Mast cells: new therapeutic target in helminth immune modulation

Health metrics for helminth infections

(2015) Charles H. King   ACTA TROPICA

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

Mast Cell and Autoimmune Diseases

(2015) Yunzhi Xu et al.   MEDIATORS OF INFLAMMATION

Potential effector and immunoregulatory functions of mast cells in mucosal immunity

(2015) L L Reber et al.   Mucosal Immunology

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

SOCS3, a Major Regulator of Infection and Inflammation

(2014) Berit Carow et al.   Frontiers in Immunology

The effects of Fasciola hepatica tegumental antigens on mast cell function

(2013) Krisztina V. Vukman et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis

(2013) R. Rodeghero et al.   JOURNAL OF IMMUNOLOGY

Fasciola hepatica Tegumental Coat Impairs Mast Cells' Ability To Drive Th1 Immune Responses

(2013) K. V. Vukman et al.   JOURNAL OF IMMUNOLOGY

Autoreactive Th1 Cells Activate Monocytes To Support Regional Th17 Responses in Inflammatory Arthritis

(2013) D. M. Simons et al.   JOURNAL OF IMMUNOLOGY

Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIOMS): study protocol for a randomized controlled trial

(2013) Berit Rosche et al.   Trials

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites

(2012) Miguel A. Pineda et al.   ARTHRITIS AND RHEUMATISM

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1

(2012) Holly C. Afferson et al.   INFECTION AND IMMUNITY

Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2012) Massimo Costanza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE

(2012) Alison L. Christy et al.   JOURNAL OF AUTOIMMUNITY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

(2012) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Mast cells: an expanding pathophysiological role from allergy to other disorders

(2012) Preet Anand et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

(2012) M. R. Hepworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

(2012) P. C. Cook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis

(2012) E. Omoyinmi et al.   RHEUMATOLOGY

Intestinal mast cells in gut inflammation and motility disturbances

(2011) Benedicte Y. De Winter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mast cells in health and disease

(2011) Charlotte L. Weller et al.   CLINICAL SCIENCE

Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function

(2011) Anne Dudeck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity

(2011) Atsushi Otsuka et al.   PLoS One

Nematode modulation of inflammatory bowel disease

(2011) Rose A. K. Whelan et al.   PROTOPLASMA

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

(2010) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Role of Mast Cells in Inflammatory Bowel Disease and Inflammation-Associated Colorectal Neoplasia in IL-10-Deficient Mice

(2010) Maciej Chichlowski et al.   PLoS One

IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

(2010) M. J. Broadhurst et al.   Science Translational Medicine

Helminth Infection Can Reduce Insulitis and Type 1 Diabetes through CD25- and IL-10-Independent Mechanisms

(2009) Q. Liu et al.   INFECTION AND IMMUNITY

Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

(2009) D. J. Dowling et al.   INFECTION AND IMMUNITY

The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function

(2009) C. M. Hamilton et al.   INFECTION AND IMMUNITY

Inducible MHC Class II Expression by Mast Cells Supports Effector and Regulatory T Cell Activation

(2009) T. Kambayashi et al.   JOURNAL OF IMMUNOLOGY

Infection with a Helminth Parasite Attenuates Autoimmunity through TGF- -Mediated Suppression of Th17 and Th1 Responses

(2009) K. P. Walsh et al.   JOURNAL OF IMMUNOLOGY

Immunity-mediated regulation of fecundity in the nematode Heligmosomoides polygyrus – the potential role of mast cells

(2009) K. HASHIMOTO et al.   PARASITOLOGY

Human schistosomiasis mansoni: Immune responses during acute and chronic phases of the infection

(2008) Iramaya Rodrigues Caldas et al.   ACTA TROPICA

Worms and the Treatment of Inflammatory Bowel Disease: Are Molecules the Answer?

(2008) Nathalie E. Ruyssers et al.   Clinical & Developmental Immunology

Therapeutic immunomodulators from nematode parasites

(2008) William Harnett et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

An update on the use of helminths to treat Crohn’s and other autoimmunune diseases

(2008) Aditya Reddy et al.   PARASITOLOGY RESEARCH

Differential activation of mast cells by antigens from Trichinella spiralis muscle larvae, adults, and newborn larvae

(2008) L. Yépez-Mulia et al.   VETERINARY PARASITOLOGY