Article
Nanoscience & Nanotechnology
Bin Ren, Zhong-Chao Cai, Xue-Jie Zhao, Lin-Song Li, Mei-Xia Zhao
Summary: This study developed a targeted AuNPs drug delivery system with good apoptotic induction effects on folate-receptor overexpressing cancer cells. Experimental results confirmed its excellent anti-tumor activity and demonstrated the mechanism of apoptosis induction by intracellular ROS production through effective internalization of AuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Aristea Anna Leventi, Henry J. Braddick, Kharmen Billimoria, Gregory Q. Wallace, Heidi Goenaga-Infante, Nicholas C. O. Tomkinson, Karen Faulds, Duncan Graham
Summary: This article reports the synthesis of nanocarriers for delivering the antitumor drug cisplatin. Multimodal imaging techniques, including surface enhanced Raman scattering and laser ablation inductively coupled plasma time of flight mass spectrometry, were used to visualize the intracellular uptake of both the nanocarrier and drug.
CHEMICAL COMMUNICATIONS
(2023)
Article
Oncology
Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, Eli Rosenbaum
Summary: Cisplatin (CP), the standard first-line treatment for bladder cancer, often cannot be used for advanced patients due to its toxic side effects on the kidneys. In this study, CP-conjugated gold nanoparticles (GNPs) were developed to prevent renal toxicity while preserving the therapeutic efficacy of CP. The results in a bladder tumor-bearing mouse model showed that high-dose CP-GNPs effectively inhibited tumor growth without causing kidney fibrosis or necrosis, and fractionated lower doses of CP-GNPs demonstrated superior anti-tumor efficacy compared to free CP treatment.
CANCER NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Richard D. Perrins, Lee-Anne Mccarthy, Angela Robinson, Kelly L. Spry, Valentin Cognet, Avelino Ferreira, John Porter, Cristina Espinosa Garcia, Miguel Angel Rodriguez, Diana Lopez, Ibon Perera, Kelly Conlon, Africa Barrientos, Tom Coulter, Alessandro Pace, Sarah J. M. Hale, Enrico Ferrari, Csanad Z. Bachrati
Summary: The study aimed to design a targeted delivery system for cytotoxic payload using cyclic arginyl-glycyl-aspartic acid peptide (cRGD) peptides with high affinity towards alpha V beta 3 integrin and the versatility of ultrasmall gold nanoparticles (usGNP). The functionalized usGNPs with cRGD demonstrated enhanced cellular uptake by cells expressing alpha V beta 3 integrin, internalized via clathrin-dependent endocytosis, accumulated in lysosomes, and showed increased cytotoxicity when loaded with mertansine.
Article
Engineering, Biomedical
Eric Volta-Duran, Naroa Serna, Laura Sanchez-Garcia, Anna Avino, Julieta M. Sanchez, Hector Lopez-Laguna, Olivia Cano-Garrido, Isolda Casanova, Ramon Mangues, Ramon Eritja, Esther Vazquez, Antonio Villaverde, Ugutz Unzueta
Summary: The study investigates the potential of conjugating tumor-targeted self-assembling protein nanoparticles with potent microbial toxins and chemically coupled chemotherapeutic drugs, resulting in multifunctional hybrid nanoconjugates with promising applications in oncology. The concept of drug combination proposed in this research could be a feasible strategy for enhancing the effectiveness of multiple drug treatments and overcoming acquired resistance in cancer therapy.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Aishwarya Shivashankarappa, K. R. Sanjay, Dhruvi Shah, Aishwarya Tagat
Summary: This study demonstrates the use of gold nanoparticles as an effective drug delivery vehicle for photodynamic cancer therapy targeting skin melanoma cells. Gold nanoparticles were synthesized from the medicinal plant Decalepis hamiltonii and conjugated with an anti-cancer drug 5-aminolevulinic acid (5-ALA). The activated gold-5ALA conjugates showed a deleterious effect on cancer cells with no significant effect on normal cells, indicating specific targeting towards cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Natalie S. Potter, Alan McLean, Evan C. Bornowski, Thomas Hopkins, Jingyi Luo, John P. Wolfe, Wei Qian, Raoul Kopelman
Summary: The synthesis of two metaiodobenzylguanidine (MIBG) derivatives, MIBG-3-MPAM and BG-3-MPAM, is reported. These molecules can be conjugated with nanocarriers and enhance the uptake of gold nanoparticles in cells. The iodine atom plays an important role in enhancing the uptake efficiency.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Chae Gyu Lee, Chaiheon Lee, Joonhee Lee, Jung Seung Nam, Byeong-Su Kim, Tae-Hyuk Kwon
Summary: This study investigates the irreversible degradation of an Ir-based photosensitizer encapsulated in nanogels through the oxidation of intracellular thiols using reactive oxygen species. The photosensitizer is stably encapsulated through hydrophobic interactions, providing high biocompatibility under normal cellular conditions. Upon photoirradiation, the photosensitizer generates high levels of reactive oxygen species, irreversibly oxidizing the thiols and inducing cancer cell apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Article
Chemistry, Multidisciplinary
Marie Kuehne, Henry Lindemann, Christian Grune, Daniel Schroeder, Zoltan Cseresnyes, Maren Godmann, Andreas Koschella, Marc Thilo Figge, Christian Eggeling, Dagmar Fischer, Thomas Heinze, Thorsten Heinzel
Summary: Bio-based nanoparticles (NPs) as drug carriers have rapid cellular uptake, no cytotoxicity, and ability to induce histone H3 hyperacetylation, making them suitable for treating inflammation, sepsis, and cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pathology
Ludovic Lhermitte, Sylvain Barreau, Daniela Morf, Paula Fernandez, Georgiana Grigore, Susana Barrena, Maaike de Bie, Juan Flores-Montero, Monika Brueggemann, Ester Mejstrikova, Stefan Nierkens, Leire Burgos, Joana Caetano, Giuseppe Gaipa, Chiara Buracchi, Elaine Sobral da Costa, Lukasz Sedek, Tomasz Szczepanski, Carmen-Mariana Aanei, Alita van der Sluijs-Gelling, Alejandro Hernandez Delgado, Rafael Fluxa, Quentin Lecrevisse, Carlos E. Pedreira, Jacques J. M. van Dongen, Alberto Orfao, Vincent H. J. van der Velden, J. J. M. van Dongen, W. M. Bitter, B. R. Lubbers, C. I. Teodosio, M. Zlei, A. J. van der Sluijs-gelling, S. de Bruin-Versteeg, M. van der Burg, M. W. Schilham, V. H. J. van der Velden, A. W. Langerak, J. te Marvelde, A. E. Bras, J. Schilperoord-Vermeulen, R. Jugooa, K. C. Heezen, A. Orfao, J. Almeida, M. B. Vidriales, J. Flores-Montero, M. Perez-Andres, S. Matarraz, L. Martin, Q. Lecrevisse, J. J. Perez-Moran, N. Puig, A. Medina Almeida, M. Gomes da Silva, T. Faria, M. Ritgen, M. Szczepanowski, S. Kohlscheen, A. Laqua, E. Harbst, J. Finke, V. Asnafi, L. Lhermitte, E. Duroyon, J. Trka, O. Hrusak, T. Kalina, E. Mejstrikova, M. Novakova, D. Thurner, V. Kanderova, T. Szczepanski, L. Sedek, J. Bulsa, L. Slota, J. Kulis, C. E. Pedreira, E. Sobral da Costa, S. Nierkens, A. de Jong, A. de Koning, M. Lima, A. H. Santos, S. Boettcher, S. Lange, R. Engelmann, D. Paape, C. Machka, G. Gaipa, C. Burracchi, C. Bugarin, E. Lopez-Granados, L. del Pino Molina, L. Campos-Guyotat, C. Aanei, J. F. San Miguel, B. Paiva, L. Burgos, N. Villamor-Casas, L. Magnano, J. Philippe, C. Bonroy, B. Denys, A. Willems, P. Breughe, J. de Wolf, A. E. Sousa, S. L. Silva, P. Fernandez, D. Morf
Summary: The study developed an automated gating and identification tool to categorize cell subsets within acute leukemia samples, using a reference database of normal samples to differentiate normal cells. The tool showed high correlation and concordance in classifying leukemic cells compared to manual analysis, demonstrating its potential to improve immunophenotyping quality in laboratories.
Editorial Material
Chemistry, Physical
Irene Rubia-Rodriguez, Antonio Santana-Otero, Simo Spassov, Etelka Tombacz, Christer Johansson, Patricia De La Presa, Francisco J. Teran, Maria del Puerto Morales, Sabino Veintemillas-Verdaguer, Nguyen T. K. Thanh, Maximilian O. Besenhard, Claire Wilhelm, Florence Gazeau, Quentin Harmer, Eric Mayes, Bella B. Manshian, Stefaan J. Soenen, Yuanyu Gu, Angel Millan, Eleni K. Efthimiadou, Jeff Gaudet, Patrick Goodwill, James Mansfield, Uwe Steinhoff, James Wells, Frank Wiekhorst, Daniel Ortega
Summary: The scientific community has put great efforts in advancing magnetic hyperthermia in the past two decades, with fruitful international cooperation and careful analysis of lessons learned providing better guarantees for the future development of this nanotherapy against cancer.
Review
Oncology
Angela-Patricia Hernandez, Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Halin Bareke, Enrique Montalvillo, Rafael Gongora, Manuel Fuentes
Summary: The concept of cancer as a single cell mass that replicates unlimitedly in isolation has been dissolved with the inclusion of immune evasion as a hallmark. Tumor microenvironment (TME) plays a crucial role in drug resistance, impacting the success of treatment. Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment, initiating a long-term adaptative immune response.
Article
Biochemistry & Molecular Biology
Manuel Fuentes, Sanjeeva Srivastava, Angela M. Gronenborn, Joshua LaBaer
Summary: Understanding transient protein interactions at the proteome scale is a challenge. This study developed a novel label-free platform by combining nucleic acid programmable protein arrays (NAPPA) with surface plasmon resonance imaging (SPRi) to measure real-time protein interactions and determine affinity and rate constants. The technique was successfully applied to study the interactions between clinical mutants of p53 and its regulator MDM2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Pablo Juanes-Velasco, Norma Galicia, Elisa Pin, Ricardo Jara-Acevedo, Javier Carabias-Sanchez, Rodrigo Garcia-Valiente, Quentin Lecrevisse, Carlos Eduardo Pedreira, Rafael Gongora, Jose Manuel Sanchez-Santos, Hector Lorenzo-Gil, Alicia Landeira-Vinuela, Halin Bareke, Alberto Orfao, Peter Nilsson, Manuel Fuentes
Summary: Exploring potential protein biomarkers through proteomics can aid in the early diagnosis and prognosis of leptomeningeal disease.
Article
Biochemistry & Molecular Biology
Alicia Landeira-Vinuela, Paula Diez, Pablo Juanes-Velasco, Quentin Lecrevisse, Alberto Orfao, Javier de las Rivas, Manuel Fuentes
Summary: The Human Proteome Project systematically characterized the protein landscape using diverse techniques in this study, which focused on a B-cell lymphoma cell line. Through integration of RNA-Seq transcriptomics, MS/MS, and antibody-based affinity proteomics, 5672 unique proteins were identified and further analyzed for insights into protein dynamics at the intracellular level. The study also developed a bioinformatic pipeline for the comprehensive and global characterization of intracellular protein profiles.
Review
Biochemistry & Molecular Biology
Carlota Arias-Hidalgo, Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Marina L. Garcia-Vaquero, Enrique Montalvillo, Rafael Gongora, Angela-Patricia Hernandez, Manuel Fuentes
Summary: In single-cell analysis, protein abundance and their relative alterations play a crucial role in biological variability. Mass spectrometry-based proteomics is a non-targeted method that can detect molecules in hundreds of individual cells. Controlling sample preparation using nanotechnological approaches is critical for high-throughput investigations. Single-cell proteomics has various applications in nanomedicine and biomedical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Angela-Patricia Hernandez, Ania Micaelo, Rafael Pinol, Marina L. Garcia-Vaquero, Jose J. Aramayona, Julio J. Criado, Emilio Rodriguez, Jose Ignacio Sanchez-Gallego, Alicia Landeira-Vinuela, Pablo Juanes-Velasco, Paula Diez, Rafael Gongora, Ricardo Jara-Acevedo, Alberto Orfao, Javier Miana-Mena, Maria Jesus Munoz, Sergio Villanueva, Angel Millan, Manuel Fuentes
Summary: This study evaluated the potential applications of cisplatin-iron oxide nanoparticles and their different functionalization stages. Through both in vitro and in vivo experiments, it was found that these nanodrugs exhibited good biocompatibility and showed therapeutic effects in tumor cells. Animal model studies also confirmed the potential of these nanoparticles as drug delivery vehicles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aisha H. A. Alsenousy, Rasha A. El-Tahan, Nesma A. Ghazal, Rafael Pinol, Angel Millan, Lamiaa M. A. Ali, Maher A. Kamel
Summary: This study found that superparamagnetic iron oxide nanoparticles (SPIONs) have an anti-obesity effect on a high-fat-diet rat model, improving weight gain, hyperglycemia, adiponectin, leptin, and dyslipidemia. At the molecular level, SPIONs treatments correct the disturbed expression and protein content of inflammatory markers, as well as parameters controlling mitochondrial biogenesis and functions.
Article
Biochemical Research Methods
Manuel Fuentes, Cristina Ruiz-Romero, Sara Misiego, Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Adrian Torres-Roda, Hector Lorenzo-Gil, Maria Gonzalez-Gonzalez, Angela P. Hernandez, Lucia Lourido, Ronald Sjoberg, Elisa Pin, Javier de Las Rivas, Jose Manuel Sanchez-Santos, Peter Nilsson, Francisco J. Blanco
Summary: Rheumatic diseases are common and complex conditions with low sensitivity to clinical diagnosis. This study developed an early diagnosis method for personalized treatment based on the identification of relevant proteins associated with the specific pathologies. By utilizing functional proteomics screening, a panel of 30 serum proteins has been identified as potential biomarkers for rheumatic diseases such as osteoarthritis, rheumatoid arthritis, and psoriatic arthritis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Oncology
Alicia Landeira-Vinuela, Miguel Alcoceba-Sanchez, Almudena Navarro-Bailon, Carlota Arias-Hidalgo, Pablo Juanes-Velasco, Jose Manuel Sanchez-Santos, Quentin Lecrevisse, Carlos Eduardo Pedreira, Marina L. Garcia-Vaquero, Angela-Patricia Hernandez, Enrique Montalvillo, Rafael Gongora, Javier de las Rivas, Marcos Gonzalez-Diaz, Alberto Orfao, Manuel Fuentes
Summary: Clonal B cell expansion in chronic lymphocytic leukemia may be triggered by persistent antigenic stimulation. Studying the dynamics of the humoral response in these patients can provide information about immunoglobulin levels and identify compromising antigens. This study offers a new perspective for patient stratification and targeted therapy selection.
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Angela-Patricia Hernandez, Laura Iglesias-Anciones, Jose Javier Vaquero-Gonzalez, Rafael Pinol, Julio J. Criado, Emilio Rodriguez, Pablo Juanes-Velasco, Marina L. Garcia-Vaquero, Carlota Arias-Hidalgo, Alberto Orfao, Angel Millan, Manuel Fuentes
Summary: The immune system is crucial in controlling tumor development, and therapeutic strategies targeting tumors from an immunological perspective are increasingly important. This study presents the characterization of the antitumor response of paramagnetic iron nanoparticles conjugated with a platinum compound. The nanoconjugate shows improved antitumor properties compared to the platinum compound and induces immunogenic cell death. This study highlights the importance of nanotechnology in the development of new approaches for onco-immunotherapy.
Article
Pharmacology & Pharmacy
Angela-Patricia Hernandez, Paula Diez, Pablo A. Garcia, Martin Perez-Andres, Anzhela Veselinova, Pablo G. Jambrina, Arturo San Feliciano, David Diez, Manuel Fuentes, Ma Angeles Castro
Summary: New lignohydroquinone conjugates (L-HQs) were synthesized using the hybridization strategy and showed dual cytotoxic effect against colorectal cancer cells. These conjugates were obtained from natural product podophyllotoxin and semisynthetic terpenylnaphthohydroquinones. The results demonstrate the validity of the hybridization strategy and suggest further research on non-lactonic cyclolignans.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
