Article
Pediatrics
Xifeng Tang, Ge Dai, Ting Wang, Huiming Sun, Wujun Jiang, Zhengrong Chen, Yongdong Yan
Summary: In this study, the clinical data of hospitalized children with lower respiratory tract infections caused by human bocavirus (HBoV) and human metapneumovirus (hMPV) were compared. The detection rate of HBoV was significantly higher than that of hMPV. Compared to hMPV, HBoV is more likely to cause severe infection and has a greater impact on children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Meghana Nadiger, Prithvi Sendi, Paul A. Martinez, Balagangadhar R. Totapally
Summary: In hospitalized children in the United States, HMPV infection is less common than RSV infection. Complex chronic conditions are more prevalent in children hospitalized with HMPV infection. Hospitalization with HMPV is associated with longer length of stay and higher hospital charges. The adjusted mortality is similar with both infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Mandy Jongbloed, Wouter T. Leijte, Catharina F. M. Linssen, Bernadette G. van den Hoogen, Eric C. M. van Gorp, Martijn D. de Kruif
Summary: The study found that during the COVID-19 pandemic, the incidence of HMPV infections remained stable, with similar clinical characteristics and outcomes in patients compared to the non-COVID-19 period, except for shorter hospital stays. HMPV infection and COVID-19 shared many clinical features, but HMPV was more common in females, elderly patients, and those with chronic conditions such as COPD and chronic heart failure.
INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Hedda Tromborg Jalving, Inger Heimdal, Jonas Valand, Kari Risnes, Sidsel Krokstad, Svein Arne Nordbo, Henrik Dollner, Andreas Christensen
Summary: Human bocavirus 1 (HBoV1) is frequently detected in asymptomatic children and is often co-detected with other viruses. This study aimed to assess the burden of HBoV1 respiratory tract infections (RTI) in hospitalized children and the impact of viral codetections, compared with respiratory syncytial virus (RSV).
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Virology
Suncanica Ljubin-Sternak, Anamarija Slovic, Maja Mijac, Mirna Jurkovic, Dubravko Forcic, Irena Ivkovic-Jurekovic, Tatjana Tot, Jasmina Vranes
Summary: The study investigated the prevalence of HBoV genotypes in pediatric patients with respiratory tract infections in Croatia, revealing that 7.6% of children were infected with HBoV, primarily belonging to the HBoV1 genotype. Co-infection was observed in 82.2% of the samples.
Review
Infectious Diseases
David Polo, Alberto Lema, Enia Gandara, Jesus L. Romalde
Summary: Through a systematic review and meta-analysis of 35 studies in Europe, it was found that HBoV has a moderate prevalence among European countries, with no significant differences in prevalence by country. The study also analyzed the prevalence of HBoV as a single infection or co-infection with other viruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Yun Du, Wei Li, Yajun Guo, Lin Li, Qiang Chen, Lin He, Shiqiang Shang
Summary: This study investigated the epidemiological and genetic characteristics of HMPV in pediatric patients in Hangzhou, China after the peak of the COVID-19 pandemic. The results showed that HMPV is an important viral respiratory pathogen in children with ARTI, occurring mainly in children older than 6 years, and with a higher diagnosis rate of lower respiratory tract infections compared to upper respiratory tract infections.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ayse Karaaslan, Ceren Cetin, Serap Demir Tekol, Ufuk Yuekselmis, Mehmet Tolga Koele, Yasemin Akin
Summary: This study aimed to investigate the effects of HBoV1 on the course of lower respiratory tract infections in cases of monoinfection and coinfection, and the effects of HBoV1 viral load on the disease in children under six years old hospitalized with a diagnosis of HBoV1-associated lower respiratory tract infections. The results showed that coinfection was associated with the length of hospitalization, while HBoV1 viral load had no effect on the severity of the disease.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Immunology
Nitipong Permpalung, Afrah S. Sait, Katrina Bazemore, Robin K. Avery, Joby Mathew, Pali D. Shah
Summary: The study found that lung transplant recipients infected with HMPVi and PIVi had similar baseline characteristics, infection parameters, treatment allocation, and allograft function outcomes. Additionally, one-third of the patients developed CLAD stage progression within 1 year post-infection.
Article
Pediatrics
Jyoti Lamichhane, Milan Upreti, Krishus Nepal, Bishnu Prasad Upadhyay, Urusha Maharjan, Ram Krishna Shrestha, Ram Hari Chapagain, Megha Raj Banjara, Upendra Thapa Shrestha
Summary: The study focused on Human Metapneumovirus (HMPV) infections and their severity among children in Nepal. HMPV was found to be the most common viral infection in children with acute respiratory infections (ARIs), especially in children under three years old. The common symptoms of HMPV infection included cough, fever, rhinorrhea, sore throat, and wheezing. HMPV was associated with pneumonia, bronchiolitis, upper respiratory tract infections, and asthma. The prevalence of HMPV was highest in late winter.
Article
Infectious Diseases
Shanshan Cong, Chao Wang, Tianli Wei, Zhiping Xie, Yiman Huang, Jingjing Tan, Aijun Chen, Fenlian Ma, Lishu Zheng
Summary: This study investigated the epidemiology and genotypic diversity of HMPV in hospitalized children with ARTIs in Beijing, China. It found that HMPV is an important cause of ARTIs in children under 5 years old, with the peak occurring in winter and spring and the A2b subtype being the most common. The study also showed a significant decrease in HMPV infection among hospitalized children with ARTIs during the COVID-19 pandemic.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Margot Miranda-Katz, John J. Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John Williams
Summary: The study identified 6 HLA-B7-restricted CD8(+) T cell epitopes in mice infected with HMPV, with M195-203 (M195) eliciting the strongest response. Immunization with pooled HLA-B7-restricted peptides reduced viral titer and protected mice from virulent infection. CD8(+) T cells from HLA-B7 positive humans also recognize the identified epitopes, providing valuable information for future HMPV vaccine design.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ji Yoon Han, Seung Beom Han
Summary: Although febrile seizures are the most common neurological complication of influenza, studies comparing seizure characteristics and outcomes between patients with influenza and other respiratory virus (RV) infections are limited. This study found that patients with influenza were older than those with other RV infections and showed a higher percentage of patients aged >= 5 years. Complex febrile seizure characteristics were more frequent in patients with other RV infections, but the frequency of epilepsy was comparable between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jae Kyoon Hwang, Jae Yoon Na, Jihye Kim, Jae-Won Oh, Yong Joo Kim, Young-Jin Choi
Summary: This study aimed to identify age-specific characteristics of respiratory viral infections. The results showed that viral infection and co-infection rates were higher in pediatric patients, with co-infections being more common in younger patients. In adult patients, the rates of viral infections and co-infections were lower, but co-infections were more common in older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Pawel Franczuk, Michal Tkaczyszyn, Maria Kulak, Esabel Domenico, Piotr Ponikowski, Ewa Anita Jankowska
Summary: Viral respiratory infections (VRI) are common and can worsen existing cardiovascular diseases and lead to new complications, especially in COVID-19.
Article
Public, Environmental & Occupational Health
Maria Gori, Clara Fappani, Silvia Bianchi, Marta Canuti, Daniela Colzani, Paolo Ottogalli, Sarah Duehren, Elisabetta Tanzi, Antonella Amendola, Antonio Boschini
Summary: Despite the COVID-19 pandemic, influenza remains a significant issue, especially in community settings where influenza outbreaks can be difficult to control and result in high attack rates. In April 2022, there was a large A(H3N2) influenza outbreak in the largest Italian drug-rehabilitation community, with 184 individuals experiencing influenza-like symptoms (attack rate of 26.2%); 56% of them had previously received the influenza vaccine. Sequence analyses revealed a genetic drift from the vaccine strain, which may have led to the observed lack of protection.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Biochemistry & Molecular Biology
Marta Canuti, Bruce Rodrigues, Andrew S. Lang, Suzanne C. Dufour, Joost T. P. Verhoeven
Summary: Metagenomic methods were used to identify two novel members of the Kitrinoviricota and Tombusviridae families in the gut of red-backed voles. These viruses likely originated from the vole's diet and represent the first members of new species. The study highlights the need to update taxonomy systems to include genomes identified through metagenomic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Donatella Panatto, Alexander Domnich, Maria Chironna, Daniela Loconsole, Christian Napoli, Alessandra Torsello, Ilaria Manini, Emanuele Montomoli, Elena Pariani, Silvana Castaldi, Andrea Orsi, Giancarlo Icardi
Summary: This study investigated the epidemiology of severe acute respiratory infections (SARI) among Italian adults and estimated the effectiveness of the 2021/22 season influenza vaccine. The results showed that influenza cases were mostly detected among non-vaccinated individuals, indicating a protective effect of influenza vaccination.
Article
Biochemistry & Molecular Biology
Claudia Vanetti, Vito Lampasona, Marta Stracuzzi, Claudio Fenizia, Mara Biasin, Irma Saulle, Fiona Limanaqi, Ahmed Abdelsalam, Cristian Loretelli, Laura Paradiso, Emma Longoni, Lucia Barcellini, Lorenzo Piemonti, Ilaria Marzinotto, Stefania Dispinseri, Antonella Amendola, Clara Fappani, Elisabetta Tanzi, Mario Salvatore Clerici, Gabriella Scarlatti, Gian Vincenzo Zuccotti, Vania Giacomet, Daria Trabattoni
Summary: This study analyzed the immune profiles of 18 hospitalized children with SARS-CoV-2 infection and found that different severity levels of children cases showed different immune characteristics. Infants with severe symptoms exhibited high inflammatory response and extreme antibody response, while mild cases had lower levels of inflammation and antibodies. Overall, the immune response in children is directly correlated with the clinical severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Elisabetta Tanzi, Silvia Bianchi, Clara Fappani, Maria Gori, Daniela Colzani, Ilaria Passera, Camilla Tincati, Marta Canuti, Mario Raviglione, Antonella Amendola
Summary: The majority of cervical cancer cases and associated deaths occur in low- and middle-income countries, where sociocultural barriers and poor access to prevention and care hinder screening coverage improvement. Using urine specimens for HPV molecular screening through automated testing platforms can help to overcome these problems.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Anna Prigitano, Elisabetta Blasi, Maria Calabro, Caterina Cavanna, Maria Cornetta, Claudio Farina, Anna Grancini, Patrizia Innocenti, Giuliana Lo Cascio, Lucia Nicola, Laura Trovato, Massimo Cogliati, Maria Carmela Esposto, Anna Maria Tortorano, Luisa Romano
Summary: The FiCoV study in Italy aims to estimate the frequency of yeast bloodstream infections in COVID-19 patients, identify factors associated with these infections, and analyze antifungal susceptibility profiles. The study found a low prevalence of yeast BSI, occurring in 1.06% of patients, mainly among older critically ill patients admitted to intensive care units. The study also revealed a high fatality rate associated with fungal co-infection and increasing resistance to antifungal medications.
Article
Respiratory System
Antonio Piralla, Francesco Mojoli, Laura Pellegrinelli, Ferruccio Ceriotti, Antonia Valzano, Giacomo Grasselli, Maria Rita Gismondo, Valeria Micheli, Antonio Castelli, Claudio Farina, Marco Arosio, Ferdinando Luca Lorini, Diana Fanti, Andrea Busni, Matteo Laratta, Fabrizio Maggi, Federica Novazzi, Luca Cabrini, Anna Paola Callegaro, Roberto Keim, Giuseppe Remuzzi, Annalisa Cavallero, Sergio Maria Ivano Malandrin, Roberto Rona, Federica Giardina, Guglielmo Ferrari, Federica Zavaglio, Piera D'angelo, Cristina Galli, Laura Bubba, Sandro Binda, Massimo Oggioni, Sara Colonia Uceda Renteria, Patrizia Bono, Andreina Baj, Francesca Drago Ferrante, Davide Guarneri, Marco Tonelli, Gavino Napolitano, Alice Nava, Lorenzo Romeo, Elena Nicolini, Rea Valaperta, Ludovica Varisano, Caterina Mele, Lucia Liguori, Monica Raggi, Silvia Mongodi, Michele Pagani, Paolo Severgnini, Dario Gasberti, Ezio Bonanomi, Paolo Gritti, Francesco Marrazzo, Ilaria Giovannini, Noemi Sacchi, Orlando Sagliocco, Danilo Cereda, Sabrina Buoro, Fausto Baldanti, Elena Pariani
Summary: This multicenter observational study included 171 COVID-19 adult patients hospitalized in the ICUs of nine hospitals in Lombardy (Northern Italy) from December, 1st 2021, to February, 9th 2022. The study found that the Delta/Omicron variant ratio of cases in ICU patients decreased with a delay of two weeks compared to that in the community. Unvaccinated patients had a higher proportion of Delta infections, while boosted patients had a higher rate of Omicron infections. The number of comorbidities and comorbidity score were positively associated with Omicron infection among ICU patients, including vaccinated individuals. The risk of severe disease and the need for ICU admission and mechanical ventilation due to Omicron versus Delta infection remains uncertain.
RESPIRATORY MEDICINE AND RESEARCH
(2023)
Article
Virology
Clara Fappani, Maria Gori, Silvia Bianchi, Mara Terraneo, Erica Bilardi, Daniela Colzani, Elisabetta Tanzi, Marta Canuti, Antonella Amendola
Summary: In order to improve surveillance and diagnosis of measles and rubella cases, researchers investigated the presence of other viral pathogens in discarded cases and used multiplex real-time PCR for differential diagnosis. They found that 65.1% of discarded cases still had at least one pathogen, with HHV-7 being the most common. The introduction of laboratory methods improves the accuracy of case classification.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Silvia Bianchi, Clara Fappani, Maria Gori, Marta Canuti, Daniela Colzani, Maria Cristina Monti, Camilla Torriani, Mario C. Raviglione, Gianvincenzo Zuccotti, Elisabetta Tanzi, Antonella Amendola
Summary: According to the study, SARS-CoV-2 was spreading in Lombardy, Italy, as early as late 2019, with detected cases of antibody-positive patients. These findings should encourage further research to investigate the possibility of pre-pandemic undetected circulation of SARS-CoV-2.
Article
Virology
Giovanni Franzo, Francesco Mira, Giorgia Schiro, Marta Canuti
Summary: Asian CPV-2c is a virus lineage that emerged in Asia around 2008 and started spreading to other continents, including Africa, Europe, and North America, after 2012. Asia is predicted to be the main source of viral dispersion, leading to multiple introductions in other continents/countries and resulting in infection establishment, persistence, and rapid evolution. Although dogs are the main hosts, other non-canine species are also involved.
Article
Medicine, General & Internal
Hadrian Jules Ang, Francesco Menegale, Giuseppe Preziosi, Elena Pariani, Maurizio Migliari, Laura Pellegrinelli, Giuseppe Maria Sechi, Sabrina Buoro, Stefano Merler, Danilo Cereda, Marcello Tirani, Piero Poletti, Ilaria Dorigatti
Summary: A study found that the social distancing measures implemented against COVID-19 disrupted the seasonal circulation of respiratory syncytial virus (RSV) in Lombardy, Italy, and resulted in a significant increase in hospitalizations during 2021-2022. The study aimed to quantify the immunity gap to RSV infection in Lombardy following the relaxation of COVID-19 restrictions and identified heterogeneity in RSV transmission by age. The findings highlight the substantial increase in population-level susceptibility to RSV in Lombardy and provide important insights for epidemic control and prevention.