Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Gastroenterology & Hepatology
Gavin Clark, Judith A. Strachan, Frank A. Carey, Thomas Godfrey, Audrey Irvine, Alisson McPherson, Jess Brand, Annie S. Anderson, Callum G. Fraser, Robert J. C. Steele
Summary: The transition from FOBT to FIT screening resulted in higher uptake and positivity rates, with a lower PPV for CRC but a higher PPV for adenomas. The FIT pilot evaluation underestimated uptake and positivity rates, leading to a significant increase in colonoscopy demand.
Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Multidisciplinary Sciences
Lina Choe, Jerrald Lau, Larry Teck-Seng Yip, Guowei Kim, Ker-Kan Tan
Summary: There is limited evidence to support upper gastrointestinal screening in all FIT-positive patients following a colonoscopy. However, opportunistic OGD may have a role in this patient group.
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Matthew T. Keys, Miquel Serra-Burriel, Natalia Martinez-Lizaga, Maria Pellise, Francesc Balaguer, Ariadna Sanchez, Enrique Bernal-Delgado, Antoni Castells
Summary: The study found that FIT-based organized colorectal cancer screening in Spain was associated with a reduction in population colorectal cancer mortality. No differences in outcome trends were observed between exposed and control provinces in the 7 years prior to screening implementation. Two years after implementation, exposed provinces experienced an increase in colorectal cancer incidence, followed by a decrease in mortality rates after 7 years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medical Laboratory Technology
Sally C. Benton, Erin Symonds, Natasha Djedovic, Samantha Jones, Liesbet Deprez, Petr Kocna, Josep Maria Auge
Summary: FIT is increasingly used in colorectal cancer screening and patient symptom assessment, but faces challenges such as pre-analytical variation and quality control materials.
CLINICA CHIMICA ACTA
(2021)
Article
Gastroenterology & Hepatology
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
Summary: A study conducted in the Veneto region of Italy found that the risk of colorectal cancer mortality is significantly higher among individuals who do not undergo colonoscopy after a positive FIT result, highlighting the importance of increasing compliance in this high-risk population.
Article
Multidisciplinary Sciences
Kogila Ramanathan, Desiree Schliemann, Nor Saleha Binti Ibrahim Tamin, Devi Mohan, Michael Donnelly, Tin Tin Su
Summary: Colorectal cancer incidence is increasing in Malaysia, with many cases being diagnosed at a late stage. This study explores participant awareness of colorectal cancer and their attitudes towards screening, as well as the barriers and facilitators to participation in screening. Trust in doctors was identified as a key factor in seeking healthcare, and participants had low awareness of colorectal cancer symptoms and screening. Emotional and logistical concerns about sending stool samples to clinics were identified as major barriers to screening. Simplified instructions, free screening, and reminders were seen as strategies to increase engagement in screening. Primary care physicians play a crucial role in reducing misunderstandings, recommending screening, and improving attendance and uptake of colorectal cancer screening.
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Medical Laboratory Technology
Liesbet Deprez, Carolyn Piggott, Eline A. E. van der Hagen, Marieke C. Frasa, Sally Benton
Summary: The study aimed to quantify the bias between different FIT systems and assess the commutability of candidate reference materials. The results showed significant differences between FIT systems, making it impossible to use a common threshold. However, two candidate reference materials were found to have better commutability, providing possibilities for further research.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Surgery
Y. Maeda, E. Gray, J. D. Figueroa, P. S. Hall, D. Weller, M. G. Dunlop, F. V. N. Din
Summary: The COVID-19 pandemic has presented unprecedented challenges to healthcare services. This study suggests that using a single qFIT as a triage test for suspected bowel cancer may lead to a high rate of missed cancers, while adding a second qFIT and CT mini-prep can reduce this risk. However, this approach also increases the rate of colonoscopy or CTVC procedures for patients.
Article
Gastroenterology & Hepatology
Szu-Min Peng, Wen-Feng Hsu, Ying-Wei Wang, Li-Ju Lin, Amy Ming-Fang Yen, Li-Sheng Chen, Yi-Chia Lee, Ming-Shiang Wu, Tony Hsiu-Hsi Chen, Han-Mo Chiu
Summary: A study in the Taiwanese Colorectal Cancer Screening Program found that subjects with negative colonoscopy after positive FIT who received subsequent FIT screening had a significantly lower risk of incident CRC, suggesting that scheduling subsequent FIT is important in reducing the risk of missed neoplasms and incident CRC in a national FIT screening program.
Article
Public, Environmental & Occupational Health
Nicholas Clarke, Patricia M. Kearney, Pamela Gallagher, Deirdre McNamara, Colm A. O'Morain, Linda Sharp
Summary: The study revealed that individuals with stronger fatalistic beliefs, those who disagreed that cancer can often be cured, and those who found the testing method disgusting or tempting fate were less likely to participate in colorectal cancer screening. Conversely, the influence of a partner on the screening decision was associated with higher participation rates.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Tytti Sarkeala, Martti Farkkila, Ahti Anttila, Marja Hyoty, Matti Kairaluoma, Tero Rautio, Markku Voutilainen, Sanni Helander, Maija Jantti, Milla Lehtinen, Lotta Patrikka, Nea Malila, Sirpa Heinavaara
Summary: The relaunched colorectal cancer screening programme with different cut-offs for men and women showed higher participation rates for women and different detection rates for CRC and advanced adenoma between genders. The results suggest that gender-specific protocols in organized CRC screening may lead to more effective outcomes.
Article
Oncology
Panagis M. Lykoudis, Stefano Partelli, Francesca Muffatti, Martyn Caplin, Massimo Falconi, Giuseppe K. Fusai
Article
Gastroenterology & Hepatology
Anne-Marie Bouvier, Michel Robaszkiewicz, Valerie Jooste, Melanie Cariou, Antoine Drouillard, Veronique Bouvier, Jean-Baptiste Nousbaum
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Oncology
Pamela Minicozzi, Massimo Vicentini, Kaire Innos, Clara Castro, Marcela Guevara, Fabrizio Stracci, Macarmen Carmona-Garcia, Miguel Rodriguez-Barranco, Katrijn Vanschoenbeek, Elisabetta Rapiti, Alexander Katalinic, Rafael Marcos-Gragera, Liesbet Van Eycken, Maria Jose Sanchez, Magdalena Bielska-Lasota, Paolo Giorgi Rossi, Milena Sant
Article
Oncology
Thibaut Raginel, Remy de Mil, Anne Garnier, Guy Launoy, Lydia Guittet
EUROPEAN JOURNAL OF CANCER PREVENTION
(2020)
Article
Multidisciplinary Sciences
Fanny Serman, Jonathan Favre, Valerie Deken, Lydia Guittet, Claire Collins, Michael Rochoy, Nassir Messaadi, Alain Duhamel, Ludivine Launay, Christophe Berkhout, Thibaut Raginel
Article
Medicine, General & Internal
Yassine Eid, Veronique Bouvier, Olivier Dejardin, Benjamin Menahem, Fabien Chaillot, Yannick Chene, Jean Jacques Dutheil, Therese Juul, Remy Morello, Arnaud Alves
Article
Oncology
Thomas Raze, Brigitte Lacour, Anne Cowppli-Bony, Patricia Delafosse, Michel Velten, Brigitte Tretarre, Gautier Defossez, Karima Hammas, Anne-Sophie Woronoff, Olivier Ganry, Sandrine Plouvier, Gaelle Coureau, Anne-Valerie Guizard, Simona Bara, Alain Monnereau, Laetitia Daubisse-Marliac, Xavier Troussard, Tania D'Almeida, Isabelle Baldi, Veronique Bouvier, Nicolas Boissel, Jacqueline Clavel, Emmanuel Desandes
Summary: This study investigated cancer survival and incidence in French adolescents and young adults, showing improvements in survival rates for some cancers but overall poorer outcomes compared to children. Further investigation is needed to address the disparities in survival rates.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Thibaut Raginel, Guillaume Grandazzi, Guy Launoy, Melanie Trocme, Veronique Christophe, Celia Berchi, Lydia Guittet
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Charles Dolladille, Guy Launoy, Veronique Bouvier, Joe-Elie Salem, Damien Legallois, Paul Milliez, Marion Sassier, Thierry Lobbedez, Lydia Guittet, Joachim Alexandre
Summary: The study aimed to investigate the association between use of anticancer drugs and cardiovascular-related hospitalization (CVRH) among patients with metastatic colorectal cancer (mCRC). Anticancer drugs were not found to be associated with a higher incidence of CVRH in mCRC patients. Male sex, increasing age, a prior history of CVRH, and a higher Charlson comorbidity index score were identified as factors associated with a higher incidence of CVRH. Additionally, CVRH was significantly associated with higher all-cause mortality.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Matthieu Wargny, Pierre Gourdy, Lisa Ludwig, Dominique Seret-Begue, Olivier Bourron, Patrice Darmon, Coralie Amadou, Matthieu Pichelin, Louis Potier, Charles Thivolet, Jean-Francois Gautier, Samy Hadjadj, Bertrand Cariou
Article
Public, Environmental & Occupational Health
Luigino Dal Maso, Chiara Panato, Andrea Tavilla, Stefano Guzzinati, Diego Serraino, Sandra Mallone, Laura Botta, Olayide Boussari, Riccardo Capocaccia, Marc Colonna, Emanuele Crocetti, Agnes Dumas, Tadek Dyba, Silvia Franceschi, Gemma Gatta, Anna Gigli, Francesco Giusti, Valerie Jooste, Pamela Minicozzi, Luciana Neamtiu, Gaelle Romain, Manuel Zorzi, Roberta De Angelis, Silvia Francisci
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Medicine, General & Internal
Marie Auge, Olivier Dejardin, Benjamin Menahem, Adrien Lee Bion, Veronique Savey, Guy Launoy, Veronique Bouvier, Arnaud Alves
Summary: This study found that male gender and more recent dates of surgery were the two independent risk factors for follow-up interruption. Older age, male gender, and higher weight loss were all independent risk factors of an irregular follow-up. Revision bariatric surgery was associated with lower risk of interruption and irregular follow-up, along with higher preoperative BMI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Bogdan Badic, Anne-Marie Bouvier, Veronique Bouvier, Marie Morvan, Valerie Jooste, Arnaud Alves, Jean-Baptiste Nousbaum, Noemi Reboux
Summary: In elderly patients with metastatic colon cancer, low comorbidity burden, curative surgery, and chemotherapy have a significant advantage in terms of overall survival. The location of metastasis, but not of the primary tumor, impacts survival outcomes.
Article
Biology
Benedicte Clin, Natacha Heutte, Mathilde Boulanger, Xavier Troussard, Edouard Cornet, Ghandi Laurent Damaj, Veronique Bouvier, Anne-Valerie Guizard, Guy Launoy, Idlir Licaj
BMC RESEARCH NOTES
(2020)
