Article
Nanoscience & Nanotechnology
Qingzhi Wu, Moyuan Qu, Han-Jun Kim, Xingwu Zhou, Xing Jiang, Yi Chen, Jixiang Zhu, Li Ren, Tyler Wolter, Heemin Kang, Chun Xu, Zhen Gu, Wujin Sun, Ali Khademhosseini
Summary: The study demonstrates a minimally invasive strategy of locally delivering anti-PD 1 using shear-thinning biomaterials, offering a simple and efficient approach to deliver immune checkpoint inhibitors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Man Liu, Wanming Hu, Yixuan Zhang, Ning Zhang, Luohai Chen, Yuan Lin, Yu Wang, Yanji Luo, Yu Guo, Minhu Chen, Jie Chen
Summary: This study characterizes the immune landscape and its correlation with clinical characteristics in thymic neuroendocrine neoplasms (T-NEN). It identifies CD8(+) tumor-infiltrating lymphocytes (TILs) as a potential marker to predict bone metastasis. The presence of an immune-inflamed landscape in T-NEN suggests that it could be a favorable target for immune checkpoint blockade (ICB) treatment. Further tailor-made clinical trials of ICB in T-NEN are urgently needed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Seung Eun Lee, Malek Shatila, Enrico N. De Toni, Helga-Paula Toeroek, Najib Ben Khaled, Nicholas Powell, Ryan Weight, David M. Faleck, Yinghong Wang
Summary: This study evaluated the efficacy of ustekinumab in treating immune checkpoint inhibitor-mediated colitis refractory to steroids plus infliximab and/or vedolizumab.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Giovanni Bocchialini, Ana-Iris Schiefer, Leonhard Muellauer, Jurgen Thanner, Jonas Bauer, Felizia Thaler, Maria Laggner, Cecilia Veraar, Walter Klepetko, Konrad Hoetzenecker, Jose Ramon Matilla, Hendrik Jan Ankersmit, Bernhard Moser
Summary: By studying the distribution and activation of immune cells in thymic carcinoma, we found that the density of TILs is associated with tumor invasiveness, recurrence, and survival rate. High density of certain TILs is associated with better prognosis, supporting the use of immune checkpoint inhibitors in thymic carcinoma patients.
BRITISH JOURNAL OF CANCER
(2022)
Article
Immunology
Tinglei Huang, Fuli Li, Xiaojiao Cheng, Jianzheng Wang, Wenhui Zhang, Baiwen Zhang, Yao Tang, Qingli Li, Cong Zhou, Shuiping Tu
Summary: In this study, it was demonstrated that inhibiting the Wnt/β-catenin signaling pathway enhances the efficacy of PD-L1 blockade therapy, overcoming immune resistance mediated by CAFs. Knocking out PD-L1 in BMFs can restore sensitivity to PD-L1 blockade therapy in BMF-mixed tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren, Liwen Yu, Qian Li, Yapeng Liu, Wenqian Qi, Yonghao Hou, Wenhai Sui, Guohai Su, Yun Zhang, Cheng Zhang, Meng Zhang
Summary: Innate immunity is the first defense line against pathogenic microorganisms, and Toll-like receptor (TLR)-mediated inflammatory responses play a crucial role. However, the regulatory mechanisms of TLRs in innate immunity are not well understood. This study showed that the E3 ligase Ring finger protein 99 (RNF99) plays a role in regulating TLR-mediated inflammatory responses and its deficiency enhances inflammatory cytokine expression in macrophages. Mechanistically, RNF99 interacts with and degrades the regulatory protein TAB2, thus regulating TLR-mediated inflammatory signaling. These findings provide new insights into TLR signal transduction and offer potential approaches for preventing bacterial infections and inflammatory diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Critical Care Medicine
Jeremie Joffre, Lisa Raia, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Paul Coppo, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
Summary: This pilot observational study aimed to explore endothelial-mediated vasoreactivity in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients at admission and its changes after plasma exchange therapy (PE). The study found that iTTP patients had impaired endothelial-mediated skin microvascular reactivity at admission, but it improved after PE.
Article
Medicine, Research & Experimental
Dong Shao, Yaping Chen, Hao Huang, Yingting Liu, Junjun Chen, Dawei Zhu, Xiao Zheng, Lujun Chen, Jingting Jiang
Summary: This study demonstrates that the combination therapy of LAG3 blockade and microwave ablation (MWA) is a unique treatment strategy for certain solid tumors, which can alter the tumor microenvironment and extend survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Qiuyu Wu, Yuanhang Xia, Xiaohe Xiong, Xinxing Duan, Xiaoxiao Pang, Fugui Zhang, Song Tang, Junlei Su, Shuqiong Wen, Li Mei, Richard D. Cannon, Ping Ji, Zhanpeng Ou
Summary: In recent years, immune checkpoint blockade (ICB) therapy assisted by focused ultrasound (FUS)-controlled small-molecule delivery systems has shown great potential in enhancing the anti-tumor effects of ICB while minimizing side effects. By using FUS to deliver genetic materials, catalysts, and chemotherapeutic agents to tumor sites, precise and targeted treatment can be achieved. This review provides an updated overview of the progress made in this field and discusses the synergetic effects and underlying mechanisms of these combination strategies, as well as the limitations and future directions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Huapan Fang, Zhaopei Guo, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li, Huayu Tian, Xuesi Chen
Summary: While immunotherapy has shown promise as a cancer treatment, durable benefits are often limited by immune escape mechanisms. This study combines epigenetic regulation with gene therapy for immune checkpoint blockade to enhance anti-tumor effects and immune responses in vivo, providing a potential strategy for tumor treatment and prevention of relapse and metastasis.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Rita Lima-Sousa, Bruna L. Melo, Catia G. Alves, Andre F. Moreira, Antonio G. Mendonca, Ilidio J. Correia, Duarte de Melo-Diogo
Summary: The combination of nanomaterial-mediated photothermal-photodynamic therapy with ICIs shows potential in targeting metastatic cancer by generating heat and reactive oxygen species within the tumor, modulating T cell populations, and inducing an anti-metastatic effect. This approach may also lead to the development of immune memory to prevent tumor recurrence.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Environmental Sciences
Benedikt Luckner, Fabian Essfeld, Steve U. Ayobahan, Elke Richling, Elke Eilebrecht, Sebastian Eilebrecht
Summary: This study analyzed the transcriptomic profiles of zebrafish embryos in response to immunosuppressive and immunostimulatory compounds, aiming to explore the immunotoxic modes of action. The research validated some genes as potential biomarkers for immunotoxicity and identified new biomarkers with differentiating power.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Yu Cui, Xinyue Han, Hongtao Liu, Qi Xie, Yaping Guan, Beibei Yin, Junjuan Xiao, Dongfeng Feng, Xuan Wang, Junwei Li, Jinghua Chen, Xiaolin Liu, Xingyu Li, Weiwei Nie, Lin Ma, Hairong Liu, Jing Liang, Yan Li, Baocheng Wang, Jun Wang
Summary: This study finds that cancer patients have higher levels of endogenous glucocorticoid (GC) compared to healthy individuals. High baseline endogenous GC levels in cancer patients are associated with reduced efficacy of immune checkpoint blockade therapy, disease progression, and shortened survival. In addition, high endogenous GC levels are correlated with decreased immune cell numbers, increased cytokine levels, and reduced tumor infiltrating immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xue Xue, Jin Li, Yu Fan, Mingwu Shen, Xiangyang Shi
Summary: The study developed a functional nanoplatform based on G5 PAMAM dendrimer-entrapped gold nanoparticles for delivering siPD-L1 to achieve PD-L1 gene silencing-mediated tumor immunotherapy. The functional Au DENPs successfully delivered siPD-L1 to cancer cells, efficiently knocking down PD-L1 protein expression and enhancing the efficacy of ICB-based immunotherapy.
SCIENCE CHINA-MATERIALS
(2021)
Review
Oncology
Wenwen Yang, Caining Lei, Shaoming Song, Wutang Jing, Chuanwei Jin, Shiyi Gong, Hongwei Tian, Tiankang Guo
Summary: There has been a paradigm shift in cancer treatment with the emergence of immune checkpoint inhibitors, targeting PD-1 and PD-L1 pathways. The efficacy of these drugs may be related to PD-L1 expression and other emerging biomarkers. Customized medication models and predictive markers are becoming the new trend in malignant tumor immunotherapy.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Casimiro Gerarduzzi, John A. Di Battista
INFLAMMATION RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Thomas Demoulinsa, Thomas Ebensen, Kai Schulze, Pavlos C. Englezou, Maria Pelliccia, Carlos A. Guzman, Nicolas Ruggli, Kenneth C. McCullough
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Medicine, Research & Experimental
Pavlos C. Englezou, Cedric Sapet, Thomas Demoulins, Panagiota Milona, Thomas Ebensen, Kai Schulze, Carlos-Alberto Guzman, Florent Poulhes, Olivier Zelphati, Nicolas Ruggli, Kenneth C. McCullough
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Multidisciplinary Sciences
Daniel Feng, Cindy Ngov, Nathalie Henley, Nadia Boufaied, Casimiro Gerarduzzi
SCIENTIFIC REPORTS
(2019)
Review
Oncology
Casimiro Gerarduzzi, Ursula Hartmann, Andrew Leask, Elliot Drobetsky
Review
Biochemistry & Molecular Biology
Daniel Feng, Casimiro Gerarduzzi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Cindy Lora Gil, Nathalie Henley, Francois A. Leblond, Naoufal Akla, Louis-Philippe Laurin, Virginie Royal, Casimiro Gerarduzzi, Vincent Pichette, Bruno Larrivee
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Thomas Demoulins, Nicolas Ruggli, Markus Gerber, Lisa J. Thomann-Harwood, Thomas Ebensen, Kai Schulze, Carlos A. Guzman, Kenneth C. McCullough
Summary: RepRNA promotes expansion of mRNA templates encoding genes of interest through their replicative nature, providing increased antigen payloads. Comparisons showed that packaging within VRP remains the most efficacious for delivery leading to induction of immune defences, while naked RepRNA had lower efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Thomas Demoulins, Melanie Brugger, Beatrice Zumkehr, Blandina I. Oliveira Esteves, Kemal Mehinagic, Amal Fahmi, Loic Borcard, Adriano Taddeo, Damian Jandrasits, Horst Posthaus, Charaf Benarafa, Nicolas Ruggli, Marco P. Alves
Summary: Using a model of newborn lambs, researchers found significant differences in the T cell compartment of the neonatal lung compared to the mature adult lung, with RSV infection exacerbating a pro-type 2 environment in the bronchoalveolar space. Regulatory T cells play a key role in dampening the pro-type 2 environment early on, affecting the severity of RSV disease.
Article
Microbiology
Melanie Brugger, Thomas Demoulins, G. Tuba Barut, Beatrice Zumkehr, Blandina I. Oliveira Esteves, Kemal Mehinagic, Quentin Haas, Aline Schogler, Marie-Anne Rameix-Welti, Jean-Francois Eleouet, Ueli Moehrlen, Thomas M. Marti, Ralph A. Schmid, Artur Summerfield, Horst Posthaus, Nicolas Ruggli, Sean R. R. Hall, Marco P. Alves
Summary: The research highlights the critical role of lung-resident MSCs in virus-induced acute lung injury, showing their involvement in immune response, repair mechanisms, and expansion of the pulmonary MSC pool following infection. These findings contribute to a better understanding of host response and lung repair mechanisms, with potential therapeutic implications.
Article
Cell Biology
Michael P. Grant, Nathalie Henley, Marion Dubuissez, Nan Chen, Ursula Hartmann, Virginie Royal, Olivier Barbier, Vincent Pichette, Casimiro Gerarduzzi
Summary: Tungsten, a naturally occurring transition element, can impair kidney function and potentially lead to the development of chronic kidney disease when exposed to for a prolonged period.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Daniel Feng, Peng Gao, Nathalie Henley, Marion Dubuissez, Nan Chen, Louis-Philippe Laurin, Virginie Royal, Vincent Pichette, Casimiro Gerarduzzi
Summary: SMOC2 is highly expressed in RCC tissue and is associated with shorter patient survival. SMOC2 induces EMT in kidney epithelial cells, promoting RCC metastasis. Mechanistically, SMOC2 activates EMT through the integrin beta 3, FAK, and paxillin pathway. In vivo studies demonstrate that SMOC2 overexpression leads to increased tumor growth and metastatic potential.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kaixuan Diao, Jing Chen, Tao Wu, Xuan Wang, Guangshuai Wang, Xiaoqin Sun, Xiangyu Zhao, Chenxu Wu, Jinyu Wang, Huizi Yao, Casimiro Gerarduzzi, Xue-Song Liu
Summary: Seq2Neo is a pipeline that predicts the immunogenicity of neoantigens by providing a solution for neoepitope feature prediction using raw sequencing data. It supports different types of genome DNA alterations and includes a CNN-based model that shows improved performance in immunogenicity prediction compared to currently available tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nils Lannes, Obdullio Garcia-Nicolas, Thomas Demoulins, Artur Summerfield, Luis Filgueira
SCIENTIFIC REPORTS
(2019)
Review
Urology & Nephrology
Samuel A. Silver, Casimiro Gerarduzzi
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2019)