Article
Multidisciplinary Sciences
Iguaracy Pinheiro-de-Sousa, Miriam H. Fonseca-Alaniz, Samantha K. Teixeira, Mariliza Rodrigues, Jose E. Krieger
Summary: This study examined the influence of different factors on endothelial dysfunction using global gene expression in human coronary artery endothelial cells, revealing a potential hierarchical interaction between surrogate risk factors of cardiovascular disease and the emergence of phenotypes affecting ED.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Jennifer Flournoy, Shahad Ashkanani, Yun Chen
Summary: Biophysical and biochemical cues cooperate to regulate angiogenesis, guiding its process during development, wound healing, and tumor progression. The mechanical microenvironment, including stiffness, ligand availability, and topography, plays a crucial role in modulating angiogenesis-related signaling pathways. Additionally, mechanical perturbations such as stretching and fluid shearing can acutely alter angiogenesis-related signal transduction, leading to gene expression changes. Tissue engineering-based approaches are also discussed for studying angiogenesis, along with proposed future directions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Mohammad Hamrangsekachaee, Ke Wen, Sidi A. Bencherif, Eno E. Ebong
Summary: Endothelium health is crucial for regulating physiological vascular functions. Dysfunction of endothelial cells (ECs) is associated with various vascular diseases, especially atherosclerosis and cardiovascular diseases. This review discusses mechanotransduction events mediated by ECs, the involved subcellular components, and potential pathways. It also reviews current research efforts using in vivo animal models and in vitro biomimetic models, along with recommendations for future modeling approaches to aid the development of novel therapies targeting atherosclerosis and related cardiovascular diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Hongxin Cheng, Wen Zhong, Lu Wang, Qing Zhang, Xiaoqing Ma, Yang Wang, Shiqi Wang, Chengqi He, Quan Wei, Chenying Fu
Summary: Different blood flow patterns in arteries alter the phenotype of vascular endothelial cells, affecting their functions and directly contributing to the occurrence of early atherosclerosis lesions. Oscillating shear stress (OSS) in curved or bifurcated arteries promotes the transformation of endothelial cells into pro-inflammatory phenotypes, leading to increased inflammation, oxidative stress, mitochondrial dysfunction, metabolic abnormalities, and enhanced endothelial permeability, thus promoting atherosclerosis progression. In contrast, stable laminar shear stress (LSS) in straight arteries facilitates the transformation of endothelial cells into an anti-inflammatory phenotype, improving their function and inhibiting atherosclerotic progression. This article outlines the relationship between vascular endothelial cell functions and different forms of fluid shear stress in atherosclerosis and explores potential therapeutic approaches targeting intracellular mechanical transductions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Sulaiman Alalawi, Faizah Albalawi, Dipak P. Ramji
Summary: Atherosclerotic cardiovascular disease (ACVD) is the leading cause of death worldwide. Punicalagin (PC), the main polyphenol present in pomegranates, possesses anti-inflammatory, antioxidant, and anti-atherogenic properties. However, further research and clinical trials are needed to fully exploit the potential of PC and its metabolites in the prevention and treatment of ACVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Katharina Urschel, Miyuki Tauchi, Stephan Achenbach, Barbara Dietel
Summary: Atherosclerosis development is influenced not only by high cholesterol but also by hemodynamic forces that affect endothelial cell function. Studying the impact of wall shear stress can help understand the mechanisms of atherosclerosis and prevent related heart diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Alexander M. Markin, Elena R. Andreeva, Ilya I. Eremin, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: Pericytes play a key role in the pathogenesis and development of atherosclerosis, being involved in plaque formation and vulnerability. They can also be targeted as a therapeutic approach to promote vessel maturity and stability, reducing plaque vulnerability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Sheng'e Su, Mingming Zhen, Chen Zhou, Xinran Cao, Zihao Sun, Yuan Xu, Lei Li, Wang Jia, Zhanfeng Wu, Chunru Wang
Summary: Atherosclerosis, the major cause of cardiac-cerebral vascular diseases worldwide, can be slowed down by fullerene-based therapies with exceptional antioxidant capacity. Oral fullerene tablets have been found to stabilize and reduce lipid deposition in plaques, providing a novel therapeutic mechanism via modulating intestinal barrier and down-regulating inflammation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Mohammad Ashrafuzzaman, Alfons Lawen, Elisaveta Skverchinskaya, Carlota Saldanha, Alessia Manca, Giuseppe Uras, Muhammad Aslam, Antonella Pantaleo
Summary: Chronic low-grade vascular inflammation and endothelial dysfunction are significant contributors to the development of cardiovascular diseases. Different patterns of blood flow shear stress can induce anti-inflammatory or pro-inflammatory signaling in endothelial cells. Endothelial mechanosensors play a crucial role in these signaling responses.
Review
Biochemistry & Molecular Biology
Ruotian Du, Long Li, Jing Ji, Yubo Fan
Summary: Understanding how receptor-ligand binding responds to mechanical stimuli is essential for uncovering the molecular mechanisms of physiological and pathological processes and has implications for drug discovery and biomedical applications. This review provides an overview of the current understanding of the effects of mechanical factors such as tension, shear stress, stretch, compression, and substrate stiffness on receptor-ligand binding. It emphasizes the importance of synergistic development of experimental and computational methods for fully understanding in situ receptor-ligand binding, and suggests that future studies should focus on the coupling effects of these mechanical factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shafiu A. Umar Shinge, Daifang Zhang, Ahmad Ud Din, FengXu Yu, YongMei Nie
Summary: This review highlights the role of mechanosensitive protein Piezo1 in atherosclerosis and its therapeutic potentials. Recent studies have shown that Piezo1 channel acts as a sensor and transducer of mechanical forces, affecting various cellular activities involved in atherosclerosis, such as proliferation, migration, apoptosis, and vascular remodeling. Understanding the mechanisms of Piezo1 and its drugability may lead to novel therapeutic strategies for treating atherosclerosis and other cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Andrey V. Grechko, Nikolay K. Shakhpazyan, Alexander N. Orekhov
Summary: KLF2 is a crucial factor in regulating atheroprotective effects in endothelial cells, preventing the development and progression of atherosclerosis. Recently, repurposed drugs and natural compounds targeting KLF2 have been identified, showing potential for treating atherosclerosis.
Article
Nanoscience & Nanotechnology
Austin Lai, Peter Thurgood, Charles D. Cox, Chanly Chheang, Karlheinz Peter, Anthony Jaworowski, Khashayar Khoshmanesh, Sara Baratchi
Summary: This study investigates the influence of extracellular matrix (ECM) composition on the mechanosensitivity of the Piezo1 ion channel in response to hemodynamic forces. The presence of ECM proteins does not affect the sensitivity of Piezo1 to shear stress, but different ECM proteins regulate Piezo1 sensitivity depending on the shear stress level. These findings demonstrate that ECM/integrin interactions play a role in Piezo1 mechanosensitivity and provide new insights into how Piezo1 senses shear stress.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Austin Lai, Peter Thurgood, Charles D. Cox, Chanly Chheang, Karlheinz Peter, Anthony Jaworowski, Khashayar Khoshmanesh, Sara Baratchi
Summary: The composition of the extracellular matrix affects the mechanosensitivity of the Piezo1 channel in response to hemodynamic forces. Different ECM proteins can regulate the sensitivity of Piezo1 to shear stress, while integrins play important roles in this process.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Biomedical
Hualin Lan, Yi Wang, Tieyin Yin, Yazhou Wang, Wanqian Liu, Xiaojuan Zhang, Qinsong Yu, Zhaoxu Wang, Guixue Wang
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2016)
Article
Engineering, Biomedical
Shuping Ge, Yi Wang, Jie Tian, Daoxi Lei, Qingsong Yu, Guixue Wang
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2016)
Article
Nanoscience & Nanotechnology
Xue Wu, Yinping Zhao, Chaojun Tang, Tieying Yin, Ruolin Du, Jie Tian, Junli Huang, Hans Gregersen, Guixue Wang
ACS APPLIED MATERIALS & INTERFACES
(2016)
Review
Medical Laboratory Technology
GaoYa, PengJuan, RenZhong, HeNi-ya, LiQing, ZhaoXue-shan, WangMei-mei, WenHong-yan, TangZhi-han, JiangZhi-sheng, WangGui-xue, LiuLu-shan
CLINICA CHIMICA ACTA
(2016)
Article
Plant Sciences
Tingzhang Hu, Shanshan Zhu, Lili Tan, Wenhua Qi, Shuai He, Guixue Wang
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2016)
Article
Environmental Sciences
Da Sun, Chuanren Duan, Yaning Shang, Yunxia Ma, Lili Tan, Jun Zhai, Xu Gao, Jingsong Guo, Guixue Wang
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2016)
Article
Nanoscience & Nanotechnology
Tian Zhou, Qinglei Dong, Yang Shen, Wei Wu, Haide Wu, Xianglin Luo, Xiaoling Liao, Guixue Wang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2016)
Article
Engineering, Biomedical
Lu Huang, Daoxi Lei, Wenxiu Dong, Chaojun Tang, Guixue Wang
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2016)
Review
Plant Sciences
Zhen-Hui Kang, Gui-Xue Wang
JOURNAL OF PLANT PHYSIOLOGY
(2016)
Article
Materials Science, Biomaterials
Da Sun, Dake Xu, Chunguang Yang, Jia Chen, M. Babar Shahzad, Ziqing Sun, Jinlong Zhao, Tingyue Gu, Ke Yang, Guixue Wang
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Plant Sciences
Guangchao Zang, Hanyan Zou, Yuchan Zhang, Zheng Xiang, Junli Huang, Li Luo, Chunping Wang, Kairong Lei, Xianyong Li, Deming Song, Ahmad Ud Din, Guixue Wang
Article
Multidisciplinary Sciences
Da Sun, Dake Xu, Chunguang Yang, M. Babar Shahzad, Ziqing Sun, Jin Xia, Jinlong Zhao, Tingyue Gu, Ke Yang, Guixue Wang
SCIENTIFIC REPORTS
(2016)
Article
Engineering, Chemical
Xiuju Yang, Jingjing Shi, Qianying Fu, Shanshan Pu, Zhixin Pan, Chunxiao Lian, Zhiyong Yin, Shengxiong Liu, Guixue Wang
Summary: By simulating small offset collisions and optimizing the parameter matching of seatbelt and airbag, a pre-tensioned force-limiting seatbelt was proposed for maximum driver protection.
Article
Virology
Razi Ullah, Jadoon Khan, Nosheen Basharat, Danqun Huo, Ahmad Ud Din, Guixue Wang
Summary: This study evaluated the association of cardiac biomarkers and CS-induced acute lung damage with disease severity and mortality in COVID-19 patients. The findings showed a correlation between elevated cardiac enzymes, inflammatory biomarkers, and cytokines with COVID-19 infection and mortality. Physicians should pay special attention to cardiac biomarkers in COVID-19 patients.
Correction
Engineering, Biomedical
Jianjun Hu, Juhui Qiu, Yiming Zheng, Tao Zhang, Tieying Yin, Xiang Xie, Guixue Wang
ANNALS OF BIOMEDICAL ENGINEERING
(2016)