Article
Clinical Neurology
Hye Rim Suh, Hwi-young Cho, Hee Chul Han
Summary: By injecting MIA into the intervertebral discs of rats, a reliable model for IVD degeneration was created. The study revealed that MIA injection led to spinal deformities, changes in the intervertebral discs and cartilage, which are crucial for understanding the mechanisms of low back pain in patients with IVD degeneration.
Article
Immunology
Yuki Yamanashi, Mika Ohmichi, Yusuke Ohmichi, Tatsunori Ikemoto, Young-Chang Arai, Yohei Maruyama, Shun Otsuka, Shuichi Hirai, Munekazu Naito, Masataka Deie
Summary: The study demonstrated that MTX administration improved pain-related behaviors and suppressed expression of pain-related mRNAs in the dorsal root ganglia and knee joint; however, MTX was not found to prevent cartilage degeneration in MIA-induced OA in rat knee.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Cell Biology
Hyun Sik Na, Ji Ye Kwon, Seon-Yeong Lee, Seung Hoon Lee, A. Ram Lee, Jin Seok Woo, KyungAh Jung, Keun-Hyung Cho, Jeong-Won Choi, Dong Hwan Lee, Hong-Ki Min, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho
Summary: The study found that metformin can slow down the progression of experimental osteoarthritis, showing both analgesic and cartilage-protecting effects. The combined administration of metformin and celecoxib was more effective in controlling cartilage damage. In chondrocytes, metformin reduced inflammatory factor expression and promoted autophagy.
Article
Multidisciplinary Sciences
Florent Barry, Feng Chai, Henry Chijcheapaza-Flores, Maria Jose Garcia-Fernandez, Nicolas Blanchemain, Romain Nicot
Summary: This study compared two drugs, monosodium iodoacetate (MIA) and collagenase type 2 (Col-2), for inducing a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction. Pain persisted for 30 days in both MIA and Col-2 groups, but Col-2 elicited a strong initial action that decreased over time, while MIA had a constant effect on pain behavior. Histological examination showed progressive degradation of TMJ components in both groups. Based on prolonged and greater sustained effect on pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creating a rat model of TMJOA for the study of drug-delivery systems (DDSs).
Article
Medicine, Research & Experimental
Hyun Sik Na, Seon-Yeong Lee, Dong Hwan Lee, Jin Seok Woo, Si-Young Choi, Keun-Hyung Cho, Seon Ae Kim, Eun Jeong Go, A. Ram Lee, Jeong-Won Choi, Seok Jung Kim, Mi-La Cho
Summary: This study evaluated the therapeutic effects of the sCCR2 E3 gene on osteoarthritis. Intra-articular injection of sCCR2 E3 reduced pain, inhibited cartilage destruction, and suppressed intestinal damage and inflammation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Anesthesiology
Ling-Jun Xu, Cui-Cui Liu, Lu-Miao Chen, Gui-Hao Wu, Xiao-Ping Wang
Summary: The study identified the crucial role of spinal cord SIRT1 in mediating the upregulation of p53 expression in persistent pain induced by osteoarthritis. Targeting the spinal cord SIRT1/p53 pathway with drug delivery treatments may offer novel therapeutic options for osteoarthritis-induced persistent pain.
Article
Chemistry, Medicinal
Nora M. Aborehab, Mahitab H. El Bishbishy
Summary: The potential of mango, orange, cantaloupe, and pomegranate fruit peels in treating osteoarthritis was evaluated. The study found that these extracts can significantly reduce inflammation and oxidative stress, and protect cartilage. Mango peel extract exhibited the best chondroprotective effect.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Acharya Balkrishna, Sandeep Sinha, Shadrak Karumuri, Jyotish Srivastava, Swati Haldar, Anurag Varshney
Summary: The study investigated the anti-osteoarthritic effects of the herbo-mineral formulation Peedanil Gold (PN-G) in a rat model of osteoarthritis induced by monosodium-iodoacetate injection. PN-G treatment improved clinical scores, reduced hyperalgesia and allodynia, ameliorated joint inflammation, and promoted cartilage regeneration. It also showed dose-dependent anti-inflammatory effects by reducing the levels of IL-6 and IL-1 beta in inflamed human macrophagic THP-1 cells. The presence of various analgesic and anti-inflammatory phytocompounds in PN-G was confirmed by UHPLC analysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sachiko Iwai, Hanako O. Ikeda, Hisashi Mera, Kohei Nishitani, Motoo Saito, Akitaka Tsujikawa, Akira Kakizuka
Summary: KUS121 is a novel medication developed to protect chondrocytes from stress-induced cell death. It has shown significant effects in both in vitro and in vivo studies, reducing apoptosis and improving gene expression in chondrocytes under stress conditions. These results suggest that KUS121 may be a promising therapeutic agent for preventing the progression of osteoarthritis.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Minji Kwon, Dongyeon Nam, Junesun Kim
Summary: This study aimed to identify pain-related behavior and pathological characteristics of the knee joint in rats with MIA-induced osteoarthritis. The results demonstrated that histopathological structural changes in the knee joint due to inflammation started soon after MIA injection, which induced OA pain from inflammation-related acute pain to spontaneous and evoked associated chronic pain.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Nutrition & Dietetics
Yun Mi Lee, Eunjung Son, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study aimed to investigate the effects of Schisandra chinensis leaf extracts (SCLE) on inflammation and pain in different animal models, and found that SCLE could effectively reduce inflammation and pain, making it a potential therapeutic candidate for osteoarthritis (OA).
Article
Biochemical Research Methods
Xiaoyun Zhang, Rilan Chen, Zilong Liao, Ying Zhu, Yueping Chen, Jianhang Liu, Xia Chen
Summary: This study investigated the therapeutic effects of XGS in rats with osteoarthritis induced by MIA. The results showed that externally applied XGS could alleviate pain, reduce inflammatory cytokines, and activate the PI3K-Akt signaling pathway. The study also found that XGS up-regulated the expression levels of certain genes associated with osteoarthritis.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Multidisciplinary Sciences
Zhizheng Fang, Xiangyu Li, Shujun Lei, Shibin Feng, Chenyu Zhou, Xiaohui Tong, Rongchun Han
Summary: This study examines the anti-inflammatory and anti-osteoarthritis properties of Pudilan Tablets (PDL), a traditional Chinese medicine formula, both in vitro and in vivo. The results suggest that PDL has potential as a promising candidate for the treatment of osteoarthritis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Emre Sahin, Cemal Orhan, Fusun Erten, Zainulabedin Saiyed, Elnaz Karimian Azari, Shane Durkee, Kazim Sahin
Summary: This study investigated the effects of different doses of undenatured type II collagen (UC-II) on improving monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in young and old rats. The results showed that all doses of undenatured collagen reduced knee diameter, while the higher doses (1.33 mg/kg and 2 mg/kg) improved Mankin score and gait measurements as early as day 14. The 2 mg/kg dose showed the best efficacy in improving Mankin score and gait measurements by 28 days post-OA induction. Undenatured collagen also reduced inflammatory and cartilage breakdown markers in both age groups.
SCIENTIFIC REPORTS
(2023)
Article
Anesthesiology
Rachel Wodarski, Ada Delaney, Camilla Ultenius, Rosie Morland, Nick Andrews, Catherine Baastrup, Luke A. Bryden, Ombretta Caspani, Thomas Christoph, Natalie J. Gardiner, Wenlong Huang, Jeffrey D. Kennedy, Suguru Koyama, Dominic Li, Marcin Ligocki, Annika Lindsten, Ian Machin, Anton Pekcec, Angela Robens, Sanziana M. Rotariu, Sabrina Voss, Marta Segerdahl, Carina Stenfors, Camilla I. Svensson, Rolf-Detlef Treede, Katsuhiro Uto, Kazumi Yamamoto, Kris Rutten, Andrew S. C. Rice