Article
Multidisciplinary Sciences
Anna Pieniazek, Joanna Bernasinska-Slomczewska, Pawel Hikisz
Summary: Chronic kidney disease leads to the accumulation of uremic toxins, such as indoxyl sulfate (IS), which has a harmful effect on mononuclear blood cells (MNCs). This study found that IS treatment decreased MNC survival and mitochondrial potential. IS also increased caspase activity and expression, DNA damage, and PARP degradation in MNCs. Furthermore, IS significantly affected the expression of Bcl-2 and Bax proteins and induced programmed cell death through the mitochondrial apoptotic pathway in MNCs.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Nicolas Gendron, Mickael Rosa, Adeline Blandinieres, Yoann Sottejeau, Elisa Rossi, Eric Van Belle, Salim Idelcadi, Severine Lecourt, Andre Vincentelli, Audrey Cras, Ramadan Jashari, Richard Chocron, Yael Baudouin, Thibault Pamart, Ivan Bieche, Nathalie Nevo, Bernard Cholley, Jeanne Rancic, Bart Staels, Pascale Gaussem, Annabelle Dupont, Alain Carpentier, Sophie Susen, David M. Smadja
Summary: The study demonstrated that human VICs isolated from patients with calcific aortic valve disease have the potential to participate in aortic valve angiogenesis by differentiating into perivascular cells and exerting paracrine effects of VEGF-A. These findings suggest a novel function of VICs in valve vascularization during calcific aortic valve disease and highlight the importance of targeting perivascular differentiation and VEGF-A in slowing disease progression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoda Janaina Ikenohuchi, Milena Daniela Souza Silva, Cristina Matiele Alves Rego, Aleff Ferreira Francisco, Sulamita da Silva Setubal, Alex Augusto Ferreira E. Ferreira, Charles Nunes Boeno, Hallison Mota Santana, Katia Paula Felipin, Anderson Maciel de Lima, Marcos Roberto de Mattos Fontes, Mauro Valentino Paloschi, Andreimar Martins Soares, Juliana Pavan Zuliani
Summary: This study aimed to investigate the effects of BjcuL from Brazilian jararacussu snake venom on the activation of NLRP3 inflammasome in PBMCs. The results demonstrated that BjcuL activates NLRP3 inflammasome through interaction with TLR4 and participation of ROS in the release of IL-1β. These findings are important for understanding the development of inflammatory reactions observed in snakebite victims.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Neil Venardos, Anna K. Gergen, Michael Jarrett, Michael J. Weyant, T. Brett Reece, Xianzhong Meng, David A. Fullerton
Summary: The use of warfarin has been found to induce osteogenic activity in both normal and diseased human aortic valve interstitial cells (AVICs). This effect is mediated by the ERK1/2 pathway in both normal and diseased AVICs, but in diseased AVICs, beta-catenin signaling also plays a role.
ANNALS OF THORACIC SURGERY
(2022)
Article
Physiology
Robin Tuscher, Alex Khang, Toni M. West, Chiara Camillo, Giovanni Ferrari, Michael S. Sacks
Summary: Calcific aortic valve disease (CAVD) is a progressive disease characterized by stiffening of the aortic valve tissues. Bicuspid aortic valve (BAV) is a congenital defect which leads to earlier development of CAVD. Surgical replacement is the current treatment for CAVD, but no pharmaceutical therapies or alternative treatments are available. This study aims to understand the biophysical changes in aortic valve interstitial cells (AVICs) in different CAVD states.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chenyang Gao, Wangxing Hu, Feng Liu, Zhiru Zeng, Qifeng Zhu, Jiaqi Fan, Jinyong Chen, Si Cheng, Kaixiang Yu, Yi Qian, Tanchen Ren, Jing Zhao, Xianbao Liu, Jian'an Wang
Summary: This study demonstrates that inhibition of Akr1B1 can attenuate calcification degree both in vitro and in vivo. The Akr1B1 inhibitor epalrestat may be a potential treatment option for CAVD.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shaoshao Zhang, Leilei Fan, Yongjun Wang, Jianjun Xu, Qiang Shen, Jianhua Xie, Zhipeng Zeng, Tingwen Zhou
Summary: This study found that dihydromyricetin (DHM) can reduce the expression of interleukin-6 (IL-6) by inhibiting the phosphorylation of c-KIT protein, thus improving the osteogenic differentiation of valvular interstitial cells (VICs) and reducing the progression of calcific aortic valve disease (CAVD).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Arseniy A. Lobov, Nadezhda V. Boyarskaya, Olga S. Kachanova, Ekaterina S. Gromova, Anastassia A. Shishkova, Bozhana R. Zainullina, Alexander S. Pishchugin, Alexey A. Filippov, Vladimir E. Uspensky, Anna B. Malashicheva
Summary: The study found that selective Notch signaling inhibitor crenigacestat can effectively inhibit osteogenic differentiation and the development of calcific aortic valve disease (CAVD). This finding contributes to the development of novel therapies targeting CAVD and vascular calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Suji Kim, You-Seok Hyun, Hong-Tae Park, Min-Kyung Shin, Han Sang Yoo
Summary: This study investigated the immune response of dogs to Mycobacterium avium-intracellulare complex (MAC) infection using a co-culture system of canine T helper cells and autologous monocyte-derived macrophages (MDMs). The results showed that M. intracellulare caused the differentiation of canine MDMs into M1-like macrophages, which in turn secreted molecules that induced Th1/Th17 cell polarization. Additionally, co-culture of canine lymphocytes with M. intracellulare-infected macrophages resulted in adaptive Th17 responses. These findings contribute to our understanding of the immune response of dogs to MAC infection and help reduce the potential zoonotic risk in One Health aspect.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jiaying Li, Qingchun Zeng, Zhenyu Xiong, Gaopeng Xian, Zuheng Liu, Qiong Zhan, Wenyan Lai, Lihua Ao, Xianzhong Meng, Hao Ren, Dingli Xu
Summary: Recent studies have shown that the choline-derived metabolite trimethylamine N-oxide (TMAO) promotes cardiovascular disease through inducing inflammation and stress, with higher TMAO levels found in patients with calcified aortic valve disease (CAVD). Experiment results indicate that TMAO induces osteogenic differentiation of aortic valve interstitial cells through endoplasmic reticulum and mitochondrial stress pathways, as demonstrated in both in vitro and in vivo experiments.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Marina Serrano-Macia, Sofia Lachiondo-Ortega, Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Alexandre Bosch, Leire Egia-Mendikute, Borja Jimenez-Lasheras, Mikel Azkargorta, Felix Elortza, Diana Martinez-Redondo, Begona Castro, Juan J. Lozano, Ruben Nogueiras, Juan Irure-Ventura, Javier Crespo, Asis Palazon, Maria Carmen Farinas, Teresa C. Delgado, Marcos Lopez-Hoyos, Maria L. Martinez-Chantar
Summary: This study reveals an increase in global neddylation levels in COVID-19 patients' serum, particularly associated with the early infection response. Additionally, the study demonstrates that overactivation of neddylation controls the activation, proliferation, and response of peripheral blood mononuclear cells (PBMCs) isolated from COVID-19 patients. Inhibition of neddylation and avoiding activation of PBMCs can reduce cytokine production, mainly IL-6 and MCP-1, and induce proteome modulation, which serves as a critical mechanism and potential approach for immunomodulating COVID-19 patients.
CELL DEATH DISCOVERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yongjun Wang, Dong Han, Tingwen Zhou, Cheng Chen, Hong Cao, Joe Z. Zhang, Ning Ma, Chun Liu, Moshi Song, Jiawei Shi, Xin Jin, Feng Cao, Nianguo Dong
Summary: The study found that dual-specificity phosphatase 26 (DUSP26) promotes calcific aortic valve disease (CAVD) progression by inhibiting dipeptidyl peptidase-4 (DPP4) degradation. This previously unrecognized mechanism could potentially serve as a new therapeutic strategy to impede the progression of CAVD.
EUROPEAN HEART JOURNAL
(2021)
Article
Immunology
Chao Niu, Yongchong Chen, Min Li, Shan Zhu, Lei Zhou, Dongsheng Xu, Zhaozhi Li, Jianting Xu, Wei Li, Yufeng Wang, Jiuwei Cui
Summary: The study found that rituximab can independently obtain highly cytotoxic NK cells from PBMCs, without the need for additional feeder cells, and these cells have stronger antitumor activity against cancer cells, depending on autologous living B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Elodie Miquelestorena-Standley, Ana Valeria Vinhais da Silva, Marina Monnier, Stephanie Chadet, Marie Piollet, Audrey Heraud, Roxane Lemoine, Thomas Bochaton, Genevieve Derumeaux, Sebastien Roger, Fabrice Ivanes, Denis Angoulvant
Summary: The pathophysiological response after acute myocardial infarction (AMI) involves three stages, including phenotypic modifications of immune cells and fibroblasts. This study characterized the immuno-inflammatory and P2Y11 expression profiles of peripheral blood mononuclear cells (PBMC) from AMI patients and found that PBMC displayed an evolving inflammatory profile with reparative characteristics the first two days after AMI, contributing to myocardial fibrosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hsiao-Huang Chang, I-Chun Lin, Chih-Wei Wu, Chun-Ying Hung, Wen-Chung Liu, Cai-Yi Wu, Ching-Li Cheng, Kay L. H. Wu
Summary: High fructose was found to stimulate osteogenic differentiation of human valve interstitial cells, possibly via activation of the PI3K/AKT/mitochondria signaling pathway. These results suggest that high fructose at physiological level may have a direct hazardous effect on the progression of AS.
BIOMEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Tsung-Hsien Chiang, Yen-Nien Chen, Yi-Ru Chen, Yu-Hua Tseng, Chun-Fu Shieh, Cheng-Ying Liu, Han-Mo Chiu, Hung Chiang, Chia-Tung Shun, Ming-Shiang Wu, Jaw-Town Lin, Yi-Chia Lee
Summary: This study demonstrates the effectiveness of PG testing for mass screening after eradication of H. pylori. Tests from different manufacturers, even using different analytical methods and cutoff criteria, can perform equivalently.
BMC GASTROENTEROLOGY
(2022)
Article
Clinical Neurology
Chin-Hsien Lin, Han-Yi Lin, En-Pong Ho, Yi-Ci Ke, Mei-Fang Cheng, Chyng-Yann Shiue, Chi-Han Wu, Peng-Hsiang Liao, Angela Yu-Huey Hsu, Li-An Chu, Ya-Ding Liu, Ya-Hui Lin, Yi-Cheng Tai, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu
Summary: The study found that LRRK2 G2019S mice are more susceptible to DSS-induced colitis, with increased inflammation and neuronal loss. TNF-alpha plays a detrimental role in the gut-brain axis of PD.
MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Chin-Hsien Lin, Han-Yi Lin, En-Pong Ho, Yi-Ci Ke, Mei-Fang Cheng, Chyng-Yann Shiue, Chi-Han Wu, Peng-Hsiang Liao, Angela Yu-Huey Hsu, Li-An Chu, Ya-Ding Liu, Ya-Hui Lin, Yi-Cheng Tai, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Peng-Hsiang Liao, Han-Lin Chiang, Chia-Tung Shun, Jen-Fan Hang, Han-Mo Chiu, Ming-Shiang Wu, Chin-Hsien Lin
Summary: This study investigated the expression of LRRK2 in colonic biopsies obtained from PD patients and healthy controls. The results showed that the fraction of LRRK2-positive cells was significantly higher in PD patients compared to controls, and individuals with LRRK2 genetic variants had higher colonic LRRK2 immunoreactivity. LRRK2 expression correlated with disease severity, and PD patients in the prodromal phase had a faster increase in colonic LRRK2 expression.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, Ko-Han Chao, Chien-Chih Tung, Hao-Chun Chang, I-Lun Shih, Been-Ren Lin, Ming-Jium Shieh, Chia-Tung Shun, Jau-Min Wong, Shu-Chen Wei
Summary: PSRCCR is a rare type of colon and rectal cancer, often diagnosed at an advanced stage with poor prognosis. Patients with PSRCCR tend to be younger, progress rapidly, exhibit unique clinical features, and require attention to diagnosis and treatment.
BMC GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Cheng-Hsuan Tsai, Che-Wei Liao, Xue-Ming Wu, Zheng-Wei Chen, Chien-Ting Pan, Yi-Yao Chang, Bo-Ching Lee, Chia-Tung Shun, Wen-Fen Wen, Chia-Hung Chou, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: The presence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is associated with worse arterial stiffness and vascular remodeling. Patients with ACS have higher prevalence of diabetes mellitus and more severe vascular fibrosis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shenq-Jie Wong, Hsiu-Po Wang, Chia-Tung Shun, Chien-Chuan Chen, Ming-Lun Han, Jiann-Hwa Chen, Chung-Tsui Huang, Tsu-Yao Cheng
Summary: This study aimed to analyze the clinicopathologic features of small endoscopic ultrasound (EUS)-suspected gastric gastrointestinal stromal tumors (GISTs) with a size of 2cm or less, and evaluate the efficacy and safety of endoscopic incisional biopsy (EIB) for these tumors. The results showed that leiomyoma is more common than GIST among these small tumors, and EIB has a higher diagnostic yield.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yu-Ting Kuo, Yu-Long Chu, Weng-Fai Wong, Ming-Lun Han, Chieh-Chang Chen, I-Shiow Jan, Wern-Cherng Cheng, Chia-Tung Shun, Ming-Chang Tsai, Tsu-Yao Cheng, Hsiu-Po Wang
Summary: This study compared two different sampling strategies for EUS-FNB and found that there was no significant difference in diagnostic accuracy between the fanning technique and contrast guidance. Therefore, the fanning technique may be a preferable option.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Jyh-Ming Liou, Xiao-Tao Jiang, Chieh-Chang Chen, Jiing-Chyuan Luo, Ming-Jong Bair, Po-Yueh Chen, Chu-Kuang Chou, Yu-Jen Fang, Mei-Jyh Chen, Chien-Chuan Chen, Ji-Yuh Lee, Tsung-Hua Yang, Chien-Chun Yu, Chia-Chi Kuo, Min-Chin Chiu, Chi-Yi Chen, Chia-Tung Shun, Wen-Hao Hu, Min-Horn Tsai, Yao-Chun Hsu, Cheng-Hao Tseng, Chi-Yang Chang, Jaw-Town Lin, Emad M. El-Omar, Ming-Shiang Wu
Summary: This study compared the effectiveness, tolerability, and short-term and long-term effects of levofloxacin-based sequential quadruple therapy and bismuth-based quadruple therapy as second-line regimens for Helicobacter pylori eradication. The results showed no significant difference between the two therapies in terms of eradication rate, antibiotic resistome, fecal microbiota composition, and metabolic parameters.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Li-Chun Chang, Chi-Yang Chang, Chi-Yi Chen, Cheng-Hao Tseng, Peng-Jen Chen, Chia-Tung Shun, Wen-Feng Hsu, Yen-Nien Chen, Chieh-Chang Chen, Tien-Yu Huang, Chia-Hung Tu, Mei-Jyh Chen, Chu-Kuang Chou, Ching-Tai Lee, Po-Yueh Chen, Ming-Shiang Wu, Han-Mo Chiu
Summary: In this multicenter randomized controlled study, it was found that cold snare polypectomy significantly reduces the risk of delayed postpolypectomy bleeding, including severe events, compared to hot snare polypectomy in the general population.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Chi-Yuan Hong, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok
Summary: The study indicated that the benefits of SIRT6 to inflammatory arthritis and bone resorption are at least partially derived from its modulation of the CREB/CCN1/COX2 pathway in osteoblasts.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chi-Yuan Hong, Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok
Summary: The study demonstrates that metformin promotes osteoblast differentiation and reduces osteoclast formation, thereby alleviating bone resorption in apical periodontitis. These findings support the role of metformin as an effective medication for treating inflammatory bone diseases.
JOURNAL OF ENDODONTICS
(2023)
Article
Medicine, Research & Experimental
Hsiang-Po Huang, Chung-Hsin Chen, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Yen-Hsiang Chao, Shih-Yu Lu, Tzu-Fan Wu, Sung-Tzu Liang, Chih-Yu Lin, Yuan Chi Lin, Shih-Ping Liu, Yu-Chuan Lu, Chia-Tung Shun, William J. Huang, Tzu-Ping Lin, Ming-Hsuan Ku, Hsiao-Jen Chung, Yen-Hwa Chang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, Kuan-Chou Chen, Chen-Hsun Ho, Pei-Wen Hsiao, Yeong-Shiau Pu
Summary: This study aimed to develop urine tests to predict potentially lethal prostate cancer, and successfully constructed four predictive models using metabolomic profiling. By combining urine metabolic markers with clinical factors, these models showed high accuracy in predicting clinically significant PC and could potentially reduce unnecessary biopsies by up to 50%.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mei-Jyh Chen, Po-Yueh Chen, Yu-Jen Fang, Ming-Jong Bair, Chieh-Chang Chen, Chien-Chuan Chen, Tsung-Hua Yang, Ji-Yuh Lee, Chien-Chun Yu, Chia-Chi Kuo, Min-Chin Chiu, Chu-Kuang Chou, Chi-Yi Chen, Wen-Hao Hu, Min-Horn Tsai, Yao-Chun Hsu, Chia-Tung Shun, Jiing-Chyuan Luo, Jaw-Town Lin, Emad M. El-Omar, Ming-Shiang Wu, Jyh-Ming Liou
Summary: This study compared the efficacy and safety of molecular testing-guided therapy and traditional culture-based susceptibility testing-guided therapy for H pylori infection in first-line and third-line treatment. The results showed that molecular testing-guided therapy was similar to susceptibility testing-guided therapy in both first-line and third-line treatment, indicating its potential use for H pylori eradication.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cheng-Hsuan Tsai, An -Li Yu, Yuan-Kun (Aden) Wu, Mao -Yuan Su, Mei -Fang Cheng, Chia -Hung Chou, Chia -Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ming -Jen Lee, Ping-Huei Tseng, Sung -Tsang Hsieh, Chi-Chao Chao, Yen-Hung Lin
Summary: This study aimed to investigate the efficacy of tafamidis in patients with hereditary A97S ATTR-CM after 6 months of treatment. The results showed that the patients had decreased levels of NT-proBNP after 6 months of tafamidis treatment, especially in those with more severe cardiac involvement.
ACTA CARDIOLOGICA SINICA
(2023)