PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes

OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

(2013) Weiwei Liu et al.   INFLAMMATION RESEARCH

Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages

(2012) Huy A. Nguyen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

(2012) Yugang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKCδ signalling regulates SR-A and CD36 expression and foam cell formation

(2012) Chin-Sheng Lin et al.   CARDIOVASCULAR RESEARCH

Sterile Inflammatory Response in Acute Pancreatitis

(2012) Rafaz Hoque et al.   PANCREAS

Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state

(2011) K. Chen et al.   BLOOD

Trauma alarmins as activators of damage-induced inflammation

(2011) J. Manson et al.   BRITISH JOURNAL OF SURGERY

Oxidative Modification of Lipoproteins: Mechanisms, Role in Inflammation and Potential Clinical Applications in Cardiovascular Disease

(2011) Sotirios Tsimikas et al.   CURRENT PHARMACEUTICAL DESIGN

IL-1R-Associated Kinase-1 Mediates Protein Kinase C -Induced IL-1  Production in Monocytes

(2011) R. L. Tiwari et al.   JOURNAL OF IMMUNOLOGY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Circulating Oxidized LDL and Inflammation in Extreme Pediatric Obesity

(2011) Anne L. Norris et al.   Obesity

The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling

(2010) Sinead Flannery et al.   BIOCHEMICAL PHARMACOLOGY

Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response

(2010) L. Chávez-Sánchez et al.   HUMAN IMMUNOLOGY

Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway

(2010) Shobha Bhaskar et al.   IMMUNOBIOLOGY

Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis

(2010) Nikhil Kothari et al.   JOURNAL OF CRITICAL CARE

Integrin  M 2 Clustering Triggers Phosphorylation and Activation of Protein Kinase C  that Regulates Transcription Factor Foxp1 Expression in Monocytes

(2010) Z.-H. Xue et al.   JOURNAL OF IMMUNOLOGY

Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC)

(2010) Laurie E. Kilpatrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1β, IL-6, and IL-10 secretion in human monocytes and macrophages

(2010) Luis Chávez-Sánchez et al.   Lipids in Health and Disease

Upregulation of TLR2/4 Expression in Mononuclear Cells in Postoperative Systemic Inflammatory Response Syndrome after Liver Transplantation

(2010) Ziqing Hei et al.   MEDIATORS OF INFLAMMATION

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

The role of NLRs and TLRs in the activation of the inflammasome

(2008) Mihai G Netea et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis

(2008) Michael Behnes et al.   JOURNAL OF CRITICAL CARE

Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages

(2008) Ming-Cheng Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE