Article
Multidisciplinary Sciences
Esmee K. van der Ploeg, Lisette Krabbendam, Heleen Vroman, Menno van Nimwegen, Marjolein J. W. de Bruijn, Geertje M. de Boer, Ingrid M. Bergen, Mirjam Kool, Gerdien A. Tramper-Standers, Gert-Jan Braunstahl, Danny Huylebroeck, Rudi W. Hendriks, Ralph Stadhouders
Summary: CD8+ cytotoxic T cells can also produce type-2 cytokines in severe asthma patients, and their abundance is associated with increased disease burden, higher exacerbation rates, and steroid insensitivity. The type-2 skewing of lung Tc cells in asthma is controlled by conventional type-1 dendritic cells and IFN gamma. Interleukin-33 (IL-33) critically promotes type-2 cytokine production by lung Tc cells in experimental allergic airway inflammation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yao Lu, Yutao Zhou, Yingying Lin, Wusun Li, Shousheng Tian, Xianghui Hao, Huiyuan Guo
Summary: The study found that oral administration of donkey milk powder can improve asthma symptoms, alleviate airway injury and fibrosis, reduce mucin accumulation, goblet cell hyperplasia, and airway inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cell Biology
Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini
Summary: This study demonstrates that NK cell depletion enhances the immune response to vaccines in a mouse model of chronic HBV infection. It was found that the up-regulation of PD-L1 on liver-resident NK cells and PD-1 on intrahepatic T cells plays a negative regulatory role in the response to therapeutic vaccination. Combining cytokine activation with PD-L1 blockade can convert NK cells into efficient helpers, boosting the CD8(+) T cell response to therapeutic vaccination.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir Np Kelada, Stephen L. Tilley
Summary: This study shows that ozone induces mast cell degranulation and bronchial hyperresponsiveness, with P2X7 receptors playing a crucial role in the process.
Article
Biochemistry & Molecular Biology
I. Patlan, M. P. Jeffrey, D. Lewis, J. Green-Johnson, S. Dogra
Summary: This study compared the effects of exercise in cold-dry and normal conditions on salivary cytokine levels and airway response in young healthy males. The results showed that IL-8 levels increased in normal conditions but not in cold-dry conditions, while the opposite trend was observed for IL-1RA.
Article
Immunology
Alexandra Kupke, Asisa Volz, Erik Dietzel, Astrid Freudenstein, Joerg Schmidt, Hosam Shams-Eldin, Sylvia Jany, Lucie Sauerhering, Verena Kraehling, Michelle Gellhorn Serra, Christiane Herden, Markus Eickmann, Stephan Becker, Gerd Sutter
Summary: This study tested two recombinant MVA-based Ebola virus vaccine candidates in mice and found that vaccination generated virus-neutralizing antibodies and specific CD8+ T cell response. Vaccinated mice survived Ebola virus infection and had significantly reduced viral loads compared to mock-vaccinated mice.
Article
Rheumatology
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzman, Gerd Sutter, Reinhold E. Schmidt, Torsten Witte, Ulrich Kalinke
Summary: Rituximab-treated patients and B cell-deficient mice showed reduced expansion of virus-specific CD8(+) T cells after vaccination/infection with different vaccines/pathogens, indicating that B cells can modulate CD8(+) T cell responses. The choice of vaccines for B cell-depleted patients needs to be re-evaluated to effectively induce protective CD8(+) T cell responses.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ruping Wang, Yinna Wang, Guoning Liao, Bohao Chen, Reynold A. Panettieri, Raymond B. Penn, Dale D. Tang
Summary: Asthma is a complex pulmonary disorder with multiple pathological mechanisms. A key pathological feature is airway remodeling, which is largely caused by the abnormal proliferation of airway smooth muscle cells. An adapter protein called Abi1 has been identified as a molecular switch that regulates the activation of certain proteins and contributes to the progression of asthma.
Article
Immunology
Helen Carrasco Hope, Gabriella Pickersgill, Pierpaolo Ginefra, Nicola Vannini, Graham P. Cook, Robert J. Salmond
Summary: TGFβ inhibits CD8(+) T cell activation by suppressing Myc-dependent metabolic reprogramming.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Wen-Chung Huang, Shu-Ju Wu, Li-Wen Fang, Tzu-Yung Lin, Chian-Jiun Liou
Summary: Phillyrin was found to alleviate airway hyperresponsiveness (AHR) and eosinophil infiltration in asthmatic mice, as well as reduce inflammatory responses in BEAS-2B cells. It also decreased serum OVA-IgE levels and Th2-associated cytokine production in asthmatic mice.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)