Vitamin A and Retinoids as Mitochondrial Toxicants

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma

(2014) H. El Hajj et al.   BLOOD

A review of vitamin A equivalency of β-carotene in various food matrices for human consumption

(2014) Carolien A. Van Loo-Bouwman et al.   BRITISH JOURNAL OF NUTRITION

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation

(2014) Marta Robotta et al.   CHEMBIOCHEM

Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications

(2014) Dale Edmondson   CURRENT PHARMACEUTICAL DESIGN

All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis

(2014) Osamu Sawada et al.   EXPERIMENTAL EYE RESEARCH

α-synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: Implications in the pathogenesis of Parkinson's disease

(2014) Aritri Bir et al.   JOURNAL OF NEUROCHEMISTRY

Organelle-specific initiation of cell death

(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

Neuroimaging in Parkinson disease: from research setting to clinical practice

(2014) Marios Politis   Nature Reviews Neurology

High-dose Vitamin A With Vaccination After 6 Months of Age: A Randomized Trial

(2014) A. B. Fisker et al.   PEDIATRICS

Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review

(2014) Lauren E. Salminen et al.   REVIEWS IN THE NEUROSCIENCES

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Neurotrophins and spinal circuit function

(2014) Vanessa S. Boyce et al.   Frontiers in Neural Circuits

Endoplasmic Reticulum Chaperones and Oxidoreductases: Critical Regulators of Tumor Cell Survival and Immunorecognition

(2014) Tomás Gutiérrez et al.   Frontiers in Oncology

Important Controversies Associated with Isotretinoin Therapy for Acne

(2013) Stephen E. Wolverton et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite

(2013) Sebastián Carballal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An update on oxidative stress-mediated organ pathophysiology

(2013) Kahkashan Rashid et al.   FOOD AND CHEMICAL TOXICOLOGY

Mood changes, depression and suicide risk during isotretinoin treatment: a prospective study

(2013) Zuzana Nevoralová et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: Potential mechanisms of hepatotoxicity

(2013) Filomena S.G. Silva et al.   TOXICOLOGY

Absorption of Vitamin A and Carotenoids by the Enterocyte: Focus on Transport Proteins

(2013) Emmanuelle Reboul   Nutrients

Provitamin A metabolism and functions in mammalian biology

(2012) Johannes von Lintig   AMERICAN JOURNAL OF CLINICAL NUTRITION

Elevación de creatinfosfocinasa e intento de autolisis durante el tratamiento con isotretinoína

(2012) R. Ballester Sánchez et al.   ANALES DE PEDIATRIA

The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: Increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased β-amyloid1–40 peptide and TNF-α contents, and susceptibility of mitochondria to an in vitro H2O2 challenge

(2012) Marcos Roberto de Oliveira et al.   BRAIN RESEARCH BULLETIN

13-cis-Retinoic Acid Induces Apoptosis by Modulating Caspase-3, bcl-2, and p53 Gene Expression and Regulates the Activation of Transcription Factors in B16F-10 Melanoma Cells

(2012) Chandrasekharan Guruvayoorappan et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Increased susceptibility of mitochondria isolated from frontal cortex and hippocampus of vitamin A-treated rats to non-aggregated amyloid-β peptides 1–40 and 1–42.

(2011) Marcos R. de Oliveira et al.   ACTA NEUROPSYCHIATRICA

Physiological insights into all-trans-retinoic acid biosynthesis

(2011) Joseph L. Napoli   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Increased 3-nitrotyrosine levels in mitochondrial membranes and impaired respiratory chain activity in brain regions of adult female rats submitted to daily vitamin A supplementation for 2 months

(2011) Marcos Roberto de Oliveira et al.   BRAIN RESEARCH BULLETIN

L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation

(2011) Matheus Augusto Bittencourt Pasquali et al.   CELL BIOCHEMISTRY AND FUNCTION

L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation

(2011) Marcos Roberto de Oliveira et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Long-term vitamin A supplementation at therapeutic doses induces mitochondrial electrons transfer chain (METC) impairment and increased mitochondrial membrane-enriched fraction (MMEF) 3-nitrotyrosine on rat heart

(2010) Ricardo F. da Rocha et al.   FREE RADICAL RESEARCH

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Total and Mitochondrial Nitrosative Stress, Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels and Glutamate Uptake, and Evidence of Endoplasmic Reticulum Stress in the Hippocampus of Vitamin A-Treated Rats

(2010) Marcos Roberto de Oliveira et al.   NEUROCHEMICAL RESEARCH

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

(2010) Johannes von Lintig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Vitamin A supplementation at pharmacological doses induces nitrosative stress on the hypothalamus of adult Wistar rats

(2009) Marcos Roberto De Oliveira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of redox and bioenergetics states in the liver of vitamin A-treated rats

(2009) Marcos R. de Oliveira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological doses of vitamin A increase caspase-3 activity selectively in cerebral cortex

(2009) Marcos Roberto De Oliveira et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

(2009) Pavel F. Pavlov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Iron as a cause of Parkinson disease – a myth or a well established hypothesis?

(2009) Andrzej Friedman et al.   PARKINSONISM & RELATED DISORDERS

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: Mitochondrial impairment, increased 3-nitrotyrosine and α-synuclein, but decreased D2 receptor contents

(2009) Marcos Roberto de Oliveira et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Short-term vitamin A supplementation at therapeutic doses induces a pro-oxidative state in the hepatic environment and facilitates calcium-ion-induced oxidative stress in rat liver mitochondria independently from permeability transition pore formation

(2008) Marcos Roberto de Oliveira et al.   CELL BIOLOGY AND TOXICOLOGY

Mammalian Cytosolic Glutathione Transferases

(2008) Daniel Dourado et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Retinoid-Mediated Regulation of Mood: Possible Cellular Mechanisms

(2008) Kally O’Reilly et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance

(2008) Akiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin A supplementation at clinical doses induces a dysfunction in the redox and bioenergetics states, but did change neither caspases activities nor TNF-α levels in the frontal cortex of adult Wistar rats

(2008) Marcos Roberto De Oliveira et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Impaired redox state and respiratory chain enzyme activities in the cerebellum of vitamin A-treated rats

(2008) Marcos Roberto De Oliveira et al.   TOXICOLOGY

Vitamin A treatment induces apoptosis through an oxidant-dependent activation of the mitochondrial pathway

(2007) F KLAMT et al.   CELL BIOLOGY INTERNATIONAL