Review
Pharmacology & Pharmacy
Alberto Alvarez-Perea, Paula Cabrera-Freitag, Victoria Fuentes-Aparicio, Sonsoles Infante
Summary: Anaphylaxis is a severe and life-threatening hypersensitivity reaction that is often difficult to diagnose, resulting in delayed management. Epinephrine is the immediate treatment of choice for anaphylaxis. The subsequent treatment depends on the response to epinephrine.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Allergy
Angela Gaspar, Natacha Santos, Emilia Faria, Ana Margarida Pereira, Eva Gomes, Rita Camara, Rodrigo Rodrigues-Alves, Luis-Miguel Borrego, Isabel Carrapatoso, Leonor Carneiro-Leao, Mario Morais-Almeida, Luis Delgado, Elisa Pedro, Manuel Branco-Ferreira
Summary: This study found that in the Portuguese pediatric population, food is the leading cause of anaphylaxis, with undertreatment with adrenaline and high recurrence rates highlighting the need for improved diagnosis and therapeutic management of this life-threatening condition.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Wojciech Francuzik, Franziska Rueeff, Andrea Bauer, Maria Beatrice Bilo, Victoria Cardona, George Christoff, Sabine Doelle-Bierke, Luis Ensina, Montserrat Fernandez Rivas, Thomas Hawranek, Jonathan O'b Hourihane, Thilo Jakob, Nicos G. Papadopoulos, Claudia Pfoehler, Iwona Poziomkowska-Gesicka, Xavier Van der Brempt, Kathrin Scherer Hofmeier, Regina Treudler, Nicola Wagner, Bettina Wedi, Margitta Worm
Summary: The study evaluated the phenotype and risk factors of venom-induced anaphylaxis (VIA) using data from the European Anaphylaxis Registry. VIA more frequently involved multiple organ systems and was associated with cardiovascular symptoms, while the absence of skin symptoms during anaphylaxis was correlated with a higher risk of severe reactions. Patients with intermediate baseline serum tryptase levels and without skin involvement had a higher risk of severe VIA. Patients receiving beta-blockers or angiotensin-converting enzyme inhibitors had a higher risk of developing severe cardiovascular symptoms in VIA and non-VIA cases, where patients experiencing VIA received epinephrine less frequently than cases with non-VIA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Konstantinos Vamvakaris, Alkmini Koumpoura, Maria Farmaki, John Lakoumentas, Maria Pasioti, Nikolaos Papadopoulos, Paraskevi Xepapadaki
Summary: This study reviewed the compliance of a pediatric Allergy Department in diagnosing and treating food-induced allergic reactions, emphasizing the importance of following guidelines, organized documentation, and continuous staff training.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
A. Gaspar, N. Santos, E. Faria, R. Camara, R. Rodrigues-Alves, I Carrapatoso, E. Gomes, A. M. Pereira, L. Carneiro-Leao, M. Morais-Almeida, L. Delgado, E. Pedro, M. Branco-Ferreira
Summary: Food is the leading cause of anaphylaxis in Portugal, while drugs were the main elicitors in adults. The study emphasizes the undertreatment with adrenaline and the high recurrence rate of anaphylaxis, highlighting the need for improved diagnostic and therapeutic approaches.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Katsumasa Kitamura, Tomoya Ito, Komei Ito
Summary: This study analyzed time trends, triggers, and adrenaline usage in pediatric anaphylaxis cases in Aichi Prefecture, Japan. It found that food was the most common trigger, with egg and milk being the most frequent, and a significant increase in tree nuts. The admission rate did not significantly differ between cases where adrenaline auto-injectors were used before hospital arrival and cases where adrenaline was administered in the hospital.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Pediatrics
Gavriela Feketea, John Lakoumentas, Evangelia Papatriantafyllou, Nikolaos Douladiris, Dimitris Efthymiou, Luminita Aurelia Stanciu, Emilia Vassilopoulou
Summary: An observational study in Greece found that school staff have limited knowledge about food allergies in schoolchildren. Female teachers showed more concern about the availability of trained personnel to manage food allergy symptoms. Schools should provide training on food allergy management, improve emergency treatment plans, and ensure access to emergency tools.
Article
Pediatrics
Weronika M. Balas, Joanna Strzelecka, Aleksandra Godynska, Adam J. Sybilski
Summary: Pollen-food allergy syndrome (PFAS) is a common allergic condition caused by cross-reactivity between pollen and plant food allergens. This report describes a unique case of systemic allergic reaction in an 11-year-old boy after consuming raw carrot juice. The patient had elevated levels of carrot-specific IgE and cross-reactivity with allergen components in the PR-10 subfamily. This case highlights the importance for healthcare professionals to be cautious and aware of the potential systemic manifestations of PFAS.
Article
Medicine, General & Internal
Kyung-Min Ahn, Byung-Keun Kim, Min-Suk Yang
Summary: Drug-induced anaphylaxis is a fatal medical condition with increasing incidence. This study investigated culprit drugs and common medication risk factors for drug-induced anaphylaxis in the Korean general population. By analyzing medical prescription histories in the Health Insurance Service and Assessment Service database, 5 common medication risk factors were identified.
Article
Allergy
Sevim Bavbek, Secil Kepil Ozdemir, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolaci, Carla Lombardo, Maria J. Torres
Summary: This paper provides evidence-based recommendations for the diagnosis and management of hypersensitivity reactions (HSRs) to proton pump inhibitors (PPIs), and calls for further in-depth research.
Article
Allergy
Asger Sverrild, John Carruthers, Kavitha Garuna Murthee, Alice Moore, Robyn Elizabeth O'Hehir, Robert Puy, Mark Hew, Celia Zubrinich
Summary: This study evaluated a published algorithm based on tryptase and clinical presentation to identify appropriate individuals for further testing for IgE-mediated perioperative hypersensitivity (POH). The results showed that the algorithm was highly sensitive but less specific in identifying patients testing positive on skin testing and/or specific IgE. Cardiovascular symptoms had high sensitivity, while the combination of respiratory symptoms and increased tryptase had the highest specificity. Respiratory involvement was more common in neuromuscular blocking agent allergy, while urticaria/angioedema was more common in antibiotic allergy.
Article
Allergy
Eray Yildiz, Sevket Arslan, Fatih Coelkesen, Recep Evcen, Filiz Sadi Aykan, Mehmet Kilinc
Summary: This study found that anaphylaxis in older adults is mainly caused by drugs. Older adults have more cardiovascular symptoms, more frequent adrenaline injections, hospitalizations, and intensive care unit admissions.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Pediatrics
Laura Polloni, Ileana Baldi, Margherita Amadi, Valentina Tonazzo, Roberta Bonaguro, Francesca Lazzarotto, Alice Toniolo, Dario Gregori, Antonella Muraro
Summary: The study found that parents were unprepared and reluctant to use auto-injectable adrenaline despite their self-rated knowledge, with fear of making mistakes, concerns about side effects, and lack of knowledge on AAI use being the main barriers. Interventions such as theoretical-practical courses, psycho-education, and written instructions were suggested as facilitators for better management of anaphylaxis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Silvia Pagani, Niccolo Lombardi, Giada Crescioli, Violetta Giuditta Vighi, Giulia Spada, Paola Andreetta, Annalisa Capuano, Alfredo Vannacci, Mauro Venegoni, Giuseppe Danilo Vighi
Summary: The aim of this study is to describe the pharmacological characteristics of drug-related allergies and anaphylaxis leading to emergency department visits. Male sex and age classes younger than 65 years were found to have a higher risk of drug-related allergies, while females and adults had a higher risk of anaphylaxis. Antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Guillaume Pouessel, Sabrina Alonzo, Amandine Divaret-Chauveau, Pascale Dumond, Elena Bradatan, Valerie Liabeuf, Pascale Beaumont, Selina Tscheiller, Remy Diesnis, Jean-Marie Renaudin, Dominique Sabouraud-Leclerc
Summary: A retrospective analysis was conducted on severe anaphylaxis cases recorded by the Allergy-Vigilance (R) Network (2002-2020) to evaluate the characteristics associated with survival, age, and allergens. The results showed that food was the main allergen for severe anaphylaxis in both children and adults, and young age, asthma history, and exercise were characteristic features of severe food anaphylaxis.
Editorial Material
Allergy
Kenji Matsumoto, Hirohisa Saito
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Critical Care Medicine
Stefano Guerra, Enrico Lombardi, Debra A. Stern, Duane L. Sherrill, Dorothy Gilbertson-Dahdal, Courtney M. Wheatley-Guy, Eric M. Snyder, Anne L. Wright, Fernando D. Martinez, Wayne J. Morgan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Tatsukuni Ohno, Takashi Nakamura, Susumu Nakae, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Kazuyoshi Takeda, Ko Okumura, Toshifumi Azuma
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kiwako Yamamoto-Hanada, Eiryo Kawakami, Mayako Saito-Abe, Miori Sato, Hiroshi Mitsubuchi, Masako Oda, Takahiko Katoh, Masafumi Sanefuji, Shouichi Ohga, Mari Kuwajima, Nathan Mise, Akihiko Ikegami, Fujio Kayama, Ayako Senju, Masayuki Shimono, Koichi Kusuhara, Shin Yamazaki, Shoji F. Nakayama, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
Article
Pediatrics
Takumi Shibazaki, Noriko Motoki, Yuka Misawa, Satoshi Ohira, Yuji Inaba, Makoto Kanai, Hiroshi Kurita, Yozo Nakazawa, Teruomi Tsukahara, Tetsuo Nomiyama
Summary: The study revealed that frequent use of indoor insecticide spray during pregnancy increases the risk of neonatal hyperbilirubinemia requiring phototherapy, while spray- or lotion-type insect repellents do not pose the same risk.
PEDIATRIC RESEARCH
(2021)
Letter
Allergy
Maiko Emi-Sugie, Hirohisa Saito, Kenji Matsumoto
ALLERGOLOGY INTERNATIONAL
(2021)
Review
Allergy
Keisuke Orimo, Masato Tamari, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae, Hideaki Morita
Summary: Discovery of innate lymphoid cells (ILCs) has changed the classical concept of allergy mechanism and led to a better understanding of non-IgE-mediated allergic inflammation. Studies have shown heterogeneity in each ILC subset in different organs and tissues, with varying functions and activating/suppressing factors. Understanding the roles of ILCs in various organs is crucial for researching and treating inflammatory diseases.
Article
Allergy
Tadech Boonpiyathad, Pongsakokorn Tantilipikorn, Kiat Ruxrungtham, Panitan Pradubpongsa, Wat Mitthamsiri, Aurelie Piedvache, Pattarawat Thantiworasit, Sunee Sirivichayakul, Alain Jacquet, Narissara Suratannon, Pantipa Chatchatee, Naho Morisaki, Hirohisa Saito, Atik Sangasapaviriya, Kenji Matsumoto, Hideaki Morita
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ken Arae, Masashi Ikutani, Kotaro Horiguchi, Sachiko Yamaguchi, Youji Okada, Hiroki Sugiyama, Keisuke Orimo, Hideaki Morita, Hajime Suto, Ko Okumura, Haruhiko Taguchi, Kenji Matsumoto, Hirohisa Saito, Katsuko Sudo, Susumu Nakae
Summary: Our study demonstrates that chitin induces the production of IL-33 and TSLP by alveolar and bronchial epithelial cells in mice. These cytokines play a crucial role in activating resident lung Th2 cells and ILC2s, leading to the development of chitin-induced airway eosinophilia.
SCIENTIFIC REPORTS
(2021)
Letter
Allergy
Hiroko Suzuki, Yoshiyuki Tsutsumi, Hideaki Morita, Kenichiro Motomura, Nagayoshi Umehara, Haruhiko Sago, Yushi Ito, Katsuhiro Arai, Takako Yoshioka, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Allergy
Keisuke Orimo, Masato Tamari, Tomohiro Takeda, Terufumi Kubo, Beate Ruckert, Kenichiro Motomura, Hiroki Sugiyama, Ayako Yamada, Kyoko Saito, Ken Arae, Motohiro Kuriyama, Mariko Hara, Michael B. Soyka, Masashi Ikutani, Sota Yamaguchi, Noriko Morimoto, Kazuhiko Nakabayashi, Kenichiro Hata, Akio Matsuda, Cezmi A. Akdis, Katsuko Sudo, Hirohisa Saito, Susumu Nakae, Jun Tamaoki, Etsuko Tagaya, Kenji Matsumoto, Hideaki Morita
Summary: The study found that platelets spontaneously adhere to ILC2, enhancing the responses of ILC2 to IL-33 in the peripheral blood and airways. In vivo, T2 inflammation and T2 cytokine production were significantly reduced in mice lacking c-mpl.
Article
Allergy
Mayu Yamamoto, Saori Nagashima, Yoshiyuki Yamada, Takatsugu Murakoshi, Yasuyuki Shimoyama, Sakuma Takahashi, Hideyuki Seki, Takashi Kobayashi, Yuichi Hara, Hiromi Tadaki, Norihisa Ishimura, Shunji Ishihara, Yoshikazu Kinoshita, Hideaki Morita, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura
Summary: This study compared the clinical features and natural histories of non-EoE EGIDs and EoE, revealing a higher prevalence of EoE in males and more serious symptoms and complications in children compared to adults. The most common natural history for both diseases was the continuous type.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Editorial Material
Allergy
Hideaki Morita, Hirohisa Saito, Kenji Matsumoto
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Allergy
Hiroki Yasudo, Tomoaki Ando, Jiro Kitaura, Nobuyuki Maruyama, Masami Narita, Osamu Natsume, Kei Uneoka, Katsushi Miura, Yoshinori Morita, Anna Kamei, Yoko Okamoto, Seigo Shirakawa, Taeru Kitabayashi, Kazuyuki Kurihara, Kazuyoshi Nogami, Yoshihiro Takasato, Mizuho Nagao, Komei Ito, Takao Fujisawa, Motohiro Ebisawa, Toshiaki Kawakami, Kenji Matsumoto, Hirohisa Saito, Shunji Hasegawa, Yukihiro Ohya
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)