Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 139, Issue 2, Pages 352-359Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2018.07.043
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Funding
- MEXT KAKENHI [17K10203]
- Grants-in-Aid for Scientific Research [17K10203] Funding Source: KAKEN
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Epidermal lamellar granules transport various lipids, proteins, and protein inhibitors from the trans-Golgi network to the extracellular space, and play an important role in skin barrier formation. We elucidated the 3-dimensional structure of lamellar granules and the trans-Golgi network in normal human skin by focused ion beam scanning electron microscopy. Reconstructed focused ion beam scanning electron microscopy 3dimensional images revealed that the overall lamellar granule structure changed from vesicular to reticular within the second layer of the stratum granulosum. Furthermore, the trans-Golgi network was well developed within this layer and spread through the cytoplasm with branched, tubular structures that connected to lamellar granules. Our study reveals the unique overall 3-dimensional structure of lamellar granules and the trans-Golgi network within the cells of the epidermis, and provides the basis for an understanding of the skin barrier formation.
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