Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 18, Pages 5490-5493Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800754r
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Proteinase activated receptor-2 plays a crucial role in a wide variety of conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists. These ligands may be useful as pharmacological tools for elucidating the complex physiological role of the PAR-2 receptors as well as for the development of PAR-2 antagonists.
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