PET radioligands targeting the brain GABAA/benzodiazepine receptor complex

Characterisation of the Contribution of the GABA-Benzodiazepine α1 Receptor Subtype to [11C]Ro15-4513 PET Images

(2012) James FM Myers et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

[11C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels

(2012) W. Gordon Frankle et al.   PLoS One

Facile aromatic radiofluorination of [18F]flumazenil from diaryliodonium salts with evaluation of their stability and selectivity

(2011) Byung Seok Moon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Use of 2-[18F]fluoroethylazide for the Staudinger ligation – Preparation and characterisation of GABAA receptor binding 4-quinolones

(2010) Alessandra Gaeta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vivo High Intrinsic Efficacy of Triazolam: A Positron Emission Tomography Study in Nonhuman Primates

(2010) Michel Bottlaender et al.   JOURNAL OF NEUROCHEMISTRY

A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions

(2010) Anne Lingford-Hughes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat

(2009) Stefanie Dedeurwaerdere et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

(2009) P. L. Pearl et al.   NEUROLOGY

Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke

(2009) Gassan Massaweh et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of microwave-based automated nucleophilic [18F]fluorination system and its application to the production of [18F]flumazenil

(2009) Katheryn S. Mandap et al.   NUCLEAR MEDICINE AND BIOLOGY

Quantitative analyses of [11C]Ro15-4513 binding to subunits of GABAA/benzodiazepine receptor in the living human brain

(2009) Yoshiyuki Asai et al.   NUCLEAR MEDICINE COMMUNICATIONS

Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABAA receptors

(2008) Erik Lager et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Radiosynthesis of novel18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET

(2008) Steffen Fischer et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

[18F]Flumazenil binding to central benzodiazepine receptor studies by PET

(2008) Ikuo Odano et al.   NEUROIMAGE

Tiagabine Increases [11C]flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects

(2008) W Gordon Frankle et al.   NEUROPSYCHOPHARMACOLOGY

Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors

(2007) Alexander Hoepping et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5-tert-Butyl-2-(4′-[18F]fluoropropynylphenyl)-1,3-dithiane oxides: potential new GABAA receptor radioligands

(2007) Xuehe Li et al.   NUCLEAR MEDICINE AND BIOLOGY

GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for α5 subunit

(2007) Yoshiyuki Asai et al.   SCHIZOPHRENIA RESEARCH