Article
Biochemistry & Molecular Biology
Rene Huber, Mareike Diekmann, Leonie Hoffmeister, Friederike Kuhl, Bastian Welz, Korbinian Brand
Summary: The research investigated the impact of MARCKS on monocytic cell functions, revealing that MARCKS is an essential molecule for ROS production in monocytic cells and is involved in a signaling cascade for ROS formation.
Article
Neurosciences
Elisa Conti, Denise Grana, Federica Angiulli, Aristotelis Karantzoulis, Chiara Villa, Romina Combi, Ildebrando Appollonio, Carlo Ferrarese, Lucio Tremolizzo
Summary: Neuroinflammation is a key mechanism in Alzheimer's disease, and this study found that oligomeric Aβ(1-42) can directly induce chemotaxis of peripheral monocytes. Interestingly, monocytes from Alzheimer's patients showed a stronger response compared to controls. TSPO was identified as a potential regulator of this process. These findings are important for future therapeutic interventions targeting monocyte motility in the central nervous system.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Ilaria Campesi, Andrea Montella, Flavia Franconi
Summary: Monocytes play a critical role in inflammation and immune response, and their activity is sex-dependent. The study found that LPS treatment led to qualitative and quantitative sex differences in monocytes, with differences in autophagy, TNF-alpha release, chemotaxis, and estrogen receptor expression between male and female cells. These results indicate that sex plays a significant role in regulating monocytes' functions in a cell- and parameter-specific manner.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Cell Biology
Sipin Zhu, Mei Liu, Samuel Bennett, Ziyi Wang, Kevin D. G. Pfleger, Jiake Xu
Summary: CCL2 is an inflammatory mediator that recruits immune cells and plays a crucial role in skeletal biology and diseases. Its interaction with CCR2 activates multiple signaling cascades affecting the skeletal system.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Chunqing Wang, Xiaoqing Zhao, Liqing Zhao, Yunqiu Wang, Yan Jia, Xiaofang Zhang, Wanshan Ma
Summary: Breast cancer metastasis is influenced by chemotaxis, and PKC zeta plays a crucial role in regulating chemotaxis through its interaction with VASP and phosphorylation at Ser157. This study provides insights into the molecular mechanism of breast cancer chemotaxis and offers a theoretical basis for developing new approaches to tumor biotherapy.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell Biology
Dina B. AbuSamra, Noorjahan Panjwani, Pablo Argueso
Summary: Members of the galectin family can promote the expression and synthesis of CXCL10 independently of interferon-gamma when they come in contact with stromal fibroblasts isolated from human cornea. This highlights the potential importance of galectins in dictating the recruitment of specific leukocyte populations into precise tissue locations.
Article
Biochemistry & Molecular Biology
Anya Nikolai-Yogerst, Paula White, Makio Iwashima
Summary: The study demonstrates that IFN-beta inhibits monocyte chemotaxis towards VEGF by downregulating NRP-1 expression, suggesting a mechanism by which type I interferons suppress angiogenesis by targeting circulating monocytes.
Article
Pharmacology & Pharmacy
Brandon Dow Chan, Wing-Yan Wong, Magnolia Muk-Lan Lee, Tsz-Wing Leung, Tan-Yu Shum, William Chi-Shing Cho, Sibao Chen, William Chi-Shing Tai
Summary: Inflammatory bowel disease (IBD) is an inflammatory disease characterized by disruption of intestinal mucosa homeostasis and abnormal activation of immune cells. Inhibiting the activation of macrophages and cytokine production may be beneficial in the treatment of IBD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryutaro Takada, Tomohiro Watanabe, Akane Hara, Ikue Sekai, Masayuki Kurimoto, Yasuo Otsuka, Yasuhiro Masuta, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Summary: This study investigated the role of NOD2 in long-term adoptive transfer colitis, revealing that Rag1(-/-)Nod2(-/-) mice were more resistant to colitis with reduced proinflammatory cytokine responses and enhanced accumulation of Tregs, mediated by TGF-beta 1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Huayang Wang, Qibing Huang, Zhijie Zhang, Jian Ji, Tao Sun, Donghai Wang
Summary: The study found that CXCR2 is transiently overexpressed in peripheral monocytes of TBI patients post-surgery, which is associated with unfavorable outcomes. Serum and CSF from TBI patients promote CXCR2 expression in monocytes, and CXCR2 antagonist can decrease monocyte chemotaxis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Engineering, Biomedical
Tingting Wang, Yan Dong, Li Yao, Fan Lu, Chenxi Wen, Zhuo Wan, Li Fan, Zhelong Li, Te Bu, Mengying Wei, Xuekang Yang, Yi Zhang
Summary: This study found that diabetes aggravated atherosclerosis, and increased expression of long-chain acyl-CoA synthetase 1 (Acsl1) in macrophages played a key role. Reprogramming macrophages by knocking down Acsl1 expression had therapeutic effects on atherosclerosis in diabetic mice.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Rydell Alvarez-Arzola, Nicolo Bancaro, Ping Lai, Giuseppe Attanasio, Laura Pellegrini, Martina Troiani, Manuel Colucci, Simone Mosole, Emiliano Pasquini, Andrea Alimonti, Circe Mesa
Summary: Androgen deprivation therapy (ADT) is a standard treatment for prostate cancer, but some patients develop castration-resistant prostate cancer (CRPC). Activating ex vivo-activated macrophages as immunotherapy shows potential for treating CRPC by inhibiting tumor growth and reducing angiogenesis and proliferation.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ewa Fuc, Dagmara Zlotkowska, Ewa Wasilewska, Barbara Wroblewska
Summary: The transfer of OVA-experienced CD4(+) T cells ameliorated the negative immune response to OVA in mice with chicken meat allergy, indicating the potential role of specific T cells in food allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Xinyi Lin, Feida Li, Qing Gu, Xiaoyan Wang, Youshi Zheng, Jiong Li, Jianhua Guan, Cuiping Yao, Xiaolong Liu
Summary: This study explores a nano-immunomodulator, AuNSP@alpha CD16, to improve the antitumor effects of adoptive NK cells by remodeling the tumor microenvironment. The AuNSP can trigger mild photothermal intervention to partially destroy tumors and collapse physical barriers, allowing infiltration of NK cells. It can also modify tumor surface with CD16 antibody, leading to strong NK cell activation. The designed AuNSP@alpha CD16 induces an immune-favorable tumor microenvironment, enhancing the killing functions of NK cells against solid tumors.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Tadeja Kuret, Blaz Burja, Snezna Sodin-Semrl, Sasa Cucnik, Katja Lakota
Summary: This study characterizes the surface expression of adhesion/chemotactic molecules on monocytes in systemic sclerosis (SSc) and investigates the correlations with the clinical presentation of SSc. The results suggest that increased CD62L expression on SSc monocytes, particularly in patients positive for anti-topoisomerase I autoantibodies, provides new insights into the pathogenesis of SSc and suggests CD62L as a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)