Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors

Munc13-4 Regulates Granule Secretion in Human Neutrophils

(2014) C. Pivot-Pajot et al.   JOURNAL OF IMMUNOLOGY

Rab27a Regulates Exocytosis of Tertiary and Specific Granules in Human Neutrophils

(2014) M. J. Herrero-Turrion et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

(2012) M. Kurowska et al.   BLOOD

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

(2012) R. K. Singh et al.   JOURNAL OF CELL SCIENCE

EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking

(2012) David E. Hokanson et al.   MOLECULAR BIOLOGY OF THE CELL

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein

(2012) Jennifer L. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

Increased Survival and Reduced Neutrophil Infiltration of the Liver in Rab27a- but Not Munc13-4-Deficient Mice in Lipopolysaccharide-Induced Systemic Inflammation

(2011) Jennifer L. Johnson et al.   INFECTION AND IMMUNITY

NADPH Oxidase Is Internalized by Clathrin-coated Pits and Localizes to a Rab27A/B GTPase-regulated Secretory Compartment in Activated Macrophages

(2011) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

(2010) K. E. Anderson et al.   BLOOD

Rab27a Negatively Regulates Phagocytosis by Prolongation of the Actin-coating Stage around Phagosomes

(2010) Kunio Yokoyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 Restricts Motility of Rab27a-expressing Vesicles to Facilitate Lipopolysaccharide-induced Priming of Exocytosis in Neutrophils

(2010) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets

(2009) O. Neumuller et al.   BLOOD

Anterograde Transport of TrkB in Axons Is Mediated by Direct Interaction with Slp1 and Rab27

(2009) Nariko Arimura et al.   DEVELOPMENTAL CELL

DNase I Inhibits a Late Phase of Reactive Oxygen Species Production in Neutrophils

(2009) Daniela B. Munafo et al.   Journal of Innate Immunity

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

(2009) Jennifer L. Johnson et al.   TRAFFIC

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice

(2008) Viktor Brovkovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a

(2008) Leonard M.G. Chavas et al.   STRUCTURE

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules

(2008) Agnieszka A. Brzezinska et al.   TRAFFIC