Article
Immunology
Jakob G. G. Habib, Danya Liu, Rebecca M. M. Crepeau, Maylene E. E. Wagener, Mandy L. L. Ford
Summary: CD28 antagonists reversed the differentiation of memory CD4+ T cells and improved skin graft survival in renal transplantation, potentially through the increase of CD8+FoxP3+ T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit
Summary: CD4(+) T cells play a role in immune responses depending on the environment and stage, with nutrient availability also impacting their functionality. TNFR2 has been identified as key in regulating T cells, particularly Tregs. This study provides new evidence for the role of TNFR2 in metabolic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mariona Baliu-Pique, Kiki Tesselaar, Jose A. M. Borghans
Summary: Timely recovery of T-cell numbers following HSCT is crucial for preventing complications. T-cell dynamics in humans are thought to be regulated in a cell density-dependent manner. However, T-cell reconstitution after HSCT is notoriously slow, raising questions about the existence of homeostatic mechanisms in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Maria Pino, Susan Pereira Ribeiro, Amelie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L. Harper, Colin T. King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A. Delman, Theron Stuart, Michael Lowe, Jason M. Brenchley, Cynthia A. Derdeyn, Kirk Easley, Rafick P. Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C. Marconi
Summary: Clinical outcomes are inferior in individuals with HIV experiencing suboptimal CD4 T-cell recovery during ART. The study found that immunologic suboptimal responders (ISR) had higher HIV-DNA levels in multiple CD4 T-cell subsets and higher expression of PD-1 and TIGIT exclusively on CM and TM CD4 T-cells pre-ART, indicating higher HIV reservoir maintenance. Additionally, ISR showed a lack of response to IL-7 and IL-15, potentially contributing to suboptimal CD4 T-cell recovery during ART.
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Clarissa Heck, Sophie Steiner, Eva M. Kaebisch, Marco Frentsch, Friedrich Wittenbecher, Carmen Scheibenbogen, Leif G. Hanitsch, Axel Nogai, Philipp le Coutre, Lars Bullinger, Igor-Wolfgang Blau, Il-Kang Na
Summary: This study revealed quantitative and functional B cell defects in multiple myeloma patients undergoing auto-HSCT, leading to compromised immune defense. Stimulation with CD40L/IL-21 partially restored TD B cell function, indicating potential extrinsic drivers of the functional B cell defect. Testing CD4+, CD19+, memory B cells, and MZ-like B cells as biomarkers in prospective studies is suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Saskia Leserer, Esteban Arrieta-Bolanos, Ulrike Buttkereit, Dietrich W. Beelen, Amin T. Turki
Summary: The study established novel cut-off levels for early CD4(+) T cells through unsupervised learning and supported the integration of host cellular immunity into clinical risk assessment after HCT in the context of CMV reactivation.
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Immunology
Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Takumi Suzuki, Riou Tanaka, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Remy Bosselut, Alan Sher
Summary: In this study, using single-cell RNA sequencing and flow cytometry, we identified distinct subsets within self-driven MP CD4(+) T lymphocytes and found that they differ from conventional foreign Ag-specific memory cells in marker expression and functional relevance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Johannes U. Mayer, Kerry L. Hilligan, Jodie S. Chandler, David A. Eccles, Samuel Old, Rita G. Domingues, Jianping Yang, Greta R. Webb, Luis Munoz-Erazo, Evelyn J. Hyde, Kirsty A. Wakelin, Shiau-Choot Tang, Sally C. Chappell, Sventja von Daake, Frank Brombacher, Charles R. Mackay, Alan Sher, Roxane Tussiwand, Lisa M. Connor, David Gallego-Ortega, Dragana Jankovic, Graham Le Gros, Matthew R. Hepworth, Olivier Lamiable, Franca Ronchese
Summary: The study demonstrates that IL-13 secreted by dermal innate lymphoid cells plays a crucial role in promoting the differentiation of a CD11b(lo) type 2 dendritic cell subset in the skin of mice and humans, supporting the development of T(H)2 cells and inhibiting T(H)17 cells. This homeostatic IL-13 fosters a noninflammatory skin environment conducive to allergic sensitization.
Article
Multidisciplinary Sciences
Felipe Valenca-Pereira, Qian Fang, Isabelle J. Marie, Emily L. Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David E. Levy, Mercedes Rincon
Summary: IL-6 enhances the mechanics of CD4 T cells, increasing their motility and mitochondrial Ca2+, ultimately improving their competitive fitness. This noncanonical pathway could lead to alternative therapeutic strategies for inflammatory diseases where IL-6 plays a pathogenic role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Maylin Merino-Wong, Barbara A. Niemeyer, Dalia Alansary
Summary: The study shows that PMCA4 expression varies in different human CD4(+) T cell compartments, with modulation of PMCA4 leading to different increases in SOCE, suggesting an important role for PMCA4 in regulating compartment stoichiometry.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Chenxi Yang, Ling Lei, Jie Pan, Cheng Zhao, Jing Wen, Fang Qin, Fei Dong, Wanling Wei
Summary: This study investigated the role of IL-35 in the activity of CD4(+) T lymphocytes and human skin fibroblasts (HSFs) as well as cytokine levels in systemic sclerosis. The results showed that IL-35 inhibits the proliferation of CD4(+) T lymphocytes and induces the differentiation of Treg cells through STAT1 signaling activation, while promoting HSF proliferation and collagen expression in systemic sclerosis.
Article
Biochemistry & Molecular Biology
Jessica Schneider, Leonie Kuhlmann, Yankai Xiao, Solaiman Raha, Gunter Bernhardt, Michael Stadler, Felicitas Thol, Michael Heuser, Matthias Eder, Arnold Ganser, Sarina Ravens, Reinhold Forster, Immo Prinz, Christian Koenecke, Christian R. Schultze-Florey
Summary: Donor lymphocyte infusion (DLI) can induce durable remission in relapsing patients after alloHSCT, but it carries the risk of graft-versus-host disease (GVHD). This study analyzed T cells in patients receiving DLI after alloHSCT and found that GVHD was associated with changes in the T-cell receptor (TCR) repertoire. The dynamics of CD4(+)CD25(+)CD127(low) regulatory T cells (T-reg cells) and CD4(+) conventional T cells (T-con cells) TCR repertoire could be helpful in diagnosing and monitoring GVHD following DLI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Alexandra Audemard-Verger, Evangeline Pillebout, Agnes Jamin, Laureline Berthelot, Cedric Auffray, Bruno Martin, Aurelie Sannier, Eric Daugas, Julie Dechanet-Merville, Yolande Richard, Renato Monteiro, Bruno Lucas
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Immunology
Jihene Klibi, Shamin Li, Ludivine Amable, Claudine Joseph, Stephane Brunet, Marc Delord, Veronique Parietti, Jean Jaubert, Julien Marie, Saoussen Karray, Gerard Eberl, Bruno Lucas, Antoine Toubert, Kamel Benlagha
INTERNATIONAL IMMUNOLOGY
(2020)
Article
Immunology
Romain Vallion, Jordane Divoux, Salome Glauzy, Emilie Ronin, Yannis Lombardi, Martina Lubrano di Ricco, Sylvie Gregoire, Ivan Nemazanyy, Aurelie Durand, Delphine Fradin, Bruno Lucas, Benoit L. Salomon
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Elodie Blondel-Tepaz, Marie Leverve, Badr Sokrat, Justine S. Paradis, Milena Kosic, Kusumika Saha, Cedric Auffray, Evelyne Lima-Fernandes, Alessia Zamborlini, Anne Poupon, Louis Gaboury, Jane Findlay, George S. Baillie, Herve Enslen, Michel Bouvier, Stephane Angers, Stefano Marullo, Mark G. H. Scott
Summary: The protein beta-arrestin2 plays a critical role in regulating the Mdm2-p53 signaling axis by promoting the nuclear-cytoplasmic shuttling of Mdm2 and enhancing p53 signaling. While beta-arrestin2 can be SUMOylated, it is the non-covalent interaction between SUMO and beta-arrestin2, mediated by a SUMO interaction motif (SIM), that is essential for its cytonuclear trafficking function. Depletion of the RanBP2/RanGAP1-SUMO nucleocytoplasmic transport hub leads to defective beta-arrestin2 nuclear entry, inhibiting its ability to displace Mdm2 from the nucleus and enhancing p53 signaling in cancer cells.
Article
Multidisciplinary Sciences
Emilie Ronin, Charlotte Pouchy, Maryam Khosravi, Morgane Hilaire, Sylvie Gregoire, Armanda Casrouge, Sahar Kassem, David Sleurs, Gaelle H. Martin, Noemie Chanson, Yannis Lombardi, Guilhem Lalle, Harald Wajant, Cedric Auffray, Bruno Lucas, Gilles Marodon, Yenkel Grinberg-Bleyer, Benoit L. Salomon
Summary: The study reveals that TNFR2-expressing Treg cells play a crucial role in suppressing autoimmune diseases in the central nervous system during peak disease, maintaining their functionality and sustained expression of suppressive genes. This late effect also provides insights into the treatment outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jihene Klibi, Claudine Joseph, Marc Delord, Aurelie Teissandier, Bruno Lucas, Christine Chomienne, Antoine Toubert, Deborah Bourc'his, Fabien Guidez, Kamel Benlagha
Summary: The study shows that acetylation-induced activation of PLZF affects the development of NKT cells, leading to a decrease in cell proportion and numbers, and blockage of transition from developmental stage 1 to stage 2. Acetylation of PLZF also alters NKT cell subset differentiation, inhibiting the development of NKT1 and NKT17 subsets while promoting the emergence of an NKT cell subset resembling cells in early developmental stages.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Rheumatology
Alice Delapierre, Benjamin Terrier, Evangeline Pillebout, Pauline Baudart, Noemie Jourde-Chiche, Bertrand Lioger, Nihal Martis, Guillaume Moulis, Etienne Riviere, Noemie Le Gouellec, Loic Raffray, Geoffrey Urbanski, Sebastien Sanges, Francois Maurier, Alban Deroux, Arsene Mekinian, Renato Monteiro, Christian Marcelli, Loic Guillevin, Francois Maillot, Bruno Lucas, Achille Aouba, Alexandra Audemard-Verger, French Vasculitis Study Group (fvsg) And The HSPrognosis Group
Summary: Joint involvement is frequent in adult IgA vasculitis and is associated with more frequent gastrointestinal involvement. Increased plasma interleukin-1 beta levels in patients with joint involvement suggest a potential target for therapy targeting this cytokine in chronic and/or refractory cases.
CLINICAL RHEUMATOLOGY
(2022)
Article
Critical Care Medicine
Aurelien Mazeraud, Matthieu Jamme, Rossella Letizia Mancusi, Claire Latroche, Bruno Megarbane, Shidasp Siami, Jonathan Zarka, Guy Moneger, Francesco Santoli, Laurent Argaud, Patrick Chillet, Gregoire Muller, Cedric Bruel, Pierre Asfar, Francois Beloncle, Jean Reignier, Christophe Vinsonneau, Caroline Schimpf, Julien Amour, Cyril Goulenok, Caroline Lemaitre, Benjamin Rohaut, Philippe Mateu, Stephane De Rudnicki, Bruno Mourvillier, Pierre-Louis Declercq, Carole Schwebel, Annabelle Stoclin, Marc Garnier, Benjamin Madeux, Stephane Gaudry, Karine Bailly, Christian Lamer, Philippe Aegerter, Christine Rieu, Khaoussou Sylla, Bruno Lucas, Tarek Sharshar
Summary: In patients with moderate-to-severe ARDS caused by COVID-19 and receiving invasive mechanical ventilation, IVIG did not improve clinical outcomes at day 28 and may be associated with an increased frequency of serious adverse events. The effect of IVIGs on earlier stages of COVID-19 should be assessed in future trials.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Rheumatology
Camelia Frantz, Anne Cauvet, Aurelie Durand, Virginie Gonzalez, Remi Pierre, Marcio Do Cruzeiro, Karine Bailly, Muriel Andrieu, Cindy Orvain, Jerome Avouac, Mina Ottaviani, Raphael Thuillet, Ly Tu, Christophe Guignabert, Bruno Lucas, Cedric Auffray, Yannick Allanore
Summary: This study investigates the imbalance between effector and regulatory arms in CD4+ T cells in the Fra-2-transgenic mice. The results suggest that restoring Treg cell homeostasis through immunotherapies could be relevant in SSc, with low-dose IL-2 injections being the most suitable treatment modality.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jean-Francois Llitjos, Cedric Auffray, Edwige Peju, Zakaria Ait Hamou, Christophe Rousseau, Aurelie Durand, Clemence Martin, Jean-Paul Mira, Pierre-Regis Burgel, Jean-Daniel Chiche, Maha Zohra Ladjemi, Bruno Lucas, Frederic Pene
Summary: Clinical observations suggest that the source of primary infection is a major determinant of further nosocomial pneumonia in critically ill patients with sepsis. This study used relevant double-hit animal models to investigate the impact of primary nonpulmonary or pulmonary sepsis on lung immunity. The results indicate that polymicrobial peritonitis and bacterial pneumonia confer susceptibility or resistance to secondary gram-negative pulmonary infection, respectively, through immune modulation and cross-talk between regulatory T cells and alveolar macrophages.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jammy Mariotton, Emmanuel Cohene, Aiwei Zhu, Cedric Auffray, Caio Cesar Barbosa Bomfim, Nicolas Barry Delongchamps, Marc Zerbib, Morgane Bomsel, Yonatan Ganor, Suryaram Gummuluru
Summary: Upon mucosal transmission, HIV-1 targets genital antigen-presenting cells, which transfer the virus to CD4(+) T cells. Previous studies have shown that calcitonin gene-related peptide (CGRP) secreted by peripheral pain-sensing neurons can inhibit HIV-1 transfer. This study finds that CGRP can be secreted by LCs following activation of their Ca2+ ion channel TRPV1, and TRPV1 activation inhibits HIV-1 infection in LCs and T cells through CGRP-dependent/independent mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Letter
Critical Care Medicine
Aurelien Mazeraud, Michel Wolff, Bruno Lucas, Tarek Sharshar
LANCET RESPIRATORY MEDICINE
(2022)