Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 52, Issue 23, Pages 7421-7431Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm900622d
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- Council of Scientific and Industrial Research (CSIR), New Delhi
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Naturally occurring antimicrobial peptides contain a large number of amino acid residues, which limits their clinical applicability. In search of short antimicrobial peptides, which represent a possible alternative for lead structures to fight antibiotic resistant microbial infections, a series of synthetic peptide analogues based oil Trp-His and His-Arg structural frameworks have been prepared and found to be active against several Gram-negative and Gram-positive bacterial strains as well as against a fungal strain with MIC values of the most potent Structures in the range of 5-20 mu g/mL ((IC50 in the range of 1-5 mu g/mL). The synthesized peptides showed no cytotoxic effect in an MTT assay up to the highest test concentration of 200 mu g/mL. A combination of small size, presence of unnatural amino acids, high antimicrobial activity, and absence of cytotoxicity reveals the synthesized Trp-His and His-Arg analogues as promising candidates for novel antimicrobial therapeutics.
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