Review
Infectious Diseases
David Polo, Alberto Lema, Enia Gandara, Jesus L. Romalde
Summary: Through a systematic review and meta-analysis of 35 studies in Europe, it was found that HBoV has a moderate prevalence among European countries, with no significant differences in prevalence by country. The study also analyzed the prevalence of HBoV as a single infection or co-infection with other viruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Chikara Ogimi, Emily T. Martin, Hu Xie, Angela P. Campbell, Alpana Waghmare, Keith R. Jerome, Wendy M. Leisenring, Filippo Milano, Janet A. Englund, Michael Boeckh
Summary: BoV respiratory tract infections in transplant recipients are rare and associated with mild symptoms. Risk factors for acquisition include younger age and exposure to children.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Microbiology
Sandra Trapani, Alice Caporizzi, Silvia Ricci, Giuseppe Indolfi
Summary: Human bocavirus (HBoV) has emerged as an increasingly reported pathogen, primarily associated with respiratory tract infections in adults and children. It can act as a co-infectious agent or an isolated viral pathogen, and has also been found in asymptomatic individuals. This review provides an overview of HBoV's epidemiology, risk factors, transmission, pathogenicity, detection methods, and clinical features, including severe infections requiring hospitalization and rare fatal cases. Tissue viral persistence, reactivation, reinfection, and the burden of HBoV disease are also evaluated.
Article
Infectious Diseases
Michal Stein, Hodaya Cohen, Ital Nemet, Nofar Atari, Limor Kliker, Ilana S. Fratty, Efrat Bucris, Miranda Geva, Ella Mendelson, Neta Zuckerman, Michal Mandelboim
Summary: This study compared the infection rates and circulating subtypes of human metapneumovirus (hMPV) in Israel before (2019-2020) and after the emergence of COVID-19 (2021). The results showed that during the COVID-19 pandemic, there was a delayed peak in hMPV infection cases and higher infection rates among young children. Viral sequencing also revealed a shift in the most prevalent circulating hMPV subtype during the study period.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Maja Mijac, Suncanica Ljubin-Sternak, Irena Ivkovic-Jurekovic, Jasmina Vranes
Summary: Human bocavirus (HBoV) is an important respiratory pathogen, especially in children, but it is often found in co-detection with other respiratory viruses, which makes the diagnostic approach challenging. We compared multiplex PCR and quantitative PCR for HBoV with multiplex tandem PCR (MT-PCR) in 55 cases of co-detection of HBoV and other respiratory viruses. In addition, we investigated whether there is a connection between the severity of the disease, measured by the localization of the infection, and amount of virus detected in the respiratory secretions. No statistically significant difference was found, but children with large amount of HBoV and other respiratory virus had a longer stay in hospital.
Article
Pediatrics
Elina Oldhoff, Rutger Bennet, Margareta Eriksson, Tobias Allander
Summary: In this study, the characteristics, seasonality, pre-existing medical conditions, codetections, clinical manifestations, and complications of HBoV1 infection in children in Stockholm were retrospectively described. The results showed that HBoV1 mainly occurred from December to March and was often co-detected with other viruses. However, the viral load was associated with patient age, single detection of HBoV1, and early season. There were few differences in clinical manifestations between different subgroups of HBoV1.
Article
Infectious Diseases
Hedda Tromborg Jalving, Inger Heimdal, Jonas Valand, Kari Risnes, Sidsel Krokstad, Svein Arne Nordbo, Henrik Dollner, Andreas Christensen
Summary: Human bocavirus 1 (HBoV1) is frequently detected in asymptomatic children and is often co-detected with other viruses. This study aimed to assess the burden of HBoV1 respiratory tract infections (RTI) in hospitalized children and the impact of viral codetections, compared with respiratory syncytial virus (RSV).
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Microbiology
Ri De, Ke-Xiang Zhang, Fang Wang, Yu-Tong Zhou, Yu Sun, Dong-Mei Chen, Ru-Nan Zhu, Qi Guo, Shuang Liu, Dong Qu, Yuan Qian, Lin-Qing Zhao
Summary: The combination results of nucleic acid, antigen, and serology tests indicate that Human bocavirus 1 (HBoV1) is a genuine pathogen for acute respiratory tract infection (ARTI) in pediatric patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Andrea Tumpa, Zrinka Stritof, Selma Pintaric
Summary: This study investigated the prevalence and antimicrobial susceptibility of enterococci isolated from dogs and cats with urinary tract infections in northwestern Croatia. The results showed that enterococci exhibited high levels of resistance to antimicrobials, especially rifampicin and enrofloxacin. There were also differences in susceptibility to antimicrobials among different species of enterococci.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Xingang Zhang, Jishan Zheng, Lihua Zhu, Huiqing Xu
Summary: This study investigated the prevalence and clinical characteristics of human bocavirus (HBoV) infection in infants with acute lower respiratory tract infection in China. The results showed that HBoV was frequently detected in infants, with the highest prevalence in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Clinical symptoms included cough, fever, and respiratory distress.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Ayse Karaaslan, Ceren Cetin, Serap Demir Tekol, Ufuk Yuekselmis, Mehmet Tolga Koele, Yasemin Akin
Summary: This study aimed to investigate the effects of HBoV1 on the course of lower respiratory tract infections in cases of monoinfection and coinfection, and the effects of HBoV1 viral load on the disease in children under six years old hospitalized with a diagnosis of HBoV1-associated lower respiratory tract infections. The results showed that coinfection was associated with the length of hospitalization, while HBoV1 viral load had no effect on the severity of the disease.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Public, Environmental & Occupational Health
C. Tanislav, K. Kostev
Summary: This study investigated the occurrence of non-COVID-19-related upper respiratory tract infections, gastrointestinal infections, and urinary tract infections during the COVID-19 pandemic in Germany. The study found that these infections were less common during the pandemic, especially among pediatric patients. Urinary tract infections were impacted to a lesser extent. The results suggest that the measures implemented to prevent the spread of COVID-19 may also have helped reduce the spread of other infectious diseases.
Article
Multidisciplinary Sciences
Wanda G. H. Han, Arno Swart, Axel Bonacic Marinovic, Dirk Eggink, Johan Reimerink, Lisa A. Wijsman, Bas van der Veer, Sharon van den Brink, Anne-Marie van den Brandt, Sophie van Tol, Gert-Jan Godeke, Fion Brouwer, Marieke Hoogerwerf, Daphne F. M. Reukers, Nynke Rots, Chantal Reusken, Adam Meijer
Summary: This study investigated the dynamics of SARS-CoV-2 infection and diagnostics in household members after exposure. It found that children had higher viral loads than adults at symptom onset, and RNA in feces could be detected for longer. SARS-CoV-2-specific antibodies were detectable with a 90% probability from 7 days (total Ig) and 18 days (IgG) since symptom onset. RT-PCR on NP and OP specimens were more sensitive for early infection, while RT-PCR on feces specimens and serology were more valuable for late infection diagnostics.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Daphne Peeters, Pieter Verhulst, Anja A. P. H. Vaessen-Verberne, Xandra W. van den Tweel, Jeroen G. Noordzij, Gertjan J. A. Driessen
Summary: The study found that 64% of children presenting with recurrent respiratory tract infections in general pediatric practice had no detectable underlying pathology. Common diagnoses included asthma/preschool wheezing and adenoid hypertrophy, with none of the children having severe primary immunodeficiency or pulmonary illnesses such as cystic fibrosis. These findings can help guide pediatricians in diagnosing children with respiratory tract infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Critical Care Medicine
Steve Cunningham, Pedro A. Piedra, Federico Martinon-Torres, Henryk Szymanski, Benedicte Brackeva, Evelyne Dombrecht, Laurent Detalle, Carmen Fleurinck
Summary: This study evaluated the safety and antiviral activity of nebulised ALX-0171 in children hospitalized with RSV lower respiratory tract infection. Results showed faster viral load reduction with ALX-0171 treatment compared to placebo, but no significant improvement in clinical outcomes. Safety profile was similar between ALX-0171 and placebo groups. Future RSV antiviral studies should consider earlier intervention and more precise measurement of objective outcomes.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Virology
Mirna Jurkovic, Anamarija Slovic, Dubravko Forcic, Jelena Ivancic-Jelecki, Tanja Kosutic-Gulija, Maja Jagusic
Summary: The frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications indicate the need for more efficient vaccines and specific antiviral therapies. Ribavirin has been shown to induce mutations in the mumps virus genome without developing resistance in long-term exposure.
Article
Virology
Anamarija Slovic, Tanja Kosutic-Gulija, Dubravko Forcic, Maja Santak, Maja Jagusic, Mirna Jurkovic, Dorotea Pali, Jelena Ivancic-Jelecki
Summary: Researchers successfully generated multiple recombinant mumps viruses using consensus sequences and different strategies, and observed variations during different passages. Characteristic substitutions were identified in the generation of recombinant viruses, and close monitoring of sub-consensus variability is necessary to prevent unwanted mutations.
Article
Immunology
Sanda Ravlic, Ana Hecimovic, Tihana Kurtovic, Jelena Ivancic Jelecki, Dubravko Forcic, Anamarija Slovic, Ivan Christian Kurolt, Zeljka Macak Safranko, Tatjana Muslin, Dina Rnjak, Ozren Jaksic, Ena Soric, Gorana Dzepina, Oktavija Dakovic Rode, Kristina Kujavec Sljivac, Tomislav Vuk, Irena Jukic, Alemka Markotic, Beata Halassy
Summary: During the COVID-19 epidemic, efforts have been made to investigate SARS-CoV-2-specific antibodies as potential therapeutics. A method of establishing antibody characterisation has been proposed, showing a positive correlation between neutralising antibodies and disease severity, with a gradual decline in convalescents.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anita Bogdanov, Laszlo Janovak, Jasmina Vranes, Tomislav Mestrovic, Suncanica Ljubin-Sternak, Zsuzsanna Cseh, Valeria Endresz, Katalin Burian, Zeljka Vanic, Dezso P. Virok
Summary: Encapsulation of azithromycin (AZT) in surface-charged elastic liposomes enhances its antibacterial action against Chlamydia trachomatis, with lower minimal inhibitory concentrations and minimal bactericidal concentrations than free AZT. This has the potential to prevent treatment failures and improve the effectiveness of AZT.
Article
Microbiology
Petra Simicic, Anamarija Slovic, Leona Radmanic, Adriana Vince, Snjezana Zidovec Lepej
Summary: The molecular epidemiology of hepatitis C virus (HCV) is highly complex due to its genetic diversity. This study analyzed the genetic diversity, transmission dynamics, and epidemic history of the most common HCV genotypes. The results showed high prevalence of baseline resistance-associated substitutions (RAS) for NS3 inhibitors and NS5A inhibitors, with differences observed among different HCV genotypes. Phylogenetic analysis identified distinct clades and transmission clusters, with a strong association between certain transmission chains and intravenous drug users.
Review
Virology
Suncanica Ljubin-Sternak, Tomislav Mestrovic
Summary: The neglect of rhinovirus as an important agent of disease was due to its perceived mildness in causing respiratory infections. However, recent reports have recognized rhinovirus as a risk factor for asthma-related pathology in children, indicating its significance in respiratory illnesses. The lack of impact from social distancing measures during the COVID-19 pandemic has further highlighted the pathogenic role of rhinovirus.
Article
Medicine, General & Internal
Maja Mijac, Suncanica Ljubin-Sternak, Irena Ivkovic-Jurekovic, Jasmina Vranes
Summary: Human bocavirus (HBoV) is an important respiratory pathogen, especially in children, but it is often found in co-detection with other respiratory viruses, which makes the diagnostic approach challenging. We compared multiplex PCR and quantitative PCR for HBoV with multiplex tandem PCR (MT-PCR) in 55 cases of co-detection of HBoV and other respiratory viruses. In addition, we investigated whether there is a connection between the severity of the disease, measured by the localization of the infection, and amount of virus detected in the respiratory secretions. No statistically significant difference was found, but children with large amount of HBoV and other respiratory virus had a longer stay in hospital.
Article
Dermatology
Mario Mafic, Iva Hojsak, Tena Niseteo, Nives Pustisek, Oleg Jadresin, Irena Ivkovic-Jurekovic, Marta Navratil
Summary: This study reports the clinical case of an infant with extremely severe atopic dermatitis. The patient experienced protein loss, electrolyte imbalance, and immune deficiency as serious complications. The main mechanism of protein loss is attributed to damaged skin and eosinophilic inflammation of the small intestine.
ACTA DERMATOVENEROLOGICA CROATICA
(2022)
Article
Pediatrics
Ivan Pavic, Marta Navratil, Maja Bosanac, Jadranka Sekelj Fures, Irena Ivkovic Jurekovic, Iva Hojsak
Summary: This study found that both acid and non-acid reflux play significant roles in the pathogenesis of GER-related BRUE in infants. MII-pH monitoring was more sensitive in diagnosing GERD in infants who experienced BRUE.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2021)
