Article
Materials Science, Multidisciplinary
Avashesh Dubey, Rakhi Narang, Manoj Saxena, Mridula Gupta
Summary: This paper presents an extensive investigation of low-frequency noise and total ionizing dose-response of junctionless accumulation mode double-gate (JAM DG) MOSFET. The simulation results show significant irradiation-induced threshold voltage shift and increase in low-frequency noise for different gate oxide thickness and channel doping concentration. Additionally, the irradiation-induced border trap densities are obtained at different doses using the gamma radiation model of Sentaurus TCAD.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Chemistry, Multidisciplinary
Marieke Olsman, Melina Muhlenpfordt, Emma Boe Olsen, Sverre H. Torp, Spiros Kotopoulis, Cristianne J. F. Rijcken, Qizhi Hu, Marielle Thewissen, Sofie Snipstad, Catharina de Lange Davies
Summary: The study demonstrated that Acoustic Cluster Therapy (ACT (R)) can increase the permeability of the blood-brain barrier and enhance the accumulation of macromolecules and clinically relevant nanoparticles in the brain, providing a crucial advancement in the treatment of various brain diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Zhiwei Xing, Zejie Zuo, Dandan Hu, Xiaona Zheng, Xiao Wang, Lifang Yuan, Lihua Zhou, Fangfang Qi, Zhibin Yao
Summary: Immune dysfunction is involved in Alzheimer's disease, and enhancing the systemic immune system may be neuroprotective. Combining influenza vaccine with moderate-dose PD-1 inhibition can effectively reduce AD pathology, improve cognitive deficits, and restore brain immune homeostasis. These findings suggest that revitalizing brain immunity through this combination therapy could be a promising immunotherapy for AD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Adrien Rapeaux, Timothy G. Constandinou
Summary: This paper describes experiments conducted on rat sciatic nerves to measure the recovery speed of A fibres from block carryover. The findings demonstrate the carryover property of high-frequency nerve block and its potential significance in reducing power requirements for stimulation in clinical applications.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sato
Summary: This study evaluated accumulated tau levels in postmortem brains depending on disease stage, brain areas, and other AD-related changes by introducing tau ELISAs that target different epitopes. The use of antibodies targeting different epitopes affected the determination of tau levels in insoluble fractions, with ELISAs combining antibodies against the later-middle to C-terminal regions of tau showing better distinction between AD and non-AD controls and closer association with neuropathological changes.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Majdolen Istaiti, Dafna Frydman, Tama Dinur, Jeff Szer, Shoshana Revel-Vilk, Ari Zimran
Summary: Ambroxol hydrochloride (ABX), an oral mucolytic drug, has shown potential as a pharmacological chaperone for mutant glucocerebrosidase. This study evaluated the safety and efficacy of 600 mg ABX per day for 12 months in three groups of Type 1 Gaucher disease patients who had a suboptimal response to standard therapies. The results showed good safety and satisfactory efficacy, suggesting that ABX could be considered as an additional treatment option for patients with GD1 who do not respond well to current therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuke Tsuruta, Mitsuhiro Nakamura, Manabu Nakata, Hideaki Hirashima, Dejun Zhou, Megumi Uto, Keiichi Takehana, Takahiro Fujimoto, Takashi Mizowaki
Summary: This study evaluated the displacement of gross tumor volume (GTV) positions in fractionated stereotactic radiotherapy (f-SRT) with single isocenter volumetric modulated arc therapy (SI-VMAT) for multiple brain metastases. The study found no significant difference in GTV dose distribution, despite GTVs being far from the isocenter, likely due to the reduction of intrafractional residual setup errors to a clinically acceptable level.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Jianling Xie, Kaikai Shen, Ashley T. Jones, Jian Yang, Andrew R. Tee, Ming Hong Shen, Mengyuan Yu, Swati Irani, Derick Wong, James E. Merrett, Roman Lenchine, Stuart De Poi, Kirk B. Jensen, Paul J. Trim, Marten F. Snel, Makoto Kamei, Sally Kim Martin, Stephen Fitter, Shuye Tian, Xuemin Wang, Lisa M. Butler, Andrew C. W. Zannettino, Christopher G. Proud
Summary: This study uncovers a novel feedback loop in which mTORC1 represses MNK2 activity and oncogenic signaling through eIF4E phosphorylation, providing insights into the reciprocal regulation of these two oncogenic pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Meghan L. Douglass, Helen Beard, Andrew Shoubridge, Nazzmer Nazri, Barbara King, Paul J. Trim, Stephen K. Duplock, Marten F. Snel, John J. Hopwood, Kim M. Hemsley
Summary: Lysosomal dysfunction may play a role in neurodegenerative disorders like Parkinson's disease. Mutations in genes encoding lysosomal enzymes have been associated with PD, and studies on mice with a Sgsh gene mutation revealed impaired behavior and brain structure, but no overt disease lesions associated with PD or other neurodegenerative disorders were observed.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Biochemical Research Methods
Jacob X. M. Truong, Xander Spotbeen, Jake White, Johannes V. Swinnen, Lisa M. Butler, Marten F. Snel, Paul J. Trim
Summary: MALDI-MSI is a molecular imaging technique used to study the abundance and distribution of lipids in tissues. Challenges in sample pre-treatment and preparation have hindered the analysis of clinical tissues. A new method has been developed to remove O.C.T. and endogenous salts simultaneously, preventing analyte suppression, simplifying data interpretation, and improving sensitivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Miranda P. Ween, Jake B. White, Hai B. Tran, Violet Mukaro, Charles Jones, Matthew Macowan, Gregory Hodge, Paul J. Trim, Marten F. Snel, Sandra J. Hodge
Summary: The study revealed that in COPD patients, CD1b expression is upregulated in the airways, levels of oxidized lipids are increased, and malondialdehyde levels are significantly elevated. Oxidized lipids can enhance CD1b expression in macrophages, cause toxicity in bronchial epithelial cells, and reduce phagocytic capacity in macrophages.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
R. D. Jolly, K. E. Dittmer, B. R. Jones, A. J. Worth, K. G. Thompson, A. C. Johnstone, D. N. Palmer, N. S. Van de Water, K. M. Hemsley, D. J. Garrick, B. G. Winchester, S. U. Walkley
Summary: In the past 50 years, there have been significant advances in knowledge and technology regarding genetic diseases, enabling more cost-effective ways to control these diseases. Research on genetic diseases of animals at Massey University has made a significant contribution to veterinary medicine, provided new biological knowledge, and advanced our understanding of similar disorders in human patients.
NEW ZEALAND VETERINARY JOURNAL
(2021)
Article
Cell Biology
Tamara L. Paget, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Madhuriben H. Panchal, Grielof Koster, Mercedes Echaide, Marten F. Snel, Anthony D. Postle, Janna L. Morrison, Jesus Perez-Gil, Sandra Orgeig
Summary: In MPS IIIA patients, alterations in biochemical and biophysical properties of alveolar surfactant in lung tissue and BALF indicate potential impairment in lung function.
Article
Oncology
Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes Swinnen
Summary: The study identified distinct lipid features in prostate cancer tissues, including enhanced fatty acid synthesis and elongation. Targeting the regulation of lipid composition may be a crucial therapeutic approach for prostate cancer.
Article
Microbiology
Felise G. Adams, Claudia Trappetti, Jack K. Waters, Maoge Zang, Erin B. Brazel, James C. Paton, Marten F. Snel, Bart A. Eijkelkamp
Summary: The study found that Acinetobacter baumannii may rely on different sources of fatty acids during infection and synthesize fatty acids in different environments. Additionally, it is the first to reveal the importance of balancing de novo synthesis and acquisition of fatty acids in a Gram-negative bacterium during infection.
Article
Chemistry, Analytical
Jake B. White, Paul J. Trim, Thalia Salagaras, Aaron Long, Peter J. Psaltis, Johan W. Verjans, Marten F. Snel
Summary: Chromatography is commonly used to simplify samples before mass spectrometry analysis, and the use of retention time (RT) for lipid identification is gaining popularity. This study demonstrates a strong correlation in chromatographic separation of lipids with different headgroups but the same fatty acid motive. The correlation is used for interclass RT conversion (IC-RTC), allowing the prediction of RT of one lipid subclass based on another. A glycerophospholipid RT library is built using ECN modeling and IC-RTC, and successfully applied to identify lipid species in a patient cohort undergoing surgery.
ANALYTICAL CHEMISTRY
(2022)
Review
Oncology
Shadrack M. Mutuku, Xander Spotbeen, Paul J. Trim, Marten F. Snel, Lisa M. Butler, Johannes Swinnen
Summary: Prostate cancer is a heterogeneous disease and treatment decisions are challenging. In this article, the emerging importance of rewired lipid metabolism as a source for biomarkers and therapeutic targets for prostate cancer is highlighted. The spatial mapping of lipids and related metabolic pathways and its potential for future implementation in treatment decision-making are evaluated. The detection and management of prostate cancer have improved, but distinguishing between indolent and aggressive forms of the disease remains a challenge. Spatial analytical approaches, such as mass spectrometry-based lipid imaging and gene-based spatial omics technologies, are discussed as potential solutions. The study aims to evaluate the future implementation of spatial lipidomics and transcriptomics for prognostication, target identification, and treatment decision-making for prostate cancer.
Article
Veterinary Sciences
R. D. Jolly, M. R. Perrott, M. R. Alley, S. A. Hunter, A. Pas, H. Beard, K. M. Hemsley, G. Greaves
Summary: This study investigated the pathogenesis of a disease in takahe (Porphyrio hochstetteri) characterized by intracytoplasmic inclusion bodies in lower motor neurons. Four takahe birds from different wildlife sanctuaries in New Zealand were examined, and two types of inclusion bodies were found in the motor neurons of the spinal cord and brain stem. The larger globoid bodies were found to be endoplasmic reticulum storage disease, while the smaller granular bodies showed misfolded protein entering the lysosomal system via endoplasmic reticulum autophagy. The cause of the disease is likely genetic or predisposed, and has clinical relevance.
NEW ZEALAND VETERINARY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Leanne K. Winner, Mary-Louise Rogers, Marten F. Snel, Kim M. Hemsley
Summary: Sanfilippo syndrome is an autosomal recessive inherited disorder that causes dementia in children. Early symptoms include delayed language development, hyperactivity, and insomnia, followed by the loss of acquired skills. There are no approved treatments, and the disease usually leads to death by age 18. Newborn screening for Sanfilippo syndrome would allow for early diagnosis and treatment, but there is a need for tools and biomarkers to provide pre-symptomatic prognosis. This review discusses the development of biomarker assays for Sanfilippo syndrome based on known neuropathological pathways.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)