Article
Food Science & Technology
Jingru Zheng, Yuanhong Gao, Jie Ding, Na Sun, Songyi Lin
Summary: The study shows that Antarctic krill peptides can repair scopolamine-induced memory impairment by enhancing SOD activity and ACh level while reducing AChE and MDA levels in hippocampal neurons.
Article
Multidisciplinary Sciences
Mir-Jamal Hosseini, Niloofar Mahmoodi, Javad Eskandari, Soroush Bijani, Ali Reza Yazdinezhad, Mahdieh Anoush
Summary: The study found that V. herbacea extract has significant therapeutic effects on Alzheimer's disease, improving learning and memory functions, enhancing antioxidant defense, and reducing oxidative stress. This highlights the important pharmacological role of V. herbacea in the treatment of Alzheimer's disease.
Article
Neurosciences
Kinjal Doshi, Stacey L. Henderson, Qianqian Fan, Kian F. Wong, Julian Lim
Summary: The study found that a cognition-focused mindfulness-based intervention had significant improvements in global cognition and delayed memory in MCI patients, although it did not show advantages over usual treatment. Depression did not change in the MBT group, and only reductions in depression were associated with improvements in cognitive functioning in this group.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
Leonardo Santos Lopes da Silva, Marcio Fernando Tasinafo Junior, Leonardo da Silva Goncalves, Arthur Polveiro da Silva, Luis Felipe Pengo Almeida Leite, Laura Scatena Favero, Mateus do Carmo Bardella, Joao Gabriel Ribeiro de Lima, Carlos Roberto Bueno Junior, Camila de Moraes
Summary: This study conducted a systematic review and meta-analysis to examine the effects of multicomponent training on the cognitive function of older adults without cognitive impairment. The results showed that multicomponent training improves cognitive function in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Immunology
Jiacheng Wu, Yuqi Zhu, Limian Zhou, Yang Lu, Tingting Feng, Mengyu Dai, Jiaxue Liu, Wen Xu, Wanpeng Cheng, Fenfen Sun, Hua Liu, Wei Pan, Xiaoying Yang
Summary: Parasite-derived excretory-secretory products (ESPs) were found to alleviate cognitive impairment and gut microbiota dysbiosis induced by a high-fat diet, suggesting a potential therapeutic avenue for obesity-associated neurodegenerative diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Chuanjun Zhuo, Hongjun Tian, Guangdong Chen, Jing Ping, Lei Yang, Chao Li, Qiuyu Zhang, Lina Wang, Xiaoyan Ma, Ranli Li, Yun Sun, Xueqin Song, Langlang Cheng
Summary: A combination of low-dose lithium and moderate-dose quetiapine improved cognitive performance in murine models of schizophrenia, while moderate-dose lithium used either as monotherapy or as an adjunct with quetiapine worsened cognitive function. Further research is needed to understand the molecular mechanisms underlying these contrasting effects.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
Michele L. Callisaya, Oshadi Jayakody, Anagha Vaidya, Velandai Srikanth, Maree Farrow, Kim Delbaere
Summary: This study aimed to examine the efficacy of a novel tablet-delivered cognitive-motor program on mobility in older people with cognitive impairment. Despite not reaching the planned sample size due to COVID-19 restrictions, the intervention group showed a trend towards improvement in gait speed.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Jeremy M. Silverman, Carolyn W. Zhu, James Schmeidler, Pearl G. Lee, Neil B. Alexander, Elizabeth Guerrero-Berroa, Michal S. Beeri, Rebecca K. West, Mary Sano, Martina Nabozny, Martha Karran
Summary: This study compared an adaptive computerized cognitive training intervention with a non-adaptive version in type 2 diabetes patients. Contrary to the hypothesis, only memory showed improvement in the adaptive arm. Post-hoc analysis combining the two arms revealed that computer-related activities may improve diabetes self-management and other outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Patrick Manser, Lars Michels, Andre Schmidt, Filip Barinka, Eling D. de Bruin
Summary: This study aims to explore the effectiveness of a newly developed exergame-based motor-cognitive training concept called Brain-IT in improving cognitive functioning in older adults with mild neurocognitive disorder. A randomized controlled trial will be conducted with 34 to 40 participants, and various outcomes such as global cognitive functioning, brain structure and function, and psychosocial factors will be assessed. Data collection is expected to be completed by December 2023, and the results will be submitted for publication in 2024.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Biochemistry & Molecular Biology
Carolina S. Marques, Oscar Lopez, Donatella Bagetta, Elisabete P. Carreiro, Sabrina Petralla, Manuela Bartolini, Matthias Hoffmann, Stefano Alcaro, Barbara Monti, Maria Laura Bolognesi, Michael Decker, Jose G. Fernandez-Bolanos, Anthony J. Burke
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Julian Hofmann, Shaimaa Fayez, Matthias Scheiner, Matthias Hoffmann, Sabrina Oerter, Antje Appelt-Menzel, Pamela Maher, Tangui Maurice, Gerhard Bringmann, Michael Decker
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Medicinal
Antonios Drakopoulos, Zsombor Koszegi, Yann Lanoiselee, Harald Huebner, Peter Gmeiner, Davide Calebiro, Michael Decker
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Filippo Basagni, Michela Rosini, Michael Decker
Review
Chemistry, Multidisciplinary
Antonios Drakopoulos, Michael Decker
Article
Chemistry, Multidisciplinary
Julian Hofmann, Tiziana Ginex, Alba Espargaro, Matthias Scheiner, Sandra Gunesch, Marc Arago, Christian Stigloher, Raimon Sabate, F. Javier Luque, Michael Decker
Summary: Research has shown that azobenzene compounds designed as bioisoteres of curcumin exhibit better activity in inhibiting Aβ42 aggregation, oxidative stress, and neuroinflammation. The most active compound can effectively prevent cell apoptosis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Medicinal
Christian Gentzsch, Matthias Hoffmann, Yasuhiro Ohshima, Naoko Nose, Xinyu Chen, Takahiro Higuchi, Michael Decker
Summary: The study presents the design and synthesis of a morpholine-based, selective inhibitor of human BChE as a PET tracer with pseudo-irreversible binding mode, aiming to enable early diagnosis of neurodegenerative diseases and monitor disease progression in some forms of cancer. The novel protecting group strategy for F-18 radiolabeling of carbamate precursors and the retention of inhibitory potency and kinetic properties of the unlabeled reference compound show promise for precise mapping of BChE distribution.
Article
Biochemistry & Molecular Biology
Diego A. Rodriguez-Soacha, Julia Fender, Yesid A. Ramirez, Juan Antonio Collado, Eduardo Munoz, Rangan Maitra, Christoph Sotriffer, Kristina Lorenz, Michael Decker
Summary: The study describes the design and synthesis of photo-rimonabant, azo-derivatives of the selective hCB(1)R antagonist SR1411716A, which showed marked affinity for CB1R and increased potency under ultraviolet light. Through various assays, it was established that compound 16a is highly selective for hCB(1)R over hCB(2)R, making it a valuable molecular tool for optical modulation of CBRs and enhancing the understanding of disorders related to the endocannabinoid system.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Feng He, C. James Chou, Matthias Scheiner, Eleonora Poeta, Natalia Yuan Chen, Sandra Gunesch, Matthias Hoffmann, Christoph Sotriffer, Barbara Monti, Tangui Maurice, Michael Decker
Summary: In this study, melatonin and ferulic acid were incorporated into tertiary amide-based histone deacetylase 6 (HDAC6) inhibitors to develop multi-target-directed inhibitors for neurodegenerative diseases, maintaining antioxidant effects while ensuring high affinity and selectivity at HDAC6. The resulting compound 10b showed significant and selective inhibition of HDAC6, comparable antioxidant abilities to ferulic acid and melatonin, and no neurotoxicity. It also exhibited immunomodulatory effects and demonstrated higher efficacy in an AD mouse model compared to the positive control HDAC6 inhibitor ACY1215 and an equimolar mixture of ACY1215, melatonin, and ferulic acid, suggesting potential disease-modifying properties.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Gentzsch, Xinyu Chen, Philipp Spatz, Urban Kosak, Damijan Knez, Naoko Nose, Stanislav Gobec, Takahiro Higuchi, Michael Decker
Summary: In this study, a selective and reversible PET tracer targeting AD diagnosis was successfully synthesized, labeled with F-18, and demonstrated promising activity and binding potential in in vitro experiments.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julian C. Schmid, Kerstin Frey, Matthias Scheiner, Jaime Felipe Guerrero Garzon, Luise Stafforst, Jan-Niklas Fricke, Michaela Schuppe, Hajo Schiewe, Axel Zeeck, Tilmann Weber, Isabel Uson, Ralf Kemkemer, Michael Decker, Stephanie Grond
Summary: Rhizolutin and Collinolactone, isolated from Streptomyces, share a novel carbon scaffold and have been studied using NMR, X-Ray crystallography, and isotope-labeled precursor feeding. Collinolactone has been found to be synthesized via a specific pathway and its analogues have inhibitory effects on L929 cell line. Additionally, certain analogues induce monopolar spindles in cells, impairing cell division in mitosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Medicinal
Matthias Scheiner, Matthias Hoffmann, Feng He, Eleonora Poeta, Arnaud Chatonnet, Barbara Monti, Tangui Maurice, Michael Decker
Summary: A series of multitarget-directed ligands (MTDLs) were designed by functionalizing a pseudo-irreversible butyrylcholinesterase (BChE) inhibitor, showing retention of antioxidative properties in vitro and maintenance of hBChE inhibition in the submicromolar range. The most promising compound demonstrated high efficacy in a pharmacological Alzheimer's disease (AD) mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Caterina Pont, Tiziana Ginex, Christian Grinan-Ferre, Matthias Scheiner, Alexia Mattellone, Noemi Martinez, Elsa M. Arce, Yolanda Soriano-Fernandez, Marina Naldi, Angela De Simone, Marta Barenys, Jesus Gomez-Catalan, Belen Perez, Raimon Sabate, Vincenza Andrisano, Maria Isabel Loza, Jose Brea, Manuela Bartolini, Maria Laura Bolognesi, Michael Decker, Merce Pallas, F. Javier Luque, Diego Munoz-Torrero
Summary: Through virtual screening, a lead compound with potential anti-AD activity has been identified, showing activity against BACE-1 and cholinesterases, while also playing a role in inhibiting Ab42 and tau aggregation, improving memory, and increasing synaptic protein levels.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Matthias Scheiner, Alexandra Sink, Matthias Hoffmann, Cassandre Vrigneau, Erik Endres, Allison Carles, Christoph Sotriffer, Tangui Maurice, Michael Decker
Summary: Selective and pseudoirreversible photoswitchable BChE inhibitors were synthesized to investigate their biological functions and the mechanisms by which they affect Alzheimer's disease. One of the compounds showed significant differences in activity both in vitro and in vivo, and exhibited complete recovery in a murine cognition-deficit AD model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Matthias Scheiner, Alexandra Sink, Philipp Spatz, Erik Endres, Michael Decker
Summary: This study focused on developing light-controlled inhibitors of the enzyme acetylcholinesterase, with a novel azobenzene-based bistacrine AChE inhibitor showing faster switching and reverse interactions compared to the known dithienylethene based bistacrine. The study also optimized a previously described light-controlled tacrine-based AChE inhibitor, demonstrating isomerization upon UV light irradiation and significant inhibitory effects on hAChE.
