Editorial Material
Cell Biology
Renzhi Hou, Aliaksandr A. Astrowski, Maksim V. Plikus
Summary: The heightened ability of spiny mice to regenerate after injury is attributed to molecular changes in the Hippo-YAP pathway that protect wound fibroblasts from a persistent contractile state, as revealed in this issue of Developmental Cell.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Haleh Mokabber, Mohammad Amin Vatankhah, Nowruz Najafzadeh
Summary: MiRNAs play an important role in the development and cyclic changes of hair. They regulate hair follicle cycling by controlling gene activation and silencing. Some miRNAs promote hair regression, while others enhance hair growth. New miRNAs have also been found to be involved in hair biology.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens Michael Seeger, Hamid Kashkar, Catherin Niemann
Summary: This study reveals the impact of Bcl-2 on the function of hair follicle stem cells, maintaining the homeostasis and regeneration of stem cells by controlling the apoptosis response, which may also suppress carcinogenesis.
Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Basharat Bhat, Mifftha Yaseen, Ashutosh Singh, Syed Mudasir Ahmad, Nazir A. Ganai
Summary: The Pashmina goat, known for its valuable Pashmina fiber, has a double coat fleece adapted to harsh cold conditions. Transcriptome analysis revealed key genes and signaling pathways regulating follicle growth phases, with differential gene expression suggesting control by pathways like Wnt, NF-Kappa, and JAK-STAT. Genes from Integrin family and Cell adhesion molecules were highly expressed during the active phase, along with potential involvement of transcription factors like RUNX3 and GATA family in fiber quality maintenance.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyung Nam, Hyun-Ah Shin, HeeJae Yun, Seung-Ah Yoo, Hyangshuk Rhim
Summary: The inactivation of HtrA2 leads to changes in skin color and delayed hair growth cycle in mice, caused by the retardation of adipocyte growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Dermatology
Jiyoon Lee, Karl R. Koehler
Summary: Culturing skin cells outside the body has long been essential to dermatological research, but artificial skin equivalents often lack the full complexity of native skin, especially in generating and maintaining skin appendages such as hair follicles and sweat glands.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell Biology
Natalia A. Veniaminova, Yunlong Y. Jia, Adrien M. Hartigan, Thomas J. Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A. Dlugosz, Scott X. Atwood, Sunny Y. Wong
Summary: This study reveals that sebaceous glands (SGs) are self-renewed by stem cells during homeostasis and their differentiation into sebocytes follows specific pathways. In response to skin injury, SG progenitors are replaced by stem cells from hair follicles, which regenerate the glands. This regenerative process is mediated by alternative stem cells from hair follicles and can be accelerated by inducing hair growth.
Review
Biology
Marie-Claire Mechin, Michel Simon
Summary: This article discusses the role of peptidylarginine deiminases (PADs) in physiological processes and their involvement in human diseases. PAD1 and PAD3 are important for keratinocyte differentiation and epidermal barrier function, while mutations in the PADI3 gene are associated with hair disorders and alopecia. The study highlights the significance of PADs in skin health and disease.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alok Jaiswal, Raghvendra Singh
Summary: This study investigates the role of the Notch signaling pathway in hair follicle and epidermal homeostasis. Loss of Notch signaling leads to the development of BCC and drug resistance in BCC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Cell Biology
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Summary: Hair-follicle-associated pluripotent (HAP) stem cells, located in hair follicles, can differentiate into multiple cell types, including neurons and cardiomyocytes. Studies have shown that HAP stem cells treated with neural-induction medium can differentiate into dopaminergic neurons, which may potentially help improve symptoms of Parkinson's disease in the future.
Article
Cell Biology
Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon, Elle Koren, Marianna Yusupova, Daniel Rosner, Alona Feldman, Shulamit Baror-Sebban, Yosef Buganim, David J. Simon, Marc Tessier-Lavigne, Yaron Fuchs
Summary: The study shows that deletion of Caspase-9 in hair follicle stem cells attenuates the apoptotic cascade, resulting in significant temporal delays. These Casp9-deficient stem cells accumulate high levels of cleaved caspase-3 and are improperly cleared due to a caspase-3/caspase-9 feedforward loop. The apoptotic cells represent a dynamic stem cell niche that drives stem cell proliferation and tissue regeneration by continuously releasing Wnt3.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Ruijun Shi, Shuwei Li, Penggang Liu, Shuhui Zhang, Zhenhui Wu, Tinghui Wu, Shujuan Gong, Yu Wan
Summary: This study analyzed Hetian sheep with different wool densities to assess their wool traits and hair follicle parameters. Transcriptome sequencing analysis was performed on the skins, revealing differentially expressed genes related to hair growth. The study provides valuable resources for enhancing the quality and production of wool in Hetian sheep.
Article
Agriculture, Dairy & Animal Science
Yanyu He, Xiu Liu, Jie De, Saihong Kang, John S. Munday
Summary: Cashmere goats in Tibet are adapted to high altitude, cold climates, and hypoxia. This study compared the morphology and immunostaining of hair follicle regulatory proteins in Tibetan cashmere goats from high and low altitude regions. Results showed that altitude and temperature influence the development of secondary hair follicles, with significant differences observed between goats from different locations. The understanding of these factors can help maximize the production of valuable fibers.
Article
Cell Biology
Carla M. Abreu, Rui L. Reis, Alexandra P. Marques
Summary: The study showed that under 5% oxygen levels, human dermal papilla cells and melanocytes exhibited improved physiological state and phenotype, with interactions between them enhancing hair growth and pigmentation. The findings provide important insights for research on hair regeneration.
CELL PROLIFERATION
(2021)
Meeting Abstract
Dermatology
K. Poterlowicz, J. Yarker, I. Malashchuk, A. N. Mardaryev, M. R. Gdula, A. Sharov, T. Kohwi-Shigematsu, V. Botchkarev, M. Y. Fessing
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Meeting Abstract
Dermatology
I. Malashchuk, J. Rudolf, T. Vafaee, K. Poterlowicz, A. Sharov, M. Y. Fessing, A. N. Mardaryev, V. Botchkarev
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Dermatology
Valentina Rapisarda, Igor Malashchuk, Inemo E. Asamaowei, Krzysztof Poterlowicz, Michael Y. Fessing, Andrey A. Sharov, Iakowos Karakesisoglou, Vladimir A. Botchkarev, Andrei Mardaryev
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Gabriele Stakaityte, Nnenna Nwogu, Jonathan D. Lippiat, G. Eric Blair, Krzysztof Poterlowicz, James R. Boyne, Andrew Macdonald, Jamel Mankouri, Adrian Whitehouse
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Meeting Abstract
Dermatology
I. Malashchuk, J. Rudolf, T. Vafaee, K. Poterlowicz, A. Sharov, M. Fessing, T. Kohwi-Shigematsu, G. Xu, A. Mardaryev, V. Botchkarev
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Dermatology
Pouria Akhbari, Desmond Tobin, Krzysztof Poterlowicz, Wayne Roberts, James R. Boyne
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Microbiology
Nnenna Nwogu, James R. Boyne, Samuel J. Dobson, Krzysztof Poterlowicz, G. Eric Blair, Andrew Macdonald, Jamel Mankouri, Adrian Whitehouse
Letter
Dermatology
Mohammed I. Ahmed, Maximilian E. Pickup, Alexander G. Rimmer, Majid Alam, Andrei N. Mardaryev, Krzysztof Poterlowicz, Natalia V. Botchkareva, Vladimir A. Botchkarev
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Biology
Katarzyna Murat, Bjoern Gruening, Paulina Wiktoria Poterlowicz, Gillian Westgate, Desmond J. Tobin, Krzysztof Poterlowicz
Article
Critical Care Medicine
Kirsty Smith, Krzystof Poterlowicz, Stephen Southern, Ajay L. Mahajan, Sharmila Jivan
Summary: The accuracy of measuring burn size on a static image was assessed with the inclusion of a standard object, resulting in an overall overestimation of burn size. Despite using a standard object, small areas of the forearm were better estimated, while the back areas were most overestimated.
Article
Biochemistry & Molecular Biology
Alexander E. Ostrovsky, Alexandru Mahmoud, Andrew J. Lonie, Anna Syme, Anne Fouilloux, Anthony Bretaudeau, Anton Nekrutenko, Anup Kumar, Arthur C. Eschenlauer, Assunta D. DeSanto, Aysam Guerler, Beatriz Serrano-Solano, Berenice Batut, Bjoern A. Gruening, Bradley W. Langhorst, Bridget Carr, Bryan A. Raubenolt, Cameron J. Hyde, Catherine J. Bromhead, Christopher B. Barnett, Coline Royaux, Cristobal Gallardo, Daniel Blankenberg, Daniel J. Fornika, Dannon Baker, Dave Bouvier, Dave Clements, David A. de Lima Morais, David Lopez Tabernero, Delphine Lariviere, Engy Nasr, Enis Afgan, Federico Zambelli, Florian Heyl, Fotis Psomopoulos, Frederik Coppens, Gareth R. Price, Gianmauro Cuccuru, Gildas Le Corguille, Greg Von Kuster, Gulsum Gudukbay Akbulut, Helena Rasche, Hotz Hans-Rudolf, Ignacio Eguinoa, Igor Makunin, Isuru J. Ranawaka, James P. Taylor, Jayadev Joshi, Jennifer Hillman-Jackson, Jeremy Goecks, John M. Chilton, Kaivan Kamali, Keith Suderman, Krzysztof Poterlowicz, Le Bras Yvan, Lucille Lopez-Delisle, Luke Sargent, Madeline E. Bassetti, Marco Antonio Tangaro, Marius van den Beek, Martin Cech, Matthias Bernt, Matthias Fahrner, Mehmet Tekman, Melanie C. Foell, Michael C. Schatz, Michael R. Crusoe, Miguel Roncoroni, Natalie Kucher, Nate Coraor, Nicholas Stoler, Nick Rhodes, Nicola Soranzo, Niko Pinter, Nuwan A. Goonasekera, Pablo A. Moreno, Pavankumar Videm, Petera Melanie, Pietro Mandreoli, Pratik D. Jagtap, Qiang Gu, Ralf J. M. Weber, Ross Lazarus, Ruben H. P. Vorderman, Saskia Hiltemann, Sergey Golitsynskiy, Shilpa Garg, Simon A. Bray, Simon L. Gladman, Simone Leo, Subina P. Mehta, Timothy J. Griffin, Vahid Jalili, Vandenbrouck Yves, Victor Wen, Vijay K. Nagampalli, Wendi A. Bacon, Willem de Koning, Wolfgang Maier, Peter J. Briggs
Summary: Galaxy is a mature and browser accessible workbench for scientific computing, allowing scientists to easily share, analyze, and visualize their data. It has a strong global community and support from national infrastructure providers. Key technical developments of Galaxy include improved user interface, interactive tools for data analysis, and a complete suite of machine learning tools. Important scientific developments enabled by Galaxy include Vertebrate Genome Project (VGP) assembly workflows and global SARS-CoV-2 collaborations.
NUCLEIC ACIDS RESEARCH
(2022)
Meeting Abstract
Respiratory System
Laura Smith, Nina Pattabhiraman, Georgina Appleyard, Ian Hutchesson, Katie Jackson, Shavanthi Wadanamby, Alexander Lister, Jamal Bhatti, Scott Hemphill, Krzysztof Poterlowicz, Dinesh Saralaya
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Dermatology
K. Smith, A. Abubakar, S. Jivan, D. Tobin, A. Mahajan, H. Ugail, K. Poterlowicz
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Meeting Abstract
Dermatology
K. Murat, G. Westgate, K. Poterlowicz
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Meeting Abstract
Dermatology
K. M. Smith, H. Ugail, D. J. Tobin, K. Poterlowicz
BRITISH JOURNAL OF DERMATOLOGY
(2018)