Improved methodologies for the study of adipose biology: insights gained and opportunities ahead

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Transcriptional Cofactor TBLR1 Controls Lipid Mobilization in White Adipose Tissue

(2013) Maria Rohm et al.   Cell Metabolism

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet

(2013) Emilie Stolarczyk et al.   Cell Metabolism

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

(2013) Claudio J. Villanueva et al.   Cell Metabolism

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

(2013) Hoon-Ki Sung et al.   Cell Metabolism

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis

(2013) Yuri Fujimoto et al.   ENDOCRINOLOGY

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Aging-Associated Reductions in Lipolytic and Mitochondrial Proteins in Mouse Adipose Tissue Are Not Rescued by Metformin Treatment

(2013) E. Mennes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Winged Helix Transcription Factor Foxa3 Regulates Adipocyte Differentiation and Depot-Selective Fat Tissue Expansion

(2013) Lingyan Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

(2013) Zachary Gerhart-Hines et al.   NATURE

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

(2013) Haruya Ohno et al.   NATURE

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Shox2 is a molecular determinant of depot-specific adipocyte function

(2013) K. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2

(2013) Jifeng Zhang et al.   Scientific Reports

Assessment of brown adipose tissue function

(2013) Sam Virtue et al.   Frontiers in Physiology

Importance of estrogen receptors in adipose tissue function

(2013) Matthias Blüher   Molecular Metabolism

The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis

(2013) Kathryn E. Davis et al.   Molecular Metabolism

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake

(2012) Daniel Zeve et al.   Cell Metabolism

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1

(2012) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots

(2012) Y. Macotela et al.   DIABETES

A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth: A Randle Cycle Favoring Fat Storage

(2012) H. Marcelino et al.   DIABETES

Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues

(2012) Tizhong Shan et al.   FASEB JOURNAL

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods

(2012) Shannon E. Mullican et al.   MOLECULAR ENDOCRINOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

(2012) Johan W. Jonker et al.   NATURE

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

(2012) Rachel B. Reinert et al.   PLoS One

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of Early Adipose Commitment by Zfp521

(2012) Sona Kang et al.   PLOS BIOLOGY

Sex differences in human adipose tissues – the biology of pear shape

(2012) Kalypso Karastergiou et al.   Biology of Sex Differences

New Powers of Brown Fat: Fighting the Metabolic Syndrome

(2011) Jan Nedergaard et al.   Cell Metabolism

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

High-Fat Diet-Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation

(2011) D. Feng et al.   DIABETES

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

(2011) Xiao Yu et al.   EMBO JOURNAL

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages

(2011) Pamela Fischer-Posovszky et al.   ENDOCRINOLOGY

Cell line models for differentiation: preadipocytes and adipocytes

(2011) Sylvia P Poulos et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach

(2011) Won Jae Huh et al.   GASTROENTEROLOGY

The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis

(2011) Antonis D. Lampidonis et al.   GENE

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue stem cells meet preadipocyte commitment: going back to the future

(2011) William P. Cawthorn et al.   JOURNAL OF LIPID RESEARCH

Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity

(2011) Xiaoyi Wei et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells

(2011) A. G. Cristancho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Adipocyte Origins: Weighing the Possibilities

(2011) Susan M. Majka et al.   STEM CELLS

ECM roles in the function of metabolic tissues

(2011) Guorui Huang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Comparative Epigenomic Analysis of Murine and Human Adipogenesis

(2010) Tarjei S. Mikkelsen et al.   CELL

Lipolysis Control: The Plot Thickens

(2010) Dawn L. Brasaemle   Cell Metabolism

Sarcolemmal ATP-Sensitive K+ Channels Control Energy Expenditure Determining Body Weight

(2010) Alexey E. Alekseev et al.   Cell Metabolism

Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

(2010) H. Guo et al.   DIABETES

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Identification and Characterization of a Promoter Cassette Conferring Adipocyte-Specific Gene Expression

(2010) Zhao V. Wang et al.   ENDOCRINOLOGY

Propagation of adipogenic signals through an epigenomic transition state

(2010) D. J. Steger et al.   GENES & DEVELOPMENT

Tamoxifen-inducible Cre-mediated recombination in adipocytes

(2010) Antonia Sassmann et al.   GENESIS

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

The Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) Regulates Adipose Tissue Accumulation and Adipocyte Insulin Sensitivityin Vivo

(2010) Maria M. Sutanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific

(2010) S. M. Majka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Participation of ERα and ERβ in glucose homeostasis in skeletal muscle and white adipose tissue

(2009) Rodrigo P. A. Barros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Sexual differences in the control of energy homeostasis

(2009) Haifei Shi et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

(2009) Christoph Lepper et al.   NATURE

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Leptin Contributes to the Adaptive Responses of Mice to High-Fat Diet Intake through Suppressing the Lipogenic Pathway

(2009) Lei Jiang et al.   PLoS One

Depot-Specific Differences in Adipogenic Progenitor Abundance and Proliferative Response to High-Fat Diet

(2009) Aaron W.B. Joe et al.   STEM CELLS

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

(2009) Junghyo Jo et al.   PLoS Computational Biology

Identification of White Adipocyte Progenitor Cells In Vivo

(2008) Matthew S. Rodeheffer et al.   CELL

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice

(2008) Qiong Wang et al.   HEPATOLOGY

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE