Article
Chemistry, Medicinal
Seungjin Jeong, Mi-Bo Kim, Suhyeon Baek, Joowon Lee, Hyeju Lee, Bei Cao, Yongeun Kim, Lei Cao, Sanggil Lee
Summary: Macrophages are important in chronic inflammatory diseases, and this study found that SHE and its Hex fraction inhibit LPS-induced inflammation and oxidative stress by modulating the polarization of macrophages.
Article
Biochemistry & Molecular Biology
Tatiana Montoya, Catalina Alarcon-de-la-Lastra, Maria Luisa Castejon, Juan Ortega-Vidal, Joaquin Altarejos, Marina Sanchez-Hidalgo
Summary: This study explores the antioxidant and anti-inflammatory effects of (-)-methyl-oleocanthal (met-OLE), a metabolite of extra virgin olive oil (EVOO), in murine peritoneal macrophages. It reveals that met-OLE inhibits the production of reactive oxygen species and pro-inflammatory enzymes, while upregulating anti-inflammatory markers. The study also suggests that met-OLE may contribute to the beneficial effects associated with EVOO consumption through epigenetic changes.
Article
Engineering, Biomedical
Qi Chu, Weiju Han, Zhichun He, Lijing Hao, Xiaoling Fu
Summary: This study reveals the importance of nuclear shape and chromatin histone modification in mediating the effects of micropatterns on macrophage phenotype and inflammatory responses.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Multidisciplinary
Massimiliano G. Bianchi, Martina Chiu, Giuseppe Taurino, Enrico Bergamaschi, Francesco Cubadda, Guido M. Macaluso, Ovidio Bussolati
Summary: Amorphous silica nanoparticles (ASNP) inhibit the response of human macrophages to natural activators, suppressing the production of pro-inflammatory and anti-inflammatory cytokines. This inhibition is achieved by suppressing NF kappa B activation and increasing the intracellular sequestration of the TLR4 receptor. Induction of glutamine synthetase (GS) may be secondary to cytokine stimulation. These findings suggest a dampening of the acute inflammatory response after exposure to ASNP.
Article
Biology
Shanshan Guo, Xian Wu, Jinkai Zheng, Mingyue Song, Ping Dong, Hang Xiao
Summary: This study is the first to report on the inhibitory mechanism of 5-Demethylnobiletin (5DN) and its metabolites on LPS-induced inflammation in macrophage cells. The metabolites showed stronger anti-inflammatory activity than the parent compound. Further investigation is needed to understand the relationship between the structural properties of the compounds and their anti-inflammatory effects.
Article
Cell Biology
Faris Almutairi, Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: RGS10 is a protein that acts as an anti-inflammatory agent by inhibiting NF-KB activation and expression of inflammatory cytokines, while LPS suppresses RGS10 expression in pulmonary macrophages through an NF-KB-mediated proinflammatory mechanism. Inhibition of the PI3K/NF-kappa B/p300/TNF-alpha signaling cascade and HDAC (1-3) enzyme activity can block LPS-induced silencing of RGS10, indicating a potential therapeutic target for inflammatory conditions.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Xingyu Liu, Jie Su, Geng Wang, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao, Shuyue Wang, Yanxin Huang
Summary: The study demonstrates that hyssopuside (HY) isolated from Hyssopus cuspidatus exhibits anti-inflammatory effects by blocking the NF-kappa B signal transduction pathways. HY could potentially serve as a promising alternative phenolic agent for alleviating excessive inflammation in various inflammation-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Debdulal Sharma, Zeaul H. Mazumder, Devashish Sengupta, Avinaba Mukherjee, Mahuya Sengupta, Ranjan Kumar Das, Monjur Hassan Barbhuiya, Partha Palit, Tarun Jha
Summary: The cis-A(2)B(2) type porphyrin derivative, PN2(OH)(2) and PN2(OH)(2)Zn, synthesized by replacing tetra-p-hydroxyphenyl porphyrin, show more promising photosensitizing and photobiological activities in cancer photodynamic therapy. These derivatives upregulate ROS and downregulate SOD in the A549 cell line, while also exhibiting immunoprotective properties towards noncancerous cells through MPO inhibition and NO downregulation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Cell Biology
Liang Chen, Lele Zhang, Guanghui Jin, Yasong Liu, Na Guo, Haobin Sun, Yong Jiang, Xiaomei Zhang, Guobin He, Guo Lv, Jinghong Yang, Xuanjun Tu, Tao Dong, Huanyi Liu, Jianhong An, Ge Si, Zhuang Kang, Hua Li, Shuhong Yi, Guihua Chen, Wei Liu, Yang Yang, Jingxing Ou
Summary: Supplementing with 5-aminolevulinate (5-ALA) improves liver regeneration and promotes anti-inflammatory macrophages via P53 signaling. The chemokine receptor CX3CR1 counterbalances these effects. Short-term treatments with both 5-ALA and AZD8797 show superior pro-regeneration outcomes in mice.
Article
Chemistry, Medicinal
Rotchana Klaram, Tida Dethoup, Fatima P. Machado, Luis Gales, Decha Kumla, Salar Hafez Ghoran, Emilia Sousa, Sharad Mistry, Artur M. S. Silva, Anake Kijjoa
Summary: Five undescribed pentaketide derivatives and a p-hydroxyphenyl-2-pyridone derivative were isolated from the ethyl acetate extract of a marine sponge-derived fungus, and their structures were determined using NMR and mass spectral analyses. The growth inhibitory activity of these compounds against various plant pathogenic fungi was also evaluated.
Article
Biochemistry & Molecular Biology
Peng Du, Jia Song, Huirui Qiu, Haorui Liu, Li Zhang, Junhan Zhou, Shengping Jiang, Jinyu Liu, Yu Zheng, Min Wang
Summary: Polyphenols extracted from Shanxi-aged vinegar exhibit anti-inflammatory effects by suppressing specific pathways and protein expressions, thus alleviating inflammatory responses.
Article
Immunology
Eunji Kang, Jae Eun Park, Youngwan Seo, Ji Sook Han
Summary: The study demonstrated that HM-chromanone isolated from Portulaca oleracea L. exhibits anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by downregulating the expression of inflammatory factors.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Chemistry, Organic
Andre L. Silva, Ines Fino, Luisa M. Ferreira, Paula S. Branco
Summary: 5-(2-Aminopropyl)benzofuran (5-APB), also known as Benzo Fury, is a new synthetic phenethylamine belonging to the novel psychoactive substances (NPS). It acts as a serotonin-norepinephrine-dopamine reuptake inhibitor, similar to MDMA and MDA, but recent toxicity events associated with its consumption have highlighted the need for a better understanding of its pharmacodynamics and toxicity. This study presents a six-step synthesis for one of the 5-APB metabolites, 2-(5-(2-aminopropyl)-2-hydroxyphenyl)acetic acid (1), with an overall yield of 11%.
Article
Immunology
Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li, Beixian Zhou
Summary: This study found that 5-methoxyflavone has a protective effect against LPS-induced ALI by inhibiting inflammatory signaling pathways, reducing oxidative stress, and suppressing M1 macrophage polarization. This suggests that it may be a potential drug candidate for ALI therapy.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Chemistry, Multidisciplinary
Andrii Pyrih, Andrzej Lapinski, Sylwia Zieba, Adam Mizera, Roman Lesyk, Mariusz Jaskolski, Andrzej K. Gzella
Summary: Three new derivatives of 5-dimethylaminomethylidene-4-phenylamino-1,3-thiazol-2(5H)-one were synthesized and their prototropic tautomerism was studied. The compounds were found to exist solely in the amino tautomeric form in both solid and liquid phases. The electronic effects, molecular conformation, and intermolecular interactions in the crystals were analyzed.
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yung-Ting Hsu, Maya Nair, Nikola Angelov, Evanthia Lalla, Chun-Teh Lee
JOURNAL OF CLINICAL PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Nima D. Sarmast, Howard H. Wang, Ali S. Sajadi, Anna M. Munne, Nikola Angelov
JOURNAL OF ENDODONTICS
(2019)
Article
Immunology
Gena D. Tribble, Nikola Angelov, Robin Weltman, Bing-Yan Wang, Sridhar Eswaran, Isabel C. Gay, Kavitha Parthasarathy, Doan-Hieu V Dao, Katherine N. Richardson, Nadia M. Ismail, Iraida G. Sharina, Embriette R. Hyde, Nadim J. Ajami, Joseph F. Petrosino, Nathan S. Bryan
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Immunology
Brittney Ferguson, Nishantha R. Bokka, Krishna Rao Maddipati, Srinivas Ayilavarapu, Robin Weltman, Lisha Zhu, Wanqi Chen, W. Jim Zheng, Nikola Angelov, Thomas E. Van Dyke, Chun-Teh Lee
FRONTIERS IN IMMUNOLOGY
(2020)
Editorial Material
Dentistry, Oral Surgery & Medicine
Karo Parsegian, Srinivas Ayilavarapu, Amity L. Gardner, Nikola Angelov
JOURNAL OF DENTAL EDUCATION
(2021)
Article
Biotechnology & Applied Microbiology
Seiko Min, Taewan Kim, Oksu Kim, Carames Goncalo, Tadahiko Utsunomiya, Takashi Matsumoto, Kayo Kuyama, Nikola Angelov
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Immunology
Chun-Teh Lee, Ruoxing Li, Lisha Zhu, Gena D. Tribble, W. Jim Zheng, Brittney Ferguson, Krishna Rao Maddipati, Nikola Angelov, Thomas E. Van Dyke
Summary: This study examined the relationship between levels of specialized pro-resolving lipid mediators (SPMs), SPM receptor gene expression, and subgingival microbiome in subjects with periodontitis compared to healthy controls. The results showed distinct profiles of lipid mediators, receptor genes, and subgingival microbiome in the different groups, with a strong correlation between lipid mediator profile and subgingival microbiome profile. Specific bacterial species and lipid mediators were found to be highly correlated in different periodontal conditions, suggesting that inflammation mediated by lipid mediators influences the microbial composition in periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lina J. Suarez, Silie Arboleda, Nikola Angelov, Roger M. Arce
Summary: This article discusses the differences between the immune systems in the oral cavity and gastrointestinal tract, including anatomy, cell-to-cell communication, antigen processing, signaling, etc., in the context of local immunity and systemic output of epithelia/lymphoid foci/MALT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Srinivas Ayilavarapu, Abbas Doctor, Chun-Teh Lee, Gena D. Tribble, Yulun Chiu, Robin L. Weltman, Nikola Angelov
Summary: This cross-sectional study aimed to investigate the gene expression in alveolar bone of healthy individuals and those with type 2 diabetes using RNA sequencing and bioinformatics analysis. The results showed that genes involved in bone turnover were significantly downregulated in patients with diabetes, indicating potential impairment in wound healing and bone homeostasis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Chemistry, Physical
Nikolaos Soldatos, Laura Nelson-Rabe, Nathan Palanker, Nikola Angelov, Georgios Romanos, Robin Weltman
Summary: The success of osseointegration depends on various factors, and the diameter and design of the drill bits significantly affect the temperature changes during bone preparation. In this study using fresh human cadaver tibiae, it was found that tapered drills generated more heat compared to straight drills, but the temperature never exceeded the critical threshold.
Editorial Material
Dentistry, Oral Surgery & Medicine
Karo Parsegian, Nikola Angelov
JOURNAL OF DENTAL EDUCATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Seiko Min, Yen-Chun Wang, Junya Hamaguchi, Chi-Ching Chang, Taewan Kim, Goncalo Carames, Alfonso Gil, Satoshi Yamaguchi, Satoshi Imazato, Nikola Angelov
Summary: This study evaluated the effectiveness and stability of phenotype modification therapy using VISTA and SCTG. The results showed that the mucosal thickness gains remained relatively stable at different positions below the CEJ. Therefore, VISTA and SCTG have the potential to be used as a strategy for phenotype modification therapy.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jennifer Chang, Ming-Feng Chang, Nikola Angelov, Chih-Yu Hsu, Hsiu-Wan Meng, Sally Sheng, Aaron Glick, Kearny Chang, Yun-Ru He, Yi-Bing Lin, Bing-Yan Wang, Srinivas Ayilavarapu
Summary: This study tested the accuracy of machine learning in classifying radiographic bone loss in diagnosing periodontitis, and promising results were obtained.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Health Care Sciences & Services
Aaron Glick, Mackenzie Clayton, Nikola Angelov, Jennifer Chang
Summary: This study investigated the interaction between artificial intelligence (AI) systems and novice clinicians in diagnosing abnormalities in dental radiographs. The findings suggest that novice clinicians tend to over-rely on AI, leading to potential lower performance. The AI system used in the study did not improve decision-making speed or confidence in novice clinicians. Developers of AI systems should consider the psychological interaction and end user experience that can potentially affect clinical performance and patient safety. However, participants using AI assistance believed that these systems have the potential to improve clinical decision-making.
Article
Dentistry, Oral Surgery & Medicine
P. Stylianou, N. Soldatos, E. K. Edmondson, N. Angelov, R. Weltman
CASE REPORTS IN DENTISTRY
(2020)