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Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R

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Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria

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Metabolism meets immunity: The role of free fatty acid receptors in the immune system

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Complex Pharmacology of Free Fatty Acid Receptors

(2016) Graeme Milligan et al.   CHEMICAL REVIEWS

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(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Priming of the neutrophil respiratory burst: role in host defense and inflammation

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A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias

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Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Regulation, Signaling, and Physiological Functions of G-Proteins

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The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

(2016) Lena Björkman et al.   MOLECULAR AND CELLULAR BIOLOGY

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

(2016) Maria E. Due-Hansen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

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Allosteric Modulation of Chemoattractant Receptors

(2016) Marcello Allegretti et al.   Frontiers in Immunology

New paradigms in GPCR drug discovery

(2015) Kenneth A. Jacobson   BIOCHEMICAL PHARMACOLOGY

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(2015) Michael Gabl et al.   EXPERIMENTAL CELL RESEARCH

Novel Allosteric Modulators of G Protein-coupled Receptors

(2015) Patrick R. Gentry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

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The SCFA Receptor GPR43 and Energy Metabolism

(2014) Ikuo Kimura et al.   Frontiers in Endocrinology

The Subcellular Localization of the Receptor for Platelet-Activating Factor in Neutrophils Affects Signaling and Activation Characteristics

(2013) Emil Andréasson et al.   Clinical & Developmental Immunology

Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics

(2013) Tomo Yonezawa et al.   CURRENT MEDICINAL CHEMISTRY

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

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Damage-Associated Molecular Patterns Control Neutrophil Recruitment

(2013) Keir Pittman et al.   Journal of Innate Immunity

GPR43/FFA2: physiopathological relevance and therapeutic prospects

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Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

(2012) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacology and therapeutic potential of pattern recognition receptors

(2012) M.J. Paul-Clark et al.   PHARMACOLOGY & THERAPEUTICS

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

(2012) Trond Ulven   Frontiers in Endocrinology

Dendritic Cells and Damage-Associated Molecular Patterns: Endogenous Danger Signals Linking Innate and Adaptive Immunity

(2011) Gary Nace et al.   Journal of Innate Immunity

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

What Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4 ?

(2011) H. Forsman et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

(2009) Yingcai Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration

(2009) Filip Kukulski et al.   CYTOKINE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

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The Host Defense Peptide LL-37 Selectively Permeabilizes Apoptotic Leukocytes

(2008) A. Bjorstad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY