Article
Endocrinology & Metabolism
Mauricio D. Dorfman, Thomas Monfeuga, Susan J. Melhorn, Jenny E. Kanter, Jeremy M. Frey, Rachael D. Fasnacht, Anandhakumar Chandran, Emaad Lala, Inmaculada Velasco, Katya B. Rubinow, Thomas H. Meek, Ellen A. Schur, Karin E. Bornfeldt, Joshua P. Thaler
Summary: A recent study found that hypogonadism in males may increase the risk of cardiovascular disease through unknown mechanisms. Low testosterone levels were associated with gliosis in the mediobasal hypothalamus, which is linked to metabolic dysfunction. Furthermore, the study showed that the interaction between CNS androgen action and hepatic PCSK9 overexpression may contribute to the increased cardiovascular risk.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lanfang Kang, Juan Che, Xiaoshuang Liu, Yating Zhao, Xiaobo Nie, Wei Wang, Jiao Liu
Summary: This study found that consuming diets with different concentrations of saturated fat can increase body weight, blood sugar, and blood lipid levels, and have detrimental effects on cardiac function and cardiomyocyte contraction. The diet with 30% saturated fat had the greatest impact on weight, blood sugar, lipid levels, and heart function. The decrease in heart function induced by the saturated fat diet may be related to up-regulation of FABP4.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Matteo Serano, Cecilia Paolini, Antonio Michelucci, Laura Pietrangelo, Flavia A. Guarnier, Feliciano Protasi
Summary: A high-fat diet may increase the susceptibility of wild type mice to heat stress, resulting in increased heat production and oxidative stress in skeletal muscles, as well as enhanced sensitivity to temperature and caffeine in isolated muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ralf Jager, Martin Purpura, Shawn D. Wells, Kylin Liao, Ashok Godavarthi
Summary: The study evaluated the potential benefits of paraxanthine supplementation on muscle mass, strength, and endurance performance compared to other commonly used ingredients by athletes. The results showed that paraxanthine had positive effects on exercise performance and may enhance cardiovascular health.
Article
Biochemistry & Molecular Biology
Sttefany Viana Gomes, Bruna Vidal Dias, Pedro Alves Machado Junior, Renata Rebeca Pereira, Debora Maria Soares de Souza, Gustavo Silveira Breguez, Wanderson Geraldo de Lima, Cintia Lopes de Brito Magalhaes, Silvia Dantas Cangussu, Andre Talvani, Karina Barbosa Queiroz, Allan Jefferson Cruz Calsavara, Daniela Caldeira Costa
Summary: High-fat diet intake can worsen metabolic adaptation and protection against pathogens in sepsis by causing immunometabolic changes in the liver and white adipose tissue. A study on female mice found that chronic high-fat diet decreased survival rate, increased serum cytokine storm, exacerbated white adipose tissue inflammation, and caused hepatocellular injury in septic mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Mengjie Li, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: The aim of this study was to evaluate the preventative effects of MCE on obesity and related metabolic syndromes and to elucidate the mechanisms from the perspective of gut microbiota and white adipose tissues transcriptomic profiles. The results showed that MCE significantly reduced body weight, inhibited adipocyte hypertrophy, and ameliorated hepatic steatosis. Additionally, MCE improved gut microbiota dysbiosis and altered gene expression profiles in white adipose tissues.
Article
Immunology
Nahdia S. Jones, Katarina Q. Watson, G. William Rebeck
Summary: The study found that APOE genotype and obesity interact to affect important processes related to inflammation and neuronal plasticity in the central nervous system (CNS). The APOE3 genotype modulates a response to high-fat diet, while the APOE4 genotype does not.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Marina Rodrigues, Caroline Bertoncini-Silva, Anderson Gregorio Joaquim, Cassia Dias Machado, Leandra Naira Zambelli Ramalho, Daniela Carlos, Priscila Giacomo Fassini, Vivian Marques Miguel Suen
Summary: This study found that eugenol has a protective effect on hepatic lipid accumulation and beneficially modulates the gut microbiota in obese mice, but it does not prevent weight gain.
Article
Nutrition & Dietetics
Zhitian Lu, Xudong Li, Min Wang, Xiaojun Zhang, Runxuan Zhuang, Fan Wu, Wenxue Li, Wei Zhu, Bo Zhang
Summary: Nobiletin (NOB), a compound found in citrus peels, has potential lipid-lowering and circadian-enhancing properties. This study showed that NOB can reduce liver triglyceride levels and regulate genes involved in lipid and cholesterol metabolism, independently of the core clock component Bmal1.
Article
Nutrition & Dietetics
Jingya Guo, Mengjie Li, Yuhan Zhao, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: In this study, the preventive benefits of Cedryl acetate (CA) on obesity and obesity-related metabolic syndrome caused by a high-fat diet (HFD) were investigated. CA supplementation significantly reduced weight gain induced by an HFD, decreased the weight of the visceral fat pads, and prevented adipocyte hypertrophy in mice. Moreover, CA showed significant improvements in metabolic parameters and gene expression related to metabolism in the liver and white adipose tissues of mice fed an HFD.
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Review
Nutrition & Dietetics
Chiara Garonzi, Gun Forsander, Claudio Maffeis
Summary: Children and adolescents with type 1 diabetes should avoid high fat intake to reduce cardiovascular risk and inflammation, and instead opt for a healthy and balanced diet as recommended by ISPAD and ADA.
Article
Nutrition & Dietetics
Kristina Pigsborg, Goezde Guerdeniz, Oscar Daniel Rangel-Huerta, Kirsten B. Holven, Lars Ove Dragsted, Stine M. Ulven
Summary: This study aimed to investigate the changes in serum metabolome after replacing SFA with PUFA and explore the association between dietary metabolites and cardiometabolic risk markers.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Editorial Material
Immunology
Salvador Valle-Reyes, Oxana Dobrovinskaya, Rosana Pelayo, Michael Schnoor
Summary: A significant amount of knowledge on T and B cell biology is obtained from research using ALL cell lines, which are crucial tools in immunology and leukemia studies. Understanding the advantages and limitations of ALL cell lines is important for their proper utilization.
TRENDS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Stahnke, Hermann Doering, Charly Kusch, David J. J. de Gorter, Sebastian Duetting, Aleks Guledani, Irina Pleines, Michael Schnoor, Michael Sixt, Robert Geffers, Manfred Rohde, Mathias Muesken, Frieda Kage, Anika Steffen, Jan Faix, Bernhard Nieswandt, Klemens Rottner, Theresia E. B. Stradal
Summary: The genetic removal of Hem1 in macrophages leads to decreased phagocytosis and cell adhesion, as well as defects in cell migration. The study also found that the WRC impacts integrin-dependent processes in a FAK-dependent manner, controlling the formation and dismantling of adhesions during cell edge expansion.
Article
Multidisciplinary Sciences
D. Cruz-Zarate, O. Lopez-Ortega, D. A. Giron-Perez, A. M. Gonzalez-Suarez, J. L. Garcia-Cordero, M. Schnoor, L. Santos-Argumedo
Summary: Myosin-1g deficiency affects the migration of B lymphocytes, reducing their ability to enter lymph nodes. Lack of Myo1g causes adhesion and chemotaxis defects, as well as flaws in adopting a migratory morphology.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Felipe Castro-Martinez, Maria Del Rocio Encarnacion-Garcia, Aurora Candelario-Martinez, Oscar Medina-Contreras, Genaro Patino-Lopez, Michael Schnoor, Porfirio Nava
Summary: The impairment of epithelial barrier and micro-erosions are associated with the development of pathologies such as inflammatory bowel diseases. The use of a 10 kDa fluorescent dye can help visualize high permeability regions in the colonic mucosa, providing an important tool for studying intestinal epithelial barrier function.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Cell Biology
Nathaniel L. Lartey, Salvador Valle-Reyes, Hilda Vargas-Robles, Karina E. Jimenez-Camacho, Idaira M. Guerrero-Fonseca, Ramon Castellanos-Martinez, Armando Montoya-Garcia, Julio Garcia-Cordero, Leticia Cedillo-Barron, Porfirio Nava, Jessica G. Filisola-Villasenor, Daniela Roa-Velazquez, Dan Zavala-Vargas, Edgar Morales-Rios, Citlaltepetl Salinas-Lara, Eduardo Vadillo, Michael Schnoor
Summary: Severe COVID-19 is characterized by lung injury, cytokine storm, and increased NLR. Inhibition of ADAM17/MMP significantly improves lung histology, prevents leukocyte infiltration, reduces proinflammatory cytokines, and lowers endothelial adhesion molecules, offering a promising treatment strategy for SARS-CoV-2-infected individuals.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Editorial Material
Cell Biology
Lei-Miao Yin, Michael Schnoor
Summary: This passage discusses membrane-cytoskeleton interactions mediated by actin-binding proteins, with a focus on ezrin as a crucial protein linking membranes to actin filaments. The potential of ezrin as a druggable target for treating inflammatory diseases and cancers is also highlighted.
TRENDS IN CELL BIOLOGY
(2022)
Editorial Material
Cell Biology
Lei-Miao Yin, Michael Schnoor, Chang-Duk Jun
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Idaira M. Guerrero-Fonseca, Alexander Garcia-Ponce, Eduardo Vadillo, Nathaniel L. Lartey, Hilda Vargas-Robles, Sandra Chanez-Paredes, Ramon Castellanos-Martinez, Porfirio Nava, Abigail Betanzos, Brittany M. Neumann, Kinga Penkala-Auguste, Craig T. Lefort, Michael Schnoor
Summary: Neutrophil recruitment plays a critical role in sepsis, while excessive recruitment can lead to tissue damage. The actin-binding protein HS1 has been identified as a key regulator in neutrophil extravasation and its importance in sepsis has been demonstrated in a lethal sepsis model. HS1-deficient mice showed better survival, reduced lung damage and inflammation in sepsis. The absence of HS1 attenuated systemic neutrophil recruitment and altered expression of various molecules.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Immunology
Nadia Moran-Garcia, Catalina Lopez-Saucedo, Adriana Becerra, Mario Meza-Segura, Felipe Hernandez-Cazares, Jair Guerrero-Baez, Silvia Galindo-Gomez, Victor Tsutsumi, Michael Schnoor, Alfonso Mendez-Tenorio, James P. Nataro, Teresa Estrada-Garcia
Summary: This study developed a novel mouse model of tEAEC infection that mimics human infection, revealing the pathogenic effects of EAEC 042 in the mouse ileum and causing dysbiosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Alexander Garcia-Ponce, Citlaltepetl Salinas-Lara, Klemens Rottner, Michael Schnoor
Summary: Cortactin plays a crucial role in regulating neutrophil trafficking and severity of sepsis-induced lung injury.
Article
Immunology
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Porfirio Nava, Emmanuel K. Kumatia, Augustine Ocloo, Michael Schnoor
Summary: Inflammatory bowel diseases (IBD) are complex inflammatory disorders of the digestive tract, which cannot be cured. A drug named Annickia polycarpa extract (APE) may serve as an additional treatment strategy for IBD, alleviating symptoms and improving life quality.
IMMUNOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Regis Joulia, Idaira Maria Guerrero-Fonseca, Tamara Girbl, Jonathon A. Coates, Monja Stein, Laura Vazquez-Martinez, Eleanor Lynam, James Whiteford, Michael Schnoor, David Voehringer, Axel Roers, Sussan Nourshargh, Mathieu-Benoit Voisin
Summary: This study reveals that perivascular mast cells regulate the final steps of neutrophil diapedesis through the outer pericyte layer via IL-17A production, potentially providing insights for inflammatory disorders driven by increased neutrophil diapedesis.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Ramon Castellanos-Martinez, Iliana I. Leon-Vega, Idaira M. Guerrero-Fonseca, Hilda Vargas-Robles, Karina E. Jimenez-Camacho, Gabriela Hernandez-Galicia, Vianney F. Ortiz-Navarrete, Klemens Rottner, Oscar Medina-Contreras, Michael Schnoor
Summary: This article investigates the role of cortactin in T cell activation and migration in T cell acute lymphoblastic leukemia (T-ALL), and its significance in T-ALL development. The study demonstrates that cortactin participates in immune synapse formation and migration in normal T cells, while its overexpression in leukemic T cells leads to organ infiltration. Therefore, cortactin could be a potential therapeutic target for T-ALL and other pathologies involving aberrant T cell responses.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Physiology
Michael Schnoor, Eduardo Vadillo, Idaira Maria Guerrero-Fonseca
Summary: The article discusses the importance of neutrophil extravasation as a critical event during immune responses to infection or injury, and the need for strict control to avoid tissue damage. It also highlights the key regulatory factors and interacting mechanisms that affect neutrophil extravasation. Potential implications and directions for future research are discussed.
CURRENT OPINION IN PHYSIOLOGY
(2021)
Meeting Abstract
Pathology
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Emmanuel K. Kumatia, Augustine Ocloo, Michael Schnoor
AMERICAN JOURNAL OF PATHOLOGY
(2021)