Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

(2013) Hsing-Chuan Tsai et al.   Clinical & Developmental Immunology

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury

(2013) Heidi Ehrentraut et al.   FASEB JOURNAL

An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality

(2013) Michael Adamzik et al.   INTENSIVE CARE MEDICINE

Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury*

(2012) Kendra N. Iskander et al.   CRITICAL CARE MEDICINE

Tregs Promote the Differentiation of Th17 Cells in Silica-Induced Lung Fibrosis in Mice

(2012) Laiyu Song et al.   PLoS One

Sequential Induction of Effector Function, Tissue Migration and Cell Death during Polyclonal Activation of Mouse Regulatory T-Cells

(2012) Daniela Langenhorst et al.   PLoS One

Programmed Death 1 Expression as a Marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient

(2012) Sean F. Monaghan et al.   SHOCK

Generation of Nitric Oxide and Reactive Oxygen Species by Neutrophils and Monocytes From Septic Patients and Association With Outcomes

(2012) Sidnéia Sousa Santos et al.   SHOCK

Role of Activated Neutrophils in Chest Trauma–Induced Septic Acute Lung Injury

(2012) Mario Perl et al.   SHOCK

Mechanisms of Indirect Acute Lung Injury

(2011) Sean F. Monaghan et al.   ANNALS OF SURGERY

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Intrapulmonary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Attenuates Acute Lung Injury by Expanding CD4+CD25+ Forkhead Boxp3 (FOXP3) + Regulatory T Cells and Balancing Anti- and Pro-inflammatory Factors

(2011) Jun Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

(2011) Pushpa Pandiyan et al.   IMMUNITY

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Pathogenesis of indirect (secondary) acute lung injury

(2011) Mario Perl et al.   Expert Review of Respiratory Medicine

Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury*

(2010) Mario Perl et al.   CRITICAL CARE MEDICINE

Therapeutic strategies for severe acute lung injury

(2010) Janet V. Diaz et al.   CRITICAL CARE MEDICINE

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

T Cell Pathways Involving CTLA4 Contribute To a Model of Acute Lung Injury

(2010) T. Nakajima et al.   JOURNAL OF IMMUNOLOGY

Naturally Occurring and Inducible T-Regulatory Cells Modulating Immune Response in Allergic Asthma

(2009) Halvor S. McGee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Programmed Death-1 Antibody Blocks Therapeutic Effects of T-Regulatory Cells in Cockroach Antigen-Induced Allergic Asthma

(2009) Halvor S. McGee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock

(2009) P. Kobbe et al.   INFLAMMATION RESEARCH

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

(2009) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphocytes in the Development of Lung Inflammation: A Role for Regulatory CD4+ T Cells in Indirect Pulmonary Lung Injury

(2009) F. Venet et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling

(2009) Neil R. Aggarwal et al.   PHYSIOLOGICAL GENOMICS

Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10

(2009) Chieh-Liang WU et al.   RESPIROLOGY

IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock

(2008) Philipp Kobbe et al.   CYTOKINE

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

IL-17 Producing γδ T Cells are Required for a Controlled Inflammatory Response after Bleomycin-induced Lung Injury

(2008) Ruedi K. Braun et al.   INFLAMMATION

IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo – effects of anti-inflammatory pharmacotherapy

(2008) Olof Prause et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS