Article
Geriatrics & Gerontology
Cathal McCrory, Giovanni Fiorito, Belinda Hernandez, Silvia Polidoro, Aisling M. O'Halloran, Ann Hever, Cliona Ni Cheallaigh, Ake T. Lu, Steve Horvath, Paolo Vineis, Rose Anne Kenny
Summary: The study indicates that the GrimAge clock is a significant improvement in predicting age-related decline in various clinical phenotypes compared to other epigenetic clocks, showing better predictive utility and promising to advance precision medicine.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Public, Environmental & Occupational Health
Linnea Evans, Michal Engelman, Alex Mikulas, Kristen Malecki
Summary: The systematic review on social epigenetics investigates how social determinants of health are conceptualized and implemented. The study identified challenges, such as convenience sampling, limited diversity in sampling frames, overreliance on individual characteristics, and focus on downstream health determinants. Future research should prioritize larger, more diverse population samples and enhance the understanding of the biological consequences of social exposures on gene expression and health disparities.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Maria I. Pozo, Benjamin J. Hunt, Gaby Van Kemenade, Jose M. Guerra-Sanz, Felix Waeckers, Eamonn B. Mallon, Hans Jacquemyn
Summary: Overall, the altered methylation patterns improved cooperation between workers without affecting abnormal worker dominance or caste determination. Treated colonies tended to develop faster with more workers at a given developmental stage, while control colonies had higher male production.
Article
Public, Environmental & Occupational Health
Brian T. Joyce, Tao Gao, Kalsea Koss, Yinan Zheng, Andres Cardenas, Jonathan Heiss, Allan Just, Kai Zhang, Linda van Horn, Norrina Bai Allen, Philip Greenland, Sheldon Cohen, Penny Gordon-Larsen, Colter Mitchell, Sara McLanahan, Lisa Schneper, Daniel Notterman, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Robert Wright, Andrea Baccarelli, Donald Lloyd-Jones, Lifang Hou
Summary: This study examines the relationship between individual, parental, and neighborhood socioeconomic status and epigenetic age acceleration (EAA), and finds that paternal education is associated with EAA.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemical Research Methods
Wubin Ding, Diljeet Kaur, Steve Horvath, Wanding Zhou
Summary: Researchers have developed informatics infrastructure and methods for DNA methylation analysis in multiple species, including domesticated animals and laboratory mice. They have created a data-driven analysis pipeline for species inference, genome-specific data preprocessing, and regression modeling. Comparative analysis has revealed the dynamics of epigenome evolution in different genomic territories and tissue types, and specific methylation differences related to mouse strain phenotypes have been identified. These methods expand epigenome research to a wide range of species by streamlining DNA methylation array analysis for undesigned genomes.
BRIEFINGS IN BIOINFORMATICS
(2023)
Review
Biochemistry & Molecular Biology
Eshaan Patnaik, Chikezie Madu, Yi Lu
Summary: Epigenetics plays a crucial role in gene regulation and tumor development. DNA methylation inhibitors and histone deacetylase inhibitors can restore normal gene expression and be effective against cancer. Understanding epigenetic modifications and utilizing inhibitors offer new possibilities for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Simeon Santourlidis, Wolfgang A. Schulz, Marcos J. Arauzo-Bravo, Daniela Gerovska, Pauline Ott, Marcelo L. Bendhack, Mohamed Hassan, Lars Erichsen
Summary: Epigenetic mechanisms play a fundamental role in the initiation and development of melanoma, but research in this area is relatively limited compared to other cancers. This review provides a brief summary of the epigenetic aspects relevant to melanoma pathogenesis and introduces new perspectives from epigenetic research in other cancers that may have potential for melanoma diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Maja Srut
Summary: The effect of environmental pollutants on epigenetic changes, including DNA methylation, histone modifications, and non-coding RNAs, is a major concern in ecotoxicology. Earthworms have been widely used as models to study the impact of environmental stress on epigenetic mechanisms and to explore the possibility of epigenetic inheritance. However, there are still many knowledge gaps that need to be filled in.
Article
Environmental Sciences
Arce Domingo-Relloso, Anne Bozack, Samara Kiihl, Zulema Rodriguez-Hernandez, Pilar Rentero-Garrido, J. Antonio Casasnovas, Montserrat Leon-Latre, Tamara Garcia-Barrera, J. Luis Gomez-Ariza, Belen Moreno, Ana Cenarro, Griselda de Marco, Faruque Parvez, Abu B. Siddique, Hasan Shahriar, Mohammad N. Uddin, Tariqul Islam, Ana Navas-Acien, Mary Gamble, Maria Tellez-Plaza
Summary: The study identified common 5-hmC and 5-mC signatures in two populations exposed to varying levels of inorganic As, but differences in As-related epigenetic sites across the study populations may also reflect low and high As-specific associations. This work contributes to a deeper understanding of potential epigenetic dysregulations of As, with further research needed to confirm biological consequences associated with DIP2C epigenetic regulation and investigate the role of 5-hmC and 5-mC separately in As-induced health disorders at different exposure levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Zhenhui Zhong, Suhua Feng, Sascha H. Duttke, Magdalena E. Potok, Yiwei Zhang, Javier Gallego-Bartolom, Wanlu Liu, Steven E. Jacobsen
Summary: DNA methylation influences chromatin accessibility, particularly in heterochromatin, in plants. Different sequence contexts of DNA methylation interact with each other, and methylation can impact chromatin structure through mechanisms other than transcription. Increased chromatin accessibility is associated with enhanced long-range chromatin interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Alessia Mongelli, Veronica Barbi, Michela Gottardi Zamperla, Sandra Atlante, Luana Forleo, Marialisa Nesta, Massimo Massetti, Alfredo Pontecorvi, Simona Nanni, Antonella Farsetti, Oronzo Catalano, Maurizio Bussotti, Laura Adelaide Dalla Vecchia, Tiziana Bachetti, Fabio Martelli, Maria Teresa La Rovere, Carlo Gaetano
Summary: COVID-19 infection leads to a range of severe sequelae, including a significant increase in biological age and telomere shortening. These sequelae are particularly pronounced in younger patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Emmanouil Stylianakis, Jackson Ping Kei Chan, Pui Pik Law, Yi Jiang, Sanjay Khadayate, Mohammad Mahdi Karimi, Richard Festenstein, Jean-Baptiste Vannier
Summary: We found that mouse HP1 & gamme; plays a crucial role in telomere function by regulating the transcription of telomere factors and TERRAs, which has profound effects on telomere stability.
Article
Chemistry, Multidisciplinary
Shirong Wang, Lin Zha, Xin Cui, Yu-Te Yeh, Ruochuan Liu, Jia Jing, Huidong Shi, Weiping Chen, John Hanover, Jun Yin, Liqing Yu, Bingzhong Xue, Hang Shi
Summary: DNA methylation plays an important role in regulating hepatic lipid metabolism. High-fat diet induces increased DNA methylation at the Klb promoter, leading to decreased Klb expression and hepatic steatosis. Targeted demethylation at the Klb promoter can increase Klb expression and fatty acid oxidation, resulting in reduced lipid accumulation.
Article
Biochemistry & Molecular Biology
Oscar Coltell, Eva M. Asensio, Jose V. Sorli, Carolina Ortega-Azorin, Rebeca Fernandez-Carrion, Eva C. Pascual, Rocio Barragan, Jose I. Gonzalez, Ramon Estruch, Juan F. Alzate, Alejandro Perez-Fidalgo, Olga Portoles, Jose M. Ordovas, Dolores Corella
Summary: This study examines the association between adherence to the Mediterranean diet and telomere length, and finds that higher adherence to the diet is associated with longer telomeres, particularly in women. Specific dietary items such as fruits and fish exhibit strong associations with telomere length. Additionally, the study identifies genetic variants and gene-diet interactions that modulate telomere length.
Review
Psychology, Clinical
Luis Alameda, Giulia Trotta, Harriet Quigley, Victoria Rodriguez, Romayne Gadelrab, Daniella Dwir, Emma Dempster, Chloe C. Y. Wong, Marta Di Forti
Summary: A significant proportion of the global burden of disease can be attributed to mental illness. Epigenetic mechanisms, including DNA methylation, have emerged as potential mediators of environmental and genetic risk factors for psychiatric disorders. This review aims to explore the role of DNA methylation in biological pathways associated with various psychiatric disorders, as well as its relationship with known risk factors such as childhood adversity and cannabis use.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Pediatrics
Rebecca R. Seltzer, Simone Thompson
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Kimberly E. Sawyer, Douglas J. Opel
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Micah Hester, Skye A. Miner
Summary: The process of soliciting a minor's assent has moral importance, even if it is not always required by regulations. It allows the child's opinion to be heard and respects their development and involvement in research. The extent of the child's involvement depends on their age, experience, and maturity.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Nicholas A. Jabre, Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Carrie M. Henderson, Renee D. Boss
Summary: An increasing number of children with serious/complex illness are living with long-term prognostic uncertainty, intensive interactions with medical systems, functional limitations, and the use of chronic medical technologies that affect their quality of life. These families often face multiple medical decision points and rely on intentional and iterative discussions to guide their care goals.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Mark T. Hughes
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
