Review
Medicine, General & Internal
Thomas Baudoux, Ines Jadot, Anne-Emilie Decleves, Marie-Helene Antoine, Jean-Marie Colet, Olivia Botton, Eric De Prez, Agnieszka Pozdzik, Cecile Husson, Nathalie Caron, Joelle L. Nortier
Summary: This review discusses the pathogenesis of aristolochic acid nephropathy (AAN) and its mechanisms of kidney damage. By reproducing human AAN in rodent models, the researchers have discovered the process of transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and identified key factors involved in this transition. These findings are important for a better understanding of the complex AKI-to-CKD transition.
FRONTIERS IN MEDICINE
(2022)
Article
Food Science & Technology
Khai Gene Leong, Elyce Ozols, John Kanellis, Frank Y. Ma, David J. Nikolic-Paterson
Summary: The study found that Cyclophilin D (CypD) facilitates aristolochic acid-induced acute kidney injury, but does not contribute to the transition from acute kidney injury to chronic kidney disease during ongoing exposure to aristolochic acid.
Article
Nutrition & Dietetics
Yu-Mei Hsueh, Ya-Li Huang, Yuh-Feng Lin, Horng-Sheng Shiue, Ying-Chin Lin, Hsi-Hsien Chen
Summary: This study found that high plasma vitamin B-12 levels may increase the risk of chronic kidney disease, especially in the presence of high levels of blood lead and cadmium, as well as total urinary arsenic levels.
Article
Biochemistry & Molecular Biology
Shingo Urate, Hiromichi Wakui, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Yoshitoshi Atobe, Kengo Funakoshi, Akio Yamashita, Kouichi Tamura
Summary: The study on the induction of renal aging by aristolochic acid demonstrates that kidneys show aging phenotypes, increased cellular senescence, proximal tubular mitochondrial abnormalities, decreased antiaging gene Klotho, leading to renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Soisungwan Satarug, Aleksandra Buha Dordevic, Supabhorn Yimthiang, David A. Vesey, Glenda C. Gobe
Summary: Cadmium is a highly toxic metal pollutant that can be found in almost all types of food. This study found that cadmium intake is associated with reduced kidney function and an increased prevalence of chronic kidney disease. The health guidance values for cadmium should be determined based on its impact on kidney function.
Article
Biochemistry & Molecular Biology
Wenxuan Dong, Kanglei Zhang, Zhonggui Gong, Tongwang Luo, Jiahui Li, Xueru Wang, Hui Zou, Ruilong Song, Jiaqiao Zhu, Yonggang Ma, Gang Liu, Zongping Liu
Summary: With the development of modern industrial civilization, cadmium has become a growing public safety issue due to its ability to induce kidney disease. This study investigated the role of SIRT1-mediated premature renal senescence in Cd-induced CKD and found that NAC inhibited premature aging and dysfunction. The SIRT1-P53 pathway may be a potential therapeutic target for Cd-induced CKD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Humairat H. Rahman, Danielle Niemann, Stuart H. Munson-McGee
Summary: This study aimed to assess the relationship between urinary metals, arsenic compounds, polycyclic aromatic hydrocarbons (PAHs), and chronic obstructive pulmonary disease (COPD) in the adult US population. The results showed that urinary PAHs, cadmium, and tin were significantly associated with COPD, while other urinary metals did not show a significant association.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Physiology
Wenguang Feng, Wei-Zhong Ying, Xingsheng Li, Lisa M. Curtis, Paul W. Sanders
Summary: The absence of STAT1 gene protected mice from kidney injury in the aristolochic acid nephropathy model, suggesting a crucial role of STAT1 in the progression of CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Environmental Sciences
Yumeng Shi, Huan Hu, Zuxiang Wu, Zhiqiang Chen, Ping Li
Summary: The interplay between blood selenium, cadmium, and lead levels and chronic kidney disease (CKD) is investigated. It is found that elevated blood selenium levels can mitigate the nephrotoxic effects of lead and cadmium. The study shows a positive association between cadmium and lead levels and CKD, while selenium has a negative association with CKD. Furthermore, high plasma selenium and low cadmium concentrations, as well as high plasma selenium and low lead concentrations, are protective factors for CKD.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Jomana Elaridi, Hani Dimassi, Osama Al Yamani, Maria Estephan, Hussein F. Hassan
Summary: This study investigated the presence of toxic metals in infant formula marketed in Lebanon, finding that As, Pb, and Cd were present in 59%, 8%, and 10% of brands, with levels ranging from 31.0-1040 μg/kg, 38.0-476 μg/kg, and 12.0-251 μg/kg respectively. There was no significant difference in metal concentrations among various types of infant formula.
Article
Environmental Sciences
Zhihui Yang, Gai Zeng, Lin Liu, Fangshu He, Chukwuma Arinzechi, Qi Liao, Weichun Yang, Mengying Si
Summary: Cationic lead/cadmium and anionic arsenic exhibit opposite geochemical behaviors in soils, making their synchronous remediation challenging. This study developed an iron-manganese modified biochar (BC-Fe-Mn) that can simultaneously immobilize lead, cadmium, and arsenic in soil. After 90 days of immobilization, the efficiency of immobilizing lead, cadmium, and arsenic reached 57%, 51%, and 35% respectively. The simultaneous immobilization mechanisms involve morphological transformation, precipitation/co-precipitation, and surface complexation.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Guoyong Li, Chunfeng Xiong, Wenhua Xu, Runhong Mei, Tao Cheng, Xuefeng Yu
Summary: This study found significant differences in the concentrations of aluminum, arsenic, cadmium, and lead in knee joint structures, with varying levels in different factors. Additionally, new interactions among these toxic elements were discovered.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Yi-Chun Tsai, Chia-Fang Wu, Wei-Wen Hung, Ping-Shaou Yu, Chia-Chu Liu, Tusty-Jiuan Hsieh, Chu-Chih Chen, Sih-Syuan Li, Jia-Jen Chen, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Tsang Wu
Summary: This prospective cohort study investigated the impact of melamine exposure on kidney outcomes in type 2 diabetes mellitus (T2D) patients. The findings showed a significant association between melamine exposure and adverse kidney outcomes in T2D patients, especially in those with male, well sugar control or good baseline kidney function.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Sandra Pietrzak, Janusz Wojcik, Piotr Baszuk, Wojciech Marciniak, Malgorzata Wojtys, Tadeusz Debniak, Cezary Cybulski, Jacek Gronwald, Jacek Alchimowicz, Bartlomiej Masojc, Piotr Waloszczyk, Darko Gajic, Tomasz Grodzki, Anna Jakubowska, Rodney J. Scott, Jan Lubinski, Marcin R. Lener
Summary: This study examined the relationship between blood concentrations of heavy metals and overall survival in lung cancer patients, finding that low blood cadmium levels may be associated with improved overall survival in treated patients with lung cancer.
Article
Agriculture, Dairy & Animal Science
Dan Xu, Chonglin Ran, Lizi Yin, Juchun Lin, Hualin Fu, Xi Peng, Xiaoling Zhao, Gang Shu
Summary: Aristolochic acid (AA) has been found to cause serious kidney damage in Tianfu broilers by disrupting the redox balance to induce oxidative stress and promote apoptosis of renal cells. The study provides suggestions for the clinical application of traditional Chinese medicine containing AA in the poultry industry.
Article
Environmental Sciences
Hung-Chieh Yeh, Yu-Sheng Lin, Chin-Chi Kuo, Darcy Weidemann, Virginia Weaver, Jeffrey Fadrowski, Alicia Neu, Ana Navas-Acien
ENVIRONMENTAL RESEARCH
(2015)
Article
Environmental Sciences
Darcy Weidemann, Chin-Chi Kuo, Ana Navas-Acien, Alison G. Abraham, Virginia Weaver, Jeffrey Fadrowski
ENVIRONMENTAL RESEARCH
(2015)
Editorial Material
Urology & Nephrology
Darcy K. Weidemann, Bradley A. Warady, Susan L. Furth
AMERICAN JOURNAL OF KIDNEY DISEASES
(2018)
Article
Pharmacology & Pharmacy
Felicity A. Pino, Darcy K. Weidemann, Lisa L. Schroeder, Damon B. Pabst, Audrey R. Kennedy
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2019)
Article
Urology & Nephrology
Darcy K. Weidemann, Alison G. Abraham, Jennifer L. Roem, Susan L. Furth, Bradley A. Warady
AMERICAN JOURNAL OF KIDNEY DISEASES
(2020)
Article
Health Care Sciences & Services
Zohreh Talebizadeh, Ayten Shah
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2018)
