Article
Immunology
Tanglin Ouyang, Liyu Song, Huiling Fang, Ji Tan, Yue Zheng, Jinping Yi
Summary: Rheumatoid arthritis is a chronic autoimmune disease that primarily affects synovial joints, leading to synovial inflammation and joint damage. Timely and effective treatment is crucial for disease control, but misdiagnosis or delayed treatment often results in worsened condition and poor prognosis, significantly impacting patients' quality of life.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Tamara Matthyssen, Wenyi Li, James A. Holden, Jason C. Lenzo, Sara Hadjigol, Neil M. O'Brien-Simpson
Summary: Antimicrobial peptides (AMPs) have broad spectrum antibacterial activity, can modulate the immune system, but face limitations such as toxicity, lower activity under physiological conditions, and susceptibility to proteolytic degradation. Modifications to AMP sequences and multimerisation can enhance antimicrobial activity and specificity while reducing toxicity to mammalian cells.
FRONTIERS IN CHEMISTRY
(2022)
Review
Oncology
Hao-Jie Wang, Ya-Ping Jiang, Jun-Ying Zhang, Xiao-Qi Tang, Jian-Shu Lou, Xin-Yun Huang
Summary: This review summarizes the role of fascin in both normal dendritic cells and intratumoral dendritic cells. In normal dendritic cells, fascin promotes immune effects by facilitating dendritic cell maturation and migration. In cancer patients, high levels of fascin expression have been observed in intratumoral dendritic cells, and activation of this subset of cells enhances antitumor immune response. Fascin inhibitors targeting intratumoral dendritic cells increase cell accumulation and activation, and cooperate with immune checkpoint inhibitors.
Review
Biochemistry & Molecular Biology
Reza Hosseini, Leila Asef-Kabiri, Hassan Yousefi, Hamzeh Sarvnaz, Majid Salehi, Mohammad Esmaeil Akbari, Nahid Eskandari
Summary: This paper delves into the impact of tumor-derived exosomes on dendritic cells and how they induce subversion of DCs differentiation, maturation, and function, as well as their significance at the therapeutic level. Understanding the exosomal content and pathways responsible for immune evasion could lead to the development of novel therapeutic approaches.
Review
Microbiology
Kristie D. Goughenour, Ayesha S. Nair, Jintao Xu, Michal A. Olszewski, Karen L. Wozniak
Summary: Fungal infections, especially Cryptococcus, are a growing public health concern. The immune response, specifically the T-cell response mediated by dendritic cells (DCs), plays a critical role in protecting the host from pulmonary Cryptococcus infections. DCs are not only important for adaptive immunity, but also armed cells of the innate immune system capable of recognizing and killing fungal cells.
Review
Nanoscience & Nanotechnology
Muhammad Ikram, Bilal Javed, Naveed Iqbal Raja, Zia-ur-Rehman Mashwani
Summary: Plant-based synthesis of selenium nanoparticles is being explored for potential health benefits and drug delivery. This approach shows promise for advancement in the pharmaceutical industry and has been shown to have potential therapeutic effects on cancer cells, microbial pathogens, viral infections, and some chronic diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Junhu Tai, Jiwon Kwak, Munsoo Han, Tae Hoon Kim
Summary: This review discusses the role of dendritic cells (DCs) in chronic rhinosinusitis (CRS) and their function in the nasal sinus mucosa. Studies have shown that DCs may play an important role in the pathogenesis of CRS and can be targeted for therapeutic intervention. Future research directions need to be further explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Kirti Singh, Abhishek Kundu, Debashis Adhikari
Summary: This article discusses the importance of ligands in coordination chemistry and highlights the impact of redox-active ligands in catalysis research. These ligands can act as redox reservoirs and also influence catalytic processes by changing the basicity of the metal.
Review
Cell Biology
Theodora Katopodi, Savvas Petanidis, Charalampos Charalampidis, Ioanna Chatziprodromidou, Panagiotis Eskitzis, Drosos Tsavlis, Paul Zarogoulidis, Christoforos Kosmidis, Dimitris Matthaios, Konstantinos Porpodis
Summary: The tumor microenvironment, particularly the dendritic cells (DCs), plays a crucial role in tumor progression, metastasis, and immunosuppression. This review examines the function of tumor-infiltrating DCs in immune cell signaling pathways, treatment resistance, tumor recurrence, and immunosuppression. Special emphasis is given to DC metabolism, differentiation, and plasticity, as well as the interaction between myeloid cells and DCs in tumor-related immunosuppression. The article also discusses the molecular immune-related mechanisms in the tumor microenvironment that lead to reduced drug sensitivity and tumor relapse, and explores innovative approaches for therapeutic modulation of immunosuppressive DCs.
Review
Biochemistry & Molecular Biology
Lily Chan, Geoffrey A. Wood, Sarah K. Wootton, Byram W. Bridle, Khalil Karimi
Summary: Neutrophils have contradictory roles in cancer development, both promoting anti-tumor responses and tumor growth. Their diverse functions can be regulated by environmental stimuli, making research on targeting neutrophils crucial. This article reviews the dual functionality of neutrophils in cancer and discusses their interactions with dendritic cells (DCs) during immune responses, as well as their implications in DC cancer vaccination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jinpu Yang, Xia Liu, Yiwen Cheng, Jingchen Zhang, Feng Ji, Zongxin Ling
Summary: Gastric cancer is the fifth most common neoplasm and the third most deadly cancer worldwide. Helicobacter pylori infection is the major cause of gastric carcinogenesis and triggers immune responses in the host. Plasmacytoid dendritic cells (pDCs), as important components of the tumor immune microenvironment, have been gaining attention for their potential roles in immunosuppression. Recent studies have shown that pDCs play vital roles in the development of immunosuppression in gastric cancer. Understanding the contribution of pDCs to the development and progression of gastric cancer may lead to improved cancer therapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng, Biao Wang
Summary: m6A modification, a common internal modification on RNA molecules, has been linked to various human diseases, making it a research hotspot. This modification plays a regulatory role in immune responses, affecting disease development.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francesco Piacente, Marta Bottero, Andrea Benzi, Tiziana Vigo, Antonio Uccelli, Santina Bruzzone, Giovanni Ferrara
Summary: Myeloid cells, including parenchymal microglia, perivascular and meningeal macrophages, and dendritic cells (DCs), have a crucial role in the central nervous system (CNS). DCs play a critical role in orchestrating the immune response and act as sentinels under steady-state conditions. The exact function of DCs in CNS disease is still debated, but their neuroprotective nature and therapeutic potential for neurological conditions are emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Maarij Khan, Zia-ur-Rehman Mashwani, Muhammad Ikram, Naveed Raja, Azza H. Mohamed, Guogang Ren, Ahmad A. Omar
Summary: This review article provides a detailed overview of the therapeutic actions and mechanisms of green synthesized cerium oxide nanoparticles in the medical field, which can contribute to the advancement and precision of medicine and provide important information for disease diagnosis and treatment strategies.
Review
Pharmacology & Pharmacy
Chengyong Ma, Hanrui Liu, Shuo Yang, Hong Li, Xuelian Liao, Yan Kang
Summary: Sepsis is a life-threatening syndrome caused by abnormal host response to infection. Immune dysfunction is central to its occurrence and development. Dysfunction of B cells in sepsis is linked to immune derangement mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Marie Lecouffe-Desprets, Caroline Hemont, Antoine Neel, Claire Toquet, Agathe Masseau, Mohamed Hamidou, Regis Josien, Jerome C. Martin
Editorial Material
Immunology
Nicolas Vince, Jeremie Poschmann, Regis Josien, Ignacio Anegon, Sophie Limou, Pierre-Antoine Gourraud
Article
Rheumatology
Antoine Neel, Marie Bucchia, Melanie Neel, Gaelle Tilly, Aurelie Caristan, Michele Yap, Marie Rimbert, Sarah Bruneau, Marion Cadoux, Christian Agard, Maryvonne Hourmant, Pascal Godmer, Sophie Brouard, Celine Bressollette, Mohamed Hamidou, Regis Josien, Fadi Fakhouri, Nicolas Degauque
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Medicine, Research & Experimental
Lyssia Belarif, Richard Danger, Laetitia Kermarrec, Veronique Nerriere-Daguin, Sabrina Pengam, Tony Durand, Caroline Mary, Elise Kerdreux, Vanessa Gauttier, Aneta Kucik, Virginie Thepenier, Jerome C. Martin, Christie Chang, Adeeb Rahman, Nina Salabert-Le Guen, Cecile Braudeau, Ahmed Abidi, Gregoire David, Florent Malard, Celine Takoudju, Bernard Martinet, Nathalie Gerard, Isabelle Neveu, Michel Neunlist, Emmanuel Coron, Thomas T. MacDonald, Pierre Desreumaux, Hoa-Le Mai, Stephanie Le Bas-Bernardet, Jean-Francois Mosnier, Miriam Merad, Regis Josien, Sophie Brouard, Jean-Paul Soulillou, Gilles Blancho, Arnaud Bourreille, Philippe Naveilhan, Bernard Vanhove, Nicolas Poirier
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Immunology
Michael R. Daws, Britt Nakken, Ana Lobato-Pascual, Regis Josien, Erik Dissen, Sigbjorn Fossum
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Laure-Helene Ouisse, Severine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, Lucas Brusselle, Nadege Vimond, Karl Rouger, Yann Pereon, Alexis Chenouard, Christele Gras-Le Guen, Cecile Braudeau, Regis Josien, Corinne Huchet, Ignacio Anegon
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Eros Marin, Laurence Bouchet-Delbos, Ophelie Renoult, Cedric Louvet, Veronique Nerriere-Daguin, Amy J. Managh, Amandine Even, Matthieu Giraud, Thien Phong Vu Manh, Audrey Aguesse, Gaelle Beriou, Elise Chiffoleau, Brigitte Alliot-Licht, Xavier Prieur, Mikael Croyal, James A. Hutchinson, Natasa Obermajer, Edward K. Geissler, Bernard Vanhove, Gilles Blancho, Marc Dalod, Regis Josien, Claire Pecqueur, Maria-Cristina Cuturi, Aurelie Moreau
Article
Biochemistry & Molecular Biology
Alexis Broquet, Anissa Besbes, Jerome Martin, Cedric Jacqueline, Mickael Vourc'h, Antoine Roquilly, Jocelyne Caillon, Regis Josien, Karim Asehnoune
MOLECULAR IMMUNOLOGY
(2020)
Article
Immunology
Ahmed Abidi, Thomas Laurent, Gaelle Beriou, Laurence Bouchet-Delbos, Cynthia Fourgeux, Cedric Louvet, Raja Triki-Marrakchi, Jeremie Poschmann, Regis Josien, Jerome Martin
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Laurence Bouchet-Delbos, Amandine Even, Emilie Varey, Soraya Saiagh, Sylvain Bercegeay, Cecile Braudeau, Brigitte Dreno, Gilles Blancho, Regis Josien, Maria-Cristina Cuturi, Aurelie Moreau
Summary: The study developed a GMP-compliant method for producing ATDCs and compared the phenotype and functions of ATDCs extracted from healthy volunteers and patients.
Article
Immunology
Jonathan Bromberg, Carla Baan, Jeremy Chapman, Ignacio Anegon, Daniel C. Brennan, Aron Chakera, Anita S. Chong, Edward K. Geissler, Carole Guillonneau, Nigel Heaton, Dennis A. Hesselink, Wayel Jassem, Christopher M. Jones, Regis Josien, Bruce Kaplan, Christina L. Kaufman, Wai Lim, Yun Ma, Emma Massey, Darin B. Ostrander, Mark S. Slaughter, Stefan Tullius, Piotr Witkowski, Germaine Wong
Article
Hematology
Laetitia Boucault, Maria-Dolores Lopez Robles, Allan Thiolat, Severine Bezie, Michael Schmueck-Henneresse, Cecile Braudeau, Nadege Vimond, Antoine Freuchet, Elodie Autrusseau, Frederic Charlotte, Rabah Redjoul, Florence Beckerich, Mathieu Leclerc, Eliane Piaggio, Regis Josien, Hans-Dieter Volk, Sebastien Maury, Jose L. Cohen, Ignacio Anegon, Carole Guillonneau
Article
Medical Laboratory Technology
Cecile Braudeau, Nina Salabert-Le Guen, Justine Chevreuil, Marie Rimbert, Jerome C. Martin, Regis Josien
Summary: This study presented an optimized protocol for rapid whole blood freezing with a specific solution, which allows effective preservation of various types of immune cells. The results showed a viability rate of over 75% for overall cells, with frequencies of major immune cell types comparable to fresh samples, albeit with a slight decrease in B cell frequencies.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2021)
Article
Medicine, General & Internal
Birgit Sawitzki, Paul N. Harden, Petra Reinke, Aurelie Moreau, James A. Hutchinson, David S. Game, Qizhi Tang, Eva C. Guinan, Manuela Battaglia, William J. Burlingham, Ian S. D. Roberts, Mathias Streitz, Regis Josien, Carsten A. Boeger, Cristiano Scotta, James F. Markmann, Joanna L. Hester, Karsten Juerchott, Cecile Braudeau, Ben James, Laura Contreras-Ruiz, Jeroen B. van der Net, Tobias Bergler, Rossana Caldara, William Petchey, Matthias Edinger, Nathalie Dupas, Michael Kapinsky, Ingrid Mutzbauer, Natalie M. Otto, Robert Oellinger, Maria P. Hernandez-Fuentes, Fadi Issa, Norbert Ahrens, Christoph Meyenberg, Sandra Karitzky, Ulrich Kunzendorf, Stuart J. Knechtle, Josep Grinyo, Peter J. Morris, Leslie Brent, Andrew Bushell, Laurence A. Turka, Jeffrey A. Bluestone, Robert I. Lechler, Hans J. Schlitt, Maria C. Cuturi, Stephan Schlickeiser, Peter J. Friend, Tewfik Miloud, Alexander Scheffold, Antonio Secchi, Kerry Crisalli, Sang-Mo Kang, Rachel Hilton, Bernhard Banas, Gilles Blancho, Hans-Dieter Volk, Giovanna Lombardi, Kathryn J. Wood, Edward K. Geissler
Article
Critical Care Medicine
Alexis Chenouard, Cecile Braudeau, Nicolas Cottron, Pierre Bourgoin, Nina Salabert, Antoine Roquilly, Regis Josien, Nicolas Joram, Karim Asehnoune
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2018)