Article
Pharmacology & Pharmacy
Cansu Ulker Turan, Ayse Metin, Yuksel Guvenilir
Summary: The study fabricated poly(?-pentadecalactone-co-?-caprolactone)/gelatin nanofibrous membranes for controlled release of tetracycline hydrochloride antibiotic. Various characterizations were applied to investigate drug incorporation and release mechanism. The drug release profile showed initial burst release followed by sustained release, providing antibacterial activity against different bacteria.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
A. Harres, W. J. S. Garcia, T. R. Salles, F. S. Bruckmann, J. B. Sulzenco, A. D. Schneider, C. R. B. Rhoden
Summary: This study investigates the magnetic properties of graphene oxide decorated with magnetite nanoparticles (GO•Fe3O4) at room temperature. The size distribution of the magnetic nanoparticles plays a significant role in the magnetic behavior, with smaller particles exhibiting superparamagnetic behavior and larger particles exhibiting ferrimagnetic behavior. The magnetic parameters, such as coercivity and remanent magnetisation, are mainly influenced by the average particle size rather than demagnetising interactions.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
L. Kilanski, R. Jedrzejewski, D. Sibera, I Kuryliszyn-Kudelska, S. Gorantla, R. Idczak, V. H. Tran, A. Jedrzejewska
Summary: The study investigated the structural and magnetic properties of graphene composites doped with various percentages of alpha-Fe2O3 and prepared using either ethanol or acetone. The choice of solvent significantly affected the magnetic properties of the composites, with samples prepared with ethanol showing higher saturation magnetization. The presence of superparamagnetic blocking in graphene + iron oxide samples made with ethanol was also observed, indicating differences in magnetic behavior based on the preparation method.
Article
Chemistry, Multidisciplinary
Marcel Buerger, Nadine Ehrhardt, Thomas Barber, Liam T. Ball, Jan C. Namyslo, Peter G. Jones, Daniel B. Werz
Summary: A phosphine-catalyzed oligomerization of arynes using selenocyanates has been developed to access alpha, omega-bisfunctionalized oligo(ortho-arylenes). The use of JohnPhos as a bulky phosphine catalyst is crucial for this reaction to occur. Various optimized conditions have been established to predominantly form dimers, but also higher oligomers, up to octamers, depending on the electronic properties of the electrophilic reaction partner. Mechanistic studies show that the cascade reaction starts with cyanide attack and rules out aryne insertion into n-mers leading to (n+1)-mers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Engineering, Environmental
Weiguo Huang, Yunru Yu, Chaoyu Yang, Xiaohui Zhang, Luoran Shang, Yan Zu, Keqing Shi
Summary: A novel magnetic graphene oxide nanoparticles (MGONs) have been developed for efficient capture of exosomes. The capture process does not affect the structure and function of the exosomes. The concentration of captured exosomes can be measured by combining with a fluorescence probe. These MGONs have significant potential in early disease diagnosis and clinical applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Cansu Ulker Turan, Yuksel Guvenilir
Summary: In recent years, there has been increasing attention on the use of biocompatible electrospun nanofibers for drug delivery applications, as they offer advantages such as high surface area and controlled drug release, while mimicking the extracellular matrix. In this study, tetracycline hydrochloride-loaded nanofibrous membranes were fabricated using a combination of synthetic polymers and natural proteins/polysaccharides to create a novel controlled drug delivery system. Various characterization techniques were used to examine the drug incorporation and release behavior, and the system showed promising drug release and antibacterial activity, making it a potential candidate for wound dressing applications in the treatment of skin infections.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Environmental Sciences
Yang Wang, Pengcheng Gao, Yingying Wei, Yajin Jin, Si Sun, Zhifei Wang, Yong Jiang
Summary: A facile and cost-effective method for the preparation of a magnetic composite decorated with silver nanoparticles was investigated for the catalytic degradation of organic dyes. The catalyst showed good catalytic performance and could be easily recovered and reused.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Engineering, Chemical
Ting Lu, Xiaobin Zhang, Ronggang Ma, Dongming Qi, Yangyi Sun, Dong Zhang, Jingang Huang, Hongting Zhao
Summary: Rapid demulsification of oil-water emulsion is crucial for oil utilization and environmental protection. Quaternary ammonium siloxane-coated magnetic nanoparticles (MNPs) were synthesized and showed higher demulsification efficiency than previous siloxane-modified MNPs. The demulsification performance of the MNPs could be adjusted by regulating the DOTAC anchoring density on the MNP surface. These modified MNPs demonstrated good separation performance in oil-water emulsion and could be easily recycled.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yi Zhang, Zongyi You, Chunsheng Hou, Liangliang Liu, Aiping Xiao
Summary: The novel electrochemical sensor Fe3O4-NH2-GN/GCE, prepared for detection of CBD, showed good detection limit and linear range, with results consistent with HPLC method for CBD detection in Cannabis sativa leaf extract.
Article
Polymer Science
Lea-Sophie Hornberger, Philipp Weingarten, Pia L. Lange, Thomas Schleid, Friederike Adams
Summary: This study reports the use of amino-alkoxy-bis(phenolate) yttrium amido and alkoxide catalysts for controlled metal-catalyzed ring-opening polymerization (ROP) of w-pentadecalactone (PDL). By controlling the reaction temperature and using a chain transfer agent, polymers with high molecular weight can be obtained. Additionally, successful synthesis of block copolymers with different block length and molecular weight was achieved, and the preservation of crystallinity in the block copolymers was confirmed.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Lourdes Urpi, Abdelilah Alla, Antxon Martinez de Ilarduya
Summary: The study focuses on the use of renewable monomers and green polymerization processes to synthesize new synthetic polymers. High molecular weight copolyesters were obtained from omega-pentadeca-lactone (PDL), dimethyl succinate (DMS), and 1,4-cyclohexanedimethanol (1,4-CHDM) through ring opening polymerization (ROP) and melt polycondensation processes. The copolyesters showed thermal stability up to 350°C, semicrystalline structure, and the melting temperatures decreased with the increased content of the counterpart comonomer. The crystalline structure and thermal transitions of the copolyesters were studied using synchrotron X-ray diffraction. Copolyesters with elastomeric properties can be obtained at intermediate compositions.
Article
Biochemistry & Molecular Biology
Masoume Fazlollahi, Adeleh Divsalar, Majid Masteri-Farahani, Unes Sahebi, Milad Rasouli
Summary: In this study, magnetic Fe3O4 nanoparticles adorned with samarium (Sm-MNPs) were successfully synthesized using ginger extract for the first time. The nanoparticles were thoroughly characterized and their biological functionalities were examined. The cytotoxicity of the nanoparticles was evaluated using colorectal cancer cells, and the results showed that the ginger-Sm-MNPs had higher cytotoxicity than both magnetite nanoparticles and ginger extract. The study suggests that ginger-Sm-MNPs have potential applications in biomedicine.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Engineering, Environmental
Chenyang He, Yu Guo, Bikash Karmakar, Attalla El -kott, Ahmed Ezzat Ahmed, Ahmed Khames
Summary: Nanotechnology involves utilizing atomic and molecular features to create modern systems, tools, and materials, with potential applications in various fields such as medical diagnostics, food, medicine, and biotechnology. Recent studies have shown promising cytotoxic effects on breast carcinoma cell lines using novel Ag NPs supported chitosan-starch composite functionalized Fe3O4 nanoparticles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Food Science & Technology
Chen Niu, Xiying Song, Yuxiang Zhang, Lu Dai, Jianping Wei, Tianli Yue, Zihan Song
Summary: In this study, antimicrobial peptides (AMPs) produced by Pediococcus acidilactici were successfully purified using silica-decorated Fe3O4 nanoparticles (SMNPs) for controlling Alicyclobacillus acidoterrestris. The AMP binding to the surface of Fe3O4 nanoparticles was confirmed by FT-IR, and the purification process showed good antimicrobial activity under different pH and temperature conditions. The proposed one-step process for the purification of antibacterial peptides using SMNPs is convenient and effective, suggesting potential applications in purifying other peptides.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Huazhong Liu, Mehdi Baghayeri, Amirhasan Amiri, Fatemeh Karimabadi, Marziyeh Nodehi, Maryam Fayazi, Behrooz Maleki, Ehsan Nazarzadeh Zare, Afsaneh Kaffash
Summary: In this work, a new dendrimer modified magnetic graphene oxide (GO) was used as a substrate for electrodeposition of Au nanoparticles. The modified magnetic electrode was employed for sensitive measuring of As(III) ion as a well-established human carcinogen. The prepared electrochemical device exhibits excellent activity towards As(III) detection using the square wave anodic stripping voltammetry (SWASV) protocol. At optimum conditions (deposition potential at -0.5 V for 100 s in 0.1 M acetate buffer with pH 5.0), a linear range from 1.0 to 125.0 μgL-1 with a low detection limit (calculated by S/N = 3) of 0.47 μg L-1 was obtained. In addition to the simplicity and sensitivity of the proposed sensor, its high selectivity against some major interfering agents, such as Cu(II) and Hg(II) makes it an appreciable sensing tool for the screening of As(III). In addition, the sensor revealed satisfactory results for detection of As(III) in different water samples, and the accuracy of obtained data were confirmed by inductively coupled plasma atomic emission spectroscopy (ICP-AES) setup. Accounting for the high sensitivity, remarkable selectivity and good reproducibility, the established electrochemical strategy has great potential for analysis of As(III) in environmental matrices.
ENVIRONMENTAL RESEARCH
(2023)
Article
Hematology
A. Krueger-Genge, C. Tondera, S. Hauser, S. Braune, J. Goers, T. Roch, R. Klopfleisch, A. T. Neffe, A. Lendlein, J. Pietzsch, F. Jung
Summary: This study demonstrated that gelatin-based hydrogels have good immunocompatibility and non-thrombogenicity, making them suitable for coating the blood-contacting surface of cardiovascular implants. Through in vitro and animal experiments, it was found that the hydrogels did not activate complement or induce reactive oxygen species in human blood, and showed compatibility with vessel functionality in tests. Further implantation tests in mice showed no adverse effects in spleen, liver, or kidney, indicating the potential of these materials for biomedical applications.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Review
Polymer Science
Stefan Baudis, Marc Behl
Summary: The high-throughput development of new multifunctional polymers is achieved through the combination of different high-throughput tools established in polymer sciences over the past decade. Important advances include robotic/high-throughput synthesis of polymer libraries, high-throughput characterization of polymers, and the application of spatially resolved polymer library formats. High-throughput polymer synthesis allows the generation of material libraries with combinatorial design motifs, while high-throughput characterization enables rapid assessment of complementary properties and determination of important surface parameters. Current methods and limitations of high-throughput robotic synthesis and characterization of multifunctional polymers are presented and discussed.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Rainhard Machatschek, Matthias Heuchel, Andreas Lendlein
Summary: Polyimides and polyetherimides (PEI) exhibit the capability to react with nucleophiles under mild conditions, allowing for surface properties adjustment through post-functionalization targeting phthalimide groups. Investigating surface functionalization using ultra-thin PEI films on a Langmuir trough, it was found that hydrolysis enhances film stability and activates ester formation. The direct amidation of PEI with Lewis acid catalyst resulted in free amine groups, showing a greater impact of hydrolysis on material properties when compared to amidation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yue Liu, Oliver E. C. Gould, Karl Kratz, Andreas Lendlein
Summary: Polymeric devices capable of controlled release of submicron particles on demand have been demonstrated using a temperature-memory polymer sheet as a matrix to embed and release polystyrene subMP based on particle size and temperature. The technology allows for sequential release of subMPs based on their size and temperature-memory effect, showing potential applications in assembly, particle sorting, and release technologies in microtechnology, catalysis, and controlled release.
Article
Materials Science, Multidisciplinary
Hanieh Moradian, Manfred Gossen, Andreas Lendlein
Summary: This study investigates the effects of different payload designs on gene co-expression, and finds that co-delivery of individual monocistronic nucleic acids is more effective than a bicistronic design.
MRS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lucile Tartivel, Anna M. Blocki, Steffen Braune, Friedrich Jung, Marc Behl, Andreas Lendlein
Summary: This study presents microporous hydrogels with an inverse shape-memory effect, which can change their shape through heating and cooling. These hydrogels can gently load bioactive components without causing activation, making them potential candidates for tissue regeneration.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shuo Zhou, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
Summary: Glycerol-based epoxy networks have great potential for surface functionalization, but the production process may lead to the presence of organochlorides, affecting cytotoxicity.
Article
Materials Science, Multidisciplinary
Shanshan Zhang, Yue Liu, Rainhard Machatschek, Andreas Lendlein
Summary: We report the successful production of cohesive and well-organized type I collagen ultrathin films of about 10 nm thickness using the Langmuir-Blodgett technique. Investigation of molecular behavior at the air-water interface reveals the existence and disappearance of a network structure in the protein nanosheet. Highly aligned and fibrillar structures are observed by atomic force microscopy and optical microscopy.
Article
Energy & Fuels
Natalia A. Tarazona, Rainhard Machatschek, Jennifer Balcucho, Andreas Lendlein, Jinneth Lorena Castro-Mayorga, Juan F. Saldarriaga
Summary: The production and consumption of commodity polymers are crucial for the development of modern society. Polymer-based materials play important roles in various fields such as healthcare, transport, food preservation, construction, electronics, and water management. However, considering the environmental crisis caused by plastic consumption, advanced polymers should incorporate functions that meet application demands and minimize environmental harm. This article discusses strategies to enhance the sustainability of plastics, including measuring and reducing negative impacts, using renewable sources for synthesis, designing biodegradable and recyclable materials, and enzymatic recycling for a circular bioeconomy. International cooperation is also emphasized for achieving the Sustainable Development Goals (SDGs) through leading-edge polymer-based materials.
MRS ENERGY & SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Falk Hoffmann, Rainhard Machatschek, Andreas Lendlein
Summary: This study investigates the degradation of polymers using mathematical models, comparing different chain cut mechanisms and analyzing the influence of internal molecular parameters. The results show that the shape of the degradation curve is similar for both chain cut mechanisms, and a characteristic time and maximum length of soluble fragments can be extracted to enhance the description and design of polymers.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hanieh Moradian, Toralf Roch, Larissa Anthofer, Andreas Lendlein, Manfred Gossen
Summary: In vitro transcribed (IVT)-mRNA is a promising therapeutic modality that can be tailored to modulate innate immune responses of human cells. Uridine modifications were found to be particularly important for IVT-mRNA performance, while 5'-end modifications had modest effects on mRNA expression and immune responses.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Materials Science, Multidisciplinary
Magdalena Mazurek-Budzynska, Marc Behl, Richard Neumann, Andreas Lendlein
Summary: This study presents multifunctional 4D actuators processed by 3D-printing, with actuator functionality integrated into the shaped body. The materials are based on crosslinked poly(carbonate-urea-urethane) networks (PCUU) synthesized in an integrated process, showing reversible deformation when thermomechanically programmed.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Muhammad Yasar Razzaq, Joamin Gonzalez-Gutierrez, Gregory Mertz, David Ruch, Daniel F. Schmidt, Stephan Westermann
Summary: This review highlights the latest advancements in 4D printing of multi-component thermo-responsive shape-memory polymers (SMPs) and their potential applications. Commonly used 4D printing technologies and actuation methods for different SMP systems are discussed. Additionally, the current challenges and future prospects for 4D printing technology are summarized.
APPLIED SCIENCES-BASEL
(2022)
Article
Polymer Science
Muhammad Yasar Razzaq, Joamin Gonzalez-Gutierrez, Muhammad Farhan, Rohan Das, David Ruch, Stephan Westermann, Daniel F. Schmidt
Summary: This research presents the 4D printing of electro-active triple-shape composites based on thermoplastic blends. The composites were suitable for 3D printing by fused filament fabrication (FFF) and the resulting parts demonstrated the triple-shape effect. By increasing voltages in a stepwise fashion, the printed demonstrators realized the triple-shape effect through a thermo-mechanical programming procedure. The 3D printing of such electroactive composites opens up possibilities for complex shapes with defined geometries and novel methods for triggering shape memory, which could have potential applications in space, robotics, and actuation technologies.
Review
Polymer Science
Muhammad Yasar Razzaq, Maria Balk, Magdalena Mazurek-Budzynska, Anke Schadewald
Summary: Nature has always been a source of inspiration for the development of novel materials and devices, and polymer actuators that mimic natural movements and functions have potential applications in various fields. In recent years, researchers have focused on electrospun fibrous meshes as actuators due to their high permeability, surface area, and easy functional modification. This review discusses the progress in electrospun actuators based on commonly used polymers such as stimuli-sensitive hydrogels, shape-memory polymers, and electroactive polymers. The design strategies inspired by nature, such as hierarchical systems and responsive interfaces, are also explored to enhance the performance and functionality of these actuators.
