Review
Cell Biology
Sarmistha Mahanty, Subba Rao Gangi Setty
Summary: Epidermal lamellar bodies (eLBs) are secretory organelles necessary for skin homeostasis, belonging to lysosome-related organelles (LROs) with a complex formation process related to other organelles. Disruption of the multistep biogenesis processes often occurs in skin disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chihiro Takeuchi, Junichi Sato, Nobutake Yamamichi, Natsuko Kageyama-Yahara, Akiko Sasaki, Takemi Akahane, Rika Aoki, Shigemi Nakajima, Masayoshi Ito, Mitsue Yamamichi, Yu-Yu Liu, Nobuyuki Sakuma, Yu Takahashi, Yoshiki Sakaguchi, Yosuke Tsuji, Kouhei Sakurai, Shuta Tomida, Keiko Niimi, Toshikazu Ushijima, Mitsuhiro Fujishiro
Summary: Autoimmune gastritis leads to distinct trans-differentiation in the gastric mucosa, accompanied by increased background gastric acid secretion.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Dermatology
Yoko Endo, Hiroyuki Yoshida, Yukiko Ota, Yumiko Akazawa, Tetsuya Sayo, Ushio Hanai, Kotaro Imagawa, Masashi Sasaki, Yoshito Takahashi
Summary: The study investigated the effects of a newly developed inducer, beta-NAG2, on epidermal proliferation and differentiation by increasing HA production. The results showed that beta-NAG2 significantly increased HA production in the skin, leading to accelerated keratinocyte proliferation and differentiation, which plays a key role in epidermal morphogenesis and homeostasis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biology
Marie-Claire Mechin, Michel Simon
Summary: This article discusses the role of peptidylarginine deiminases (PADs) in physiological processes and their involvement in human diseases. PAD1 and PAD3 are important for keratinocyte differentiation and epidermal barrier function, while mutations in the PADI3 gene are associated with hair disorders and alopecia. The study highlights the significance of PADs in skin health and disease.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Dermatology
Mao-Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias
Summary: Nitric oxide (NO) plays a regulatory role in epidermal permeability barrier functions, affecting processes such as barrier homeostasis and wound healing. While insufficient NO can lead to disorders like diabetes and hypertension, excessive levels can induce cellular oxidative stress. iNOS remains essential for epidermal permeability barrier homeostasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Immunology
Kaixuan Ren, Yumin Xia
Summary: Lipocalin 2 plays a crucial role in the pathogenesis of psoriatic inflammation by exerting versatile effects on skin resident cells and infiltrating immune cells. Neutralizing lipocalin 2 or relevant cytokines can alleviate psoriasis, highlighting lipocalin 2 as an effective interfering target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Jung Hwa Lim, Dae Hun Kim, Kyung Hee Noh, Cho-Rok Jung, Hyun Mi Kang
Summary: This study identified epidermal progenitor cells that possess unlimited proliferation and multipotent differentiation capacity. These cells can form organotypic skin models and mimic the morphologic and biochemical processes of human epidermis. The proliferation and differentiation of these cells rely on the expression of Integrin beta 1 (ITGB1). Furthermore, the in vitro and in vivo wound healing capacity of these cells was examined.
CELL PROLIFERATION
(2022)
Article
Multidisciplinary Sciences
Sarah M. Lloyd, Daniel B. Leon, Mari O. Brady, Deborah Rodriguez, Madison P. McReynolds, Junghun Kweon, Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Xiaomin Bao
Summary: In this study, the researchers found that the Super Elongation Complex (SEC) controls fate decisions of progenitor cells by suppressing a group of rapid response genes. The repressive role of SEC depends on the AFF1 scaffold, but not AFF4. The expression of these rapid response genes is regulated by CDK9 activity. The findings suggest that the activity switch of SEC-associated CDK9 is a key initial process in determining the fate of progenitor cells.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Xuan Wang, Shuyong Wang, Baolin Guo, Yuxin Su, Zuolong Tan, Mingyang Chang, Jinmei Diao, Yi Zhao, Yunfang Wang
Summary: The study presents a method for establishing and expanding human primary epidermal organoids under a chemically defined condition, which show tolerance to dermatophyte infections caused by Trichophyton Rubrum. This experimental model provides new insights into the pathogenesis of T. rubrum infections and serves as a potential tool for studying and testing antifungal drugs.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Letian Zhang, Minna Piipponen, Zhuang Liu, Dongqing Li, Xiaowei Bian, Guanglin Niu, Jennifer Geara, Maria A. Toma, Pehr Sommar, Ning Xu Landen
Summary: HOXC13-AS, a long noncoding RNA, is a crucial regulator of human epidermal differentiation. It promotes keratinocyte differentiation by interfering with Golgi-to-endoplasmic reticulum molecular transport, leading to ER stress.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Christabel Thembela Dube, Fathima Rifkhana Shah Jahan, Chin Yan Lim
Summary: Dynamic shifts in chromatin states occur during embryonic epidermal development and aging, with distinct histone modifications being retained from embryonic development to adulthood. Changes in the chromatin profiles in aged tissues, especially in basal epidermis, paralleled alterations in the corresponding histone modifier expression.
Article
Multidisciplinary Sciences
Noreen Karim, Lo-Wei Lin, Joel P. Van Eenennaam, Nann A. Fangue, Andrea D. Schreier, Marjorie A. Phillips, Robert H. Rice
Summary: Using an optimized system for propagating human keratinocytes, researchers cultured skin samples from white and green sturgeons, generating epithelial cells capable of forming cross-linked protein envelopes. They identified two distinct forms of TGM1-like mRNA in these cells, which accounted for their envelope forming ability. The researchers also established continuous lines of white sturgeon epidermal cells and observed improvements in growth rate over multiple passages.
Review
Dermatology
Francesca Prignano, Elena Donetti
Summary: This review provides an overview of the recent research on IL-22, including its biological role, molecular mechanism, and clinical implications in healthy and unhealthy skin. The recent experimental evidence suggests a homeostatic role of IL-22 in normal human skin and offers a new perspective on its clinical relevance.
Article
Dermatology
Bin Chen, Nan Lu, KeeSuh Lee, Lei Ye, Chiho Hasegawa, Kazuhisa Maeda
Summary: This study demonstrates that mevalonolactone (MVL) improves epidermal barrier function in dry skin by promoting fatty acid transport and increasing the expression of ABCA12 and PPAR beta/delta.
SKIN RESEARCH AND TECHNOLOGY
(2022)
