of COVID-19. The platform utilizes fluorescent, colorimetric, and chemiluminescent immunoassays, and can simultaneously detect multiple samples, providing high sensitivity and fast detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ebba Gloersen Muller, Caroline Stokke, Henning Langen Stokmo, Trine Holt Edwin, Anne-Brita Knapskog, Mona-Elisabeth Revheim
Summary: The study assessed quantitative measurements of F-18-Flutemetamol PET images using different software, finding similar performance in discriminating visually positive and negative PET images. Thresholds should be software-specific and cautiously applied across different software.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Dmitrii O. Antuganov, Michail A. Nadporojskii, Yulia A. Kondratenko
Summary: The possibility of (AlF)-F-18-radiolabeling using the N,N'-bis [2-hydroxy-5-(2-carboxyethyl)benzyl] ethylenediamine-N, N'-diacetic acid motif in protic alkanolammonium ionic liquids is reported for the first time. Ionic liquids containing triethanolammonium or triisopropanolammonium cations were found to be the most promising, achieving high radiochemical conversion with minimal precursor amounts.
MENDELEEV COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Jing Liu, Bin Wang, Huachuan Huang, Dan Jian, Yunan Lu, Yanke Shan, Shouyu Wang, Fei Liu
Summary: A quantum dot microsphere-based immunochromatographic quantitative CIP test strip has been designed, providing a low detection limit and wide linear detection range with high sensitivity, accuracy, selectivity, reproducibility, and stability. Additionally, a smartphone-based test strip reader has been fabricated for automatic and quantitative CIP detection, with the entire process being cost-efficient.
Article
Pharmacology & Pharmacy
Gaelle Hugon, Sebastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier
Summary: Focused ultrasound in combination with microbubbles enhances therapeutics delivery to the brain by increasing blood-brain barrier permeability. PET imaging using [F-18]FDS is evaluated as a marker for BBB integrity, showing significantly increased distribution in the brain after FUS. These findings demonstrate the potential of [F-18]FDS PET as a sensitive and reproducible marker for noninvasive monitoring of BBB disruption induced by FUS in vivo.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fernando U. Kay, Vinh Ho, Edmund B. Dosunmu, Avneesh Chhabra, Keenan Brown, Xinhui Duan, Orhan K. Oz
Summary: Low bone mineral density (BMD) was found to be common in oncologic patients undergoing F-18-FDG PET/CT. Decreased F-18-FDG avidity of bone marrow correlated with decreased BMD, validating the link between osteoporosis and bone marrow fat. CT attenuation value of L1 vertebrae could serve as a simple and accurate approach for detecting patients at risk for osteoporosis-related fractures using PET/CT data.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Chemistry, Analytical
Di Xu, Lili Zhang, Guangying Zhang, Wenyue Liu, Ying Lu
Summary: A novel and portable detection platform was developed for the rapid screening and detection of pesticide residues in food. The platform combines simple sample pretreatment, lateral flow test strips based on multi-branched gold nanoparticle, and a smartphone as a portable signal analyzer. The platform enables ultrasensitive quantitative detection of procymidone in red wine, as well as rapid detection of various fruits and vegetables.
Article
Multidisciplinary Sciences
Ella Nissan, Uri Amit, Leo Baron, Amit Zabatani, Damien Urban, Iris Barshack, Tima Davidson
Summary: In this study, the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome) was assessed. Results showed a relatively good effectiveness of [18F]FDG-PET/CT in detecting primary tumors, especially in non-SCC type patients. However, the detection rate was lower in SCC patients. Additionally, [18F]FDG-PET/CT had a positive impact on the clinical management of patients with discovered primary tumors.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Interdisciplinary Applications
Liupengfei Wu, Weisheng Lu, Fan Xue, Xiao Li, Rui Zhao, Maohong Tang
Summary: This study developed a blockchain-enabled IoT-BIM platform for off-site production management in modular construction to address the single point of failure and provenance issues. By comparing with existing IoT-enabled BIM platforms, it was found that the new system can effectively reduce storage costs, avoid single points of failure, and ensure the provenance of BIM modifications.
COMPUTERS IN INDUSTRY
(2022)
