Article
Engineering, Biomedical
Saba Ghassemi, Joseph S. Durgin, Selene Nunez-Cruz, Jai Patel, John Leferovich, Marilia Pinzone, Feng Shen, Katherine D. Cummins, Gabriela Plesa, Vito Adrian Cantu, Shantan Reddy, Frederic D. Bushman, Saar Gill, Una O'Doherty, Roddy S. O'Connor, Michael C. Milone
Summary: Non-activated CAR T cells can be generated within 24 hours from T cells derived from peripheral blood, without the need for T-cell activation. This rapid manufacturing method has the potential to reduce production costs and broaden the applicability of CAR T cells.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Immunology
Jaishree Sharma, Srinivasu Mudalagiriyappa, Som Gowda Nanjappa
Summary: In recent years, significant findings have been made in the field of antifungal T-cell immunity research, particularly in understanding the development and role of antifungal memory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Srinivasu Mudalagiriyappa, Jaishree Sharma, Miranda D. Vieson, Som Gowda Nanjappa
Summary: GM-CSF+ Tc17 cells play a crucial role in fungal vaccine immunity by enhancing pulmonary fungal immunity without causing pathology. IL-1 and IL-23 are key factors for inducing these cells.
Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Astrid Hendriks, Malgorzata Ewa Mnich, Bruna Clemente, Ana Rita Cruz, Simona Tavarini, Fabio Bagnoli, Elisabetta Soldaini
Summary: The skin, as an immunocompetent tissue, contains various immune cells and a diverse microbiome. CD4(+) T cells play a crucial role in protecting against Staphylococcus aureus infection, and skin-specific CD4(+) T cells have been identified in response to S. aureus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Suzanna Paterson, Satwik Kar, Seng Kuong Ung, Zoe Gardener, Emma Bergstrom, Stephanie Ascough, Mohini Kalyan, Joanna Zyla, Jeroen Maertzdorf, Hans-Joachim Mollenkopf, January Weiner, Agnieszka Jozwik, Hannah Jarvis, Akhilesh Jha, Bradly P. Nicholson, Timothy Veldman, Chris W. Woods, Patrick Mallia, Onn Min Kon, Stefan H. E. Kaufmann, Peter J. Openshaw, Christopher Chiu
Summary: The study highlighted the suboptimal vaccine immunogenicity, antigenic mismatch, and poor uptake leading to influenza remaining a major global disease. Investigating the kinetics, phenotypes, and function of influenza virus-specific CD8(+) resident memory T cells in the lower airway, it was found that CD8(+) Trm cells in the human lung display innate-like gene and protein expression that demonstrates blurred divisions between innate and adaptive immunity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Di Wang, Yu Jiang, Yangzi Song, Yongqin Zeng, Cuilin Li, Xinyue Wang, Ying Liu, Jiang Xiao, Yaxian Kong, Hongxin Zhao
Summary: The study revealed that CD4(+) T cells in PLHIV exhibited enhanced secretion of proinflammatory cytokines and polyfunctionality due to HIV disease progression, while altered T-cell subsets led to discordant results in total and CD4(+) T-cell subsets.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Article
Cell Biology
Daan K. J. Pieren, Noortje A. M. Smits, Jeroen Hoeboer, Vinitha Kandiah, Rimke J. Postel, Rob Mariman, Josine van Beek, Debbie van Baarle, Jelle de Wit, Teun Guichelaar
Summary: A novel human CD8(+) T-cell subset, KIR(+)RA(+) T cells, has been identified to accumulate with age in healthy individuals and become activated in older adults suffering from acute respiratory viral infections. These cells are associated with longer duration of respiratory symptoms in older adults with influenza A infection, suggesting a potential role in susceptibility to viral respiratory diseases in old age.
Article
Biology
Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi H. O. Nguyen, Lilith F. Allen, Katherine Kedzierska, Yanliang Jin, Mei-Rong Du, Wanping Chen, Liangjing Lu, Nan Shen, Zheng Liu, Ian A. Cockburn, Wenjing Luo, Di Yu
Summary: A defining feature of successful vaccination is the induction of long-lived antigen-specific memory cells. This study reveals that Tfh17 cells play a key role in maintaining and enhancing humoral immune responses. The results from both mouse and human experiments suggest that Tfh17-induced immunization might be preferable for long-term protection in vaccine development.
Article
Immunology
Masaya Suematsu, Shigeki Yagyu, Nobuyoshi Nagao, Susumu Kubota, Yuto Shimizu, Miyuki Tanaka, Yozo Nakazawa, Toshihiko Imamura
Summary: Research shows that piggyBac (PB)-mediated CD19 CAR-T cells exhibit a memory-rich phenotype and superior antitumor activity. CD45RA(+) PBMCs could be an efficient starting material for PB-CAR-T cell manufacturing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Min Li, Di Xie, Xinfeng Tang, Chen Yang, Yanqiong Shen, Han Zhou, Wuxian Deng, Jiwei Liu, Shanbao Cai, Li Bai, Yucai Wang
Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.
Article
Multidisciplinary Sciences
Nina Koerber, Alina Priller, Sarah Yazici, Tanja Bauer, Cho-Chin Cheng, Hrvoje Mijocevic, Hannah Wintersteller, Samuel Jeske, Emanuel Vogel, Martin Feuerherd, Kathrin Tinnefeld, Christof Winter, Juergen Ruland, Markus Gerhard, Bernhard Haller, Catharina Christa, Otto Zelger, Hedwig Roggendorf, Martin Halle, Johanna Erber, Paul Lingor, Oliver Keppler, Dietmar Zehn, Ulrike Protzer, Percy A. Knolle
Summary: Anti-viral immunity declines over time after SARS-CoV-2 infection, but convalescents can achieve enhanced immune response through vaccination. Virus-specific antibody titers decline rapidly, while virus-specific polyfunctional T cells persist.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Katherine M. Audsley, Teagan Wagner, Clara Ta, Hannah Newnes, Anthony C. Buzzai, Samantha A. Barnes, Ben Wylie, Jesse Armitage, Tsuneyasu Kaisho, Anthony Bosco, Alison McDonnell, Mark Cruickshank, Vanessa S. Fear, Bree Foley, Jason Waithman
Summary: The study found that in comparison to other subtypes, IFN beta, in combination with vaccination, can significantly increase the expansion of tumor-specific CD8(+) T cells. This optimal expansion is dependent on the presence of XCR1(+) dendritic cells, CD4(+) T cells, and CD40/CD40L signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Lia P. Iglesias, Heliana B. Fernandes, Aline S. de Miranda, Malena M. Perez, Lucia H. Faccioli, Carlos A. Sorgi, Leandro J. Bertoglio, Daniele C. Aguiar, Carsten T. Wotjak, Fabricio A. Moreira
Summary: This study found that hippocampal TRPV1 channels play a role in the modulation of fear memories. Endocannabinoid signaling may mediate the effects of TRPV1 blockers. The intensity of the aversive stimulus affects the regulation of fear memories by TRPV1 channels. TRPV1 blockers also promote the transcription of specific genes, leading to a decrease in fear memory reinstatement.
Article
Immunology
Carlos A. Fuzo, Thais F. C. Fraga-Silva, Sandra R. Maruyama, Victor A. F. Bastos, Luana A. Rogerio, Nayore T. Takamiya, Pedro V. da Silva-Neto, Vinicius E. Pimentel, Diana M. Toro, Malena M. Perez, Jonatan C. S. de Carvalho, Ingryd Carmona-Garcia, Camilla N. S. Oliveira, Augusto M. Degiovani, Fatima M. Ostini, Leticia F. Constant, Alessandro P. de Amorim, Fernando C. Vilar, Marley R. Feitosa, Rogerio S. Parra, Jose J. R. da Rocha, Omar Feres, Gilberto G. Gaspar, Angelina L. Viana, Ana P. M. Fernandes, Isabel K. F. M. Santos, Elisa M. S. Russo, Cristina R. B. Cardoso, Carlos A. Sorgi, Lucia H. Faccioli, Vania L. D. Bonato, Marcelo Dias-Baruffi
Summary: COVID-19 patients exhibit a wide range of clinical manifestations due to the heterogeneity of the host immune response. By analyzing blood transcriptome, demographic data, clinical aspects, and laboratory findings, we identified perturbations in the blood-leukocyte transcriptional profile that are associated with COVID-19 aggravation and stratify patients according to disease severity. These molecular changes involve processes that inhibit lymphocyte activation and promote neutrophil activation, and the central genes of this unique neutrophil signature are S100A9, ANXA3, CEACAM6, VNN1, OLFM4, IL1R2, TCN1, and CD177.
Review
Biochemistry & Molecular Biology
Mohamed Amine Jmel, Hanne Voet, Ricardo N. Araujo, Lucas Tirloni, Anderson Sa-Nunes, Michail Kotsyfakis
Summary: Kunitz domain-containing proteins are serine protease inhibitors with therapeutic potential. They inhibit key proteases involved in inflammation or hemostasis through competitive inhibition. Tick saliva contains Kunitz-type inhibitors that play a role in host inhibition and blood feeding. Understanding their effects on host immunity and hemostasis may lead to novel therapies and vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Naiara Naiana Dejani, Carolina F. Nicoletti, Perla Pizzi Argentato, Ludmilla da Silva Pereira, Amanda Correia Saraiva, Leticia Montanha de Assis, Patricia Yury Nakandakare, Livia Patricia Rodrigues Batista, Laisla de Franca da Silva Teles, Maria Paula Leitao, Liania Alves Luzia, Alexandra Ivo de Medeiros, Patricia Helen Rondo
Summary: This study investigates the associations between maternal and cord blood cytokine patterns and newborn size and body composition. A total of 70 pregnant women and their healthy newborns were included. The results show that maternal plasma TGF-b1 concentration is inversely associated with newborn weight, length, head circumference, and fat-free mass. However, after adjusting for confounding factors, the association remains significant only for head circumference and ponderal index.
JORNAL DE PEDIATRIA
(2023)
Review
Immunology
C. Henrique Serezani, Maziar Divangahi, Marc Peters-Golden
Summary: The article provides an overview of the various roles of Leukotrienes (LTs) in host defense, including their protective effects against pathogens, involvement in cell signal transduction mechanisms, promotion of tissue damage, and their roles in noninfectious immune-related conditions such as inflammation and cancer.
JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Neil T. Sprenkle, C. Henrique Serezani, Heather H. Pua
Summary: Macrophages are important immune cells that maintain tissue homeostasis and contribute to inflammation. MicroRNAs play a role in macrophage function and regulate cellular programming and macrophage-driven pathology. Understanding the gene networks regulated by microRNAs provides insight into macrophage function and potential miRNA-based therapies.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Oncology
Sandra P. Palma Albornoz, Thais F. C. Fraga-Silva, Renan V. H. de Carvalho, Tamara S. Rodrigues, Ana Flavia Gembre, Romulo Silva de Oliveira, Fernanda Mesquita de Souza, Giseli Furlan Correa, Leandra N. Z. Ramalho, Daniela Carlos, Danilo C. de Almeida, Niels O. S. Camara, Dario S. Zamboni, Viviani Nardini Takahashi, Carlos A. Sorgi, Lucia H. Faccioli, Alexandra Medeiros, Diego Luis Costa, Vania L. D. Bonato
Summary: A low-grade and persistent inflammation in obesity requires the participation of NLRP3 and cell death. However, during obesity-tuberculosis comorbidity, NLRP3 signaling may play a detrimental role by inducing excessive inflammation. The study shows that NLRP3 signaling promotes cell death without affecting bacterial loads.
JOURNAL OF PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rafaela Silva dos Santos, Flavio Protassio Veras, Goncalves Pedro Netto, Carlos Arterio Sorgi, Lucia Helena Faccioli, Luciano Rezende Vilela, Giovane Galdino
Summary: The study found that bacterial LPS can induce pain in mice, but CBD treatment can attenuate this pain by inhibiting the activation of TLR4. CBD may be a potential treatment strategy for controlling LPS-induced pain.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Flavia Amadeu de Oliveira, Cintia K. Tokuhara, Vimal Veeriah, Joao Paulo Domezi, Mariana R. Santesso, Tania M. Cestari, Talita M. O. Ventura, Adriana A. Matos, Thiago Dionisio, Marcel R. Ferreira, Rafael C. Ortiz, Marco A. H. Duarte, Marilia A. R. Buzalaf, Jose B. Ponce, Carlos A. Sorgi, Lucia H. Faccioli, Camila Peres Buzalaf, Rodrigo Cardoso de Oliveira
Summary: This study found that the absence of 5-LO enzyme enhances osteoblast differentiation and mineralization but inhibits their proliferation, resulting in increased bone formation. However, it has negative effects on the function of osteoclasts. These findings demonstrate the association of 5-LO deficiency with a stronger osteogenic profile.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rafaela dos Santos, Flavio Veras, Goncalves Netto, Livia Elisei, Carlos Sorgi, Lucia Faccioli, Giovane Galdino
Summary: This study aimed to investigate the effect of CBD on TLR4, glial cells, and pro-inflammatory cytokines during PTX-induced neuropathic pain. The results showed that CBD prevented PTX-induced neuropathic pain, possibly through inhibition of TLR4 and activation of the endocannabinoid system. CBD also increased levels of endocannabinoids and reduced cytokine levels in mice with neuropathic pain.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Virology
Jonatan C. S. de Carvalho, Pedro V. da Silva-Neto, Diana M. Toro, Carlos A. Fuzo, Viviani Nardini, Vinicius E. Pimentel, Malena M. Perez, Thais F. C. Fraga-Silva, Camilla N. S. Oliveira, Augusto M. Degiovani, Fatima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Jose J. R. da Rocha, Omar Feres, Fernando C. Vilar, Gilberto G. Gaspar, Isabel K. F. M. Santos, Ana P. M. Fernandes, Sandra R. Maruyama, Elisa M. S. Russo, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Lucia H. Faccioli, Carlos A. Sorgi
Summary: COVID-19 is associated with immune dysregulation, and glucocorticoids (GCs) have attracted attention for their role in inhibiting pro-inflammatory cytokines. The endocannabinoid (eCB) system also regulates immune response. However, the effect of GCs on the lipid pathway in COVID-19 therapy is still unknown.
Article
Cell Biology
Diana Mota V. Toro, Pedro V. da Silva-Neto, Jonatan C. S. A. de Carvalho, Carlos A. M. Fuzo, Malena M. Perez, Vinicius E. Pimentel, Thais F. C. Fraga-Silva, Camilla N. S. R. Oliveira, Glaucia R. Caruso, Adriana F. L. Vilela, Pedro V. Nobre-Azevedo, Thiago V. Defelippo-Felippe, Jamille G. M. M. Argolo, Augusto M. Degiovani, Fatima M. R. Ostini, Marley R. S. Feitosa, Rogerio S. C. Parra, Fernando C. G. Vilar, Gilberto G. Gaspar, Jose J. R. da Rocha, Omar P. Feres, Gabriel P. Costa, Sandra R. C. Maruyama, Elisa M. S. Russo, Ana Paula M. Fernandes, Isabel K. F. M. Santos, Adriana T. Malheiro, Ruxana T. Sadikot, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Atila A. Trape, Lucia H. A. Faccioli, Carlos A. Sorgi, ImmunoCovid Consortium Grp
Summary: SARS-CoV-2 infection leads to distinct disease patterns with significant changes in host regulatory responses. Severe cases suffer from lung inflammation and systemic effects, while critically ill patients experience a lipid storm that affects inflammation and tissue damage. Sphingolipids play critical roles in various cellular processes and may serve as potential biomarkers and therapeutic targets for COVID-19.
Article
Parasitology
Andrade Yasmin Monara Ferreira de Sousa, Monara Viera de Castro, Victor de Souza Tavares, Rayane da Silva Oliveira Souza, Lucia Helena Faccioli, Jonilson Berlink Lima, Carlos Arterio Sorgi, Valeria M. Borges, Theo Araujo-Santos
Summary: This study compared lipid droplet (LD) formation and eicosanoid production in different Leishmania species that cause different clinical forms of leishmaniasis. The results show that LD formation and eicosanoid production are regulated by different polyunsaturated fatty acids (PUFAs) in different Leishmania species. Furthermore, Leishmania species with equivalent tissue tropism have similar protein mutations.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
